<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A087WZ28_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Transmembrane and coiled-coil domains 3 </Name>
  <CrossRef>
    <PDBTM id="8by2">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8bxg">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4bwz">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5bz3">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5bz2">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="9emb">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="TMCO3_HUMAN">
      <Alignment>
        <CrossRefSeq>ITKREVEDDLGLSMLIDSQNNQYILTKPRDSTIPRADHHFIKDIVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLRKVWKISLQGPCYMT</CrossRefSeq>
        <OrigSeq>ITKREVEDDLGLSMLIDSQNNQYILTKPRDSTIPRADHHFIKDIVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLRKVRTSST---CYCS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="KEFC_ECOBW">
      <Alignment>
        <CrossRefSeq>HTLIQALIYLGSAALI-VPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFIIGLELDPQRLWKLRAA</CrossRefSeq>
        <OrigSeq>HHFIKDIVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLRKVRTS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="Q12SB3_SHEDO">
      <Alignment>
        <CrossRefSeq>MLEMAVIYLAAAIVAVPVAKRLGLGSVLGYLLAGILIGPFLLGLVGEQTDVMHFAEFGVVMMLFLVGLELQPSRLWKLRHSII</CrossRefSeq>
        <OrigSeq>FIKDIVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLRKVRTSST</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="YBAL_ECOLI">
      <Alignment>
        <CrossRefSeq>PLITTIVGGLVLAFILGMLANKLRISPLVGYLLAGVLAGPFTPGFVADTKLAPELAELGVILLMFGVGLHFSLKDLMAVKAIAI</CrossRefSeq>
        <OrigSeq>HFIKDIVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLRKVRTSST</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="KHA1_YEAST">
      <Alignment>
        <CrossRefSeq>FLFQACLILLVCNLIHIPFSMMRQPKVISEVISGVILGPTIFGQIPNYTNTIFPTSSIPGLNLVANLGIILFMFFLGLEVDIAFIKKHLKKALVIG</CrossRefSeq>
        <OrigSeq>FIKDIVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSI----------KSIVQVETLGEFGVFFTLFLVGLEFSPEKLRKVRTSSTCYC</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="126" CheckSum="cadd9d2e98e4e0a6fd429ca5c594a064">
    <Seq>
      ITKREVEDDL GLSMLIDSQN NQYILTKPRD STIPRADHHF IKDIVTIGML
      SLPCGWLCTA IGLPTMFGYI ICGVLLGPSG LNSIKSIVQV ETLGEFGVFF
      TLFLVGLEFS PEKLRKVRTS STCYCS
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="76.13">
    <Region from="1" to="44" loc="I"/>
    <Region from="45" to="72" loc="M"/>
    <Region from="73" to="86" loc="O"/>
    <Region from="87" to="108" loc="M"/>
    <Region from="109" to="126" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="43" loc="I"/>
      <Region from="44" to="71" loc="M"/>
      <Region from="72" to="95" loc="O"/>
      <Region from="96" to="110" loc="M"/>
      <Region from="111" to="126" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="41" loc="O"/>
      <Region from="42" to="60" loc="M"/>
      <Region from="61" to="63" loc="I"/>
      <Region from="64" to="79" loc="M"/>
      <Region from="80" to="92" loc="O"/>
      <Region from="93" to="108" loc="M"/>
      <Region from="109" to="126" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="39" loc="I"/>
      <Region from="40" to="70" loc="M"/>
      <Region from="71" to="74" loc="O"/>
      <Region from="75" to="77" loc="L"/>
      <Region from="78" to="87" loc="O"/>
      <Region from="88" to="108" loc="M"/>
      <Region from="109" to="126" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="51" loc="I"/>
      <Region from="52" to="77" loc="M"/>
      <Region from="78" to="86" loc="O"/>
      <Region from="87" to="109" loc="M"/>
      <Region from="110" to="126" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="53" loc="I"/>
      <Region from="54" to="76" loc="M"/>
      <Region from="77" to="87" loc="O"/>
      <Region from="88" to="109" loc="M"/>
      <Region from="110" to="126" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="45" loc="I"/>
      <Region from="46" to="66" loc="M"/>
      <Region from="67" to="86" loc="O"/>
      <Region from="87" to="107" loc="M"/>
      <Region from="108" to="126" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="46" loc="I"/>
      <Region from="47" to="68" loc="M"/>
      <Region from="69" to="88" loc="O"/>
      <Region from="89" to="110" loc="M"/>
      <Region from="111" to="126" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="55" loc="O"/>
      <Region from="56" to="75" loc="M"/>
      <Region from="76" to="126" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="38" loc="O"/>
      <Region from="39" to="59" loc="M"/>
      <Region from="60" to="64" loc="I"/>
      <Region from="65" to="85" loc="M"/>
      <Region from="86" to="88" loc="O"/>
      <Region from="89" to="109" loc="M"/>
      <Region from="110" to="126" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="54" loc="I"/>
      <Region from="55" to="77" loc="M"/>
      <Region from="78" to="86" loc="O"/>
