<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A087X1C4_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Transmembrane phosphatase with tensin homology </Name>
  <CrossRef>
    <PDBTM id="4g7v">
      <Chain id="S"/>
    </PDBTM>
    <PDBTM id="4g80">
      <Chain id="T"/>
      <Chain id="I"/>
      <Chain id="J"/>
      <Chain id="S"/>
    </PDBTM>
    <PDBTM id="4g7y">
      <Chain id="S"/>
    </PDBTM>
    <TOPDB id="Q4W8A1_CIOIN">
      <Alignment>
        <CrossRefSeq>VRAVIDHLGMRVFGVFLIFLDIILMIIDLSLPGKSESSQSFYDGMALALSCYFMLDLGLRIFAYGPKNFFTN</CrossRefSeq>
        <OrigSeq>VHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSD</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="140" CheckSum="b9aa642a310b4f64e17e3defe5632dfb">
    <Seq>
      MNESPDPTDL AGVIIELGPN DSPHTSEFKG AARVSPISES VLARLSKFEV
      EDAENVASYD SKIKKIVHSI VSSFAFGLFG VFLVLLDVTL ILADLIFTDS
      KLYIPLEYRS ISLAIALFFL MDVLLRVFVE RRQQYFSDLF 
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="95.63">
    <Region from="1" to="69" loc="I"/>
    <Region from="70" to="92" loc="M"/>
    <Region from="93" to="108" loc="O"/>
    <Region from="109" to="128" loc="M"/>
    <Region from="129" to="140" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="69" loc="I"/>
      <Region from="70" to="93" loc="M"/>
      <Region from="94" to="110" loc="O"/>
      <Region from="111" to="125" loc="M"/>
      <Region from="126" to="140" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="67" loc="I"/>
      <Region from="68" to="95" loc="M"/>
      <Region from="96" to="108" loc="O"/>
      <Region from="109" to="127" loc="M"/>
      <Region from="128" to="140" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="66" loc="I"/>
      <Region from="67" to="97" loc="M"/>
      <Region from="98" to="108" loc="O"/>
      <Region from="109" to="129" loc="M"/>
      <Region from="130" to="140" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="69" loc="I"/>
      <Region from="70" to="93" loc="M"/>
      <Region from="94" to="107" loc="O"/>
      <Region from="108" to="129" loc="M"/>
      <Region from="130" to="140" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="73" loc="I"/>
      <Region from="74" to="98" loc="M"/>
      <Region from="99" to="109" loc="O"/>
      <Region from="110" to="129" loc="M"/>
      <Region from="130" to="140" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="71" loc="I"/>
      <Region from="72" to="92" loc="M"/>
      <Region from="93" to="108" loc="O"/>
      <Region from="109" to="129" loc="M"/>
      <Region from="130" to="140" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="67" loc="I"/>
      <Region from="68" to="88" loc="M"/>
      <Region from="89" to="108" loc="O"/>
      <Region from="109" to="129" loc="M"/>
      <Region from="130" to="140" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="72" loc="I"/>
      <Region from="73" to="93" loc="M"/>
      <Region from="94" to="107" loc="O"/>
      <Region from="108" to="128" loc="M"/>
      <Region from="129" to="140" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="72" loc="I"/>
      <Region from="73" to="93" loc="M"/>
      <Region from="94" to="107" loc="O"/>
      <Region from="108" to="128" loc="M"/>
      <Region from="129" to="140" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="69" loc="I"/>
      <Region from="70" to="92" loc="M"/>
      <Region from="93" to="106" loc="O"/>
      <Region from="107" to="129" loc="M"/>
      <Region from="130" to="140" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="4g7v_S">
      <ConstraintRegion from="139" to="148" loc="O" subId="17089448" subSource="4g7v_S"/>
      <ConstraintRegion from="205" to="209" loc="O" subId="17089452" subSource="4g7v_S"/>
