Otoferlin LIKISQEAPEEKMKTVLSDFISRSSAFISEAEKKPKMLNQTTLDKKRLTLCWQELEAMCKEAKGIIQQQKKKLSVDEMIHEAQNFVEKIRFLVDEPQHTIPDVFIWMLSNNRRVAYARIASKDLLYSPVAGQMGKHCGKIKTHFLKPPGKR---PAGWSVQAKVDVYLWLGSIKHASAILDNLPVGYEAEMSSKGAGTNH-PPSNLLYQEQHVFQLRAHMYQARGLIAADSNGLSDPFAKVTFLSHCQTTKIISQTLSPTWNQMLLFNDLVLHGDVKELAESPPLVVVELYDSDAVGKPEYLGATVAAPVVKLADQDYE----PPRLCYHPIFCGNLSGGDLLAVFELLQVPPSGLQGLPPVEPP---DITQIYPVPANIRPVLSKYRVEVLFWGVREMKKVQLLSVDRPQALIECGGQGVKSCVIQSYKNNPNFSIQADAFEVELPENELLHPPLSICVVDWRAFGRSTLVGTYTINYLKQFLCKLREPLAPI--TQVDGTQPGHDISDSLTATESSGAHSSSQDPPADHIYVDVEPPPTVVPDSAQAQPAILVDVPDSSPMLEPEHTPVAQEPPKDGKPKDPRKPSRRSTKRRKRTIADESAENVIDWWSKYYASL---------------KKAQKAKERNPKGKKGNTEAKPDEVVVDIEDGPKKKKDKMLKKKPKDDGI-PNLAILQIYDGDLESEFNNFEDWVKTFELFRGKSTEDDHG-LDGDRVIGKFKGSFCIYKSPQDSSSEDSGQ----LRIQQGIPPNHPVTVLIRVYIVAAFNLSPADPDGKSDPYIVIKLGKTEIKDRDKYIPKQLNPVFGRSFEIQATFPKESLLSILIYDHDMIGTDDLIGETKIDLENRFYSKHRAICGLQSQYEIEGYNAWRDTSKPTEILTKLCKDNKLDGPYFHP-GKIQIGNQVFSGKTIFTEEDTDETVESYEHLALKVLHSWEDIPEVGCRLVPEHIETRPLYHKDKPGMEQGRLQMWVDMFPKDMPQPGPPVDISPRRPKGYELRVTIWNTEDVILEDENIFTGQKSSDIYVKGWLKGLEDDKQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVITKRENIFSLEKMECKTPAVLVLQVWDFERLSSDDFLGTLEMNLNSFPRAAKSAKACDLAKFENASEETKISIFQQKRVRGWWPFSKSKE-----LTGKVEAEFHLVTAEEAEKNPVGKARKEPEPLAKPNRPDTSFSWFMSPFKCLYYLIWKNYKKYIIIAFILIILIIFLVLFIYTLPGAISRRIV MIKTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQAR-MLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQIGPAGKADLPPINGPVDVDRGPIMPVPMGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECAGKGVQSSLIHNYKKNPNFNTLVKWFEVDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRSAPSWNTTVRLLRRCRVLCNGGSSSHSTGEVVVTMEPEVPI-----KKLETMVKLDATSEAVVKVDVAEEEKEKKKKKKGTAEEPEEE-----------------------EPDESMLDWWSKYFASIDTMKEQLRQQEPSGIDLEEKEEVDNTEGLKGSMKGKEKARAAKEEKKKKTQSSGSGQGSEAPEKKKPKIDELKVYPKELESEFDNFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDSTYGMFQGIPSNDPINVLVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCKDGKVDGPHFGPPGRVKVANRVFTGPSEI-EDENGQRKPTDEHVALLALRHWEDIPRAGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYELRVIIWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAKQCTMEMATGEVDVPLVSIFKQKRVKGWWPLLARNENDEFELTGKVEAELHLLTAEEAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKLLLLLLLLLLLALFLYSVPGYLVKKIL MLRVFILYAENVHTPD-TDISDAYCSAVFAG--VKKRTKVIKNSVNPVWNEGFEWDLKGIPLDQGSELHVVVKDHETMGRNRFLGEAKVPLREVL LVRVYVVRATDLHPADINGKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIE---ASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRF KIPANQLAELWLKLIDEVIEDTRYTLPLTE---GKANVTVLDTQIRKLRSRSLSQIHEAAVRMRSEATD--VKSTLAEIEDWLDKLMQLTEEPQNSMPDIIIWMIRGEKRLAYARIPAHQVLYSTSGENASGKYCGKTQTIFLKYPQEKNNGP---KVPVELRVNIWLGLSAVEKKFNS KTEKSYPERRLRGVLEELSCGCCRFLSLADKDQGHSSRTRLDRERLKSCMRELENMGQQARMLRAQVKRHTVRDKLRLCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARVPSKDLLFSIVEEE-TGKDCAKVKTLFLKLPGKRGFGSAGWTVQAKVELYLWLGLSKQRKEFLC SIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELLLSLCYNPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPIFNESFAFDIP-------TEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKSGPGEVKHWKDMIARPRQPVAQWHQLK LSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQ-----SQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADE----AYCPPRFPPQLEYYQIY