<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A2R8YDA3_HUMAN" transmembrane="yes" evidence="Prediction">
  <Name>Transmembrane channel-like protein </Name>
  <CrossRef>
    <PDBTM id="7usx">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7usw">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7usy">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8tkp">
      <Chain id="A"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="6wud">
      <Chain id="B"/>
    </PDBTM>
    <TOPDB id="TMC1_MOUSE">
      <Alignment>
        <CrossRefSeq>DENRQMIATVKCKPWKMEKKIEVLKEAKKFVSENEGALGKGKGKKWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFVLTFSLIMLPEYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWLNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFCSWDYLIGNPETADNKFNSITMNFKEAIIEERAAQVEENIHLIRFLRFLANFFVFLTLGASGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNESLSGLSGNTTGAPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLTIYYLNATAKGQKAANLDL</CrossRefSeq>
        <OrigSeq>EPEPEDEETRKAREKERRRRLKRGAEAKKFVSENEGALGKGKGKRWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFILTFSLIMLPEYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWMNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFTSWDYLIGNPETADNKFNSITMNFKEAITEEKAAQVEENVHLIRFLRFLANFFVFLTLGGSGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNAS---FSENSTGPPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLAIYYLNATAKGQKAANLDL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TMC2_CAEEL">
      <Alignment>
        <CrossRefSeq>SSPVVETHMFGPNSDWNETTVNAASPTGATTRASLRMSQGGLCWETIIGQEITKLVTMDLYMTVASIFLIDFLRGLACRYLNLYWPWDLERTFPEYGEFKVAENVLHLVNNQGMIWLGLFFVPLLPMLNNIKLIILMYIRGWAAMTCNVPASQIFRASRSSNFFFALLILFLFLCTLPVGFVIASKTPSKSCGPFGNQSFFYSVITDVLHENLDKTLVNGIKYSLSPGIIIPVLVLLSLVIYFLIAMVTGLSQANQDL</CrossRefSeq>
        <OrigSeq>ITLWEANMIKAYNASFSENSTGPPFFVHPAD------VPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLAIYYLNATAKGQKAANLDL</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="688" CheckSum="e860ea2e1b2d9ed0e712c8e0fdb5fd6b">
    <Seq>
      MSPKKVQIKV EEKEDETEES SSEEEEEVED KLPRRESLRP KRKRTRDVIN
      EDDPEPEPED EETRKAREKE RRRRLKRGAE AKKFVSENEG ALGKGKGKRW
      FAFKMMMAKK WAKFLRDFEN FKAACVPWEN KIKAIESQFG SSVASYFLFL
      RWMYGVNMVL FILTFSLIML PEYLWGLPYG SLPRKTVPRA EEASAANFGV
      LYDFNGLAQY SVLFYGYYDN KRTIGWMNFR LPLSYFLVGI MCIGYSFLVV
      LKAMTKNIGD DGGGDDNTFN FSWKVFTSWD YLIGNPETAD NKFNSITMNF
      KEAITEEKAA QVEENVHLIR FLRFLANFFV FLTLGGSGYL IFWAVKRSQE
      FAQQDPDTLG WWEKNEMNMV MSLLGMFCPT LFDLFAELED YHPLIALKWL
      LGRIFALLLG NLYVFILALM DEINNKIEEE KLVKANITLW EANMIKAYNA
      SFSENSTGPP FFVHPADVPR GPCWETMVGQ EFVRLTVSDV LTTYVTILIG
      DFLRACFVRF CNYCWCWDLE YGYPSYTEFD ISGNVLALIF NQGMIWMGSF
      FAPSLPGINI LRLHTSMYFQ CWAVMCCNVP EARVFKASRS NNFYLGMLLL
      ILFLSTMPVL YMIVSLPPSF DCGPFSGKNR MFEVIGETLE HDFPSWMAKI
      LRQLSNPGLV IAVILVMVLA IYYLNATAKG QKAANLDL
    </Seq>
  </Sequence>
  <Topology numTm="8" reliability="75.41">
    <Region from="1" to="151" loc="I"/>
    <Region from="152" to="170" loc="M"/>
    <Region from="171" to="230" loc="O"/>
    <Region from="231" to="250" loc="M"/>
    <Region from="251" to="320" loc="I"/>
    <Region from="321" to="342" loc="M"/>
    <Region from="343" to="366" loc="O"/>
    <Region from="367" to="384" loc="M"/>
    <Region from="385" to="399" loc="I"/>
    <Region from="400" to="419" loc="M"/>
    <Region from="420" to="535" loc="O"/>
    <Region from="536" to="557" loc="M"/>
    <Region from="558" to="591" loc="I"/>
    <Region from="592" to="613" loc="M"/>
    <Region from="614" to="653" loc="O"/>
    <Region from="654" to="674" loc="M"/>
    <Region from="675" to="688" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="152" loc="I"/>
      <Region from="153" to="170" loc="M"/>
      <Region from="171" to="323" loc="O"/>
      <Region from="324" to="345" loc="M"/>
      <Region from="346" to="403" loc="I"/>
