<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A0G2JMP8_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>Transmembrane channel-like protein </Name>
  <CrossRef>
    <PDBTM id="8tkp">
      <Chain id="A"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="7usw">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7usx">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7usy">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6wud">
      <Chain id="B"/>
    </PDBTM>
    <TOPDB id="TMC1_MOUSE">
      <Alignment>
        <CrossRefSeq>RLKALLDENRQMIATVKCKPWKMEKKIEVLKEAKKFVSENEGALGKGKGKKWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFVLTFSLIMLPEYLWGLPYGSL-PRKTVP----RAEEASAANFGV----LYDFNGLAQYSVLFYGYYDNKRTIGWLNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNIGDDGGG-DDNTFNFSWKVFCSWDYLIGNPETADNK----FNSITMNFKEAIIEERAAQVEENIHLIRFL-RFLANFFVFLTLGASGYLIFWAVKRSQEFAQ----QDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNESLSGLSGNTTGAPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLTIYYLNATAKGQKAANLDLKKKMKQQALENKM</CrossRefSeq>
        <OrigSeq>AFTEVTQTELQDPHPSRELPWPMQARRAYRQR-----NASRDQVVYGSGTKTDRWARLLRRSKEKTKEGLRSL----QPWAWTLKRIGGQFGAGTESYFSLLRFLLLLNVLASVLMACMTLLPTWLGGAPPGPPGPDISSPCGSYNPHSQGLVTFATQLFNLLSGEGYLEWSPLFYGFYPPRP-------RLAVTYLCWAFAVGLICLLLILHRSVSGLKQTLLAESEALTSYSHRVFSAWDFGLCGDVHVRLRQRIILYELKVELEETVVRRQAAVRTLGQQARVWLVRVLLNLLVVALLGAAFYGVYWATGCTVELQEMPLVQELPLLKLGVNYLPSIFIAGVNFVLPPVFKLIAPLEGYTRSRQIVFILLRTVFLRLASLVVLLFSLWNQITCGGDSEA------------------------------EDCKTCGYNYKQLPCWETVLGQEMYKLLLFDLLTVLAVALLIQFPRKLLCG-----LCPGALGRLAGTQEFQVPDEVLGLIYAQTVVWVGSFFCPLLPLLNTVKFLLLFYLKKLTLFSTCSPAARTFRASAANFFFPLVLLLGLAISSVPLLYSIFLIPPSKLCGPFRGQSSIWAQIPESIS-SLPETTQNFLFFLGTQAFAVPLLLISSILMAYTVALANSYGRLISELKRQRQTEA-QNKV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TMC2_CAEEL">
      <Alignment>
        <CrossRefSeq>WNETTVNAASPTGATTRASLRMSQGGLCWETIIGQEITKLVTMDLYMTVASIFLIDFLRGLACRYLNLYWPWDLERTFPEYGEFKVAENVLHLVNNQGMIWLGLFFVPLLPMLNNIKLIILMYIRGWAAMTCNVPASQIFRASRSSNFFFALLILFLFLCTLPVGFVIASKTPSKSCGPFGNQSFFYSVITDVLHENLDKTLVNGIKYSLSPGIIIPVLVLLSLVIYFLIAMVTGLSQANQDLSFQLMVERTEEKKKIFELAGGKKKK</CrossRefSeq>
        <OrigSeq>LWNQITCGGDSEAEDCKTCGYNYKQLPCWETVLGQEMYKLLLFDLLTVLAVALLIQFPRKLLCG-----LCPGALGRLAGTQEFQVPDEVLGLIYAQTVVWVGSFFCPLLPLLNTVKFLLLFYLKKLTLFSTCSPAARTFRASAANFFFPLVLLLGLAISSVPLLYSIFLIPPSKLCGPFRGQSSIWAQIPESI-SSLPETTQNFLFFLGTQAFAVPLLLISSILMAYTVALANSYGRLISELKRQRQTEAQNKVFLARRAVALTSTK</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="706" CheckSum="1ec73cc1224af36d706bae0fc5fe4b55">
    <Seq>
      MEENPTLESE AWGSSREWLA PREARGGPSL SSVLNELPSA ATLRYRDPGV
      LPWGALEEEE EDGGRSRKAF TEVTQTELQD PHPSRELPWP MQARRAYRQR
      NASRDQVVYG SGTKTDRWAR LLRRSKEKTK EGLRSLQPWA WTLKRIGGQF
      GAGTESYFSL LRFLLLLNVL ASVLMACMTL LPTWLGGAPP GPPGPDISSP
      CGSYNPHSQG LVTFATQLFN LLSGEGYLEW SPLFYGFYPP RPRLAVTYLC
      WAFAVGLICL LLILHRSVSG LKQTLLAESE ALTSYSHRVF SAWDFGLCGD
      VHVRLRQRII LYELKVELEE TVVRRQAAVR TLGQQARVWL VRVLLNLLVV
      ALLGAAFYGV YWATGCTVEL QEMPLVQELP LLKLGVNYLP SIFIAGVNFV
      LPPVFKLIAP LEGYTRSRQI VFILLRTVFL RLASLVVLLF SLWNQITCGG
      DSEAEDCKTC GYNYKQLPCW ETVLGQEMYK LLLFDLLTVL AVALLIQFPR
