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<HtpItem id="A0A1B0GW98_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Calcium voltage-gated channel subunit alpha1 D </Name>
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        <CrossRefSeq>VLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELE------------------IMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKR-STFDNFPQALLTVFQILTGEDWNAVMYDGIMAYG-----------GPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAE</CrossRefSeq>
        <OrigSeq>VFTGVFTVEMVLKVIAFKPKHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLT</OrigSeq>
      </Alignment>
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      <Alignment>
        <CrossRefSeq>LALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETK------------------VMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG-----------GPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEVVGKPALEEAKEEKIELKSITADGESPPTTKINMDDLQPNESEDK</CrossRefSeq>
        <OrigSeq>TGVFTVEMVLKVIAFKPKHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSE-YDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTV</OrigSeq>
      </Alignment>
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    <TOPDB id="CAC1C_HUMAN">
      <Alignment>
        <CrossRefSeq>LALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETK------------------IMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQ-TRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYG-----------GPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEL</CrossRefSeq>
        <OrigSeq>TGVFTVEMVLKVIAFKPKHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSE-YDPEAKGRI</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1C_RAT">
      <Alignment>
        <CrossRefSeq>LFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFD--------VKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQ----------------DAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEE---DLKGYLDWITQAEDIDPENEDEGMDEDKPRNMS</CrossRefSeq>
        <OrigSeq>VFTGVFTVEMVLKVIAFK----PKHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGK---------------------------------------VAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1S_MOUSE">
      <Alignment>
        <CrossRefSeq>FLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTVILEQVNIIQTNTAPMSSKG-------AGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEKPSPCARTGSGRPCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCISMEGWTDVLY----------------WVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLEEDLRGYMSWITQGEVMDVDDLREGKLSLDEGGSDTESLYEIEGLNKII</CrossRefSeq>
        <OrigSeq>FTGVFTVEMVLKVIAFKPK----HYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGK------------VAMRDNNQINRN----------------------------NNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSE----------------YDPEAKGRIKHLDVVTLLRRIQPPLGFGKLC</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1S_HUMAN">
      <Alignment>
        <CrossRefSeq>FLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKG-------AGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLY----------------WVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLDE</CrossRefSeq>
        <OrigSeq>FTGVFTVEMVLKVIAFKPK----HYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGK------------VAMRDNNQINRN----------------------------NNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1A_MOUSE">
      <Alignment>
        <CrossRefSeq>FIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD------------------------LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLY----------------NSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF--AKERERVENRRAFLKLRR-QQQIERELNGYMEWISKAEEVILAEDETDVEQRHPFDGALRRATLKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQ</CrossRefSeq>