      <Region from="404" to="420" loc="M"/>
      <Region from="421" to="657" loc="O"/>
      <Region from="658" to="678" loc="M"/>
      <Region from="679" to="688" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="143" loc="I"/>
      <Region from="144" to="174" loc="M"/>
      <Region from="175" to="230" loc="O"/>
      <Region from="231" to="253" loc="M"/>
      <Region from="254" to="320" loc="I"/>
      <Region from="321" to="345" loc="M"/>
      <Region from="346" to="366" loc="O"/>
      <Region from="367" to="384" loc="M"/>
      <Region from="385" to="398" loc="I"/>
      <Region from="399" to="422" loc="M"/>
      <Region from="423" to="482" loc="O"/>
      <Region from="483" to="511" loc="M"/>
      <Region from="512" to="536" loc="I"/>
      <Region from="537" to="558" loc="M"/>
      <Region from="559" to="561" loc="O"/>
      <Region from="562" to="577" loc="M"/>
      <Region from="578" to="591" loc="I"/>
      <Region from="592" to="614" loc="M"/>
      <Region from="615" to="651" loc="O"/>
      <Region from="652" to="676" loc="M"/>
      <Region from="677" to="688" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="141" loc="I"/>
      <Region from="142" to="156" loc="M"/>
      <Region from="157" to="157" loc="O"/>
      <Region from="158" to="172" loc="M"/>
      <Region from="173" to="193" loc="I"/>
      <Region from="194" to="214" loc="M"/>
      <Region from="215" to="229" loc="O"/>
      <Region from="230" to="250" loc="M"/>
      <Region from="251" to="321" loc="I"/>
      <Region from="322" to="342" loc="M"/>
      <Region from="343" to="362" loc="O"/>
      <Region from="363" to="383" loc="M"/>
      <Region from="384" to="397" loc="I"/>
      <Region from="398" to="418" loc="M"/>
      <Region from="419" to="484" loc="O"/>
      <Region from="485" to="499" loc="M"/>
      <Region from="500" to="500" loc="I"/>
      <Region from="501" to="515" loc="M"/>
      <Region from="516" to="536" loc="O"/>
      <Region from="537" to="567" loc="M"/>
      <Region from="568" to="589" loc="I"/>
      <Region from="590" to="610" loc="M"/>
      <Region from="611" to="654" loc="O"/>
      <Region from="655" to="675" loc="M"/>
      <Region from="676" to="688" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="149" loc="I"/>
      <Region from="150" to="170" loc="M"/>
      <Region from="171" to="230" loc="O"/>
      <Region from="231" to="251" loc="M"/>
      <Region from="252" to="323" loc="I"/>
      <Region from="324" to="345" loc="M"/>
      <Region from="346" to="366" loc="O"/>
      <Region from="367" to="386" loc="M"/>
      <Region from="387" to="398" loc="I"/>
      <Region from="399" to="419" loc="M"/>
      <Region from="420" to="537" loc="O"/>
      <Region from="538" to="561" loc="M"/>
      <Region from="562" to="592" loc="I"/>
      <Region from="593" to="614" loc="M"/>
      <Region from="615" to="653" loc="O"/>
      <Region from="654" to="676" loc="M"/>
      <Region from="677" to="688" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="153" loc="I"/>
      <Region from="154" to="175" loc="M"/>
      <Region from="176" to="194" loc="O"/>
      <Region from="195" to="217" loc="M"/>
      <Region from="218" to="228" loc="I"/>
      <Region from="229" to="251" loc="M"/>
      <Region from="252" to="323" loc="O"/>
      <Region from="324" to="345" loc="M"/>
      <Region from="346" to="365" loc="I"/>
      <Region from="366" to="388" loc="M"/>
      <Region from="389" to="399" loc="O"/>
      <Region from="400" to="420" loc="M"/>
      <Region from="421" to="592" loc="I"/>
      <Region from="593" to="614" loc="M"/>
      <Region from="615" to="653" loc="O"/>
      <Region from="654" to="674" loc="M"/>
      <Region from="675" to="688" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="148" loc="I"/>
      <Region from="149" to="169" loc="M"/>
      <Region from="170" to="230" loc="O"/>
      <Region from="231" to="251" loc="M"/>
