<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A2R8Y4M0_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>SPG7 matrix AAA peptidase subunit, paraplegin </Name>
  <CrossRef>
    <PDBTM id="7y53">
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="F"/>
      <Chain id="E"/>
    </PDBTM>
    <PDBTM id="7y4w">
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="F"/>
      <Chain id="E"/>
    </PDBTM>
    <PDBTM id="7y59">
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="F"/>
      <Chain id="E"/>
    </PDBTM>
    <PDBTM id="1lv7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2cea">
      <Chain id="A"/>
      <Chain id="F"/>
      <Chain id="B"/>
      <Chain id="E"/>
      <Chain id="D"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="2ce7">
      <Chain id="A"/>
      <Chain id="F"/>
      <Chain id="B"/>
      <Chain id="E"/>
      <Chain id="D"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6nyy">
      <Chain id="E"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="B"/>
      <Chain id="F"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3kds">
      <Chain id="F"/>
      <Chain id="G"/>
      <Chain id="E"/>
    </PDBTM>
    <PDBTM id="4eiw">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="E"/>
      <Chain id="B"/>
      <Chain id="D"/>
      <Chain id="F"/>
    </PDBTM>
    <PDBTM id="2dhr">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="E"/>
      <Chain id="B"/>
      <Chain id="D"/>
      <Chain id="F"/>
    </PDBTM>
    <PDBTM id="7tdo">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="E"/>
      <Chain id="F"/>
    </PDBTM>
    <PDBTM id="2r62">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="2r65">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="E"/>
    </PDBTM>
    <PDBTM id="5a5b">
      <Chain id="J"/>
      <Chain id="H"/>
      <Chain id="K"/>
      <Chain id="I"/>
    </PDBTM>
    <PDBTM id="1iy0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5ubv">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1iy2">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2qz4">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1iy1">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1ixz">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4ww0">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="4z8x">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <TOPDB id="SPG7_HUMAN">
      <Alignment>
        <CrossRefSeq>VRLWQLLGGTFYFNTSRLKQKNKEKDKSKGKAPEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGALMR</CrossRefSeq>
        <OrigSeq>VRLWQLLGGTFYFNTSRLKQKNKEKDKSKGKAPEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDVFYA--EIEELKLVNRRAETGVSLSR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="AFG32_HUMAN">
      <Alignment>
        <CrossRefSeq>DDSHWWSRFQKGDIPWDDKDFRMFFLWTALFWGGVMFYL-LLKRSGREITWKDFVNNYLSKGVVDRLEVV-NKRFVRVTFTPGKT----PVDGQYVWFNIGSVDTFERNLETLQQELGIEGENRVPVVYIAESD-GSFLLSMLPTVLIIAFLLYTIRRGPAGIGRTGRGMGGLFSVGETTAKVLKDEIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRGNFG-GQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLR</CrossRefSeq>
        <OrigSeq>GKAPEEDEEERRRRERDDQMYR-ERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDVFY--AEIEELKLVNRRAETGVSLSR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="FTSH_ECOLI">
      <Alignment>