        <OrigSeq>FTGVFTVEMVLKVIAFKPK----HYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMR------------------------------------DNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLL----RRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNAT------LFALVRTALKIKTEGNLEQANEELRAVIKKIWKKT</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1A_HUMAN">
      <Alignment>
        <CrossRefSeq>VFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEF-------------------GNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRE---CGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQDRTPLMFQRMEPPSPTQEGGPGQNALPSTQL---DPGGALMAHESGLKE</CrossRefSeq>
        <OrigSeq>VFTGVFTVEMVLKVIAFKPKHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKV--------AMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKI---KTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFK</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1E_HUMAN">
      <Alignment>
        <CrossRefSeq>FTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTD----------------SKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQ-KNAPMFQRMEPSSLPQEIIANAKALPYLQQDPVSGLSGRSG</CrossRefSeq>
        <OrigSeq>FTGVFTVEMVLKVIAFKPKHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPES--DYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKI---KTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEETKRE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1B_RABIT">
      <Alignment>
        <CrossRefSeq>FIGIFCFEAGIKILALGFVLHKGSYLRNGWNVMDFVVVLTGILATAGTDFD------------------------LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDPDPVGDFPCGKEAPARLCEGDTECREYWAGPNFGITNFDNILFAILTVFQCITMEGWTDILY----------------NTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF--AKERERVENRRAFLKLRRQQQ---------------------------IERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDAVLKRAAAKKSRSDLIQAEEGEGRLTGLCAPGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKA</CrossRefSeq>
        <OrigSeq>FTGVFTVEMVLKVIAFKPK----HYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF-GKVAMRDNNQINRN----------------------------------NNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVI-----KKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQD</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1B_RAT">
      <Alignment>
        <CrossRefSeq>FIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTEILATAGTDFD------------------------LRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCDSDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILY----------------NTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEF--AKERERVENRRAFLKLRRQQQ---------------------------IERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDAVLKRAATKKSRNDLIHAEEGEDRFVDLCAAGSPFARASLKSGKTESSSYFRRKEKMFRFLIRRMVKAQS</CrossRefSeq>
        <OrigSeq>FTGVFTVEMVLKVIAFKPK----HYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF-GKVAMRDNNQINR----------------------------------NNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANE-ELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFK</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1B_HUMAN">
      <Alignment>
        <CrossRefSeq>VFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIA-----------------ETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATE-----CGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLSNGGAIQNQESGIKE</CrossRefSeq>
        <OrigSeq>VFTGVFTVEMVLKVIAFKPKHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPL-NSDGTVMFNATLFALVRTALKIK---TEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKN-TTIALQAGLRTLHDIGPEIRR------AISCDLQDDEPEETKREEEDDVFK</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCN9A_HUMAN">
      <Alignment>
        <CrossRefSeq>VFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEG-----------------------LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEV----------------AGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLNTKKENYIS-------NHTLAEMSKGH------NFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEPE</CrossRefSeq>
