<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A494C0L9_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>Pro-neuregulin-1, membrane-bound isoform </Name>
  <CrossRef>
    <PDBTM id="1hre">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1hrf">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1hae">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1haf">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3u7u">
      <Chain id="H"/>
      <Chain id="J"/>
      <Chain id="L"/>
      <Chain id="K"/>
      <Chain id="G"/>
      <Chain id="I"/>
    </PDBTM>
    <PDBTM id="8u4i">
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="8u4l">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7mn5">
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="7mn6">
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="7mn8">
      <Chain id="H"/>
    </PDBTM>
    <TOPDB id="NRG1_HUMAN">
      <Alignment>
        <CrossRefSeq>MPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERY</CrossRefSeq>
        <OrigSeq>QPQTTE-TNLQTAPKLSTSTSTTGTS-------------HLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERH</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="522" CheckSum="32f5720429784c98c0844b1ac3a7142d">
    <Seq>
      MEIYSPDMSE VAAERSSSPS TQLSADPSLD GLPAAEDMPE PQTEDGRTPG
      LVGLAVPCCA CLEAERLRGC LNSEKICIVP ILACLVSLCL CIAGLKWVFV
      DKIFEYDSPT HLDPGGLGQD PIISLDATAA SAVWVSSEAY TSPVSRAQSE
      SEVQVTVQGD KAVVSFEPSA APTPKNRIFA FSFLPSTAPS FPSPTRNPEV
      RTPKSATQPQ TTETNLQTAP KLSTSTSTTG TSHLVKCAEK EKTFCVNGGE
      CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYKHLGI EFMEAEELYQ
      KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RKKLHDRLRQ SLRSERNNMM
      NIANGPHHPN PPPENVQLVN QYVSKNVISS EHIVEREAET SFSTSHYTST
      AHHSTTVTQT PSHSWSNGHT ESILSESHSV IVMSSVENSR HSSPTGGPRG
      RLNGTGGPRE CNSFLRHARE TPDSYRDSPH SERHNLIAEL RRNKAHRSKC
      MQIQLSATHL RSSSIPHLGF IL
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="99">
    <Region from="1" to="75" loc="I"/>
    <Region from="76" to="95" loc="M"/>
    <Region from="96" to="302" loc="O"/>
    <Region from="303" to="324" loc="M"/>
    <Region from="325" to="522" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="75" loc="I"/>
      <Region from="76" to="95" loc="M"/>
      <Region from="96" to="302" loc="O"/>
      <Region from="303" to="324" loc="M"/>
      <Region from="325" to="522" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="75" loc="I"/>
      <Region from="76" to="99" loc="M"/>
      <Region from="100" to="302" loc="O"/>
      <Region from="303" to="325" loc="M"/>
      <Region from="326" to="522" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="56" loc="I"/>
      <Region from="57" to="62" loc="L"/>
      <Region from="63" to="75" loc="I"/>
      <Region from="76" to="96" loc="M"/>
      <Region from="97" to="303" loc="O"/>
      <Region from="304" to="324" loc="M"/>
      <Region from="325" to="514" loc="I"/>
      <Region from="515" to="518" loc="L"/>
      <Region from="519" to="522" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="75" loc="I"/>
      <Region from="76" to="99" loc="M"/>
      <Region from="100" to="302" loc="O"/>
      <Region from="303" to="325" loc="M"/>
      <Region from="326" to="522" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="75" loc="I"/>
      <Region from="76" to="99" loc="M"/>
      <Region from="100" to="302" loc="O"/>
      <Region from="303" to="325" loc="M"/>
      <Region from="326" to="522" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="75" loc="I"/>
      <Region from="76" to="96" loc="M"/>
      <Region from="97" to="302" loc="O"/>
      <Region from="303" to="323" loc="M"/>
      <Region from="324" to="522" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="75" loc="I"/>
      <Region from="76" to="97" loc="M"/>
      <Region from="98" to="302" loc="O"/>
      <Region from="303" to="323" loc="M"/>
      <Region from="324" to="522" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="77" loc="I"/>
      <Region from="78" to="98" loc="M"/>
      <Region from="99" to="304" loc="O"/>
      <Region from="305" to="325" loc="M"/>
      <Region from="326" to="522" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="77" loc="I"/>
      <Region from="78" to="98" loc="M"/>
      <Region from="99" to="304" loc="O"/>
      <Region from="305" to="325" loc="M"/>
      <Region from="326" to="522" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="75" loc="I"/>
      <Region from="76" to="98" loc="M"/>
      <Region from="99" to="302" loc="O"/>
      <Region from="303" to="325" loc="M"/>
      <Region from="326" to="522" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
