<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A590UJH5_HUMAN" transmembrane="yes" evidence="Experiment">
  <Name>LDL receptor related protein 8 </Name>
  <CrossRef>
    <PDBTM id="8s9p">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6l6r">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4dg6">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5gje">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8ffe">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5b4x">
      <Chain id="B"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="3s94">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8ctg">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="3p5c">
      <Chain id="L"/>
    </PDBTM>
    <PDBTM id="3p5b">
      <Chain id="L"/>
    </PDBTM>
    <PDBTM id="3m0c">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8dvm">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8dvn">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3s2k">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5fww">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8dvl">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3s8z">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3s8v">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6h16">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6h15">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4a0p">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8em4">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="1n7d">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3v65">
      <Chain id="D"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8em7">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="1ijq">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3v64">
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="3sob">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3soq">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3sov">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7nam">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1rwi">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1rwl">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1hz8">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1i0u">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1hj7">
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="LRP8_HUMAN">
      <Alignment>
        <CrossRefSeq>LDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAA</CrossRefSeq>
        <OrigSeq>LDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LRP4_RAT">
      <Alignment>
        <CrossRefSeq>VDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPS--PETYLLFSSRGSIRRISLDTDDHTDVHVPVPGLNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGS----NMETVIGHGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINADLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVS---HVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQ----TGTNACGVNNGGCSHLCF------ARASDFVCACPD----EPDSHPCSLVPGLMPPAPRATSLNEKSPVLPNTLPTTLHSSTTRTRTS--PEGAEGRCSERDAQLGLCAHSNEAVP</CrossRefSeq>
        <OrigSeq>LDQKTCGDIDEC-KDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS---RLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LRP4_HUMAN">
      <Alignment>
        <CrossRefSeq>VDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPS--PETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGS----NMETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVS---HVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQ----TGTNACGVNNGGCTHLCF------ARASDFVCACPD----EPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLYSSTTRTRTSLEEVEGRCSE</CrossRefSeq>
        <OrigSeq>LDQKTCGDIDEC-KDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVK---RNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LDLR_HUMAN">
      <Alignment>
        <CrossRefSeq>QRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLF-FTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSST-----AVRTQHTTTRPVPDTSRLPGATPGL------TTVEIVTMSHQALGDVAGRGNEKKPS----SVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTT----EDEVHICHN-QDGYSYPSRQMVSLEDD</CrossRefSeq>