        <OrigSeq>VFTGVFTVEMVLKVIAFKPKHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRN-----NNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPH------HLDEFKRIWSEYDPEAKGRI--KHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCN2A_HUMAN">
      <Alignment>
        <CrossRefSeq>FTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDL------------------------GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICV-KAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKK</CrossRefSeq>
        <OrigSeq>FTGVFTVEMVLKVIAFKPK----HYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF-GKVAMRDNNQINRNNNFQTFPQAVL---------LLFRCATGEAWQEIMLA------------------------CLPGKLCDPESDYNPGEEYTCGSNFAI------------------------------VYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCN5A_RAT">
      <Alignment>
        <CrossRefSeq>VFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRM-----------------------GNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRHRISDSGLLPRWHMMDFFHAFLIIFRILCGE-WIETMWDCME</CrossRefSeq>
        <OrigSeq>VFTGVFTVEMVLKVIAFKPKHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINR-----NNNFQTFPQAVLLLFRCATGEAWQEIMLACLP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCN2A_RAT">
      <Alignment>
        <CrossRefSeq>FTGIYTFESLIKILARGFCLEDFTFLRNPWNWLDFTVITFAYVTEFV------------------------NLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSTFEINITSFFNNSLDWNGTAFNRTVNMFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICV-KAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKK</CrossRefSeq>
        <OrigSeq>FTGVFTVEMVLKVIAFKPK----HYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF-GKVAMRDNNQINRNNNFQTFPQAVLL---------LFRCATGEAWQEIMLA------------------------CLPGKLCDPESDYNPGEEYTCGSNFAI------------------------------VYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCN5A_HUMAN">
      <Alignment>
        <CrossRefSeq>VFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSN-----------------------LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE-WIETMWDCME</CrossRefSeq>
        <OrigSeq>VFTGVFTVEMVLKVIAFKPKHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVA---MRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCN4A_HUMAN">
      <Alignment>
        <CrossRefSeq>VFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLSLVELGLA-----------------------NVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGE-WIETMWDCME</CrossRefSeq>
        <OrigSeq>VFTGVFTVEMVLKVIAFKPKHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQIN-----RNNNFQTFPQAVLLLFRCATGEAWQEIMLACLP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CAC1A_DROME">
      <Alignment>
        <CrossRefSeq>FTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDAL----------------WMEFGHDDSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAP--GEYCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSPLARSPSPRRRGHQ</CrossRefSeq>
        <OrigSeq>FTGVFTVEMVLKVIAFKPKHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRD-NNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLE--QANEELRAVIKKIWKKTSMKLLDQVVPPAGDDE---VTVGKFYATFLIQDYFRKFKKRKEQG--------LVGKYPAKNTTIALQAG-LRTLHDIGPEIRRAIS----CDLQDDEPEETKREEE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCN1A_RAT">
      <Alignment>
        <CrossRefSeq>VFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLA-----------------------NVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIATDCKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCME</CrossRefSeq>
        <OrigSeq>VFTGVFTVEMVLKVIAFKPKHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRN-----NNFQTFPQAVLLLFRCATGEAWQEIMLACLP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SCNAA_RAT">
      <Alignment>
        <CrossRefSeq>VFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSLLELSAS-----------------------KKGSLSVLRTFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTFILAIIVFIFALVGKQLLSEDYGCRKDGVSVWNGEKLRWHMCDFFHSFLVVFRILCGE-WIENMWVCMEV----------------SQKSICLILFLTVMVLGNLVVLNLFIALLLNSFS</CrossRefSeq>
