<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A669KBJ4_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>non-specific serine/threonine protein kinase </Name>
  <CrossRef>
    <PDBTM id="6mm5">
      <Chain id="E"/>
    </PDBTM>
    <PDBTM id="3o7l">
      <Chain id="D"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6mm7">
      <Chain id="A"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="6mm6">
      <Chain id="E"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6mm8">
      <Chain id="C"/>
    </PDBTM>
    <TOPDB id="DMPK_HUMAN">
      <Alignment>
        <CrossRefSeq>SAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGT--------------VRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLG--VHLPFVGYSYSCMAL----RDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATDPPSHLDGPPAVAVGQC---------------------PLVGPGPMHRRHLLLPA------------RVPRPGLSEALSLLLFA</CrossRefSeq>
        <OrigSeq>AAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSCDSPDTPETDDSIEGHGASLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIG-ALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVIL-------RQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDE--IVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIRQFSSCSPRFNKVYSSMERLSLLEERRTPPPTKRSLSEEK--EDHSDGLA---GLKGRDRSWVIGSPEILRKRLSVSESSHTESDSSPPMTVRRRCSGLLDAPRFPEGPEEASSTLR-------------RQPQEGIWVLTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLAEGATAKAISDLAVRRARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPS</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="1655" CheckSum="d859bc2c5882dfc0b75b22e29b20e529">
    <Seq>
      MMKRRQERLG APCLRIHCRT SNRKSLIVTS STSPTLPRPH SPLHGHTGNS
      PLDSPRNFSP NAPAHFSFVP ARSHSHRADR TDGRRWSLAS LPSSGYGTNT
      PSSTVSSSCS SQEKLHQLPF QPTADELHFL TKHFSTESVP DEEGRQSPAM
      RPRSRSLSPG RSPVSFDSEI IMMNHVYKER FPKATAQMEE RLAEFISSNT
      PDSVLPLADG ALSFIHHQVI EMARDCLDKS RSGLITSQYF YELQDNLEKL
      LQDAHERSES SEVAFVMQLV KKLMIIIARP ARLLECLEFD PEEFYHLLEA
      AEGHAKEGQG IKCDIPRYIV SQLGLTRDPL EEMAQLSSCD SPDTPETDDS
      IEGHGASLPS KKTPSEEDFE TIKLISNGAY GAVFLVRHKS TRQRFAMKKI
      NKQNLILRNQ IQQAFVERDI LTFAENPFVV SMFCSFDTKR HLCMVMEYVE
      GGDCATLLKN IGALPVDMVR LYFAETVLAL EYLHNYGIVH RDLKPDNLLI
      TSMGHIKLTD FGLSKIGLMS LTTNLYEGHI EKDAREFLDK QVCGTPEYIA
      PEVILRQGYG KPVDWWAMGI ILYEFLVGCV PFFGDTPEEL FGQVISDEIV
      WPEGDEALPP DAQDLTSKLL HQNPLERLGT GSAYEVKQHP FFTGLDWTGL
      LRQKAEFIPQ LESEDDTSYF DTRSERYHHM DSEDEEEVSE DGCLEIRQFS
      SCSPRFNKVY SSMERLSLLE ERRTPPPTKR SLSEEKEDHS DGLAGLKGRD
      RSWVIGSPEI LRKRLSVSES SHTESDSSPP MTVRRRCSGL LDAPRFPEGP
      EEASSTLRRQ PQEGIWVLTP PSGEGVSGPV TEHSGEQRPK LDEEAVGRSS
      GSSPAMETRG RGTSQLAEGA TAKAISDLAV RRARHRLLSG DSTEKRTARP
      VNKVIKSASA TALSLLIPSE HHTCSPLASP MSPHSQSSNP SSRDSSPSRD
      FLPALGSMRP PIIIHRAGKK YGFTLRAIRV YMGDSDVYTV HHMVWHVEDG
      GPASEAGLRQ GDLITHVNGE PVHGLVHTEV VELILKSGNK VAISTTPLEN
      TSIKVGPARK GSYKAKMARR SKRSRGKDGQ ESRKRSSLFR KITKQASLLH
      TSRSLSSLNR SLSSGESGPG SPTHSHSLSP RSPTQGYRVT PDAVHSVGGN
      SSQSSSPSSS VPSSPAGSGH TRPSSLHGLA PKLQRQYRSP RRKSAGSIPL
      SPLAHTPSPP PPTASPQRSP SPLSGHVAQA FPTKLHLSPP LGRQLSRPKS
      AEPPRSPLLK RVQSAEKLAA ALAASEKKLA TSRKHSLDLP HSELKKELPP
      REVSPLEVVG ARSVLSGKGA LPGKGVLQPA PSRALGTLRQ DRAERRESLQ
      KQEAIREVDS SEDDTEEGPE NSQGAQELSL APHPEVSQSV APKGAGESGE
      EDPFPSRDPR SLGPMVPSLL TGITLGPPRM ESPSGPHRRL GSPQAIEEAA
      SSSSAGPNLG QSGATDPIPP EGCWKAQHLH TQALTALSPS TSGLTPTSSC
      SPPSSTSGKL SMWSWKSLIE GPDRASPSRK ATMAGGLANL QDLENTTPAQ
      PKNLSPREQG KTQPPSAPRL AHPSYEDPSQ GWLWESECAQ AVKEDPALSI
      TQVPDASGDR RQDVPCRGCP LTQKSEPSLR RGQEPGGHQK HRDLALVPDE
      LLKQT
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="75.58">
    <Region from="1" to="468" loc="I"/>
    <Region from="469" to="480" loc="M"/>
    <Region from="481" to="565" loc="O"/>
    <Region from="566" to="577" loc="M"/>
    <Region from="578" to="1655" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="373" loc="I"/>
      <Region from="374" to="385" loc="M"/>
      <Region from="386" to="566" loc="O"/>
      <Region from="567" to="578" loc="M"/>
      <Region from="579" to="1655" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="561" loc="O"/>
      <Region from="562" to="577" loc="M"/>
      <Region from="578" to="1655" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="380" loc="I"/>
      <Region from="381" to="393" loc="L"/>
      <Region from="394" to="464" loc="I"/>
      <Region from="465" to="485" loc="M"/>
      <Region from="486" to="564" loc="O"/>
      <Region from="565" to="585" loc="M"/>
      <Region from="586" to="1479" loc="I"/>
      <Region from="1480" to="1490" loc="L"/>
      <Region from="1491" to="1655" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="564" loc="I"/>
      <Region from="565" to="584" loc="M"/>
      <Region from="585" to="1655" loc="O"/>
    </Prediction>
    <Prediction name="Pro">
      <Region/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="562" loc="I"/>
      <Region from="563" to="583" loc="M"/>
      <Region from="584" to="1655" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
