<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A2R8Y291_HUMAN" transmembrane="yes" evidence="3D">
  <Name>ATP binding cassette subfamily B member 4 </Name>
  <CrossRef>
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      <Chain id="A"/>
    </PDBTM>
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      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
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      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5kpd">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5kpj">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6lr0">
      <Chain id="U"/>
    </PDBTM>
    <PDBTM id="7o9w">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5koy">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4m2s">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4m2t">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3g60">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3g61">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4ksb">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4ksc">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4ksd">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6gdi">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6q81">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7oti">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4q9j">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4q9k">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4q9l">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7otg">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4m1m">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4q9h">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4xwk">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6ujp">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6ujr">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6ujs">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3g5u">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4lsg">
      <Chain id="A"/>
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    </PDBTM>
    <PDBTM id="6qee">
      <Chain id="A"/>
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      <Chain id="A"/>
    </PDBTM>
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      <Chain id="A"/>
    </PDBTM>
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      <Chain id="A"/>
    </PDBTM>
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      <Chain id="A"/>
    </PDBTM>
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      <Chain id="A"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
    </PDBTM>
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      <Chain id="U"/>
    </PDBTM>
    <PDBTM id="6fn1">
      <Chain id="A"/>
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      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8pee">
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      <Chain id="A"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
    </PDBTM>
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      <Chain id="A"/>
    </PDBTM>
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      <Chain id="A"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
    </PDBTM>
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      <Chain id="A"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
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    <PDBTM id="8woo">
      <Chain id="A"/>
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      <Chain id="A"/>
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    <PDBTM id="8pm6">
      <Chain id="A"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
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      <Chain id="A"/>
    </PDBTM>
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      <Chain id="A"/>
    </PDBTM>
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      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3wme">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3wmf">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3wmg">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6a6m">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6a6n">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7fc9">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7vr5">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7dqv">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7ehl">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5och">