      KLLCGLCPGA LGRLAGTQEF QVPDEVLGLI YAQTVVWVGS FFCPLLPLLN
      TVKFLLLFYL KKLTLFSTCS PAARTFRASA ANFFFPLVLL LGLAISSVPL
      LYSIFLIPPS KLCGPFRGQS SIWAQIPESI SSLPETTQNF LFFLGTQAFA
      VPLLLISSIL MAYTVALANS YGRLISELKR QRQTEAQNKV FLARRAVALT
      STKPAL
    </Seq>
  </Sequence>
  <Topology numTm="8" reliability="88.83">
    <Region from="1" to="162" loc="I"/>
    <Region from="163" to="181" loc="M"/>
    <Region from="182" to="243" loc="O"/>
    <Region from="244" to="263" loc="M"/>
    <Region from="264" to="339" loc="I"/>
    <Region from="340" to="361" loc="M"/>
    <Region from="362" to="385" loc="O"/>
    <Region from="386" to="405" loc="M"/>
    <Region from="406" to="419" loc="I"/>
    <Region from="420" to="440" loc="M"/>
    <Region from="441" to="533" loc="O"/>
    <Region from="534" to="558" loc="M"/>
    <Region from="559" to="582" loc="I"/>
    <Region from="583" to="604" loc="M"/>
    <Region from="605" to="647" loc="O"/>
    <Region from="648" to="667" loc="M"/>
    <Region from="668" to="706" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="162" loc="I"/>
      <Region from="163" to="181" loc="M"/>
      <Region from="182" to="243" loc="O"/>
      <Region from="244" to="264" loc="M"/>
      <Region from="265" to="342" loc="I"/>
      <Region from="343" to="364" loc="M"/>
      <Region from="365" to="534" loc="O"/>
      <Region from="535" to="560" loc="M"/>
      <Region from="561" to="579" loc="I"/>
      <Region from="580" to="607" loc="M"/>
      <Region from="608" to="647" loc="O"/>
      <Region from="648" to="668" loc="M"/>
      <Region from="669" to="706" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="154" loc="I"/>
      <Region from="155" to="185" loc="M"/>
      <Region from="186" to="245" loc="O"/>
      <Region from="246" to="267" loc="M"/>
      <Region from="268" to="338" loc="I"/>
      <Region from="339" to="364" loc="M"/>
      <Region from="365" to="389" loc="O"/>
      <Region from="390" to="406" loc="M"/>
      <Region from="407" to="421" loc="I"/>
      <Region from="422" to="443" loc="M"/>
      <Region from="444" to="478" loc="O"/>
      <Region from="479" to="506" loc="M"/>
      <Region from="507" to="527" loc="I"/>
      <Region from="528" to="549" loc="M"/>
      <Region from="550" to="552" loc="O"/>
      <Region from="553" to="568" loc="M"/>
      <Region from="569" to="582" loc="I"/>
      <Region from="583" to="605" loc="M"/>
      <Region from="606" to="640" loc="O"/>
      <Region from="641" to="667" loc="M"/>
      <Region from="668" to="706" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="151" loc="I"/>
      <Region from="152" to="166" loc="M"/>
      <Region from="167" to="167" loc="O"/>
      <Region from="168" to="182" loc="M"/>
      <Region from="183" to="205" loc="I"/>
      <Region from="206" to="236" loc="M"/>
      <Region from="237" to="243" loc="O"/>
      <Region from="244" to="264" loc="M"/>
      <Region from="265" to="341" loc="I"/>
      <Region from="342" to="362" loc="M"/>
      <Region from="363" to="385" loc="O"/>
      <Region from="386" to="406" loc="M"/>
      <Region from="407" to="420" loc="I"/>
      <Region from="421" to="441" loc="M"/>