        <CrossRefSeq>MAKNLILWLVIAVVLMSVFQSFGPSESNGRKVDYSTFLQE-VNNDQVREARINGREINV------------TKKDSNRYTTYIPVQDP---KLLDNLLTKNVKVVGEPP---EEPSLLASIFISWFPMLLLIGVWIFFMRQMQGGGGKG-AMSFGKSKAR----MLTEDQIKTTFADVAGCDEAKEEVAELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAGLGG-GHDEREQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPALLR</CrossRefSeq>
        <OrigSeq>MYRERLRTLLVIAVVMSLLNALSTS---GGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDVFYAE--IEELKLVNRRAETGVSLSR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="FTSH_THEMA">
      <Alignment>
        <CrossRefSeq>MNRSNIWNLLFTILIIVTLFWLARFFYVENSPVSKLSYTSFVQMVED----------ERSVVSEVVIRDDGVLRVYTKDGRVYEVDAPWA-VNDSQLIEKLVSKGIKVSGE---RSGSSSFWINVLGTLIPTILFIVVWLFIMR--SLSGRNNQAFTFTKSRATMYKPSGNK---RVTFKDVGGAEEAIEELKEVVEFLKDPSKFNRIGARMPKGILLVGPPGTGKTLLARAVAGEANVPFFHISGSDFVELFVGVGAARVRDLFAQAKAHAPCIVFIDEIDAVGRHRGAGLGG-GHDEREQTLNQLLVEMDGFDSKEGIIVMAATNRPDILDPALLR</CrossRefSeq>
        <OrigSeq>ERDDQMYRERLRTLLVIAVVMS--LLNALSTSGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDVFYA--EIEELKLVNRRAETGVSLSR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="FTSH_HELPY">
      <Alignment>
        <CrossRefSeq>KPTNEPKKPFFQSPIILAVLGGILLIFFLRSFNSDGSFSDNFLASSTKNVSYHE-IKQLISNNEVENVSIGQ--TLIKASHKEGN------NRVIYIAKRVPDLT-----LVPLLDEKKINYSG-----FSESNFFTDMLGWLMPILVILGLWMFMANRMQKNMGGG------IFGMGSAKKLINAEKPNVRFNDMAGNEEAKEEVVEIVDFLKYPERYANLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAHVPFFSMGGSSFIEMFVGLGASRVRDLFETAKKQAPSIIFIDEIDAIGKSRAAGGVVSGNDEREQTLNQLLAEMDGFGSENAPVIVLAATNRPEILDPALMR</CrossRefSeq>
        <OrigSeq>RRRRERDDQMYRERLRTLLVIAVVMSLL------------NALSTSGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDVFYAE---IEELKLVNRRAETGVSLSR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="FTSH_AQUAE">
      <Alignment>
        <CrossRefSeq>FNLFEGKREFTTKVSLNEVV-KLVEEGKVSYAEVRGNTAIIQ------------TKDGQKLEVTLPPNTNLVDKMVEKGVRVEVANPEPP------GGWLVNVFLSWLPILFFIGIWIFLLRQMSGGGNVNRAFNFGKSRAKVY----IEEKPKVTFKDVAGIEEVKEEVKEIIEYLKDPVKFQKLGGRPPKGVLLYGEPGVGKTLLAKAIAGEAHVPFISVSGSDFVEMFVGVGAARVRDLFETAKKHAPCIIFIDEIDAVGRARGAIPVGGGHDEREQTLNQLLVEMDGFDTSDGIIVIAATNRPDILDPALLR</CrossRefSeq>
        <OrigSeq>MSLLNALSTSGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDVFYA--EIEELKLVNRRAETGVSLSR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="FTSH_THET8">
      <Alignment>
        <CrossRefSeq>LVLGLAFLAWAFSLAGTVGAPSGTVNYTTFL-EDLKAGRVKEVVVRAGDTRIQGVLEDGSAF-------TTYAASPPDNATLEGWM-----ARGVSVRVEPPQGQNALGFLWPLLLVGLLIGAL-----YYFSRNGRAGPSDSAFSFTKSRARVLT-----EAPKVTFKDVAGAEEAKEELKEIVEFLKNPSRFHEMGARIPKGVLLVGPPGVGKTHLARAVAGEARVPFITASGSDFVEMFVGVGAARVRDLFETAKRHAPCIVFIDEIDAVGRKRGSGVGG-GNDEREQTLNQLLVEMDGFEKDTAIVVMAATNRPDILDPALLR</CrossRefSeq>
        <OrigSeq>RLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDVFYAE--IEELKLVNRRAETGVSLSR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="G2QPI5_THET4">
      <Alignment>
        <CrossRefSeq>GSNGSKNGPLHVIVDETFGTAALRWIKFLLWFGLCAYLSLVLVTMVVEGMTS---LKRPSKVDGIDPKAENQKARFSDVHGCDEAKEELQELVEFLRNPEKFSNLGGKLPKGVLLVGPPGTGKTLLARAVAGEAGVPFFYMSGSEFDEIYVGVGAKRVRELFNAAKAKAPSIVFIDELDAIGGRRNSRDA----TYVRQTLNQLLTEMDGFAQNSGVIILGATNFPESLDKALTR</CrossRefSeq>
        <OrigSeq>NIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGK-MGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDVF--YAEIEELKLVNRRAETGVSLSR</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="383" CheckSum="942e6bcd0081ac4e51d44526e22fd40c">
    <Seq>
      XVRLWQLLGG TFYFNTSRLK QKNKEKDKSK GKAPEEDEEE RRRRERDDQM