LRKKDL--MGGADPFVKIKLSEDKIPSKKTTVKHKNLNPEWNEEFKFSVRDPQTQVLEFSVYD--------WEQVGNPEKMGMNVLALKEMVPDEHKAFTLELRKTLDGGEDGQPPDKYRGKLEVELLY-----KPFTEEEMPKGFEETQAVQKAPEGTP---------AAGGMLVVIVHSAEDVEGKH---HTNPYVRIYFKGEERKTKHVKKNRDPRWNEEFTFMLEEPPVREK--------LHVEVLSTSSRIGLLHPKETLGYVDIPVVDVVNNKRMN SCMRELENMGQQARMLRAQVKRHTVRDKLR------LCQNFLQKLRFLADEPQHSIPDIFIWMMSNNKRVAYARV--PSKDLLFSIVEEETGKDCAKVKTLFLKLPGKRGF-GSAGWTVQAKVELYLWLGLSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDS----MGKADFMGRTFAKPLVKMADEAYC SGTSDPFVKIYLLPDKKHKLETKVKRKNL----NPHWNETFLFEGFPYEKVVQR------------------VLYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELLLSLCYNPSANSIIVNIIKARNLK EKSSDIFVRGWLKGQQEDKQDTDVHYHSLTGEGNFNWRYLFPFDYLAAEEKIVISKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAI-----ELDLNRFPRGAKTAKQCT----------MEMATGEVDVP-LVSIFKQKRVK SIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELLLSLCYNPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTKKRNLNPIFNESFAFDIP-------TEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKSGPGEVKHWKDMIARPRQPVAQWHQLK LSKQRKEFLCGLPCGFQEVKAAQGLGLHAFPPVSLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQC-----TEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADE----AYCPPRFPPQLEYYQIY NSGDLTIMSRSAENLIASDLNGYSDPYLKYYINNEEDCAYKTKVVKKTLNPKWN---------DEGTIQINNRLNDVLRIKVMDWDSTSADDTIGTAEI-PLNKVKVEGTTELDVPVE----GLENAGQDGGMLHLAFSFKPR QAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQS---QCTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGRTFAKPLVKMADEAYCPPRFPPQLEYYQIYRGNATAGDLLAAFELLQI RGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSR--VIDEELNPQWGETYEVMVHEVPGQEIEVEVF-DKDPDKDDFLGRMKLDVGKVLQASVLDDWFPLQGGQGQ--VHLRLEWLSLLSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQDLPLKKGNKEPNPMVQ NVLVRVYVVRATDLHPADIN------GKADPYIAIRLGKTDIRDKENYISKQLNPVFGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRF----YSKHRATCGIAQTYSTHGYNIWRDPMKPSQILTRLCK-DGKVDGPHFGPPGRVKVANRVFTGPSEIEDENGQRKPTDE MIKTEKSYPE RRLRGVLEEL SCGCCRFLSL ADKDQGHSSR TRLDRERLKS CMRELENMGQ QARMLRAQVK RHTVRDKLRL CQNFLQKLRF LADEPQHSIP DIFIWMMSNN KRVAYARVPS KDLLFSIVEE ETGKDCAKVK TLFLKLPGKR GFGSAGWTVQ AKVELYLWLG LSKQRKEFLC GLPCGFQEVK AAQGLGLHAF PPVSLVYTKK QAFQLRAHMY QARSLFAADS SGLSDPFARV FFINQSQCTE VLNETLCPTW DQMLVFDNLE LYGEAHELRD DPPIIVIEIY DQDSMGKADF MGRTFAKPLV KMADEAYCPP RFPPQLEYYQ IYRGNATAGD LLAAFELLQI GPAGKADLPP INGPVDVDRG PIMPVPMGIR PVLSKYRVEV LFWGLRDLKR VNLAQVDRPR VDIECAGKGV QSSLIHNYKK NPNFNTLVKW FEVDLPENEL LHPPLNIRVV DCRAFGRYTL VGSHAVSSLR RFIYRPPDRS APSWNTTVRL LRRCRVLCNG GSSSHSTGEV VVTMEPEVPI KKLETMVKLD ATSEAVVKVD VAEEEKEKKK KKKGTAEEPE EEEPDESMLD WWSKYFASID TMKEQLRQQE PSGIDLEEKE EVDNTEGLKG SMKGKEKARA AKEEKKKKTQ SSGSGQGSEA PEKKKPKIDE LKVYPKELES EFDNFEDWLH TFNLLRGKTG DDEDGSTEEE RIVGRFKGSL CVYKVPLPED VSREAGYDST YGMFQGIPSN DPINVLVRVY VVRATDLHPA DINGKADPYI AIRLGKTDIR DKENYISKQL NPVFGKSFDI EASFPMESML TVAVYDWDLV GTDDLIGETK IDLENRFYSK HRATCGIAQT YSTHGYNIWR DPMKPSQILT RLCKDGKVDG PHFGPPGRVK VANRVFTGPS EIEDENGQRK PTDEHVALLA LRHWEDIPRA GCRLVPEHVE TRPLLNPDKP GIEQGRLELW VDMFPMDMPA PGTPLDISPR KPKKYELRVI IWNTDEVVLE DDDFFTGEKS SDIFVRGWLK GQQEDKQDTD VHYHSLTGEG NFNWRYLFPF DYLAAEEKIV ISKKESMFSW DETEYKIPAR LTLQIWDADH FSADDFLGAI ELDLNRFPRG AKTAKQCTME MATGEVDVPL VSIFKQKRVK GWWPLLARNE NDEFELTGKV EAELHLLTAE EAEKNPVGLA RNEPDPLEKP NRPDTSFIWF LNPLKSARYF LWHTYRWLLL KLLLLLLLLL LLALFLYSVP GYLVKKILGA