      <Chain id="H"/>
      <Chain id="E"/>
      <Chain id="D"/>
      <Chain id="G"/>
      <Chain id="F"/>
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8jwi">
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="ABCBB_HUMAN">
      <Alignment>
        <CrossRefSeq>EDRKDKDIPVQEEVEPAPVRRILKFSAP-EWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFS----------------IPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDAS</CrossRefSeq>
        <OrigSeq>GISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFD--INDTTELNTRLTECDL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="MDR1_HUMAN">
      <Alignment>
        <CrossRefSeq>MDLEGDRNGGAKKK------NFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS</CrossRefSeq>
        <OrigSeq>MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKIL----EEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTECDL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="MDR1A_MOUSE">
      <Alignment>
        <CrossRefSeq>GPHDQDRKLSTKEALDEDVPPASFWRILKL-NSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGG---------------PPETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLAND</CrossRefSeq>
        <OrigSeq>GDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFD--INDTTELNTRLTEC</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="MDR1_CRIGR">
      <Alignment>
        <CrossRefSeq>GPHDQDRKLSTKEALDEDVPPISFWRILKL-NSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFTRNTDDETK---------------RHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALTTRLAND</CrossRefSeq>
        <OrigSeq>GDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFD--INDTTELNTRLTEC</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="MDR1B_MOUSE">
      <Alignment>
        <CrossRefSeq>QDQERRLSMKEAVDEDVPLVSFWRILNL-NLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIVGVFSRDDDHETKRQNCNL---------------FSLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDDHKNSTGSLTTRLASDAS</CrossRefSeq>
        <OrigSeq>FELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFD--INDTTELNTRLTECDL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="MDR65_DROME">
      <Alignment>
        <CrossRefSeq>LNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLA-KQEWCYLILGTISAVAVGFLYPAFAVIFGEF----------------YAALAEKDPEDALRRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLS</CrossRefSeq>
        <OrigSeq>MDLEAAKNGTAW-RPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFD--INDTTELNTRLT</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="STE6_YEAST">
      <Alignment>
        <CrossRefSeq>IFRYVNIRNDYRLLMIMIIGTVATGLVPAITSILTGRVFDLLSVFVANGS------------HQGLYSQLVQRSMAVMALGAASVPVMWLSLTSWMHIGERQGFRIRSQILEAYLEEKPMEWYDNN</CrossRefSeq>
        <OrigSeq>LFRYSD-WQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAIL-RQEIGWFDIN</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TAP1_HUMAN">
      <Alignment>
        <CrossRefSeq>GEMAIPFFTGRLTDWILQDGSADTFTRNLT-------------------LMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTS</CrossRefSeq>
        <OrigSeq>GLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTECDL</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="183" CheckSum="3fcb41b9c1c7a2689fc8ba28edc2f916">
    <Seq>
      MDLEAAKNGT AWRPTSAEGD FELGISSKQK RKKTKTVKMI GVLTLFRYSD
      WQDKLFMSLG TIMAIAHGSG LPLMMIVFGE MTDKFVDTAG NFSFPVNFSL
      SLLNPGKILE EEMTRYAYYY SGLGAGVLVA AYIQVSFWTL AAGRQIRKIR
      QKFFHAILRQ EIGWFDINDT TELNTRLTEC DLF
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="87.03">
    <Region from="1" to="54" loc="I"/>
    <Region from="55" to="77" loc="M"/>
    <Region from="78" to="120" loc="O"/>
    <Region from="121" to="141" loc="M"/>
    <Region from="142" to="183" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="54" loc="I"/>
      <Region from="55" to="77" loc="M"/>
      <Region from="78" to="121" loc="O"/>
      <Region from="122" to="143" loc="M"/>
      <Region from="144" to="183" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="51" loc="I"/>
      <Region from="52" to="82" loc="M"/>
      <Region from="83" to="115" loc="O"/>
      <Region from="116" to="142" loc="M"/>
      <Region from="143" to="183" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="47" loc="I"/>
      <Region from="48" to="78" loc="M"/>
      <Region from="79" to="117" loc="O"/>