        <OrigSeq>VFTGVFTVEMVLKVIAFKPKHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNN------NFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFD</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="NALCN_HUMAN">
      <Alignment>
        <CrossRefSeq>VFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFA-------------------LLNAYTYMMGACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGE--NINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRV-KFLLRLLRGRLEVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEEEVAKQTIRMW--LKKCLKRIRAKQQQSCSIIHSLRESQQQELSRFLNPPSIETTQPSEDTNANSQDNSMQPETSSQQQLLSPTLSDR-GGSRQDAADAGKPQRKFGQ</CrossRefSeq>
        <OrigSeq>VFTGVFTVEMVLKVIAFKPKHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLT--RDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQ--ANEELRAVIKKIWKKTSMKLLDQVVPPAGDDEVTVGK-FYATFLIQDYFRKFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQDDEPEETKREEEDDVFKQEIRC</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TPC1_ARATH">
      <Alignment>
        <CrossRefSeq>VFGWIYVLEMALKIYTYGFENYWREGANRFDFLVTWVIVIGETATFITPDENTFFSNGEW------------IRYLLLARMLRLIRLLMNVQRYRAFIATFITLIPSLMPYLGTIFCVLCIYCSIGVQVFGGLVNAGNKKLFETELAEDDYLLFNFNDYPNGMVTLFNLLVMGNWQVWM----------------ESYKDLTGTWWSITYFVSFYVITILLLLNLVVAFVLEAFFTELDLEEEEKCQGQDSQEKRNRRRSAGSKSRSQRVDTLLHHMLGDELSKPE</CrossRefSeq>
        <OrigSeq>VFTGVFTVEMVLKVIAFKPKHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRN---------NNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFD---YLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TPC2_MOUSE">
      <Alignment>
        <CrossRefSeq>IFILYYLLELLFKVFALGLPGYLSYHSNVFDGLLTIILLVSEICTLAVYRLPHSGWKPEQYGPLSLWDMTRLMNTLIVFRFLRI---IPNIKPMAEVANTILGLIPNLRAFGGILVVAYYVFAMIGINLFRGVIVPPGNSSLVPDNNSAVCGSFEQLGYWPNNFDDFAAALITLWNVMVVNNWQVILEAYKRY-----------------AGPWSMVYFVLWWLVSSVIWINLFLALLLENFLHRWDPQ</CrossRefSeq>
        <OrigSeq>VFTGVFTVEMVLKVIAFKPKHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKV----------------AMRDNNQINR-NNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDW</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="453" CheckSum="2ce538259153716c5b6452dcfdc9be6a">
    <Seq>
      XVFTGVFTVE MVLKVIAFKP KHYFTDAWNT FDALIVVGSV VDIAITEVNP
      TESENVPVPT ATPGNSEESN RISITFFRLF RVMRLVKLLS RGEGIRTLLW
      TFIKSFQALP YVALLIAMLF FIYAVIGMQM FGKVAMRDNN QINRNNNFQT
      FPQAVLLLFR CATGEAWQEI MLACLPGKLC DPESDYNPGE EYTCGSNFAI
      VYFISFYMLC AFLIINLFVA VIMDNFDYLT RDWSILGPHH LDEFKRIWSE
      YDPEAKGRIK HLDVVTLLRR IQPPLGFGKL CPHRVACKRL VAMNMPLNSD
      GTVMFNATLF ALVRTALKIK TEGNLEQANE ELRAVIKKIW KKTSMKLLDQ
      VVPPAGDDEV TVGKFYATFL IQDYFRKFKK RKEQGLVGKY PAKNTTIALQ
      AGLRTLHDIG PEIRRAISCD LQDDEPEETK REEEDDVFKQ EIRCVITIIT
      IIP
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="79.92">
    <Region from="1" to="105" loc="I"/>
    <Region from="106" to="127" loc="M"/>
    <Region from="128" to="198" loc="O"/>
    <Region from="199" to="222" loc="M"/>
    <Region from="223" to="453" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="1" loc="O"/>
      <Region from="2" to="18" loc="M"/>
      <Region from="19" to="107" loc="I"/>
      <Region from="108" to="126" loc="M"/>
      <Region from="127" to="197" loc="O"/>
      <Region from="198" to="222" loc="M"/>
      <Region from="223" to="453" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="3" loc="O"/>
      <Region from="4" to="19" loc="M"/>
      <Region from="20" to="30" loc="I"/>
      <Region from="31" to="46" loc="M"/>
      <Region from="47" to="73" loc="O"/>
      <Region from="74" to="89" loc="M"/>
      <Region from="90" to="98" loc="I"/>
      <Region from="99" to="129" loc="M"/>
      <Region from="130" to="197" loc="O"/>
      <Region from="198" to="224" loc="M"/>
      <Region from="225" to="453" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="1" loc="I"/>
      <Region from="2" to="22" loc="M"/>
      <Region from="23" to="26" loc="O"/>
