<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A2R8Y434_HUMAN" transmembrane="yes" evidence="Prediction">
  <Name>Transmembrane channel-like protein </Name>
  <CrossRef>
    <PDBTM id="7usw">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7usx">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8tkp">
      <Chain id="A"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="7usy">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6wud">
      <Chain id="B"/>
    </PDBTM>
    <TOPDB id="TMC1_MOUSE">
      <Alignment>
        <CrossRefSeq>MMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFVLTFSLIMLPEYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWLNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFCSWDYLIGNPETADNKFNSITMNFKEAIIEERAAQVEENIHLIRFLRFLANFFVFLTLGASGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNESLSGLSGNTTGAPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLTIYYLNATAKGQKAANLDLKKKMKQQALENKMR</CrossRefSeq>
        <OrigSeq>MMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFILTFSLIMLPEYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWMNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFTSWDYLIGNPETADNKFNSITMNFKEAITEEKAAQVEENVHLIRFLRFLANFFVFLTLGGSGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYN---ASFSENSTGPPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLAIYYLNATAKGQKAANLDLKKKMKMLQLLVASN</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TMC2_CAEEL">
      <Alignment>
        <CrossRefSeq>AASPTGATTRASLRMSQGGLCWETIIGQEITKLVTMDLYMTVASIFLIDFLRGLACRYLNLYWPWDLERTFPEYGEFKVAENVLHLVNNQGMIWLGLFFVPLLPMLNNIKLIILMYIRGWAAMTCNVPASQIFRASRSSNFFFALLILFLFLCTLPVGFVIASKTPSKSCGPFGNQSFFYSVITDVLHENLDKTLVNGIKYSLSPGIIIPVLVLLSLVIYFLIAMVTGLSQANQDLSFQLMVERTEEKKK</CrossRefSeq>
        <OrigSeq>SENSTGPPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLAIYYLNATAKGQKAANLDLKKKMKMLQLLVASN</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="627" CheckSum="9773f87928001fedf82117d72fc53a17">
    <Seq>
      MMMAKKWAKF LRDFENFKAA CVPWENKIKA IESQFGSSVA SYFLFLRWMY
      GVNMVLFILT FSLIMLPEYL WGLPYGSLPR KTVPRAEEAS AANFGVLYDF
      NGLAQYSVLF YGYYDNKRTI GWMNFRLPLS YFLVGIMCIG YSFLVVLKAM
      TKNIGDDGGG DDNTFNFSWK VFTSWDYLIG NPETADNKFN SITMNFKEAI
      TEEKAAQVEE NVHLIRFLRF LANFFVFLTL GGSGYLIFWA VKRSQEFAQQ
      DPDTLGWWEK NEMNMVMSLL GMFCPTLFDL FAELEDYHPL IALKWLLGRI
      FALLLGNLYV FILALMDEIN NKIEEEKLVK ANITLWEANM IKAYNASFSE
      NSTGPPFFVH PADVPRGPCW ETMVGQEFVR LTVSDVLTTY VTILIGDFLR
      ACFVRFCNYC WCWDLEYGYP SYTEFDISGN VLALIFNQGM IWMGSFFAPS
      LPGINILRLH TSMYFQCWAV MCCNVPEARV FKASRSNNFY LGMLLLILFL
      STMPVLYMIV SLPPSFDCGP FSGKNRMFEV IGETLEHDFP SWMAKILRQL
      SNPGLVIAVI LVMVLAIYYL NATAKGQKAA NLDLKKKMKM LQLLVASNKY
      PESPEKVHFA LLFKSNAICE RPENKHC
    </Seq>
  </Sequence>
  <Topology numTm="8" reliability="76.58">
    <Region from="1" to="47" loc="I"/>
    <Region from="48" to="66" loc="M"/>
    <Region from="67" to="126" loc="O"/>
    <Region from="127" to="146" loc="M"/>
    <Region from="147" to="216" loc="I"/>
    <Region from="217" to="238" loc="M"/>
    <Region from="239" to="262" loc="O"/>
    <Region from="263" to="281" loc="M"/>
    <Region from="282" to="295" loc="I"/>
    <Region from="296" to="315" loc="M"/>
    <Region from="316" to="438" loc="O"/>
    <Region from="439" to="457" loc="M"/>
    <Region from="458" to="488" loc="I"/>
    <Region from="489" to="509" loc="M"/>
    <Region from="510" to="552" loc="O"/>
    <Region from="553" to="572" loc="M"/>
    <Region from="573" to="627" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="48" loc="I"/>
      <Region from="49" to="66" loc="M"/>
      <Region from="67" to="219" loc="O"/>
      <Region from="220" to="241" loc="M"/>
      <Region from="242" to="299" loc="I"/>
      <Region from="300" to="316" loc="M"/>
      <Region from="317" to="439" loc="O"/>
      <Region from="440" to="457" loc="M"/>