      <Region from="118" to="138" loc="M"/>
      <Region from="139" to="183" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="54" loc="I"/>
      <Region from="55" to="78" loc="M"/>
      <Region from="79" to="118" loc="O"/>
      <Region from="119" to="142" loc="M"/>
      <Region from="143" to="183" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="54" loc="I"/>
      <Region from="55" to="78" loc="M"/>
      <Region from="79" to="116" loc="O"/>
      <Region from="117" to="142" loc="M"/>
      <Region from="143" to="183" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="54" loc="I"/>
      <Region from="55" to="75" loc="M"/>
      <Region from="76" to="122" loc="O"/>
      <Region from="123" to="143" loc="M"/>
      <Region from="144" to="183" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="55" loc="I"/>
      <Region from="56" to="76" loc="M"/>
      <Region from="77" to="121" loc="O"/>
      <Region from="122" to="142" loc="M"/>
      <Region from="143" to="183" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="121" loc="O"/>
      <Region from="122" to="141" loc="M"/>
      <Region from="142" to="183" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="119" loc="O"/>
      <Region from="120" to="140" loc="M"/>
      <Region from="141" to="183" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="54" loc="I"/>
      <Region from="55" to="77" loc="M"/>
      <Region from="78" to="115" loc="O"/>
      <Region from="116" to="138" loc="M"/>
      <Region from="139" to="183" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="6qee_A">
      <ConstraintRegion from="31" to="44" loc="I" subId="17262130" subSource="6qee_A"/>
      <ConstraintRegion from="45" to="69" loc="H" subId="17262132" subSource="6qee_A"/>
      <ConstraintRegion from="70" to="116" loc="O" subId="17262134" subSource="6qee_A"/>
      <ConstraintRegion from="117" to="139" loc="H" subId="17262136" subSource="6qee_A"/>
      <ConstraintRegion from="140" to="185" loc="I" subId="17262138" subSource="6qee_A"/>
      <ConstraintRegion from="186" to="207" loc="H" subId="17262140" subSource="6qee_A"/>
      <ConstraintRegion from="208" to="214" loc="O" subId="17262142" subSource="6qee_A"/>
      <ConstraintRegion from="215" to="238" loc="H" subId="17262144" subSource="6qee_A"/>
      <ConstraintRegion from="239" to="289" loc="I" subId="17262146" subSource="6qee_A"/>
      <ConstraintRegion from="290" to="312" loc="H" subId="17262148" subSource="6qee_A"/>
      <ConstraintRegion from="313" to="332" loc="O" subId="17262150" subSource="6qee_A"/>
      <ConstraintRegion from="333" to="355" loc="H" subId="17262152" subSource="6qee_A"/>
      <ConstraintRegion from="356" to="629" loc="I" subId="17262153" subSource="6qee_A"/>
      <ConstraintRegion from="693" to="695" loc="I" subId="17262155" subSource="6qee_A"/>
      <ConstraintRegion from="696" to="703" loc="F" subId="17262157" subSource="6qee_A"/>
      <ConstraintRegion from="704" to="706" loc="I" subId="17262158" subSource="6qee_A"/>
      <ConstraintRegion from="707" to="731" loc="H" subId="17262159" subSource="6qee_A"/>
      <ConstraintRegion from="732" to="755" loc="O" subId="17262161" subSource="6qee_A"/>
      <ConstraintRegion from="756" to="779" loc="H" subId="17262163" subSource="6qee_A"/>
      <ConstraintRegion from="780" to="827" loc="I" subId="17262165" subSource="6qee_A"/>
      <ConstraintRegion from="828" to="850" loc="H" subId="17262166" subSource="6qee_A"/>
      <ConstraintRegion from="851" to="856" loc="O" subId="17262167" subSource="6qee_A"/>
      <ConstraintRegion from="857" to="881" loc="H" subId="17262169" subSource="6qee_A"/>
      <ConstraintRegion from="882" to="931" loc="I" subId="17262171" subSource="6qee_A"/>
      <ConstraintRegion from="932" to="955" loc="H" subId="17262173" subSource="6qee_A"/>
      <ConstraintRegion from="956" to="975" loc="O" subId="17262174" subSource="6qee_A"/>
      <ConstraintRegion from="976" to="997" loc="H" subId="17262175" subSource="6qee_A"/>
      <ConstraintRegion from="998" to="1275" loc="I" subId="17262177" subSource="6qee_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="3wmg_A">
      <ConstraintRegion from="102" to="102" loc="I" subId="17399872" subSource="3wmg_A"/>
      <ConstraintRegion from="103" to="116" loc="F" subId="17399874" subSource="3wmg_A"/>
      <ConstraintRegion from="117" to="118" loc="I" subId="17399876" subSource="3wmg_A"/>