      YRERLRTLLV IAVVMSLLNA LSTSGGSISW NDFVHEMLAK GEVQRVQVVP
      ESDVVEVYLH PGAVVFGRPR LALMYRMQVA NIDKFEEKLR AAEDELNIEA
      KDRIPVSYKR TGFFGNALYS VGMTAVGLAI LWYVFRLAGM TGREGGFSAF
      NQLKMARFTI VDGKMGKGVS FKDVAGMHEA KLEVREFVDY LKSPERFLQL
      GAKVPKGALL LGPPGCGKTL LAKAVATEAQ VPFLAMAGPE FVEVIGGLGA
      ARVRSLFKEA RARAPCIVYI DEIDAVGKKR STTMSGFSNT EEEQTLNQLL
      VEMDVFYAEI EELKLVNRRA ETGVSLSRCS TQK
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="93.35">
    <Region from="1" to="56" loc="I"/>
    <Region from="57" to="71" loc="M"/>
    <Region from="72" to="165" loc="O"/>
    <Region from="166" to="185" loc="M"/>
    <Region from="186" to="383" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="3" loc="O"/>
      <Region from="4" to="15" loc="M"/>
      <Region from="16" to="56" loc="I"/>
      <Region from="57" to="68" loc="M"/>
      <Region from="69" to="166" loc="O"/>
      <Region from="167" to="185" loc="M"/>
      <Region from="186" to="383" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="53" loc="I"/>
      <Region from="54" to="69" loc="M"/>
      <Region from="70" to="161" loc="O"/>
      <Region from="162" to="185" loc="M"/>
      <Region from="186" to="383" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="4" loc="I"/>
      <Region from="5" to="11" loc="L"/>
      <Region from="12" to="54" loc="I"/>
      <Region from="55" to="75" loc="M"/>
      <Region from="76" to="164" loc="O"/>
      <Region from="165" to="185" loc="M"/>
      <Region from="186" to="268" loc="I"/>
      <Region from="269" to="283" loc="M"/>
      <Region from="284" to="284" loc="O"/>
      <Region from="285" to="299" loc="M"/>
      <Region from="300" to="383" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="54" loc="I"/>
      <Region from="55" to="78" loc="M"/>
      <Region from="79" to="164" loc="O"/>
      <Region from="165" to="185" loc="M"/>
      <Region from="186" to="383" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="57" loc="I"/>
      <Region from="58" to="80" loc="M"/>
      <Region from="81" to="166" loc="O"/>
      <Region from="167" to="185" loc="M"/>
      <Region from="186" to="383" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="50" loc="I"/>
      <Region from="51" to="71" loc="M"/>
      <Region from="72" to="164" loc="O"/>
      <Region from="165" to="185" loc="M"/>
      <Region from="186" to="383" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="50" loc="I"/>
      <Region from="51" to="71" loc="M"/>
      <Region from="72" to="165" loc="O"/>
      <Region from="166" to="186" loc="M"/>
      <Region from="187" to="267" loc="I"/>
      <Region from="268" to="288" loc="M"/>
      <Region from="289" to="383" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="52" loc="I"/>
      <Region from="53" to="73" loc="M"/>
      <Region from="74" to="166" loc="O"/>
      <Region from="167" to="187" loc="M"/>
      <Region from="188" to="383" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="52" loc="I"/>
      <Region from="53" to="73" loc="M"/>
      <Region from="74" to="166" loc="O"/>
      <Region from="167" to="187" loc="M"/>
      <Region from="188" to="383" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="57" loc="I"/>
      <Region from="58" to="80" loc="M"/>
      <Region from="81" to="162" loc="O"/>
      <Region from="163" to="185" loc="M"/>
      <Region from="186" to="383" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