      <Region from="442" to="483" loc="O"/>
      <Region from="484" to="504" loc="M"/>
      <Region from="505" to="527" loc="I"/>
      <Region from="528" to="542" loc="M"/>
      <Region from="543" to="543" loc="O"/>
      <Region from="544" to="558" loc="M"/>
      <Region from="559" to="580" loc="I"/>
      <Region from="581" to="601" loc="M"/>
      <Region from="602" to="644" loc="O"/>
      <Region from="645" to="665" loc="M"/>
      <Region from="666" to="706" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="163" loc="I"/>
      <Region from="164" to="185" loc="M"/>
      <Region from="186" to="243" loc="O"/>
      <Region from="244" to="264" loc="M"/>
      <Region from="265" to="337" loc="I"/>
      <Region from="338" to="361" loc="M"/>
      <Region from="362" to="387" loc="O"/>
      <Region from="388" to="409" loc="M"/>
      <Region from="410" to="421" loc="I"/>
      <Region from="422" to="443" loc="M"/>
      <Region from="444" to="534" loc="O"/>
      <Region from="535" to="557" loc="M"/>
      <Region from="558" to="582" loc="I"/>
      <Region from="583" to="606" loc="M"/>
      <Region from="607" to="647" loc="O"/>
      <Region from="648" to="672" loc="M"/>
      <Region from="673" to="706" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="162" loc="I"/>
      <Region from="163" to="185" loc="M"/>
      <Region from="186" to="244" loc="O"/>
      <Region from="245" to="264" loc="M"/>
      <Region from="265" to="338" loc="I"/>
      <Region from="339" to="363" loc="M"/>
      <Region from="364" to="387" loc="O"/>
      <Region from="388" to="408" loc="M"/>
      <Region from="409" to="419" loc="I"/>
      <Region from="420" to="443" loc="M"/>
      <Region from="444" to="477" loc="O"/>
      <Region from="478" to="496" loc="M"/>
      <Region from="497" to="582" loc="I"/>
      <Region from="583" to="607" loc="M"/>
      <Region from="608" to="648" loc="O"/>
      <Region from="649" to="672" loc="M"/>
      <Region from="673" to="706" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="162" loc="I"/>
      <Region from="163" to="183" loc="M"/>
      <Region from="184" to="243" loc="O"/>
      <Region from="244" to="264" loc="M"/>
      <Region from="265" to="342" loc="I"/>
      <Region from="343" to="363" loc="M"/>
      <Region from="364" to="383" loc="O"/>
      <Region from="384" to="404" loc="M"/>
      <Region from="405" to="419" loc="I"/>
      <Region from="420" to="440" loc="M"/>
      <Region from="441" to="537" loc="O"/>
      <Region from="538" to="558" loc="M"/>
      <Region from="559" to="578" loc="I"/>
      <Region from="579" to="599" loc="M"/>
      <Region from="600" to="647" loc="O"/>
      <Region from="648" to="668" loc="M"/>
      <Region from="669" to="706" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="163" loc="I"/>
      <Region from="164" to="184" loc="M"/>
      <Region from="185" to="243" loc="O"/>
      <Region from="244" to="264" loc="M"/>
      <Region from="265" to="342" loc="I"/>
      <Region from="343" to="363" loc="M"/>
      <Region from="364" to="383" loc="O"/>
      <Region from="384" to="404" loc="M"/>
      <Region from="405" to="419" loc="I"/>
      <Region from="420" to="440" loc="M"/>