      <Region from="252" to="323" loc="I"/>
      <Region from="324" to="344" loc="M"/>
      <Region from="345" to="364" loc="O"/>
      <Region from="365" to="385" loc="M"/>
      <Region from="386" to="396" loc="I"/>
      <Region from="397" to="417" loc="M"/>
      <Region from="418" to="553" loc="O"/>
      <Region from="554" to="574" loc="M"/>
      <Region from="575" to="594" loc="I"/>
      <Region from="595" to="615" loc="M"/>
      <Region from="616" to="653" loc="O"/>
      <Region from="654" to="674" loc="M"/>
      <Region from="675" to="688" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="150" loc="I"/>
      <Region from="151" to="171" loc="M"/>
      <Region from="172" to="230" loc="O"/>
      <Region from="231" to="251" loc="M"/>
      <Region from="252" to="321" loc="I"/>
      <Region from="322" to="342" loc="M"/>
      <Region from="343" to="367" loc="O"/>
      <Region from="368" to="388" loc="M"/>
      <Region from="389" to="399" loc="I"/>
      <Region from="400" to="420" loc="M"/>
      <Region from="421" to="484" loc="O"/>
      <Region from="485" to="505" loc="M"/>
      <Region from="506" to="537" loc="I"/>
      <Region from="538" to="558" loc="M"/>
      <Region from="559" to="562" loc="O"/>
      <Region from="563" to="583" loc="M"/>
      <Region from="584" to="594" loc="I"/>
      <Region from="595" to="615" loc="M"/>
      <Region from="616" to="649" loc="O"/>
      <Region from="650" to="670" loc="M"/>
      <Region from="671" to="688" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="149" loc="O"/>
      <Region from="150" to="169" loc="M"/>
      <Region from="170" to="230" loc="I"/>
      <Region from="231" to="250" loc="M"/>
      <Region from="251" to="321" loc="O"/>
      <Region from="322" to="341" loc="M"/>
      <Region from="342" to="365" loc="I"/>
      <Region from="366" to="385" loc="M"/>
      <Region from="386" to="402" loc="O"/>
      <Region from="403" to="422" loc="M"/>
      <Region from="423" to="489" loc="I"/>
      <Region from="490" to="509" loc="M"/>
      <Region from="510" to="534" loc="O"/>
      <Region from="535" to="554" loc="M"/>
      <Region from="555" to="592" loc="I"/>
      <Region from="593" to="612" loc="M"/>
      <Region from="613" to="653" loc="O"/>
      <Region from="654" to="674" loc="M"/>
      <Region from="675" to="688" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="149" loc="I"/>
      <Region from="150" to="170" loc="M"/>
      <Region from="171" to="230" loc="O"/>
      <Region from="231" to="251" loc="M"/>
      <Region from="252" to="323" loc="I"/>
      <Region from="324" to="344" loc="M"/>
      <Region from="345" to="364" loc="O"/>
      <Region from="365" to="385" loc="M"/>
      <Region from="386" to="403" loc="I"/>
      <Region from="404" to="424" loc="M"/>
      <Region from="425" to="481" loc="O"/>
      <Region from="482" to="502" loc="M"/>
      <Region from="503" to="534" loc="I"/>
      <Region from="535" to="555" loc="M"/>
      <Region from="556" to="556" loc="O"/>
      <Region from="557" to="577" loc="M"/>
      <Region from="578" to="592" loc="I"/>
      <Region from="593" to="613" loc="M"/>
      <Region from="614" to="657" loc="O"/>
      <Region from="658" to="678" loc="M"/>
      <Region from="679" to="688" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="147" loc="I"/>
      <Region from="148" to="170" loc="M"/>
      <Region from="171" to="228" loc="O"/>
      <Region from="229" to="251" loc="M"/>
      <Region from="252" to="320" loc="I"/>
      <Region from="321" to="343" loc="M"/>
      <Region from="344" to="394" loc="O"/>
      <Region from="395" to="417" loc="M"/>
      <Region from="418" to="592" loc="I"/>
      <Region from="593" to="615" loc="M"/>
      <Region from="616" to="653" loc="O"/>
      <Region from="654" to="676" loc="M"/>
      <Region from="677" to="688" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
