<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A087X0Y2_HUMAN" transmembrane="yes" evidence="3D">
  <Name>[histone H3]-trimethyl-L-lysine(27) demethylase </Name>
  <CrossRef>
    <PDBTM id="6b85">
      <Chain id="J"/>
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="E"/>
      <Chain id="F"/>
      <Chain id="G"/>
      <Chain id="H"/>
      <Chain id="I"/>
      <Chain id="K"/>
      <Chain id="L"/>
      <Chain id="M"/>
      <Chain id="N"/>
      <Chain id="O"/>
      <Chain id="P"/>
    </PDBTM>
    <PDBTM id="6vfk">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6vfh">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6vfi">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4eqf">
      <Chain id="A"/>
    </PDBTM>
  </CrossRef>
  <Sequence Length="1399" CheckSum="d0ffb737e60134c7adb3e78d22d66b1d">
    <Seq>
      MKSCAVSLTT AAVAFGDEAK KMAEGKASRE SEEESVSLTV EEREALGGMD
      SRLFGFVRLH EDGARTKTLL GKAVRCYESL ILKAEGKVES DFFCQLGHFN
      LLLEDYSKAL SAYQRYYSLQ ADYWKNAAFL YGLGLVYFYY NAFHWAIKAF
      QDVLYVDPSF CRAKEIHLRL GLMFKVNTDY KSSLKHFQLA LIDCNPCTLS
      NAEIQFHIAH LYETQRKYHS AKEAYEQLLQ TENLPAQVKA TVLQQLGWMH
      HNMDLVGDKA TKESYAIQYL QKSLEADPNS GQSWYFLGRC YSSIGKVQDA
      FISYRQSIDK SEASADTWCS IGVLYQQQNQ PMDALQAYIC AVQLDHGHAA
      AWMDLGTLYE SCNQPQDAIK CYLNAARSKR CSNTSTLAAR IKFLQAYRAH
      DPNTEHVLNH SQTPILQQSL SLHMITSSQV EGLSSPAKKK RTSSPTKNGS
      DNWNGGQSLS HHPVQQVYSL CLTPQKLQHL EQLRANRDNL NPAQKHQLEQ
      LESQFVLMQQ MRHKEVAQVR TTGIHNGAIT DSSLPTNSVS NRQPHGALTR
      VSSVSQPGVR PACVEKLLSS GAFSAGCIPC GTSKILGSTD TILLGSNCIA
      GSESNGNVPY LQQNTHTLPH NHTDLNSSTE EPWRKQLSNS AQGLHKSQSS
      CLSGPNEEQP LFSTGSAQYH QATSTGIKKA NEHLTLPSNS VPQGDADSHL
      SCHTATSGGQ QGIMFTKESK PSKNRSLVPE TSRHTGDTSN GCADVKGLSN
      HVHQLIADAV SSPNHGDSPN LLIADNPQLS ALLIGKANGN VGTGTCDKVN
      NIHPAVHTKT DHSVASSPSS AISTATPSPK STEQRSINSV TSLNSPHSGL
      HTVNGEGLGK SQSSTKVDLP LASHRSTSQI LPSMSVSICP SSTEVLKACR
      NPGKNGLSNS CILLDKCPPP RPPTSPYPPL PKDKLNPPTP SIYLENKRDA
      FFPPLHQFCT NPKNPVTVIR GLAGALKLDL GLFSTKTLVE ANNEHMVEVR
      TQLLQPADEN WDPTGTKKIW RCESNRSHTT IAKYAQYQAS SFQESLREEN
      EKRTQHKDHS DNESTSSENS GRRRKGPFKT IKFGTNIDLS DNKKWKLQLH
      ELTKLPAFAR VVSAGNLLTH VGHTILGMNT VQLYMKVPGS RTPGHQENNN
      FCSVNINIGP GDCEWFVVPE DYWGVLNDFC EKNNLNFLMS SWWPNLEDLY
      EANVPVYRFI QRPGDLVWIN AGTVHWVQAV GWCNNIAWNV GPLTACQYKL
      AVERYEWNKL KSVKSPVPMV HLSWNMARNI KVSDPKLFEM IKYCLLKILK
      QYQTLREALV AAGKEVIWHG RTNDEPAHYC SICEVEVFNL LFVTNESNTQ
      KTYIVHCHDC ARKTSKSLEN FVVLEQYKME DLIQVYDQFT LALSLSSSS
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="68.58">
    <Region from="1" to="963" loc="I"/>
    <Region from="964" to="975" loc="M"/>
    <Region from="976" to="1104" loc="O"/>
    <Region from="1105" to="1116" loc="M"/>
    <Region from="1117" to="1399" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="126" loc="I"/>
      <Region from="127" to="138" loc="M"/>
      <Region from="139" to="1399" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="958" loc="I"/>
      <Region from="959" to="974" loc="M"/>
      <Region from="975" to="1399" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="3" loc="O"/>