      <Region from="458" to="490" loc="I"/>
      <Region from="491" to="512" loc="M"/>
      <Region from="513" to="553" loc="O"/>
      <Region from="554" to="574" loc="M"/>
      <Region from="575" to="627" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="39" loc="I"/>
      <Region from="40" to="70" loc="M"/>
      <Region from="71" to="126" loc="O"/>
      <Region from="127" to="149" loc="M"/>
      <Region from="150" to="216" loc="I"/>
      <Region from="217" to="241" loc="M"/>
      <Region from="242" to="262" loc="O"/>
      <Region from="263" to="280" loc="M"/>
      <Region from="281" to="294" loc="I"/>
      <Region from="295" to="317" loc="M"/>
      <Region from="318" to="377" loc="O"/>
      <Region from="378" to="407" loc="M"/>
      <Region from="408" to="432" loc="I"/>
      <Region from="433" to="454" loc="M"/>
      <Region from="455" to="457" loc="O"/>
      <Region from="458" to="473" loc="M"/>
      <Region from="474" to="487" loc="I"/>
      <Region from="488" to="510" loc="M"/>
      <Region from="511" to="547" loc="O"/>
      <Region from="548" to="573" loc="M"/>
      <Region from="574" to="627" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="36" loc="I"/>
      <Region from="37" to="51" loc="M"/>
      <Region from="52" to="52" loc="O"/>
      <Region from="53" to="67" loc="M"/>
      <Region from="68" to="89" loc="I"/>
      <Region from="90" to="110" loc="M"/>
      <Region from="111" to="125" loc="O"/>
      <Region from="126" to="146" loc="M"/>
      <Region from="147" to="217" loc="I"/>
      <Region from="218" to="238" loc="M"/>
      <Region from="239" to="258" loc="O"/>
      <Region from="259" to="279" loc="M"/>
      <Region from="280" to="293" loc="I"/>
      <Region from="294" to="314" loc="M"/>
      <Region from="315" to="380" loc="O"/>
      <Region from="381" to="395" loc="M"/>
      <Region from="396" to="396" loc="I"/>
      <Region from="397" to="411" loc="M"/>
      <Region from="412" to="432" loc="O"/>
      <Region from="433" to="463" loc="M"/>
      <Region from="464" to="485" loc="I"/>
      <Region from="486" to="506" loc="M"/>
      <Region from="507" to="527" loc="O"/>
      <Region from="528" to="531" loc="L"/>
      <Region from="532" to="551" loc="O"/>
      <Region from="552" to="572" loc="M"/>
      <Region from="573" to="627" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="45" loc="I"/>
      <Region from="46" to="67" loc="M"/>
      <Region from="68" to="126" loc="O"/>
      <Region from="127" to="147" loc="M"/>
      <Region from="148" to="219" loc="I"/>
      <Region from="220" to="241" loc="M"/>
      <Region from="242" to="262" loc="O"/>
      <Region from="263" to="282" loc="M"/>
      <Region from="283" to="294" loc="I"/>
      <Region from="295" to="315" loc="M"/>
      <Region from="316" to="433" loc="O"/>
      <Region from="434" to="457" loc="M"/>
      <Region from="458" to="488" loc="I"/>
      <Region from="489" to="510" loc="M"/>
      <Region from="511" to="549" loc="O"/>
      <Region from="550" to="570" loc="M"/>
      <Region from="571" to="627" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="49" loc="I"/>
      <Region from="50" to="71" loc="M"/>
      <Region from="72" to="90" loc="O"/>
      <Region from="91" to="113" loc="M"/>
      <Region from="114" to="124" loc="I"/>
      <Region from="125" to="147" loc="M"/>
      <Region from="148" to="219" loc="O"/>
      <Region from="220" to="241" loc="M"/>
      <Region from="242" to="261" loc="I"/>
      <Region from="262" to="284" loc="M"/>
      <Region from="285" to="295" loc="O"/>
      <Region from="296" to="316" loc="M"/>
      <Region from="317" to="488" loc="I"/>
      <Region from="489" to="510" loc="M"/>
      <Region from="511" to="549" loc="O"/>
      <Region from="550" to="570" loc="M"/>
      <Region from="571" to="627" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="44" loc="I"/>
