<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A2R8Y7N2_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>SPG7 matrix AAA peptidase subunit, paraplegin </Name>
  <CrossRef>
    <PDBTM id="1lv7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5a5b">
      <Chain id="K"/>
      <Chain id="M"/>
      <Chain id="J"/>
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="6nyy">
      <Chain id="E"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="B"/>
      <Chain id="A"/>
      <Chain id="F"/>
    </PDBTM>
    <PDBTM id="2cea">
      <Chain id="A"/>
      <Chain id="F"/>
      <Chain id="B"/>
      <Chain id="E"/>
      <Chain id="D"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="2ce7">
      <Chain id="A"/>
      <Chain id="F"/>
      <Chain id="B"/>
      <Chain id="E"/>
      <Chain id="D"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="3kds">
      <Chain id="F"/>
      <Chain id="G"/>
      <Chain id="E"/>
    </PDBTM>
    <PDBTM id="2r62">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="2r65">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="E"/>
    </PDBTM>
    <PDBTM id="4eiw">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="E"/>
      <Chain id="B"/>
      <Chain id="D"/>
      <Chain id="F"/>
    </PDBTM>
    <PDBTM id="2dhr">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="E"/>
      <Chain id="D"/>
      <Chain id="F"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7tdo">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="E"/>
      <Chain id="F"/>
    </PDBTM>
    <PDBTM id="4z8x">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="2qz4">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1iy0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1iy2">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1iy1">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1ixz">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5ubv">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4ww0">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <TOPDB id="SPG7_HUMAN">
      <Alignment>
        <CrossRefSeq>AWSPGFPARPGRGRPYMASRPPGDLAEAGGRALQSLQLRLLTPTFEGINGLLLKQHLVQNPVRLWQLLGGTFYFNTSRLKQKNKEKDKSKGKAPEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGMGT-TDHVIVLASTNRADILD</CrossRefSeq>
        <OrigSeq>AWSPGFPARPGRGRPYMASRPPGDLAEAGGRALQSLQLRLLTPTFEGINGLLLKQHLVQNPVRLWQLLGGTFYFNTSRLKQKNKEKDKSKGKAPEEDEEERRRRERDDQMYRERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLK-------LGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDVFYAEIEELKLVYPYHG--VLH</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="AFG32_HUMAN">
      <Alignment>
        <CrossRefSeq>RLWGRGGCWPRGLQQLLVPGGVGPGEQPCLRTLYRFVTTQARASRNSLL---------TDIIAAYQRFCSRPPKGFEKYFPNGKNGKKASEPKEVMGEKKESKPAATTRSSGGGGGGGGKRGGKKDDSHWWSRFQKGDIPWDDKDFRMFFLWTALFWGGVMFYL-LLKRSGREITWKDFVNNYLSKGVVDRLEVVNKRFV-RVTFTPGKT----PVDGQYVWFNIGSVDTFERNLETLQQELGIEGENRVPVVYIAESD-GSFLLSMLPTVLIIAFLLYTIRRGPAGIGRTGRGMGGLFSVGETTAKVLKDEIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRGNFG-GQSEQENTLNQLLVEMDGFNTTT-NVVILAGTNRPDILD</CrossRefSeq>
        <OrigSeq>PLWGPGPAWSPGFP----ARPGRGRPYMASRPPGDLAEAGGRALQSLQLRLLTPTFEGINGLLLKQHLVQNPVRLWQLLGGTFYF--NTSRLKQKNKEKDKSKG----------------------KAPEEDEEERRRRERDDQMYR-ERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLK-------LGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDVFYAEIEELKLVYPYHG--VLH</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="FTSH_ECOLI">
      <Alignment>