      <Region from="4" to="24" loc="M"/>
      <Region from="25" to="55" loc="I"/>
      <Region from="56" to="76" loc="M"/>
      <Region from="77" to="92" loc="O"/>
      <Region from="93" to="97" loc="L"/>
      <Region from="98" to="124" loc="O"/>
      <Region from="125" to="145" loc="M"/>
      <Region from="146" to="382" loc="I"/>
      <Region from="383" to="392" loc="L"/>
      <Region from="393" to="963" loc="I"/>
      <Region from="964" to="984" loc="M"/>
      <Region from="985" to="1106" loc="O"/>
      <Region from="1107" to="1112" loc="L"/>
      <Region from="1113" to="1217" loc="O"/>
      <Region from="1218" to="1248" loc="M"/>
      <Region from="1249" to="1399" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region/>
    </Prediction>
    <Prediction name="Phobius">
      <Region/>
    </Prediction>
    <Prediction name="Pro">
      <Region/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="1105" loc="I"/>
      <Region from="1106" to="1125" loc="M"/>
      <Region from="1126" to="1221" loc="O"/>
      <Region from="1222" to="1242" loc="M"/>
      <Region from="1243" to="1399" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="122" loc="I"/>
      <Region from="123" to="145" loc="M"/>
      <Region from="146" to="1399" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="6b85_J">
      <ConstraintRegion from="1" to="8" loc="I" subId="16988111" subSource="6b85_J"/>
      <ConstraintRegion from="9" to="31" loc="H" subId="16988112" subSource="6b85_J"/>
      <ConstraintRegion from="32" to="42" loc="O" subId="16988113" subSource="6b85_J"/>
      <ConstraintRegion from="43" to="65" loc="H" subId="16988115" subSource="6b85_J"/>
      <ConstraintRegion from="66" to="215" loc="I" subId="16988117" subSource="6b85_J"/>
      <ConstraintRegion from="1" to="8" loc="I" subId="16988121" subSource="6b85_D"/>
      <ConstraintRegion from="9" to="31" loc="H" subId="16988123" subSource="6b85_D"/>
      <ConstraintRegion from="32" to="42" loc="O" subId="16988125" subSource="6b85_D"/>
      <ConstraintRegion from="43" to="65" loc="H" subId="16988127" subSource="6b85_D"/>
      <ConstraintRegion from="66" to="215" loc="I" subId="16988129" subSource="6b85_D"/>
      <ConstraintRegion from="1" to="8" loc="I" subId="16988134" subSource="6b85_E"/>
      <ConstraintRegion from="9" to="31" loc="H" subId="16988135" subSource="6b85_E"/>
      <ConstraintRegion from="32" to="42" loc="O" subId="16988137" subSource="6b85_E"/>
      <ConstraintRegion from="43" to="65" loc="H" subId="16988139" subSource="6b85_E"/>
      <ConstraintRegion from="66" to="215" loc="I" subId="16988141" subSource="6b85_E"/>
      <ConstraintRegion from="1" to="8" loc="I" subId="16988147" subSource="6b85_F"/>
      <ConstraintRegion from="9" to="31" loc="H" subId="16988149" subSource="6b85_F"/>
      <ConstraintRegion from="32" to="42" loc="O" subId="16988152" subSource="6b85_F"/>
      <ConstraintRegion from="43" to="65" loc="H" subId="16988155" subSource="6b85_F"/>
      <ConstraintRegion from="66" to="215" loc="I" subId="16988158" subSource="6b85_F"/>
    </Constraint>
  </Constraints>
</HtpItem>