        <OrigSeq>QKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVALSLEDD</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LRP6_HUMAN">
      <Alignment>
        <CrossRefSeq>NECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTF---LLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR-IVLEDSNILQ-PVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPC---AQDNGGCSHICL-----VKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC-----PVCSESQFQCASGQCIDGALRCN-GDANCQDKSDEKNC</CrossRefSeq>
        <OrigSeq>DECKD-PDACSQICVNYK-GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS---RLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDP-KEQEVLIDEQLH-SPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQ-AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHEL-KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMT-RTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSK</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LRP6_MOUSE">
      <Alignment>
        <CrossRefSeq>NECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPSTF---LLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNSIRKAHEDGGQGFNVVANSVANQNLEIQPYDLSIDIYSRYIYWTCEATNVIDVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSKLGKLFWADSDLRRIESSDLSGANR-IVLEDSNILQ-PVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPC---AQDNGGCSHICL-----VKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGDIDCIPVAWRCDGFTECEDHSDELNC-----PVCSESQFQCASGQCIDGALRCN-GDANCQDKSDEKNC</CrossRefSeq>
        <OrigSeq>DECKD-PDACSQICVNYK-GYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYS---RLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQL--HSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQ-AKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHEL-KQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMT-RTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSK</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="VLDLR_HUMAN">
      <Alignment>
        <CrossRefSeq>IDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVG-KEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASID---DKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDME-NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVT-----------------------YSETKDTNTTEISATSGLVPGGINVTTA--VSEVSVPPKGTS-------------------AAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIG-RHSASVGHTYPAISVVSTDDD</CrossRefSeq>
        <OrigSeq>LDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVALSLEDD</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LRP1_HUMAN">
      <Alignment>
        <CrossRefSeq>NVCAVANGGCQQLCLYRGRGQRACACAHGM-LAEDGASCREYAGYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGS-----RRITIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPV--HPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPC---RINNGGCQDLCLLT-----HQGHVNCSCRGGRILQDD-LTCRAVNSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSY-CNSRRCKKTFRQCSNGRCVSNM-LWCNGADDCGDGSDEIPCN</CrossRefSeq>
        <OrigSeq>DECKD-PDACSQICVNY-KGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLI----PMLKNVVALDVEVAT-------NRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR-----RRTLFSRNLS-EPRAIAVDPLRGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLN-NPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP-QSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKM</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LRP2_MOUSE">
      <Alignment>
        <CrossRefSeq>NPCA-SATCSHLCLLSAQEPRHYSCACPSGWNLSDDSVNCVRGDQPFLISVRENVIFGISLDPEVKSNDAMVPISGIQHGYDVEFDDSEQFIYWVENPGE-IHRVKTDGS---NRTAFAPLSLLGSSLGLALDWVSRNIYYTTPASRSIEVLTLRGDTRYGKTLITNDGTPLGVGFPVGIAVDPARGKLYWSDHGTDSGVPAKIASANMDGTSLKILFTGNMEHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGTERMILV---HHLAHPWGLVVHGSFLYYSDEQYEVIERVDKSSGSNKVVFRDNIPYLRGLRVYHHRNAADSSNGCSNNPNA---CQQICLPVPG-----GMFSCACASGFKLSPDGRSCSPYNSFIVVSMLPAVRGFSLELSDH------------------SEAMVPVAGQGRNVLHADVDVANGFIYWCDFSSSVRSSNGIRRIKPNGSNFTNIVTYGIGANGIRGVAVDWVAGNLYFTNAFVYETLIEVIRINTTYRRVLLKVSVDMPRHIV-------VDPKHRYLFWADYG</CrossRefSeq>
