<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A590UJL0_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Steroid sulfatase </Name>
  <CrossRef>
    <PDBTM id="8eg3">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="1p49">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <TOPDB id="STS_HUMAN">
      <Alignment>
        <CrossRefSeq>MKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR</CrossRefSeq>
        <OrigSeq>MKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ARSL_HUMAN">
      <Alignment>
        <CrossRefSeq>LPAMLAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGDCARWELSEKRVNLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHADCFLMRNHTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFVTPVFQPEGAGACYGRKVCPCFGEKVVHHDPPLLFDLSRDPSETHILTPASEPVFYQVMERVQQAVWEHQRTLSPVPLQLDRLGNIWRPWLQPCCGPFPL-CWCLREDDPQ</CrossRefSeq>
        <OrigSeq>IPFLLLFFLWEAESHA----ASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDK</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ARSD_HUMAN">
      <Alignment>
        <CrossRefSeq>CEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTLTNDCDPGRPPEVDAALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLFFISWYSSFGFVRRWNCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQKDSGSVWKVHYTTPQFHPEGAGACYGRGVCPCSGEGVTHHRPPLLFDLSRDPSEARPLTPDSEPLYHAVIARVGAAVSEHRQTLSPVPQQFSMSNILWKPWLQPCCGHFP-FCSCHEDGD</CrossRefSeq>
        <OrigSeq>WEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQ</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="578" CheckSum="35c15de4ed32e3f4bea745f23225558a">
    <Seq>
      MKIPFLLLFF LWEAESHAAS RPNIILVMAD DLGIGDPGCY GNKTIRTPNI
      DRLASGGVKL TQHLAASPLC TPSRAAFMTG RYPVRSGMAS WSRTGVFLFT
      ASSGGLPTDE ITFAKLLKDQ GYSTALIGKW HLGMSCHSKT DFCHHPLHHG
      FNYFYGISLT NLRDCKPGEG SVFTTGFKRL VFLPLQIVGV TLLTLAALNC
      LGLLHVPLGV FFSLLFLAAL ILTLFLGFLH YFRPLNCFMM RNYEIIQQPM
      SYDNLTQRLT VEAAQFIQRN TETPFLLVLS YLHVHTALFS SKDFAGKSQH
      GVYGDAVEEM DWSVGQILNL LDELRLANDT LIYFTSDQGA HVEEVSSKGE
      IHGGSNGIYK GGKANNWEGG IRVPGILRWP RVIQAGQKID EPTSNMDIFP
      TVAKLAGAPL PEDRIIDGRD LMPLLEGKSQ RSDHEFLFHY CNAYLNAVRW
      HPQNSTSIWK AFFFTPNFNP VGSNGCFATH VCFCFGSYVT HHDPPLLFDI
      SKDPRERNPL TPASEPRFYE ILKVMQEAAD RHTQTLPEVP DQFSWNNFLW
      KPWLQLCCPS TGLSCQCDRE KQDKRLSR
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="85.54">
    <Region from="1" to="18" loc="S"/>
    <Region from="19" to="175" loc="O"/>
    <Region from="176" to="199" loc="M"/>
    <Region from="200" to="205" loc="I"/>
    <Region from="206" to="229" loc="M"/>
    <Region from="230" to="578" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="18" loc="S"/>
      <Region from="19" to="178" loc="O"/>
      <Region from="179" to="203" loc="M"/>
      <Region from="204" to="205" loc="I"/>
      <Region from="206" to="229" loc="M"/>
      <Region from="230" to="578" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="18" loc="S"/>
      <Region from="19" to="213" loc="I"/>
      <Region from="214" to="229" loc="M"/>
      <Region from="230" to="578" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="18" loc="S"/>
      <Region from="19" to="206" loc="I"/>
      <Region from="207" to="227" loc="M"/>
      <Region from="228" to="578" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="18" loc="S"/>
      <Region from="19" to="180" loc="I"/>
      <Region from="181" to="203" loc="M"/>
      <Region from="204" to="209" loc="O"/>
      <Region from="210" to="232" loc="M"/>
      <Region from="233" to="578" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="18" loc="S"/>
      <Region from="19" to="179" loc="I"/>
      <Region from="180" to="204" loc="M"/>
      <Region from="205" to="209" loc="O"/>
      <Region from="210" to="232" loc="M"/>
      <Region from="233" to="578" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="18" loc="S"/>
      <Region from="19" to="210" loc="O"/>
      <Region from="211" to="231" loc="M"/>
      <Region from="232" to="578" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="18" loc="S"/>
      <Region from="19" to="181" loc="I"/>
      <Region from="182" to="202" loc="M"/>
      <Region from="203" to="211" loc="O"/>
      <Region from="212" to="232" loc="M"/>
      <Region from="233" to="578" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="18" loc="S"/>
      <Region from="19" to="179" loc="I"/>
      <Region from="180" to="200" loc="M"/>
      <Region from="201" to="208" loc="O"/>
      <Region from="209" to="229" loc="M"/>
      <Region from="230" to="578" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="18" loc="S"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region from="1" to="18" loc="S"/>
      <Region from="1" to="18" loc="S"/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="18" loc="S"/>
      <Region from="19" to="180" loc="O"/>
      <Region from="181" to="203" loc="M"/>
      <Region from="204" to="209" loc="I"/>
      <Region from="210" to="232" loc="M"/>
      <Region from="233" to="578" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