      <Region from="45" to="65" loc="M"/>
      <Region from="66" to="126" loc="O"/>
      <Region from="127" to="147" loc="M"/>
      <Region from="148" to="219" loc="I"/>
      <Region from="220" to="240" loc="M"/>
      <Region from="241" to="260" loc="O"/>
      <Region from="261" to="281" loc="M"/>
      <Region from="282" to="292" loc="I"/>
      <Region from="293" to="313" loc="M"/>
      <Region from="314" to="449" loc="O"/>
      <Region from="450" to="470" loc="M"/>
      <Region from="471" to="490" loc="I"/>
      <Region from="491" to="511" loc="M"/>
      <Region from="512" to="549" loc="O"/>
      <Region from="550" to="570" loc="M"/>
      <Region from="571" to="627" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="45" loc="I"/>
      <Region from="46" to="66" loc="M"/>
      <Region from="67" to="126" loc="O"/>
      <Region from="127" to="147" loc="M"/>
      <Region from="148" to="219" loc="I"/>
      <Region from="220" to="240" loc="M"/>
      <Region from="241" to="263" loc="O"/>
      <Region from="264" to="284" loc="M"/>
      <Region from="285" to="295" loc="I"/>
      <Region from="296" to="316" loc="M"/>
      <Region from="317" to="439" loc="O"/>
      <Region from="440" to="460" loc="M"/>
      <Region from="461" to="490" loc="I"/>
      <Region from="491" to="511" loc="M"/>
      <Region from="512" to="549" loc="O"/>
      <Region from="550" to="570" loc="M"/>
      <Region from="571" to="627" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="45" loc="O"/>
      <Region from="46" to="65" loc="M"/>
      <Region from="66" to="126" loc="I"/>
      <Region from="127" to="146" loc="M"/>
      <Region from="147" to="217" loc="O"/>
      <Region from="218" to="237" loc="M"/>
      <Region from="238" to="261" loc="I"/>
      <Region from="262" to="281" loc="M"/>
      <Region from="282" to="298" loc="O"/>
      <Region from="299" to="318" loc="M"/>
      <Region from="319" to="385" loc="I"/>
      <Region from="386" to="405" loc="M"/>
      <Region from="406" to="430" loc="O"/>
      <Region from="431" to="450" loc="M"/>
      <Region from="451" to="488" loc="I"/>
      <Region from="489" to="508" loc="M"/>
      <Region from="509" to="553" loc="O"/>
      <Region from="554" to="574" loc="M"/>
      <Region from="575" to="627" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="45" loc="I"/>
      <Region from="46" to="66" loc="M"/>
      <Region from="67" to="126" loc="O"/>
      <Region from="127" to="147" loc="M"/>
      <Region from="148" to="214" loc="I"/>
      <Region from="215" to="235" loc="M"/>
      <Region from="236" to="261" loc="O"/>
      <Region from="262" to="282" loc="M"/>
      <Region from="283" to="299" loc="I"/>
      <Region from="300" to="320" loc="M"/>
      <Region from="321" to="377" loc="O"/>
      <Region from="378" to="398" loc="M"/>
      <Region from="399" to="430" loc="I"/>
      <Region from="431" to="451" loc="M"/>
      <Region from="452" to="452" loc="O"/>
      <Region from="453" to="473" loc="M"/>
      <Region from="474" to="488" loc="I"/>
      <Region from="489" to="509" loc="M"/>
      <Region from="510" to="553" loc="O"/>
      <Region from="554" to="574" loc="M"/>
      <Region from="575" to="627" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="43" loc="I"/>
      <Region from="44" to="66" loc="M"/>
      <Region from="67" to="124" loc="O"/>
      <Region from="125" to="147" loc="M"/>
      <Region from="148" to="216" loc="I"/>
      <Region from="217" to="239" loc="M"/>
      <Region from="240" to="290" loc="O"/>
      <Region from="291" to="313" loc="M"/>
      <Region from="314" to="488" loc="I"/>
      <Region from="489" to="511" loc="M"/>
      <Region from="512" to="549" loc="O"/>
      <Region from="550" to="572" loc="M"/>
      <Region from="573" to="627" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