      <Region from="27" to="47" loc="M"/>
      <Region from="48" to="97" loc="I"/>
      <Region from="98" to="112" loc="M"/>
      <Region from="113" to="113" loc="O"/>
      <Region from="114" to="128" loc="M"/>
      <Region from="129" to="149" loc="I"/>
      <Region from="150" to="170" loc="M"/>
      <Region from="171" to="199" loc="O"/>
      <Region from="200" to="220" loc="M"/>
      <Region from="221" to="453" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="105" loc="I"/>
      <Region from="106" to="127" loc="M"/>
      <Region from="128" to="198" loc="O"/>
      <Region from="199" to="223" loc="M"/>
      <Region from="224" to="453" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="107" loc="I"/>
      <Region from="108" to="131" loc="M"/>
      <Region from="132" to="198" loc="O"/>
      <Region from="199" to="223" loc="M"/>
      <Region from="224" to="453" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="107" loc="I"/>
      <Region from="108" to="128" loc="M"/>
      <Region from="129" to="200" loc="O"/>
      <Region from="201" to="221" loc="M"/>
      <Region from="222" to="453" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="2" loc="O"/>
      <Region from="3" to="23" loc="M"/>
      <Region from="24" to="105" loc="I"/>
      <Region from="106" to="126" loc="M"/>
      <Region from="127" to="200" loc="O"/>
      <Region from="201" to="221" loc="M"/>
      <Region from="222" to="453" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="107" loc="I"/>
      <Region from="108" to="128" loc="M"/>
      <Region from="129" to="202" loc="O"/>
      <Region from="203" to="223" loc="M"/>
      <Region from="224" to="453" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="111" loc="O"/>
      <Region from="112" to="132" loc="M"/>
      <Region from="133" to="197" loc="I"/>
      <Region from="198" to="218" loc="M"/>
      <Region from="219" to="453" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="104" loc="O"/>
      <Region from="105" to="127" loc="M"/>
      <Region from="128" to="199" loc="I"/>
      <Region from="200" to="222" loc="M"/>
      <Region from="223" to="453" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="5hvx_A">
      <ConstraintRegion from="-1" to="12" loc="I" subId="17113713" subSource="5hvx_A"/>
      <ConstraintRegion from="13" to="32" loc="H" subId="17113715" subSource="5hvx_A"/>
      <ConstraintRegion from="33" to="44" loc="O" subId="17113717" subSource="5hvx_A"/>
      <ConstraintRegion from="45" to="65" loc="H" subId="17113719" subSource="5hvx_A"/>
      <ConstraintRegion from="66" to="72" loc="I" subId="17113721" subSource="5hvx_A"/>
      <ConstraintRegion from="73" to="91" loc="H" subId="17113723" subSource="5hvx_A"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17113727" subSource="5hvx_A"/>
      <ConstraintRegion from="101" to="118" loc="H" subId="17113729" subSource="5hvx_A"/>
      <ConstraintRegion from="119" to="119" loc="I" subId="17113730" subSource="5hvx_A"/>
      <ConstraintRegion from="120" to="149" loc="H" subId="17113732" subSource="5hvx_A"/>
      <ConstraintRegion from="150" to="167" loc="O" subId="17113734" subSource="5hvx_A"/>
      <ConstraintRegion from="168" to="178" loc="L" subId="17113735" subSource="5hvx_A"/>
      <ConstraintRegion from="179" to="196" loc="O" subId="17113737" subSource="5hvx_A"/>
      <ConstraintRegion from="197" to="222" loc="H" subId="17113739" subSource="5hvx_A"/>
      <ConstraintRegion from="223" to="262" loc="I" subId="17113740" subSource="5hvx_A"/>
      <ConstraintRegion from="-1" to="12" loc="I" subId="17113745" subSource="5hvx_B"/>
      <ConstraintRegion from="13" to="32" loc="H" subId="17113746" subSource="5hvx_B"/>
      <ConstraintRegion from="33" to="44" loc="O" subId="17113747" subSource="5hvx_B"/>
      <ConstraintRegion from="45" to="65" loc="H" subId="17113748" subSource="5hvx_B"/>
