<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A6E1ZAN8_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Otopetrin 2 </Name>
  <CrossRef>
    <PDBTM id="6nf6">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6o84">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6nf4">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
  </CrossRef>
  <Sequence Length="206" CheckSum="8d1a92a27f6f03c349789515a3d937e3">
    <Seq>
      MSEELAQGPK ESPPAPRAGP REVWKKGGRL LSVLLAVNVL LLACTLISGG
      AFNKVAVYDT DVFALLTAMM LLATLWILFY LLRTVRCPCA VPYRDAHAGP
      IWLRGGLVLF GICTLIMDVF KTGYYSSFFE CQSAIKILHP LIQAVFVIIQ
      LWIMPAFGAR PHFSNTVEVD FYGYSLWAVI VNICLPFGIF YRMHAVSSLL
      EVYVLS
    </Seq>
  </Sequence>
  <Topology numTm="5" reliability="82.75">
    <Region from="1" to="29" loc="I"/>
    <Region from="30" to="49" loc="M"/>
    <Region from="50" to="60" loc="O"/>
    <Region from="61" to="80" loc="M"/>
    <Region from="81" to="100" loc="I"/>
    <Region from="101" to="120" loc="M"/>
    <Region from="121" to="136" loc="O"/>
    <Region from="137" to="156" loc="M"/>
    <Region from="157" to="170" loc="I"/>
    <Region from="171" to="190" loc="M"/>
    <Region from="191" to="206" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="29" loc="I"/>
      <Region from="30" to="47" loc="M"/>
      <Region from="48" to="61" loc="O"/>
      <Region from="62" to="82" loc="M"/>
      <Region from="83" to="104" loc="I"/>
      <Region from="105" to="120" loc="M"/>
      <Region from="121" to="175" loc="O"/>
      <Region from="176" to="190" loc="M"/>
      <Region from="191" to="206" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="40" loc="I"/>
      <Region from="41" to="56" loc="M"/>
      <Region from="57" to="61" loc="O"/>
      <Region from="62" to="83" loc="M"/>
      <Region from="84" to="102" loc="I"/>
      <Region from="103" to="125" loc="M"/>
      <Region from="126" to="135" loc="O"/>
      <Region from="136" to="157" loc="M"/>
      <Region from="158" to="171" loc="I"/>
      <Region from="172" to="200" loc="M"/>
      <Region from="201" to="206" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="32" loc="I"/>
      <Region from="33" to="53" loc="M"/>
      <Region from="54" to="60" loc="O"/>
      <Region from="61" to="81" loc="M"/>
      <Region from="82" to="98" loc="I"/>
      <Region from="99" to="113" loc="M"/>
      <Region from="114" to="114" loc="O"/>
      <Region from="115" to="129" loc="M"/>
      <Region from="130" to="134" loc="I"/>
      <Region from="135" to="155" loc="M"/>
      <Region from="156" to="174" loc="O"/>
      <Region from="175" to="205" loc="M"/>
      <Region from="206" to="206" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="29" loc="I"/>
      <Region from="30" to="52" loc="M"/>
      <Region from="53" to="61" loc="O"/>
      <Region from="62" to="82" loc="M"/>
      <Region from="83" to="100" loc="I"/>
      <Region from="101" to="120" loc="M"/>
      <Region from="121" to="136" loc="O"/>
      <Region from="137" to="159" loc="M"/>
      <Region from="160" to="170" loc="I"/>
      <Region from="171" to="191" loc="M"/>
      <Region from="192" to="206" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="29" loc="O"/>
      <Region from="30" to="50" loc="M"/>
      <Region from="51" to="61" loc="I"/>
      <Region from="62" to="81" loc="M"/>
      <Region from="82" to="100" loc="O"/>
      <Region from="101" to="120" loc="M"/>
      <Region from="121" to="140" loc="I"/>
      <Region from="141" to="159" loc="M"/>
      <Region from="160" to="170" loc="O"/>
      <Region from="171" to="191" loc="M"/>
      <Region from="192" to="206" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="30" loc="I"/>
      <Region from="31" to="51" loc="M"/>
      <Region from="52" to="61" loc="O"/>
      <Region from="62" to="82" loc="M"/>
      <Region from="83" to="102" loc="I"/>
      <Region from="103" to="123" loc="M"/>
      <Region from="124" to="134" loc="O"/>
      <Region from="135" to="155" loc="M"/>
      <Region from="156" to="170" loc="I"/>
      <Region from="171" to="191" loc="M"/>
      <Region from="192" to="206" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="26" loc="I"/>
      <Region from="27" to="47" loc="M"/>
      <Region from="48" to="59" loc="O"/>
      <Region from="60" to="80" loc="M"/>
      <Region from="81" to="100" loc="I"/>
      <Region from="101" to="121" loc="M"/>
      <Region from="122" to="133" loc="O"/>
      <Region from="134" to="154" loc="M"/>
