<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A0C4DGN3_HUMAN" transmembrane="yes" evidence="3D">
  <Name>ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 </Name>
  <CrossRef>
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      <Chain id="A"/>
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    <PDBTM id="6zhg">
      <Chain id="A"/>
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    <PDBTM id="6a69">
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="AT2A2_MOUSE">
      <Alignment>
        <CrossRefSeq>ESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNLTQWLMVLKISLPVILMDETLKFVARNYLEQ</CrossRefSeq>
        <OrigSeq>ESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSRNHMHA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ATC1_YEAST">
      <Alignment>
        <CrossRefSeq>TARDTTMTFTCFVFFDMFNALACRHNTKSIFEIGFFTNKMFNYAVGLSLLGQMCAIYIPFFQSIFKTEKLGISDILLLLLISSSVFIVDELRKLWTRKKNEEDS</CrossRefSeq>
        <OrigSeq>SRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSRNHMHACL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ATP4A_RABIT">
      <Alignment>
        <CrossRefSeq>TVFFISIEMCQIADVLIRKTRRLSAFQQGFFRNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGVR</CrossRefSeq>
        <OrigSeq>TMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ATP4A_PIG">
      <Alignment>
        <CrossRefSeq>TVFFISIEMCQIADVLIRKTRRLSAFQQGFFRNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGVR</CrossRefSeq>
        <OrigSeq>TMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ACA8_ARATH">
      <Alignment>
        <CrossRefSeq>TRVKNTIIFNAFVLCQAFNEFNARKPDEKNIFKGVIKNRLFMGIIVITLVLQVII--VEFLGKFASTTKLNWKQWLICVGIGVISWPLALVGKFI</CrossRefSeq>
        <OrigSeq>SRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ACA2_ARATH">
      <Alignment>
        <CrossRefSeq>NTLIFNCFVFCQVFNEISSREMEEIDVFKGILDNYVFVVVIGATVFFQIIII--EFLGTFASTTPLTITQWIFSIFIGFLGMPIAAGLKTI</CrossRefSeq>
        <OrigSeq>TTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="AT2B2_HUMAN">
      <Alignment>
        <CrossRefSeq>TIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKP--FSCSPLQLDQWMWCIFIGL</CrossRefSeq>
        <OrigSeq>TMALSVLVTIEMCNALNSVS-ENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="AT2B1_HUMAN">
      <Alignment>
        <CrossRefSeq>TIVFNTFVLMQLFNEINARKIHGERNVFE-GIFNNAIFCTIVLGTFVVQIIIVQFGGKP--FSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLK</CrossRefSeq>
        <OrigSeq>TMALSVLVTIEMCNALNSV--SENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSRNHMH</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="153" CheckSum="b524324c4b976ffa3bf85d9e1db7ff8b">
    <Seq>
      ESRFPTTMAL SVLVTIEMCN ALNSVSENQS LLRMPPWMNP WLLVAVAMSM
      ALHFLILLVP PLPLIFQVTP LSGRQWVVVL QISLPVILLD EALKYLSRNH
      MHACLYPGLL RTVSQAWSRQ PLTTSWTPDH TGARDTASSR CQSCSEREEA
      GKK
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="65.44">
    <Region from="1" to="39" loc="I"/>
    <Region from="40" to="59" loc="M"/>
    <Region from="60" to="75" loc="O"/>
    <Region from="76" to="89" loc="M"/>
    <Region from="90" to="153" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="8" loc="O"/>
      <Region from="9" to="25" loc="M"/>
      <Region from="26" to="41" loc="I"/>
      <Region from="42" to="59" loc="M"/>
      <Region from="60" to="76" loc="O"/>
      <Region from="77" to="89" loc="M"/>
      <Region from="90" to="153" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="7" loc="O"/>
      <Region from="8" to="23" loc="M"/>
      <Region from="24" to="41" loc="I"/>
      <Region from="42" to="60" loc="M"/>
      <Region from="61" to="75" loc="O"/>
      <Region from="76" to="95" loc="M"/>
      <Region from="96" to="153" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="16" loc="O"/>
      <Region from="17" to="19" loc="L"/>
      <Region from="20" to="39" loc="O"/>
      <Region from="40" to="60" loc="M"/>
      <Region from="61" to="71" loc="I"/>
      <Region from="72" to="92" loc="M"/>