      <ConstraintRegion from="119" to="142" loc="H" subId="17399878" subSource="3wmg_A"/>
      <ConstraintRegion from="143" to="163" loc="O" subId="17399880" subSource="3wmg_A"/>
      <ConstraintRegion from="164" to="186" loc="H" subId="17399882" subSource="3wmg_A"/>
      <ConstraintRegion from="187" to="236" loc="I" subId="17399884" subSource="3wmg_A"/>
      <ConstraintRegion from="237" to="255" loc="H" subId="17399886" subSource="3wmg_A"/>
      <ConstraintRegion from="256" to="266" loc="O" subId="17399888" subSource="3wmg_A"/>
      <ConstraintRegion from="267" to="287" loc="H" subId="17399890" subSource="3wmg_A"/>
      <ConstraintRegion from="288" to="334" loc="I" subId="17399892" subSource="3wmg_A"/>
      <ConstraintRegion from="335" to="358" loc="H" subId="17399894" subSource="3wmg_A"/>
      <ConstraintRegion from="359" to="383" loc="O" subId="17399896" subSource="3wmg_A"/>
      <ConstraintRegion from="384" to="404" loc="H" subId="17399898" subSource="3wmg_A"/>
      <ConstraintRegion from="405" to="690" loc="I" subId="17399901" subSource="3wmg_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6a6n_A">
      <ConstraintRegion from="102" to="102" loc="I" subId="16963838" subSource="6a6n_A"/>
      <ConstraintRegion from="103" to="116" loc="F" subId="16963839" subSource="6a6n_A"/>
      <ConstraintRegion from="117" to="117" loc="I" subId="16963840" subSource="6a6n_A"/>
      <ConstraintRegion from="118" to="142" loc="H" subId="16963841" subSource="6a6n_A"/>
      <ConstraintRegion from="143" to="165" loc="O" subId="16963842" subSource="6a6n_A"/>
      <ConstraintRegion from="166" to="188" loc="H" subId="16963843" subSource="6a6n_A"/>
      <ConstraintRegion from="189" to="235" loc="I" subId="16963844" subSource="6a6n_A"/>
      <ConstraintRegion from="236" to="256" loc="H" subId="16963845" subSource="6a6n_A"/>
      <ConstraintRegion from="257" to="263" loc="O" subId="16963846" subSource="6a6n_A"/>
      <ConstraintRegion from="264" to="284" loc="H" subId="16963847" subSource="6a6n_A"/>
      <ConstraintRegion from="285" to="337" loc="I" subId="16963848" subSource="6a6n_A"/>
      <ConstraintRegion from="338" to="361" loc="H" subId="16963849" subSource="6a6n_A"/>
      <ConstraintRegion from="362" to="381" loc="O" subId="16963850" subSource="6a6n_A"/>
      <ConstraintRegion from="382" to="403" loc="H" subId="16963851" subSource="6a6n_A"/>
      <ConstraintRegion from="404" to="688" loc="I" subId="16963852" subSource="6a6n_A"/>
      <ConstraintRegion from="102" to="102" loc="I" subId="16963853" subSource="6a6n_B"/>
      <ConstraintRegion from="103" to="116" loc="F" subId="16963854" subSource="6a6n_B"/>
      <ConstraintRegion from="117" to="117" loc="I" subId="16963855" subSource="6a6n_B"/>
      <ConstraintRegion from="118" to="142" loc="H" subId="16963856" subSource="6a6n_B"/>
      <ConstraintRegion from="143" to="165" loc="O" subId="16963857" subSource="6a6n_B"/>
      <ConstraintRegion from="166" to="188" loc="H" subId="16963858" subSource="6a6n_B"/>
      <ConstraintRegion from="189" to="235" loc="I" subId="16963859" subSource="6a6n_B"/>
      <ConstraintRegion from="236" to="256" loc="H" subId="16963860" subSource="6a6n_B"/>
      <ConstraintRegion from="257" to="263" loc="O" subId="16963861" subSource="6a6n_B"/>
      <ConstraintRegion from="264" to="284" loc="H" subId="16963862" subSource="6a6n_B"/>
      <ConstraintRegion from="285" to="337" loc="I" subId="16963863" subSource="6a6n_B"/>
      <ConstraintRegion from="338" to="361" loc="H" subId="16963864" subSource="6a6n_B"/>
      <ConstraintRegion from="362" to="381" loc="O" subId="16963865" subSource="6a6n_B"/>
      <ConstraintRegion from="382" to="403" loc="H" subId="16963866" subSource="6a6n_B"/>
      <ConstraintRegion from="404" to="688" loc="I" subId="16963867" subSource="6a6n_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="7vr5_A">
      <ConstraintRegion from="101" to="117" loc="I" subId="17369768" subSource="7vr5_A"/>
      <ConstraintRegion from="118" to="140" loc="H" subId="17369770" subSource="7vr5_A"/>
      <ConstraintRegion from="141" to="166" loc="O" subId="17369773" subSource="7vr5_A"/>
      <ConstraintRegion from="167" to="189" loc="H" subId="17369776" subSource="7vr5_A"/>
      <ConstraintRegion from="190" to="233" loc="I" subId="17369778" subSource="7vr5_A"/>
      <ConstraintRegion from="234" to="256" loc="H" subId="17369782" subSource="7vr5_A"/>