        <OrigSeq>DECKDPDACSQICV---NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLV--KRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRR--RTLFSRNL-----SEPRAIAVDPLRGFMYW----SDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSN-----HSQHYANEDSKMGSTVTAAVIGIIVP--IVVIALLCMSGYLIWRNWKRKN--TKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVALSLEDDG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LRP2_RAT">
      <Alignment>
        <CrossRefSeq>NPCA-SASCSHLCLLSAQAPRHYSCACPSGWNLSDDSVNCVRGDQPFLMSVRDNIIFGISLDPEVKSNDAMVPISGIQHGYDVEFDDSEQFIYWVENPGE-IHRVKTDGS---NRTVFAPLSLLGSSLGLALDWVSRNIYYTTPASRSIEVLTLKGDTRYGKTLIANDGTPLGVGFPVGIAVDPARGKLYWSDHGTDSGVPAKIASANMDGTSLKILFTGNLQHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGTERMILV---HHLAHPWGLVVYGSFLYYSDEQYEVIERVDKSSGNNKVVLRDNVPYLRGLRVYHRRNAADSSNGCSNNPNA---CQQICLPVPG-----GMFSCACASGFKLSPDGRSCSPYNSF-----------MVVSMLPAVRGFSLELSDHSEAMVPVAGQGRNVLHADVDVANGFIYWCDFS--SSVRSSNGIRRIKPDGSNFTNVVTYGIGANGIRGVALDWAAGNLYFTNAFVYETLIEVLRINTTYRRVLLKVSVDMPRHII-------VDPKHRYLFWADYG</CrossRefSeq>
        <OrigSeq>DECKDPDACSQICV---NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLV--KRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRR--RTLFSRNL-----SEPRAIAVDPLRGFMYW----SDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVP--IVVIALLCMSGYLIWRNWKRKN--TKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVALSLEDDG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LRP_CAEEL">
      <Alignment>
        <CrossRefSeq>NPCSTN-PCSHLCLLNNKNTFTCKCPMGEKLDASGKKCIDDAKPFLVIIQKTNVFGIEMNSASEKETPVLAGMVPLSGLGNAFDAAYDALSEEMFILEHTNHAKTLAQITTDSAIYRSTVNGGNKTKMFSSAVPDD---AYCLGFDWNGRNLVVGNKITQTIEIIRTQGKQYRSVILSNDQSPTAVVTPVAIAVDADKGYVFWLDRGGGAADAKVARAGLDGSNPLVIASNDLAELDHIAIDTTNTRVYFSEAKAGRISSVTYDGQDRHYVLS--DGGRQPNGLAFYGDRLFYADSAFDSIEVATINGDSQ---PPQWTHFKKDVENLANIKALQPRASSSGHPCHINNGNCDHICIPLMFAQR-----TCTCANGYV--KDGQTSCKLFDESF------------VIVATKTKVIGYPIDETQSKGVAMEPIGGLSITGVDYDYESKTIYVAEASGINKGITAYTIGESSPRAVIRDSIGS---LTIKSLAIDWINYNMYFINHDAERTNIEVSKLDGTYRKILLTTKTETPSSIA-------VDPVSRYLYWADQG</CrossRefSeq>
        <OrigSeq>DECKDPDACSQICV-NYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRH-EVRRIDLVKRNYSRL-----IPMLKNVVALDVEVATNRIYWCDLSYRK-----------IYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGG-RRRTLFSRN-----LSEPRAIAVDPLRGFMYWSDWG---DQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELK--QPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKR-CYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVP-RAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWR--NWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVALSLEDDG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="EGF_HUMAN">
      <Alignment>
        <CrossRefSeq>HWSCPEGTLAGNGNSTCVGPAPF---LIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGS-----RQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSA-LKYPANVAVDPVERFIFWS-SEVAGSLYRADLDGVGVKALLETSEKI-TAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVH--ISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIA-------VHPMAKRLFWTDTGI</CrossRefSeq>
        <OrigSeq>KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWV----DSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISIL--AENLNNPHDIVIFHELKQPRAPDAC-----ELSVQPNGGCE----------YLCLPA--------------------------PQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMT----------------------------------------RTVPATTRAPGTTVHRSTYQNHST----------------------ETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVALSLEDDGL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="EGF_MOUSE">
      <Alignment>
        <CrossRefSeq>CQPG--PLERSERSGTCAGPAPFLVFSQGKSISRIDPDGTNHQQLVVDAGISADMDIHYKKERLYWVDVERQVLLRVFLNGTGLEK-----VCNVERKVSGLAIDWIDDEVLWVDQQNGVITVTDMTGKNSRVLLSS-LKHPSNIAVDPIERLMFWS-SEVTGSLHRAHLKGVDVKTLLETGGI--SVLTLDVLDKRLFWVQDSGEGSHAYIHSCDYEGGSVRLI--RHQARHSLSSMAFFGDRIFYSVLKSKAIWIANKHTGKDTVRINLHPSFVTPGKLMVVHPRAQPRTEDAAKDPDPELLKQRGRPCRFGLCERDPKSHSSACAEGYTLSRDRKYCEDVNECATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGKQCHELVSCPGNVSKCSHGCVLTSDGPRCICPAGSVLGRDGKTCTGCSSPDNGGCSQICLPLRPGSWECDCFPGYDLQSDRKSCAASGPQPLLLFANSQDIRHMHFDGTDYKVLLSRQMGMVFALDYDPVESKIYFAQTALKWIERANMDGSQRERLITEGVDTLEGLALDWIGRRIYWTDSGKSVVGGSDLSGKHHRIIIQERISRPRGIA-------VHPRARRLFWTDVGM</CrossRefSeq>