      <ConstraintRegion from="66" to="72" loc="I" subId="17113749" subSource="5hvx_B"/>
      <ConstraintRegion from="73" to="91" loc="H" subId="17113750" subSource="5hvx_B"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17113752" subSource="5hvx_B"/>
      <ConstraintRegion from="101" to="118" loc="H" subId="17113753" subSource="5hvx_B"/>
      <ConstraintRegion from="119" to="119" loc="I" subId="17113754" subSource="5hvx_B"/>
      <ConstraintRegion from="120" to="149" loc="H" subId="17113755" subSource="5hvx_B"/>
      <ConstraintRegion from="150" to="167" loc="O" subId="17113756" subSource="5hvx_B"/>
      <ConstraintRegion from="168" to="178" loc="L" subId="17113757" subSource="5hvx_B"/>
      <ConstraintRegion from="179" to="196" loc="O" subId="17113758" subSource="5hvx_B"/>
      <ConstraintRegion from="197" to="222" loc="H" subId="17113759" subSource="5hvx_B"/>
      <ConstraintRegion from="223" to="262" loc="I" subId="17113760" subSource="5hvx_B"/>
      <ConstraintRegion from="-1" to="12" loc="I" subId="17113766" subSource="5hvx_C"/>
      <ConstraintRegion from="13" to="32" loc="H" subId="17113768" subSource="5hvx_C"/>
      <ConstraintRegion from="33" to="44" loc="O" subId="17113770" subSource="5hvx_C"/>
      <ConstraintRegion from="45" to="65" loc="H" subId="17113772" subSource="5hvx_C"/>
      <ConstraintRegion from="66" to="72" loc="I" subId="17113774" subSource="5hvx_C"/>
      <ConstraintRegion from="73" to="91" loc="H" subId="17113776" subSource="5hvx_C"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17113780" subSource="5hvx_C"/>
      <ConstraintRegion from="101" to="118" loc="H" subId="17113782" subSource="5hvx_C"/>
      <ConstraintRegion from="119" to="119" loc="I" subId="17113784" subSource="5hvx_C"/>
      <ConstraintRegion from="120" to="149" loc="H" subId="17113786" subSource="5hvx_C"/>
      <ConstraintRegion from="150" to="167" loc="O" subId="17113788" subSource="5hvx_C"/>
      <ConstraintRegion from="168" to="178" loc="L" subId="17113790" subSource="5hvx_C"/>
      <ConstraintRegion from="179" to="196" loc="O" subId="17113792" subSource="5hvx_C"/>
      <ConstraintRegion from="197" to="222" loc="H" subId="17113794" subSource="5hvx_C"/>
      <ConstraintRegion from="223" to="262" loc="I" subId="17113796" subSource="5hvx_C"/>
      <ConstraintRegion from="-1" to="12" loc="I" subId="17113803" subSource="5hvx_D"/>
      <ConstraintRegion from="13" to="32" loc="H" subId="17113804" subSource="5hvx_D"/>
      <ConstraintRegion from="33" to="44" loc="O" subId="17113805" subSource="5hvx_D"/>
      <ConstraintRegion from="45" to="65" loc="H" subId="17113806" subSource="5hvx_D"/>
      <ConstraintRegion from="66" to="72" loc="I" subId="17113807" subSource="5hvx_D"/>
      <ConstraintRegion from="73" to="91" loc="H" subId="17113808" subSource="5hvx_D"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17113810" subSource="5hvx_D"/>
      <ConstraintRegion from="101" to="118" loc="H" subId="17113811" subSource="5hvx_D"/>
      <ConstraintRegion from="119" to="119" loc="I" subId="17113812" subSource="5hvx_D"/>
      <ConstraintRegion from="120" to="149" loc="H" subId="17113813" subSource="5hvx_D"/>
      <ConstraintRegion from="150" to="167" loc="O" subId="17113814" subSource="5hvx_D"/>
      <ConstraintRegion from="168" to="178" loc="L" subId="17113815" subSource="5hvx_D"/>
      <ConstraintRegion from="179" to="196" loc="O" subId="17113816" subSource="5hvx_D"/>
      <ConstraintRegion from="197" to="222" loc="H" subId="17113817" subSource="5hvx_D"/>
      <ConstraintRegion from="223" to="262" loc="I" subId="17113818" subSource="5hvx_D"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6yz0_A">
      <ConstraintRegion from="-1" to="-1" loc="I" subId="17448533" subSource="6yz0_A"/>
      <ConstraintRegion from="0" to="9" loc="F" subId="17448535" subSource="6yz0_A"/>
      <ConstraintRegion from="10" to="12" loc="I" subId="17448537" subSource="6yz0_A"/>