      <Region from="93" to="153" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="40" loc="I"/>
      <Region from="41" to="62" loc="M"/>
      <Region from="63" to="76" loc="O"/>
      <Region from="77" to="93" loc="M"/>
      <Region from="94" to="153" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="40" loc="I"/>
      <Region from="41" to="62" loc="M"/>
      <Region from="63" to="73" loc="O"/>
      <Region from="74" to="93" loc="M"/>
      <Region from="94" to="153" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="4" loc="O"/>
      <Region from="5" to="25" loc="M"/>
      <Region from="26" to="36" loc="I"/>
      <Region from="37" to="57" loc="M"/>
      <Region from="58" to="153" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="4" loc="O"/>
      <Region from="5" to="25" loc="M"/>
      <Region from="26" to="36" loc="I"/>
      <Region from="37" to="57" loc="M"/>
      <Region from="58" to="68" loc="O"/>
      <Region from="69" to="89" loc="M"/>
      <Region from="90" to="153" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="39" loc="I"/>
      <Region from="40" to="60" loc="M"/>
      <Region from="61" to="153" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="38" loc="I"/>
      <Region from="39" to="59" loc="M"/>
      <Region from="60" to="153" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="43" loc="O"/>
      <Region from="44" to="66" loc="M"/>
      <Region from="67" to="153" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="B6CAM1_RABIT">
      <ConstraintRegion from="1" to="53" loc="I" subId="17035776" subSource="2dqs_A"/>
      <ConstraintRegion from="54" to="73" loc="H" subId="17035778" subSource="2dqs_A"/>
      <ConstraintRegion from="74" to="89" loc="O" subId="17035780" subSource="2dqs_A"/>
      <ConstraintRegion from="90" to="111" loc="H" subId="17035782" subSource="2dqs_A"/>
      <ConstraintRegion from="112" to="253" loc="I" subId="17035784" subSource="2dqs_A"/>
      <ConstraintRegion from="254" to="276" loc="H" subId="17035787" subSource="2dqs_A"/>
      <ConstraintRegion from="277" to="295" loc="O" subId="17035789" subSource="2dqs_A"/>
      <ConstraintRegion from="296" to="318" loc="H" subId="17035791" subSource="2dqs_A"/>
      <ConstraintRegion from="319" to="759" loc="I" subId="17035793" subSource="2dqs_A"/>
      <ConstraintRegion from="760" to="781" loc="H" subId="17035795" subSource="2dqs_A"/>
      <ConstraintRegion from="782" to="785" loc="O" subId="17035796" subSource="2dqs_A"/>
      <ConstraintRegion from="786" to="808" loc="H" subId="17035797" subSource="2dqs_A"/>
      <ConstraintRegion from="809" to="832" loc="I" subId="17035799" subSource="2dqs_A"/>
      <ConstraintRegion from="833" to="852" loc="H" subId="17035801" subSource="2dqs_A"/>
      <ConstraintRegion from="853" to="897" loc="O" subId="17035803" subSource="2dqs_A"/>
      <ConstraintRegion from="898" to="916" loc="H" subId="17035805" subSource="2dqs_A"/>
      <ConstraintRegion from="917" to="926" loc="I" subId="17035806" subSource="2dqs_A"/>
      <ConstraintRegion from="927" to="948" loc="H" subId="17035808" subSource="2dqs_A"/>
      <ConstraintRegion from="949" to="966" loc="O" subId="17035810" subSource="2dqs_A"/>
      <ConstraintRegion from="967" to="987" loc="H" subId="17035812" subSource="2dqs_A"/>
      <ConstraintRegion from="988" to="993" loc="I" subId="17035814" subSource="2dqs_A"/>
      <ConstraintRegion from="1" to="56" loc="I" subId="18963120" subSource="2zbd_A"/>
      <ConstraintRegion from="57" to="78" loc="H" subId="18963121" subSource="2zbd_A"/>
      <ConstraintRegion from="79" to="85" loc="O" subId="18963122" subSource="2zbd_A"/>
      <ConstraintRegion from="86" to="104" loc="H" subId="18963123" subSource="2zbd_A"/>
      <ConstraintRegion from="105" to="257" loc="I" subId="18963124" subSource="2zbd_A"/>
      <ConstraintRegion from="258" to="276" loc="H" subId="18963125" subSource="2zbd_A"/>
      <ConstraintRegion from="277" to="292" loc="O" subId="18963126" subSource="2zbd_A"/>
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</HtpItem>