        <CrossRefSeq>MAKNLILWLVIAVVLMSVFQSFGPSESNGRKVDYSTFLQE------------VNNDQVREARINGREINVTKKDSNRYTTYIPVQDPKLLDNLLTKNVKVVGEPP-------EEPSLLASIFISWFPMLLLIGVWIFFMRQMQG-GGGKGAMSFGKSKAR----MLTEDQIKTTFADVAGCDEAKEEVAELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAGLGG-GHDEREQTLNQMLVEMDGFEGN-EGIIVIAATNRPDVLD</CrossRefSeq>
        <OrigSeq>MYRERLRTLLVIAVVMSLLNALSTS---GGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYL-------KLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDVFYAEIEELKLVYPYHG--VLH</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="FTSH_THEMA">
      <Alignment>
        <CrossRefSeq>NRSNIWNLLFTILIIVTLFWLARFFYVENSPVSKLSYTSFVQMVEDERSVVSEVVIRDDGVLRVYTKDGRVYEVDA-------PWAVNDSQLIEKLVSKGIKVSGE-------RSGSSSFWINVLGTLIPTILFIVVWLFIMR--SLSGRNNQAFTFTKSRATMYKPSG---NKRVTFKDVGGAEEAIEELKEVVEFLKDPSKFNRIGARMPKGILLVGPPGTGKTLLARAVAGEANVPFFHISGSDFVELFVGVGAARVRDLFAQAKAHAPCIVFIDEIDAVGRHRGAGLGG-GHDEREQTLNQLLVEMDGFDSK-EGIIVMAATNRPDILD</CrossRefSeq>
        <OrigSeq>DDQMYRERLRTLLVIAVVMSLLNAL---STSGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLK-------LGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDVFYAEIEELKLVYPYHG--VLH</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="FTSH_AQUAE">
      <Alignment>
        <CrossRefSeq>NALKNFFIWAIIIGAAIVAFNLFEGKREFTTKVSLNEVV-KLVEEGKVSYAEVRGNTAIIQ------------TKDGQKLEVTLPPNTNLVDKMVEKGVRVEVANPEPP------GGWLVNVFLSWLPILFFIGIWIFLLRQMSGGGNVNRAFNFGKSRAKVY----IEEKPKVTFKDVAGIEEVKEEVKEIIEYLKDPVKFQKLGGRPPKGVLLYGEPGVGKTLLAKAIAGEAHVPFISVSGSDFVEMFVGVGAARVRDLFETAKKHAPCIIFIDEIDAVGRARGAIPVGGGHDEREQTLNQLLVEMDGFDT-SDGIIVIAATNRPDILD</CrossRefSeq>
        <OrigSeq>QMYRERLRTLLVIAVVMSLLNALSTS---GGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLE-------VREFVDYLKLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDVFYAEIEELKLVYPYHG--VLH</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="FTSH_HELPY">
      <Alignment>
        <CrossRefSeq>KPTNEPKKPFFQSPIILAVLGGILLIFFLRSFNSDGSFSDNFLASSTKNVSYHE-IKQLISNNEVENVSI--GQTLIKASHKEGNNRVIYIAKRVPDLTLVPLLDE---------KKINYSG-------FSESNFFTDMLGWLMPILVILGLWMFMANRMQKNMGGG------IFGMGSAKKLINAEKPNVRFNDMAGNEEAKEEVVEIVDFLKYPERYANLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAHVPFFSMGGSSFIEMFVGLGASRVRDLFETAKKQAPSIIFIDEIDAIGKSRAAGGVVSGNDEREQTLNQLLAEMDGFGSENAPVIVLAATNRPEILD</CrossRefSeq>
        <OrigSeq>RRRRERDDQMYRERLRTLLVIAVVMSLL------------NALSTSGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLK-------LGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDVFYAEIEELKLVYPYHG--VLH</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="FTSH_THET8">
      <Alignment>
        <CrossRefSeq>ALVLGLAFLAWAFSLAGTVGAPSGTVNYTTFL-EDLKAGRVKEVVVRAGDTRIQGVLEDGSA----------FTTYAASPPDNATLEGWMAR--GVSVRVEPPQGQNALGFLWPLLLVGLLIGAL-----YYFSRNGRAGPSDSAFSFTKSRARVLT-----EAPKVTFKDVAGAEEAKEELKEIVEFLKNPSRFHEMGARIPKGVLLVGPPGVGKTHLARAVAGEARVPFITASGSDFVEMFVGVGAARVRDLFETAKRHAPCIVFIDEIDAVGRKRGSGVGG-GNDEREQTLNQLLVEMDGFEKDTA-IVVMAATNRPDILD</CrossRefSeq>
        <OrigSeq>ERLRTLLVIAVVMSLLNALSTSGGSISWNDFVHEMLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEEKLRAAEDELNIEAKDRIPVSYKRTGFFGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLK-------LGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDVFYAEIEELKLVYPYHG--VLH</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="G2QPI5_THET4">
      <Alignment>
        <CrossRefSeq>FGTAALRWIKFLLWFGLCAYLSLVLVTMVVEGMTSLKRPSKVD--GIDPKAENQKARFSDVHGCDEAKEELQELVEFLRNPEKFSNLGGKLPKGVLLVGPPGTGKTLLARAVAGEAGVPFFYMSGSEFDEIYVGVGAKRVRELFNAAKAKAPSIVFIDELDAIGGRRNSRDATY----VRQTLNQLLTEMDGFAQNS</CrossRefSeq>
        <OrigSeq>FGNALYSVGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKMGKGVSFKDVAGMHEAKLEVREFVDYLK-------LGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDVFYAEI</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="456" CheckSum="3d89fae84b7d15b6e9565c0f6d2c4118">