      <ConstraintRegion from="257" to="263" loc="O" subId="17369785" subSource="7vr5_A"/>
      <ConstraintRegion from="264" to="285" loc="H" subId="17369788" subSource="7vr5_A"/>
      <ConstraintRegion from="286" to="337" loc="I" subId="17369790" subSource="7vr5_A"/>
      <ConstraintRegion from="338" to="361" loc="H" subId="17369792" subSource="7vr5_A"/>
      <ConstraintRegion from="362" to="381" loc="O" subId="17369795" subSource="7vr5_A"/>
      <ConstraintRegion from="382" to="404" loc="H" subId="17369798" subSource="7vr5_A"/>
      <ConstraintRegion from="405" to="688" loc="I" subId="17369801" subSource="7vr5_A"/>
      <ConstraintRegion from="101" to="117" loc="I" subId="17369812" subSource="7vr5_B"/>
      <ConstraintRegion from="118" to="140" loc="H" subId="17369814" subSource="7vr5_B"/>
      <ConstraintRegion from="141" to="166" loc="O" subId="17369817" subSource="7vr5_B"/>
      <ConstraintRegion from="167" to="189" loc="H" subId="17369821" subSource="7vr5_B"/>
      <ConstraintRegion from="190" to="233" loc="I" subId="17369824" subSource="7vr5_B"/>
      <ConstraintRegion from="234" to="256" loc="H" subId="17369826" subSource="7vr5_B"/>
      <ConstraintRegion from="257" to="263" loc="O" subId="17369828" subSource="7vr5_B"/>
      <ConstraintRegion from="264" to="285" loc="H" subId="17369830" subSource="7vr5_B"/>
      <ConstraintRegion from="286" to="337" loc="I" subId="17369831" subSource="7vr5_B"/>
      <ConstraintRegion from="338" to="361" loc="H" subId="17369833" subSource="7vr5_B"/>
      <ConstraintRegion from="362" to="381" loc="O" subId="17369835" subSource="7vr5_B"/>
      <ConstraintRegion from="382" to="404" loc="H" subId="17369838" subSource="7vr5_B"/>
      <ConstraintRegion from="405" to="688" loc="I" subId="17369841" subSource="7vr5_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="7dqv_A">
      <ConstraintRegion from="101" to="101" loc="I" subId="17036392" subSource="7dqv_A"/>
      <ConstraintRegion from="102" to="117" loc="F" subId="17036394" subSource="7dqv_A"/>
      <ConstraintRegion from="118" to="139" loc="H" subId="17036396" subSource="7dqv_A"/>
      <ConstraintRegion from="140" to="165" loc="O" subId="17036398" subSource="7dqv_A"/>
      <ConstraintRegion from="166" to="189" loc="H" subId="17036400" subSource="7dqv_A"/>
      <ConstraintRegion from="190" to="233" loc="I" subId="17036402" subSource="7dqv_A"/>
      <ConstraintRegion from="234" to="256" loc="H" subId="17036404" subSource="7dqv_A"/>
      <ConstraintRegion from="257" to="263" loc="O" subId="17036406" subSource="7dqv_A"/>
      <ConstraintRegion from="264" to="284" loc="H" subId="17036408" subSource="7dqv_A"/>
      <ConstraintRegion from="285" to="338" loc="I" subId="17036410" subSource="7dqv_A"/>
      <ConstraintRegion from="339" to="361" loc="H" subId="17036412" subSource="7dqv_A"/>
      <ConstraintRegion from="362" to="382" loc="O" subId="17036414" subSource="7dqv_A"/>
      <ConstraintRegion from="383" to="405" loc="H" subId="17036416" subSource="7dqv_A"/>
      <ConstraintRegion from="406" to="689" loc="I" subId="17036418" subSource="7dqv_A"/>
      <ConstraintRegion from="101" to="101" loc="I" subId="17036422" subSource="7dqv_B"/>
      <ConstraintRegion from="102" to="117" loc="F" subId="17036424" subSource="7dqv_B"/>
      <ConstraintRegion from="118" to="139" loc="H" subId="17036426" subSource="7dqv_B"/>
      <ConstraintRegion from="140" to="165" loc="O" subId="17036429" subSource="7dqv_B"/>
      <ConstraintRegion from="166" to="189" loc="H" subId="17036430" subSource="7dqv_B"/>
      <ConstraintRegion from="190" to="233" loc="I" subId="17036432" subSource="7dqv_B"/>
      <ConstraintRegion from="234" to="256" loc="H" subId="17036434" subSource="7dqv_B"/>
      <ConstraintRegion from="257" to="263" loc="O" subId="17036437" subSource="7dqv_B"/>
      <ConstraintRegion from="264" to="284" loc="H" subId="17036439" subSource="7dqv_B"/>
      <ConstraintRegion from="285" to="338" loc="I" subId="17036441" subSource="7dqv_B"/>
      <ConstraintRegion from="339" to="361" loc="H" subId="17036443" subSource="7dqv_B"/>
      <ConstraintRegion from="362" to="382" loc="O" subId="17036446" subSource="7dqv_B"/>
      <ConstraintRegion from="383" to="405" loc="H" subId="17036448" subSource="7dqv_B"/>
      <ConstraintRegion from="406" to="689" loc="I" subId="17036450" subSource="7dqv_B"/>
    </Constraint>
  </Constraints>
</HtpItem>