      <ConstraintRegion from="101" to="104" loc="I" subId="17089444" subSource="4g7v_S"/>
      <ConstraintRegion from="114" to="120" loc="I" subId="17089446" subSource="4g7v_S"/>
      <ConstraintRegion from="168" to="182" loc="I" subId="17089450" subSource="4g7v_S"/>
      <ConstraintRegion from="235" to="236" loc="I" subId="17089454" subSource="4g7v_S"/>
      <ConstraintRegion from="105" to="113" loc="F" subId="17089445" subSource="4g7v_S"/>
      <ConstraintRegion from="121" to="138" loc="H" subId="17089447" subSource="4g7v_S"/>
      <ConstraintRegion from="149" to="167" loc="H" subId="17089449" subSource="4g7v_S"/>
      <ConstraintRegion from="183" to="204" loc="H" subId="17089451" subSource="4g7v_S"/>
      <ConstraintRegion from="210" to="234" loc="H" subId="17089453" subSource="4g7v_S"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="4g80_T">
      <ConstraintRegion from="106" to="118" loc="I" subId="17089211" subSource="4g80_T"/>
      <ConstraintRegion from="170" to="182" loc="I" subId="17089215" subSource="4g80_T"/>
      <ConstraintRegion from="232" to="236" loc="I" subId="17089219" subSource="4g80_T"/>
      <ConstraintRegion from="244" to="244" loc="I" subId="17089221" subSource="4g80_T"/>
      <ConstraintRegion from="141" to="145" loc="O" subId="17089213" subSource="4g80_T"/>
      <ConstraintRegion from="205" to="212" loc="O" subId="17089217" subSource="4g80_T"/>
      <ConstraintRegion from="237" to="243" loc="F" subId="17089220" subSource="4g80_T"/>
      <ConstraintRegion from="119" to="140" loc="H" subId="17089212" subSource="4g80_T"/>
      <ConstraintRegion from="146" to="169" loc="H" subId="17089214" subSource="4g80_T"/>
      <ConstraintRegion from="183" to="204" loc="H" subId="17089216" subSource="4g80_T"/>
      <ConstraintRegion from="213" to="231" loc="H" subId="17089218" subSource="4g80_T"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="4g80_S">
      <ConstraintRegion from="106" to="118" loc="I" subId="17089200" subSource="4g80_S"/>
      <ConstraintRegion from="170" to="182" loc="I" subId="17089204" subSource="4g80_S"/>
      <ConstraintRegion from="232" to="233" loc="I" subId="17089208" subSource="4g80_S"/>
      <ConstraintRegion from="141" to="146" loc="O" subId="17089202" subSource="4g80_S"/>
      <ConstraintRegion from="205" to="212" loc="O" subId="17089206" subSource="4g80_S"/>
      <ConstraintRegion from="119" to="140" loc="H" subId="17089201" subSource="4g80_S"/>
      <ConstraintRegion from="147" to="169" loc="H" subId="17089203" subSource="4g80_S"/>
      <ConstraintRegion from="183" to="204" loc="H" subId="17089205" subSource="4g80_S"/>
      <ConstraintRegion from="213" to="231" loc="H" subId="17089207" subSource="4g80_S"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="4g7y_S">
      <ConstraintRegion from="139" to="148" loc="O" subId="17089482" subSource="4g7y_S"/>
      <ConstraintRegion from="205" to="209" loc="O" subId="17089493" subSource="4g7y_S"/>
      <ConstraintRegion from="104" to="106" loc="I" subId="17089476" subSource="4g7y_S"/>
      <ConstraintRegion from="172" to="173" loc="I" subId="17089486" subSource="4g7y_S"/>
      <ConstraintRegion from="180" to="180" loc="I" subId="17089490" subSource="4g7y_S"/>
      <ConstraintRegion from="107" to="113" loc="F" subId="17089478" subSource="4g7y_S"/>
      <ConstraintRegion from="174" to="179" loc="F" subId="17089488" subSource="4g7y_S"/>
      <ConstraintRegion from="114" to="138" loc="H" subId="17089480" subSource="4g7y_S"/>
      <ConstraintRegion from="149" to="171" loc="H" subId="17089484" subSource="4g7y_S"/>
      <ConstraintRegion from="181" to="204" loc="H" subId="17089492" subSource="4g7y_S"/>
      <ConstraintRegion from="210" to="234" loc="H" subId="17089494" subSource="4g7y_S"/>
    </Constraint>
  </Constraints>
</HtpItem>
