<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A3B3ITW5_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>Cystic fibrosis transmembrane conductance regulator </Name>
  <CrossRef>
    <PDBTM id="8v81">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8xol">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8xom">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8iz8">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8iz7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8wi3">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8wi2">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8wi0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8iz9">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8kci">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8iza">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8v7z">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8izp">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8wi5">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8wi4">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sql">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sqm">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8izr">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sq0">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8ti2">
      <Chain id="E"/>
      <Chain id="H"/>
      <Chain id="G"/>
      <Chain id="F"/>
    </PDBTM>
    <PDBTM id="8ti1">
      <Chain id="E"/>
      <Chain id="H"/>
      <Chain id="G"/>
      <Chain id="F"/>
    </PDBTM>
  </CrossRef>
  <Sequence Length="1187" CheckSum="d4b0d06d8442153ff39f75800d86cd7d">
    <Seq>
      MQRSPLEKAS VVSKLFFSWT RPILRKGYRQ RLELSDIYQI PSVDSADNLS
      EKLEREWDRE LASKKNPKLI NALRRCFFWR FMFYGIFLYL GEVTKAVQPL
      LLGRIIASYD PDNKEERSIA IYLGIGLCLL FIVRTLLLHP AIFGLHHIGM
      QMRIAMFSLI YKKTLKLSSR VLDKISIGQL VSLLSNNLNK FDEGLALAHF
      VWIAPLQVAL LMGLIWELLQ ASAFCGLGFL IVLALFQAGL GRMMMKYRDQ
      RAGKISERLV ITSEMIENIQ SVKAYCWEEA MEKMIENLRQ TELKLTRKAA
      YVRYFNSSAF FFSGFFVVFL SVLPYALIKG IILRKIFTTI SFCIVLRMAV
      TRQFPWAVQT WYDSLGAINK IQDFLQKQEY KTLEYNLTTT EVVMENVTAF
      WEETSLLMVI MGELEPSEGK IKHSGRISFC SQFSWIMPGT IKENIIFGVS
      YDEYRYRSVI KACQLEEDIS KFAEKDNIVL GEGGITLSGG QRARISLARA
      VYKDADLYLL DSPFGYLDVL TEKEIFESCV CKLMANKTRI LVTSKMEHLK
      KADKILILHE GSSYFYGTFS ELQNLQPDFS SKLMGCDSFD QFSAERRNSI
      LTETLHRFSL EGDAPVSWTE TKKQSFKQTG EFGEKRKNSI LNPINSIRKF
      SIVQKTPLQM NGIEEDSDEP LERRLSLVPD SEQGEAILPR ISVISTGPTL
      QARRRQSVLN LMTHSVNQGQ NIHRKTTAST RKVSLAPQAN LTELDIYSRR
      LSQETGLEIS EEINEEDLKE CFFDDMESIP AVTTWNTYLR YITVHKSLIF
      VLIWCLVIFL AEVAASLVVL WLLGNTPLQD KGNSTHSRNN SYAVIITSTS
      SYYVFYIYVG VADTLLAMGF FRGLPLVHTL ITVSKILHHK MLHSVLQAPM
      STLNTLKAGG ILNRFSKDIA ILDDLLPLTI FDFIQLLLIV IGAIAVVAVL
      QPYIFVATVP VIVAFIMLRA YFLQTSQQLK QLESEGRSPI FTHLVTSLKG
      LWTLRAFGRQ PYFETLFHKA LNLHTANWFL YLSTLRWFQM RIEMIFVIFF
      IAVTFISILT TGEGEGRVGI ILTLAMNIMS TLQWAVNSSI DVDSLMRSVS
      RVFKFIDMPT EGKPTKSTKP YKNGQLSKVM IIENSHVKKD DIWPSGGQMT
      VKDLTAKYTE GGNAILENIS FSISPGQRVR FEHCLLC
    </Seq>
  </Sequence>
  <Topology numTm="12" reliability="74.28">
    <Region from="1" to="75" loc="I"/>
    <Region from="76" to="94" loc="M"/>
    <Region from="95" to="118" loc="O"/>
    <Region from="119" to="142" loc="M"/>
    <Region from="143" to="195" loc="I"/>
    <Region from="196" to="215" loc="M"/>
    <Region from="216" to="220" loc="O"/>
    <Region from="221" to="240" loc="M"/>
    <Region from="241" to="306" loc="I"/>
    <Region from="307" to="326" loc="M"/>
    <Region from="327" to="330" loc="O"/>
    <Region from="331" to="350" loc="M"/>
    <Region from="351" to="796" loc="I"/>
    <Region from="797" to="820" loc="M"/>
    <Region from="821" to="852" loc="O"/>
    <Region from="853" to="871" loc="M"/>
    <Region from="872" to="925" loc="I"/>
    <Region from="926" to="949" loc="M"/>
    <Region from="950" to="952" loc="O"/>
    <Region from="953" to="972" loc="M"/>