    <Seq>
      MAVLLLLLRA LRRGPGPGPR PLWGPGPAWS PGFPARPGRG RPYMASRPPG
      DLAEAGGRAL QSLQLRLLTP TFEGINGLLL KQHLVQNPVR LWQLLGGTFY
      FNTSRLKQKN KEKDKSKGKA PEEDEEERRR RERDDQMYRE RLRTLLVIAV
      VMSLLNALST SGGSISWNDF VHEMLAKGEV QRVQVVPESD VVEVYLHPGA
      VVFGRPRLAL MYRMQVANID KFEEKLRAAE DELNIEAKDR IPVSYKRTGF
      FGNALYSVGM TAVGLAILWY VFRLAGMTGR EGGFSAFNQL KMARFTIVDG
      KMGKGVSFKD VAGMHEAKLE VREFVDYLKL GAKVPKGALL LGPPGCGKTL
      LAKAVATEAQ VPFLAMAGPE FVEVIGGLGA ARVRSLFKEA RARAPCIVYI
      DEIDAVGKKR STTMSGFSNT EEEQTLNQLL VEMDVFYAEI EELKLVYPYH
      GVLHSD
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="91.28">
    <Region from="1" to="141" loc="I"/>
    <Region from="142" to="159" loc="M"/>
    <Region from="160" to="252" loc="O"/>
    <Region from="253" to="272" loc="M"/>
    <Region from="273" to="456" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="143" loc="I"/>
      <Region from="144" to="165" loc="M"/>
      <Region from="166" to="253" loc="O"/>
      <Region from="254" to="272" loc="M"/>
      <Region from="273" to="456" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="140" loc="I"/>
      <Region from="141" to="156" loc="M"/>
      <Region from="157" to="250" loc="O"/>
      <Region from="251" to="272" loc="M"/>
      <Region from="273" to="456" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="50" loc="O"/>
      <Region from="51" to="71" loc="M"/>
      <Region from="72" to="90" loc="I"/>
      <Region from="91" to="98" loc="L"/>
      <Region from="99" to="141" loc="I"/>
      <Region from="142" to="162" loc="M"/>
      <Region from="163" to="251" loc="O"/>
      <Region from="252" to="272" loc="M"/>
      <Region from="273" to="348" loc="I"/>
      <Region from="349" to="363" loc="M"/>
      <Region from="364" to="364" loc="O"/>
      <Region from="365" to="379" loc="M"/>
      <Region from="380" to="456" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="141" loc="I"/>
      <Region from="142" to="165" loc="M"/>
      <Region from="166" to="251" loc="O"/>
      <Region from="252" to="272" loc="M"/>
      <Region from="273" to="456" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="144" loc="I"/>
      <Region from="145" to="167" loc="M"/>
      <Region from="168" to="253" loc="O"/>
      <Region from="254" to="272" loc="M"/>
      <Region from="273" to="456" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="137" loc="I"/>
      <Region from="138" to="158" loc="M"/>
      <Region from="159" to="251" loc="O"/>
      <Region from="252" to="272" loc="M"/>
      <Region from="273" to="456" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="137" loc="I"/>
      <Region from="138" to="158" loc="M"/>
      <Region from="159" to="252" loc="O"/>
      <Region from="253" to="273" loc="M"/>
      <Region from="274" to="456" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="139" loc="I"/>
      <Region from="140" to="160" loc="M"/>
      <Region from="161" to="253" loc="O"/>
      <Region from="254" to="274" loc="M"/>
      <Region from="275" to="456" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="139" loc="I"/>
      <Region from="140" to="160" loc="M"/>
      <Region from="161" to="253" loc="O"/>
      <Region from="254" to="274" loc="M"/>
      <Region from="275" to="456" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="144" loc="O"/>
      <Region from="145" to="167" loc="M"/>
      <Region from="168" to="249" loc="I"/>
      <Region from="250" to="272" loc="M"/>
      <Region from="273" to="456" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