      <Region from="87" to="109" loc="M"/>
      <Region from="110" to="126" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="5bz2_A">
      <ConstraintRegion from="3" to="6" loc="O" subId="17002355" subSource="5bz2_A"/>
      <ConstraintRegion from="7" to="27" loc="H" subId="17002357" subSource="5bz2_A"/>
      <ConstraintRegion from="28" to="28" loc="I" subId="17002359" subSource="5bz2_A"/>
      <ConstraintRegion from="29" to="43" loc="H" subId="17002362" subSource="5bz2_A"/>
      <ConstraintRegion from="44" to="56" loc="O" subId="17002364" subSource="5bz2_A"/>
      <ConstraintRegion from="57" to="75" loc="H" subId="17002366" subSource="5bz2_A"/>
      <ConstraintRegion from="76" to="87" loc="I" subId="17002368" subSource="5bz2_A"/>
      <ConstraintRegion from="88" to="106" loc="H" subId="17002370" subSource="5bz2_A"/>
      <ConstraintRegion from="107" to="117" loc="O" subId="17002372" subSource="5bz2_A"/>
      <ConstraintRegion from="118" to="131" loc="H" subId="17002373" subSource="5bz2_A"/>
      <ConstraintRegion from="132" to="149" loc="I" subId="17002375" subSource="5bz2_A"/>
      <ConstraintRegion from="150" to="167" loc="H" subId="17002377" subSource="5bz2_A"/>
      <ConstraintRegion from="168" to="181" loc="O" subId="17002379" subSource="5bz2_A"/>
      <ConstraintRegion from="182" to="199" loc="H" subId="17002381" subSource="5bz2_A"/>
      <ConstraintRegion from="200" to="209" loc="I" subId="17002383" subSource="5bz2_A"/>
      <ConstraintRegion from="210" to="233" loc="H" subId="17002385" subSource="5bz2_A"/>
      <ConstraintRegion from="234" to="234" loc="O" subId="17002387" subSource="5bz2_A"/>
      <ConstraintRegion from="235" to="249" loc="H" subId="17002389" subSource="5bz2_A"/>
      <ConstraintRegion from="250" to="260" loc="I" subId="17002391" subSource="5bz2_A"/>
      <ConstraintRegion from="261" to="278" loc="H" subId="17002393" subSource="5bz2_A"/>
      <ConstraintRegion from="279" to="290" loc="O" subId="17002395" subSource="5bz2_A"/>
      <ConstraintRegion from="291" to="312" loc="H" subId="17002397" subSource="5bz2_A"/>
      <ConstraintRegion from="313" to="325" loc="I" subId="17002399" subSource="5bz2_A"/>
      <ConstraintRegion from="326" to="341" loc="H" subId="17002400" subSource="5bz2_A"/>
      <ConstraintRegion from="342" to="353" loc="O" subId="17002401" subSource="5bz2_A"/>
      <ConstraintRegion from="354" to="370" loc="H" subId="17002403" subSource="5bz2_A"/>
      <ConstraintRegion from="371" to="386" loc="I" subId="17002404" subSource="5bz2_A"/>
      <ConstraintRegion from="3" to="6" loc="O" subId="17002408" subSource="5bz2_B"/>
      <ConstraintRegion from="7" to="27" loc="H" subId="17002410" subSource="5bz2_B"/>
      <ConstraintRegion from="28" to="28" loc="I" subId="17002412" subSource="5bz2_B"/>
      <ConstraintRegion from="29" to="42" loc="H" subId="17002413" subSource="5bz2_B"/>
      <ConstraintRegion from="43" to="58" loc="O" subId="17002415" subSource="5bz2_B"/>
      <ConstraintRegion from="59" to="75" loc="H" subId="17002418" subSource="5bz2_B"/>
      <ConstraintRegion from="76" to="84" loc="I" subId="17002420" subSource="5bz2_B"/>
      <ConstraintRegion from="85" to="102" loc="H" subId="17002422" subSource="5bz2_B"/>
      <ConstraintRegion from="103" to="120" loc="O" subId="17002423" subSource="5bz2_B"/>
      <ConstraintRegion from="121" to="134" loc="H" subId="17002425" subSource="5bz2_B"/>
      <ConstraintRegion from="135" to="148" loc="I" subId="17002427" subSource="5bz2_B"/>
      <ConstraintRegion from="149" to="165" loc="H" subId="17002429" subSource="5bz2_B"/>
      <ConstraintRegion from="166" to="184" loc="O" subId="17002431" subSource="5bz2_B"/>
      <ConstraintRegion from="185" to="202" loc="H" subId="17002433" subSource="5bz2_B"/>
      <ConstraintRegion from="203" to="209" loc="I" subId="17002435" subSource="5bz2_B"/>
      <ConstraintRegion from="210" to="233" loc="H" subId="17002437" subSource="5bz2_B"/>
      <ConstraintRegion from="234" to="235" loc="O" subId="17002439" subSource="5bz2_B"/>
      <ConstraintRegion from="236" to="249" loc="H" subId="17002441" subSource="5bz2_B"/>
      <ConstraintRegion from="250" to="257" loc="I" subId="17002443" subSource="5bz2_B"/>
      <ConstraintRegion from="258" to="277" loc="H" subId="17002445" subSource="5bz2_B"/>
      <ConstraintRegion from="278" to="294" loc="O" subId="17002447" subSource="5bz2_B"/>
      <ConstraintRegion from="295" to="314" loc="H" subId="17002449" subSource="5bz2_B"/>
      <ConstraintRegion from="315" to="321" loc="I" subId="17002451" subSource="5bz2_B"/>
      <ConstraintRegion from="322" to="340" loc="H" subId="17002453" subSource="5bz2_B"/>
      <ConstraintRegion from="341" to="356" loc="O" subId="17002455" subSource="5bz2_B"/>
      <ConstraintRegion from="357" to="372" loc="H" subId="17002457" subSource="5bz2_B"/>
      <ConstraintRegion from="373" to="386" loc="I" subId="17002459" subSource="5bz2_B"/>
    </Constraint>
  </Constraints>
</HtpItem>