    <Region from="973" to="1041" loc="I"/>
    <Region from="1042" to="1060" loc="M"/>
    <Region from="1061" to="1067" loc="O"/>
    <Region from="1068" to="1086" loc="M"/>
    <Region from="1087" to="1187" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="75" loc="I"/>
      <Region from="76" to="90" loc="M"/>
      <Region from="91" to="118" loc="O"/>
      <Region from="119" to="133" loc="M"/>
      <Region from="134" to="135" loc="I"/>
      <Region from="136" to="149" loc="M"/>
      <Region from="150" to="193" loc="O"/>
      <Region from="194" to="219" loc="M"/>
      <Region from="220" to="221" loc="I"/>
      <Region from="222" to="236" loc="M"/>
      <Region from="237" to="308" loc="O"/>
      <Region from="309" to="333" loc="M"/>
      <Region from="334" to="335" loc="I"/>
      <Region from="336" to="350" loc="M"/>
      <Region from="351" to="797" loc="O"/>
      <Region from="798" to="810" loc="M"/>
      <Region from="811" to="812" loc="I"/>
      <Region from="813" to="824" loc="M"/>
      <Region from="825" to="935" loc="O"/>
      <Region from="936" to="950" loc="M"/>
      <Region from="951" to="952" loc="I"/>
      <Region from="953" to="967" loc="M"/>
      <Region from="968" to="1020" loc="O"/>
      <Region from="1021" to="1035" loc="M"/>
      <Region from="1036" to="1044" loc="I"/>
      <Region from="1045" to="1059" loc="M"/>
      <Region from="1060" to="1187" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="73" loc="I"/>
      <Region from="74" to="102" loc="M"/>
      <Region from="103" to="119" loc="O"/>
      <Region from="120" to="150" loc="M"/>
      <Region from="151" to="195" loc="I"/>
      <Region from="196" to="216" loc="M"/>
      <Region from="217" to="219" loc="O"/>
      <Region from="220" to="243" loc="M"/>
      <Region from="244" to="298" loc="I"/>
      <Region from="299" to="329" loc="M"/>
      <Region from="330" to="332" loc="O"/>
      <Region from="333" to="351" loc="M"/>
      <Region from="352" to="790" loc="I"/>
      <Region from="791" to="821" loc="M"/>
      <Region from="822" to="851" loc="O"/>
      <Region from="852" to="882" loc="M"/>
      <Region from="883" to="927" loc="I"/>
      <Region from="928" to="950" loc="M"/>
      <Region from="951" to="953" loc="O"/>
      <Region from="954" to="972" loc="M"/>
      <Region from="973" to="1030" loc="I"/>
      <Region from="1031" to="1059" loc="M"/>
      <Region from="1060" to="1067" loc="O"/>
      <Region from="1068" to="1089" loc="M"/>
      <Region from="1090" to="1187" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="72" loc="I"/>
      <Region from="73" to="87" loc="M"/>
      <Region from="88" to="88" loc="O"/>
      <Region from="89" to="103" loc="M"/>
      <Region from="104" to="116" loc="I"/>
      <Region from="117" to="137" loc="M"/>
      <Region from="138" to="138" loc="O"/>
      <Region from="139" to="159" loc="M"/>
      <Region from="160" to="173" loc="I"/>
      <Region from="174" to="180" loc="L"/>
      <Region from="181" to="194" loc="I"/>
      <Region from="195" to="215" loc="M"/>
      <Region from="216" to="217" loc="O"/>
      <Region from="218" to="238" loc="M"/>
      <Region from="239" to="302" loc="I"/>
      <Region from="303" to="317" loc="M"/>
      <Region from="318" to="318" loc="O"/>
      <Region from="319" to="333" loc="M"/>
      <Region from="334" to="334" loc="I"/>
      <Region from="335" to="355" loc="M"/>
      <Region from="356" to="792" loc="O"/>
      <Region from="793" to="807" loc="M"/>
      <Region from="808" to="808" loc="I"/>
      <Region from="809" to="823" loc="M"/>
      <Region from="824" to="841" loc="O"/>
      <Region from="842" to="847" loc="L"/>
      <Region from="848" to="851" loc="O"/>
      <Region from="852" to="882" loc="M"/>
      <Region from="883" to="926" loc="I"/>
      <Region from="927" to="947" loc="M"/>
      <Region from="948" to="948" loc="O"/>
      <Region from="949" to="969" loc="M"/>
      <Region from="970" to="987" loc="I"/>