      <ConstraintRegion from="13" to="30" loc="H" subId="17448538" subSource="6yz0_A"/>
      <ConstraintRegion from="31" to="47" loc="O" subId="17448540" subSource="6yz0_A"/>
      <ConstraintRegion from="48" to="65" loc="H" subId="17448542" subSource="6yz0_A"/>
      <ConstraintRegion from="66" to="75" loc="I" subId="17448544" subSource="6yz0_A"/>
      <ConstraintRegion from="76" to="91" loc="H" subId="17448545" subSource="6yz0_A"/>
      <ConstraintRegion from="92" to="92" loc="O" subId="17448547" subSource="6yz0_A"/>
      <ConstraintRegion from="100" to="102" loc="O" subId="17448549" subSource="6yz0_A"/>
      <ConstraintRegion from="103" to="118" loc="H" subId="17448551" subSource="6yz0_A"/>
      <ConstraintRegion from="119" to="119" loc="I" subId="17448553" subSource="6yz0_A"/>
      <ConstraintRegion from="120" to="147" loc="H" subId="17448555" subSource="6yz0_A"/>
      <ConstraintRegion from="148" to="163" loc="O" subId="17448557" subSource="6yz0_A"/>
      <ConstraintRegion from="164" to="175" loc="F" subId="17448559" subSource="6yz0_A"/>
      <ConstraintRegion from="176" to="197" loc="O" subId="17448561" subSource="6yz0_A"/>
      <ConstraintRegion from="198" to="222" loc="H" subId="17448564" subSource="6yz0_A"/>
      <ConstraintRegion from="223" to="262" loc="I" subId="17448567" subSource="6yz0_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6yz2_A">
      <ConstraintRegion from="-1" to="-1" loc="I" subId="17448704" subSource="6yz2_A"/>
      <ConstraintRegion from="0" to="9" loc="F" subId="17448706" subSource="6yz2_A"/>
      <ConstraintRegion from="10" to="15" loc="I" subId="17448709" subSource="6yz2_A"/>
      <ConstraintRegion from="16" to="31" loc="H" subId="17448711" subSource="6yz2_A"/>
      <ConstraintRegion from="32" to="44" loc="O" subId="17448713" subSource="6yz2_A"/>
      <ConstraintRegion from="45" to="61" loc="H" subId="17448716" subSource="6yz2_A"/>
      <ConstraintRegion from="62" to="76" loc="I" subId="17448718" subSource="6yz2_A"/>
      <ConstraintRegion from="77" to="91" loc="H" subId="17448721" subSource="6yz2_A"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17448722" subSource="6yz2_A"/>
      <ConstraintRegion from="101" to="114" loc="H" subId="17448723" subSource="6yz2_A"/>
      <ConstraintRegion from="115" to="127" loc="F" subId="17448726" subSource="6yz2_A"/>
      <ConstraintRegion from="128" to="131" loc="I" subId="17448728" subSource="6yz2_A"/>
      <ConstraintRegion from="132" to="149" loc="H" subId="17448731" subSource="6yz2_A"/>
      <ConstraintRegion from="150" to="167" loc="O" subId="17448734" subSource="6yz2_A"/>
      <ConstraintRegion from="168" to="178" loc="L" subId="17448735" subSource="6yz2_A"/>
      <ConstraintRegion from="179" to="196" loc="O" subId="17448736" subSource="6yz2_A"/>
      <ConstraintRegion from="197" to="218" loc="H" subId="17448739" subSource="6yz2_A"/>
      <ConstraintRegion from="219" to="262" loc="I" subId="17448741" subSource="6yz2_A"/>
      <ConstraintRegion from="-1" to="-1" loc="I" subId="17448745" subSource="6yz2_B"/>
      <ConstraintRegion from="0" to="9" loc="F" subId="17448747" subSource="6yz2_B"/>
      <ConstraintRegion from="10" to="15" loc="I" subId="17448749" subSource="6yz2_B"/>
      <ConstraintRegion from="16" to="31" loc="H" subId="17448751" subSource="6yz2_B"/>
      <ConstraintRegion from="32" to="44" loc="O" subId="17448753" subSource="6yz2_B"/>
      <ConstraintRegion from="45" to="61" loc="H" subId="17448756" subSource="6yz2_B"/>
      <ConstraintRegion from="62" to="76" loc="I" subId="17448758" subSource="6yz2_B"/>
      <ConstraintRegion from="77" to="91" loc="H" subId="17448760" subSource="6yz2_B"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17448763" subSource="6yz2_B"/>
      <ConstraintRegion from="101" to="114" loc="H" subId="17448766" subSource="6yz2_B"/>
      <ConstraintRegion from="115" to="127" loc="F" subId="17448769" subSource="6yz2_B"/>