      <Region from="441" to="478" loc="O"/>
      <Region from="479" to="499" loc="M"/>
      <Region from="500" to="501" loc="I"/>
      <Region from="502" to="522" loc="M"/>
      <Region from="523" to="542" loc="O"/>
      <Region from="543" to="563" loc="M"/>
      <Region from="564" to="583" loc="I"/>
      <Region from="584" to="604" loc="M"/>
      <Region from="605" to="647" loc="O"/>
      <Region from="648" to="668" loc="M"/>
      <Region from="669" to="706" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="159" loc="I"/>
      <Region from="160" to="180" loc="M"/>
      <Region from="181" to="243" loc="O"/>
      <Region from="244" to="263" loc="M"/>
      <Region from="264" to="335" loc="I"/>
      <Region from="336" to="355" loc="M"/>
      <Region from="356" to="387" loc="O"/>
      <Region from="388" to="407" loc="M"/>
      <Region from="408" to="426" loc="I"/>
      <Region from="427" to="446" loc="M"/>
      <Region from="447" to="477" loc="O"/>
      <Region from="478" to="497" loc="M"/>
      <Region from="498" to="525" loc="I"/>
      <Region from="526" to="545" loc="M"/>
      <Region from="546" to="547" loc="O"/>
      <Region from="548" to="567" loc="M"/>
      <Region from="568" to="586" loc="I"/>
      <Region from="587" to="606" loc="M"/>
      <Region from="607" to="647" loc="O"/>
      <Region from="648" to="668" loc="M"/>
      <Region from="669" to="706" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="160" loc="I"/>
      <Region from="161" to="181" loc="M"/>
      <Region from="182" to="242" loc="O"/>
      <Region from="243" to="263" loc="M"/>
      <Region from="264" to="339" loc="I"/>
      <Region from="340" to="360" loc="M"/>
      <Region from="361" to="387" loc="O"/>
      <Region from="388" to="408" loc="M"/>
      <Region from="409" to="426" loc="I"/>
      <Region from="427" to="447" loc="M"/>
      <Region from="448" to="477" loc="O"/>
      <Region from="478" to="498" loc="M"/>
      <Region from="499" to="525" loc="I"/>
      <Region from="526" to="546" loc="M"/>
      <Region from="547" to="547" loc="O"/>
      <Region from="548" to="568" loc="M"/>
      <Region from="569" to="583" loc="I"/>
      <Region from="584" to="604" loc="M"/>
      <Region from="605" to="647" loc="O"/>
      <Region from="648" to="668" loc="M"/>
      <Region from="669" to="706" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="163" loc="I"/>
      <Region from="164" to="186" loc="M"/>
      <Region from="187" to="241" loc="O"/>
      <Region from="242" to="264" loc="M"/>
      <Region from="265" to="342" loc="I"/>
      <Region from="343" to="365" loc="M"/>
      <Region from="366" to="384" loc="O"/>
      <Region from="385" to="407" loc="M"/>
      <Region from="408" to="419" loc="I"/>
      <Region from="420" to="442" loc="M"/>
      <Region from="443" to="536" loc="O"/>
      <Region from="537" to="559" loc="M"/>
      <Region from="560" to="579" loc="I"/>
      <Region from="580" to="602" loc="M"/>
      <Region from="603" to="648" loc="O"/>
      <Region from="649" to="671" loc="M"/>
      <Region from="672" to="706" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