      <Region from="988" to="1008" loc="M"/>
      <Region from="1009" to="1037" loc="O"/>
      <Region from="1038" to="1058" loc="M"/>
      <Region from="1059" to="1059" loc="I"/>
      <Region from="1060" to="1080" loc="M"/>
      <Region from="1081" to="1187" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="75" loc="I"/>
      <Region from="76" to="97" loc="M"/>
      <Region from="98" to="118" loc="O"/>
      <Region from="119" to="143" loc="M"/>
      <Region from="144" to="194" loc="I"/>
      <Region from="195" to="216" loc="M"/>
      <Region from="217" to="220" loc="O"/>
      <Region from="221" to="241" loc="M"/>
      <Region from="242" to="303" loc="I"/>
      <Region from="304" to="323" loc="M"/>
      <Region from="324" to="330" loc="O"/>
      <Region from="331" to="351" loc="M"/>
      <Region from="352" to="799" loc="I"/>
      <Region from="800" to="823" loc="M"/>
      <Region from="824" to="853" loc="O"/>
      <Region from="854" to="876" loc="M"/>
      <Region from="877" to="924" loc="I"/>
      <Region from="925" to="947" loc="M"/>
      <Region from="948" to="952" loc="O"/>
      <Region from="953" to="973" loc="M"/>
      <Region from="974" to="1041" loc="I"/>
      <Region from="1042" to="1061" loc="M"/>
      <Region from="1062" to="1067" loc="O"/>
      <Region from="1068" to="1087" loc="M"/>
      <Region from="1088" to="1187" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="71" loc="I"/>
      <Region from="72" to="91" loc="M"/>
      <Region from="92" to="118" loc="O"/>
      <Region from="119" to="143" loc="M"/>
      <Region from="144" to="194" loc="I"/>
      <Region from="195" to="215" loc="M"/>
      <Region from="216" to="220" loc="O"/>
      <Region from="221" to="241" loc="M"/>
      <Region from="242" to="303" loc="I"/>
      <Region from="304" to="326" loc="M"/>
      <Region from="327" to="331" loc="O"/>
      <Region from="332" to="350" loc="M"/>
      <Region from="351" to="797" loc="I"/>
      <Region from="798" to="822" loc="M"/>
      <Region from="823" to="841" loc="O"/>
      <Region from="842" to="866" loc="M"/>
      <Region from="867" to="924" loc="I"/>
      <Region from="925" to="947" loc="M"/>
      <Region from="948" to="952" loc="O"/>
      <Region from="953" to="972" loc="M"/>
      <Region from="973" to="1043" loc="I"/>
      <Region from="1044" to="1062" loc="M"/>
      <Region from="1063" to="1067" loc="O"/>
      <Region from="1068" to="1086" loc="M"/>
      <Region from="1087" to="1187" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="76" loc="I"/>
      <Region from="77" to="97" loc="M"/>
      <Region from="98" to="117" loc="O"/>
      <Region from="118" to="138" loc="M"/>
      <Region from="139" to="195" loc="I"/>
      <Region from="196" to="216" loc="M"/>
      <Region from="217" to="220" loc="O"/>
      <Region from="221" to="241" loc="M"/>
      <Region from="242" to="307" loc="I"/>
      <Region from="308" to="328" loc="M"/>
      <Region from="329" to="330" loc="O"/>
      <Region from="331" to="351" loc="M"/>
      <Region from="352" to="797" loc="I"/>
      <Region from="798" to="818" loc="M"/>
      <Region from="819" to="850" loc="O"/>
      <Region from="851" to="871" loc="M"/>
      <Region from="872" to="929" loc="I"/>
      <Region from="930" to="950" loc="M"/>
      <Region from="951" to="952" loc="O"/>
      <Region from="953" to="973" loc="M"/>
      <Region from="974" to="1041" loc="I"/>
      <Region from="1042" to="1062" loc="M"/>
      <Region from="1063" to="1066" loc="O"/>
      <Region from="1067" to="1087" loc="M"/>
      <Region from="1088" to="1187" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="75" loc="I"/>
      <Region from="76" to="96" loc="M"/>
      <Region from="97" to="130" loc="O"/>
      <Region from="131" to="151" loc="M"/>
      <Region from="152" to="197" loc="I"/>
      <Region from="198" to="218" loc="M"/>
      <Region from="219" to="220" loc="O"/>
      <Region from="221" to="241" loc="M"/>