      <ConstraintRegion from="128" to="131" loc="I" subId="17448772" subSource="6yz2_B"/>
      <ConstraintRegion from="132" to="149" loc="H" subId="17448775" subSource="6yz2_B"/>
      <ConstraintRegion from="150" to="167" loc="O" subId="17448778" subSource="6yz2_B"/>
      <ConstraintRegion from="168" to="178" loc="L" subId="17448781" subSource="6yz2_B"/>
      <ConstraintRegion from="179" to="196" loc="O" subId="17448784" subSource="6yz2_B"/>
      <ConstraintRegion from="197" to="218" loc="H" subId="17448787" subSource="6yz2_B"/>
      <ConstraintRegion from="219" to="262" loc="I" subId="17448790" subSource="6yz2_B"/>
      <ConstraintRegion from="-1" to="-1" loc="I" subId="17448800" subSource="6yz2_C"/>
      <ConstraintRegion from="0" to="9" loc="F" subId="17448803" subSource="6yz2_C"/>
      <ConstraintRegion from="10" to="15" loc="I" subId="17448807" subSource="6yz2_C"/>
      <ConstraintRegion from="16" to="31" loc="H" subId="17448811" subSource="6yz2_C"/>
      <ConstraintRegion from="32" to="44" loc="O" subId="17448814" subSource="6yz2_C"/>
      <ConstraintRegion from="45" to="61" loc="H" subId="17448817" subSource="6yz2_C"/>
      <ConstraintRegion from="62" to="76" loc="I" subId="17448820" subSource="6yz2_C"/>
      <ConstraintRegion from="77" to="91" loc="H" subId="17448823" subSource="6yz2_C"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17448827" subSource="6yz2_C"/>
      <ConstraintRegion from="101" to="114" loc="H" subId="17448830" subSource="6yz2_C"/>
      <ConstraintRegion from="115" to="127" loc="F" subId="17448833" subSource="6yz2_C"/>
      <ConstraintRegion from="128" to="131" loc="I" subId="17448836" subSource="6yz2_C"/>
      <ConstraintRegion from="132" to="149" loc="H" subId="17448839" subSource="6yz2_C"/>
      <ConstraintRegion from="150" to="167" loc="O" subId="17448843" subSource="6yz2_C"/>
      <ConstraintRegion from="168" to="178" loc="L" subId="17448846" subSource="6yz2_C"/>
      <ConstraintRegion from="179" to="196" loc="O" subId="17448849" subSource="6yz2_C"/>
      <ConstraintRegion from="197" to="218" loc="H" subId="17448852" subSource="6yz2_C"/>
      <ConstraintRegion from="219" to="262" loc="I" subId="17448855" subSource="6yz2_C"/>
      <ConstraintRegion from="-1" to="-1" loc="I" subId="17448864" subSource="6yz2_D"/>
      <ConstraintRegion from="0" to="9" loc="F" subId="17448866" subSource="6yz2_D"/>
      <ConstraintRegion from="10" to="15" loc="I" subId="17448868" subSource="6yz2_D"/>
      <ConstraintRegion from="16" to="31" loc="H" subId="17448871" subSource="6yz2_D"/>
      <ConstraintRegion from="32" to="44" loc="O" subId="17448874" subSource="6yz2_D"/>
      <ConstraintRegion from="45" to="61" loc="H" subId="17448878" subSource="6yz2_D"/>
      <ConstraintRegion from="62" to="76" loc="I" subId="17448882" subSource="6yz2_D"/>
      <ConstraintRegion from="77" to="91" loc="H" subId="17448885" subSource="6yz2_D"/>
      <ConstraintRegion from="100" to="100" loc="O" subId="17448888" subSource="6yz2_D"/>
      <ConstraintRegion from="101" to="114" loc="H" subId="17448892" subSource="6yz2_D"/>
      <ConstraintRegion from="115" to="127" loc="F" subId="17448896" subSource="6yz2_D"/>
      <ConstraintRegion from="128" to="131" loc="I" subId="17448900" subSource="6yz2_D"/>
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      <ConstraintRegion from="219" to="262" loc="I" subId="17448922" subSource="6yz2_D"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="5hvd_A">
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    </Constraint>
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    </Constraint>
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    </Constraint>
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    </Constraint>
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    </Constraint>
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    </Constraint>
  </Constraints>
</HtpItem>