        <OrigSeq>CYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWV-DSKLH---QLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISIL--AENLNNPHDIVIFHELKQPRAPD-----ACELSVQPNGGCEY-LCLPAP-----------------------------------QISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPS----------LTAAVPSSVSVPRAP----------------------------------------------------SISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVALSLEDDGL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SORL_HUMAN">
      <Alignment>
        <CrossRefSeq>PCPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGST---GQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVIL---DNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKN-TGSNACVPR-----PCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLK--NNTCVKQENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC--PTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQ</CrossRefSeq>
        <OrigSeq>CKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRL-IPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRN-LSEPRAIAVDPLRGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISS-------------HSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGST</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="PKND_MYCTO">
      <Alignment>
        <CrossRefSeq>DFRLSPSGVAVDSAGNVYVTSEGMYGRVVKLATGSTGTTVLPFNGLYQPQGLAVDGA-GTVYVTDFNNRVVTLA-----AGSNNQTVLPFDGLNYPEGLAVD-TQGAVYVADRGNNRV-VKLAAGSKTQTVLPFTGLNDPDGVAVDNS-GNVYVTDTDNNRVVKLEA-ESNNQVVLPFTDITAPWGIAVD-EAGTVYVTEHNTNQVVKL-LAGSTTSTVLPFTG-LNTPLAVAVDSDRTVYVADRGNDRVVKLTS</CrossRefSeq>
        <OrigSeq>GYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFS-RNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDK-VFWTDLENEAIFSANR</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="537" CheckSum="e66e1821212e9e71da678fbf26198029">
    <Seq>
      XLDQKTCGDI DECKDPDACS QICVNYKGYF KCECYPGYEM DLLTKNCKAA
      AGKSPSLIFT NRHEVRRIDL VKRNYSRLIP MLKNVVALDV EVATNRIYWC
      DLSYRKIYSA YMDKASDPKE QEVLIDEQLH SPEGLAVDWV HKHIYWTDSG
      NKTISVATVD GGRRRTLFSR NLSEPRAIAV DPLRGFMYWS DWGDQAKIEK
      SGLNGVDRQT LVSDNIEWPN GITLDLLSQR LYWVDSKLHQ LSSIDFSGGN
      RKTLISSTDF LSHPFGIAVF EDKVFWTDLE NEAIFSANRL NGLEISILAE
      NLNNPHDIVI FHELKQPRAP DACELSVQPN GGCEYLCLPA PQISSHSPKY
      TCACPDTMWL GPDMKRCYRA PQSTSTTTLA STMTRTVPAT TRAPGTTVHR
      STYQNHSTET PSLTAAVPSS VSVPRAPSIS PSTLSPATSN HSQHYANEDS
      KMGSTVTAAV IGIIVPIVVI ALLCMSGYLI WRNWKRKNTK SMNFDNPVYR
      KTTEEEDEDE LHIGRTAQIG HVYPARVALS LEDDGLP
    </Seq>
  </Sequence>
  <Topology numTm="1" reliability="81.8">
    <Region from="1" to="455" loc="O"/>
    <Region from="456" to="480" loc="M"/>
    <Region from="481" to="537" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="452" loc="O"/>
      <Region from="453" to="480" loc="M"/>
      <Region from="481" to="537" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="456" loc="I"/>
      <Region from="457" to="480" loc="M"/>
      <Region from="481" to="537" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="455" loc="O"/>
      <Region from="456" to="476" loc="M"/>
      <Region from="477" to="537" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="457" loc="O"/>
      <Region from="458" to="481" loc="M"/>
      <Region from="482" to="537" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="455" loc="O"/>
      <Region from="456" to="481" loc="M"/>
      <Region from="482" to="537" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="458" loc="I"/>
      <Region from="459" to="480" loc="M"/>
      <Region from="481" to="537" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="460" loc="O"/>
      <Region from="461" to="480" loc="M"/>
      <Region from="481" to="537" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="460" loc="O"/>
      <Region from="461" to="481" loc="M"/>
      <Region from="482" to="537" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="458" loc="O"/>
      <Region from="459" to="481" loc="M"/>
      <Region from="482" to="537" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