      <Region from="242" to="308" loc="I"/>
      <Region from="309" to="329" loc="M"/>
      <Region from="330" to="333" loc="O"/>
      <Region from="334" to="354" loc="M"/>
      <Region from="355" to="798" loc="I"/>
      <Region from="799" to="819" loc="M"/>
      <Region from="820" to="853" loc="O"/>
      <Region from="854" to="874" loc="M"/>
      <Region from="875" to="928" loc="I"/>
      <Region from="929" to="949" loc="M"/>
      <Region from="950" to="953" loc="O"/>
      <Region from="954" to="974" loc="M"/>
      <Region from="975" to="1035" loc="I"/>
      <Region from="1036" to="1056" loc="M"/>
      <Region from="1057" to="1066" loc="O"/>
      <Region from="1067" to="1087" loc="M"/>
      <Region from="1088" to="1187" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="72" loc="O"/>
      <Region from="73" to="92" loc="M"/>
      <Region from="93" to="117" loc="I"/>
      <Region from="118" to="137" loc="M"/>
      <Region from="138" to="140" loc="O"/>
      <Region from="141" to="160" loc="M"/>
      <Region from="161" to="198" loc="I"/>
      <Region from="199" to="218" loc="M"/>
      <Region from="219" to="222" loc="O"/>
      <Region from="223" to="242" loc="M"/>
      <Region from="243" to="307" loc="I"/>
      <Region from="308" to="327" loc="M"/>
      <Region from="328" to="330" loc="O"/>
      <Region from="331" to="350" loc="M"/>
      <Region from="351" to="797" loc="I"/>
      <Region from="798" to="817" loc="M"/>
      <Region from="818" to="853" loc="O"/>
      <Region from="854" to="873" loc="M"/>
      <Region from="874" to="924" loc="I"/>
      <Region from="925" to="944" loc="M"/>
      <Region from="945" to="954" loc="O"/>
      <Region from="955" to="974" loc="M"/>
      <Region from="975" to="1019" loc="I"/>
      <Region from="1020" to="1039" loc="M"/>
      <Region from="1040" to="1041" loc="O"/>
      <Region from="1042" to="1062" loc="M"/>
      <Region from="1063" to="1187" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="75" loc="I"/>
      <Region from="76" to="96" loc="M"/>
      <Region from="97" to="120" loc="O"/>
      <Region from="121" to="141" loc="M"/>
      <Region from="142" to="198" loc="I"/>
      <Region from="199" to="219" loc="M"/>
      <Region from="220" to="220" loc="O"/>
      <Region from="221" to="241" loc="M"/>
      <Region from="242" to="300" loc="I"/>
      <Region from="301" to="321" loc="M"/>
      <Region from="322" to="330" loc="O"/>
      <Region from="331" to="351" loc="M"/>
      <Region from="352" to="797" loc="I"/>
      <Region from="798" to="818" loc="M"/>
      <Region from="819" to="857" loc="O"/>
      <Region from="858" to="878" loc="M"/>
      <Region from="879" to="932" loc="I"/>
      <Region from="933" to="953" loc="M"/>
      <Region from="954" to="954" loc="O"/>
      <Region from="955" to="975" loc="M"/>
      <Region from="976" to="1039" loc="I"/>
      <Region from="1040" to="1060" loc="M"/>
      <Region from="1061" to="1187" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="83" loc="I"/>
      <Region from="84" to="106" loc="M"/>
      <Region from="107" to="120" loc="O"/>
      <Region from="121" to="143" loc="M"/>
      <Region from="144" to="195" loc="I"/>
      <Region from="196" to="215" loc="M"/>
      <Region from="216" to="218" loc="O"/>
      <Region from="219" to="241" loc="M"/>
      <Region from="242" to="303" loc="I"/>
      <Region from="304" to="326" loc="M"/>
      <Region from="327" to="797" loc="O"/>
      <Region from="798" to="820" loc="M"/>
      <Region from="821" to="839" loc="I"/>
      <Region from="840" to="862" loc="M"/>
      <Region from="863" to="924" loc="O"/>
      <Region from="925" to="947" loc="M"/>
      <Region from="948" to="953" loc="I"/>
      <Region from="954" to="973" loc="M"/>
      <Region from="974" to="1036" loc="O"/>
      <Region from="1037" to="1059" loc="M"/>
      <Region from="1060" to="1187" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