      <Region from="155" to="170" loc="I"/>
      <Region from="171" to="190" loc="M"/>
      <Region from="191" to="206" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="27" loc="I"/>
      <Region from="28" to="48" loc="M"/>
      <Region from="49" to="61" loc="O"/>
      <Region from="62" to="81" loc="M"/>
      <Region from="82" to="100" loc="I"/>
      <Region from="101" to="120" loc="M"/>
      <Region from="121" to="136" loc="O"/>
      <Region from="137" to="156" loc="M"/>
      <Region from="157" to="170" loc="I"/>
      <Region from="171" to="190" loc="M"/>
      <Region from="191" to="206" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="29" loc="I"/>
      <Region from="30" to="50" loc="M"/>
      <Region from="51" to="61" loc="O"/>
      <Region from="62" to="82" loc="M"/>
      <Region from="83" to="104" loc="I"/>
      <Region from="105" to="125" loc="M"/>
      <Region from="126" to="136" loc="O"/>
      <Region from="137" to="157" loc="M"/>
      <Region from="158" to="170" loc="I"/>
      <Region from="171" to="191" loc="M"/>
      <Region from="192" to="206" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="29" loc="I"/>
      <Region from="30" to="52" loc="M"/>
      <Region from="53" to="61" loc="O"/>
      <Region from="62" to="81" loc="M"/>
      <Region from="82" to="100" loc="I"/>
      <Region from="101" to="120" loc="M"/>
      <Region from="121" to="139" loc="O"/>
      <Region from="140" to="159" loc="M"/>
      <Region from="160" to="170" loc="I"/>
      <Region from="171" to="193" loc="M"/>
      <Region from="194" to="206" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="6nf6_A">
      <ConstraintRegion from="49" to="55" loc="I" subId="17205571" subSource="6nf6_A"/>
      <ConstraintRegion from="108" to="116" loc="I" subId="17205576" subSource="6nf6_A"/>
      <ConstraintRegion from="124" to="127" loc="I" subId="17205578" subSource="6nf6_A"/>
      <ConstraintRegion from="181" to="193" loc="I" subId="17205588" subSource="6nf6_A"/>
      <ConstraintRegion from="276" to="283" loc="I" subId="17205599" subSource="6nf6_A"/>
      <ConstraintRegion from="304" to="305" loc="I" subId="17205602" subSource="6nf6_A"/>
      <ConstraintRegion from="357" to="366" loc="I" subId="17205612" subSource="6nf6_A"/>
      <ConstraintRegion from="375" to="382" loc="I" subId="17205614" subSource="6nf6_A"/>
      <ConstraintRegion from="432" to="438" loc="I" subId="17205623" subSource="6nf6_A"/>
      <ConstraintRegion from="487" to="498" loc="I" subId="17205626" subSource="6nf6_A"/>
      <ConstraintRegion from="553" to="560" loc="I" subId="17205633" subSource="6nf6_A"/>
      <ConstraintRegion from="78" to="84" loc="O" subId="17205573" subSource="6nf6_A"/>
      <ConstraintRegion from="149" to="161" loc="O" subId="17205584" subSource="6nf6_A"/>
      <ConstraintRegion from="217" to="227" loc="O" subId="17205593" subSource="6nf6_A"/>
      <ConstraintRegion from="246" to="254" loc="O" subId="17205595" subSource="6nf6_A"/>
      <ConstraintRegion from="329" to="335" loc="O" subId="17205607" subSource="6nf6_A"/>
      <ConstraintRegion from="405" to="410" loc="O" subId="17205619" subSource="6nf6_A"/>
      <ConstraintRegion from="520" to="530" loc="O" subId="17205631" subSource="6nf6_A"/>
      <ConstraintRegion from="56" to="77" loc="H" subId="17205572" subSource="6nf6_A"/>
      <ConstraintRegion from="85" to="107" loc="H" subId="17205574" subSource="6nf6_A"/>
      <ConstraintRegion from="128" to="148" loc="H" subId="17205581" subSource="6nf6_A"/>
      <ConstraintRegion from="162" to="180" loc="H" subId="17205586" subSource="6nf6_A"/>
      <ConstraintRegion from="194" to="216" loc="H" subId="17205591" subSource="6nf6_A"/>
      <ConstraintRegion from="255" to="275" loc="H" subId="17205597" subSource="6nf6_A"/>
      <ConstraintRegion from="306" to="328" loc="H" subId="17205604" subSource="6nf6_A"/>
      <ConstraintRegion from="336" to="356" loc="H" subId="17205609" subSource="6nf6_A"/>
      <ConstraintRegion from="383" to="404" loc="H" subId="17205616" subSource="6nf6_A"/>
      <ConstraintRegion from="411" to="431" loc="H" subId="17205621" subSource="6nf6_A"/>
      <ConstraintRegion from="499" to="519" loc="H" subId="17205628" subSource="6nf6_A"/>
      <ConstraintRegion from="531" to="552" loc="H" subId="17205632" subSource="6nf6_A"/>
      <ConstraintRegion from="49" to="55" loc="I" subId="17205636" subSource="6nf6_B"/>
      <ConstraintRegion from="108" to="116" loc="I" subId="17205644" subSource="6nf6_B"/>
      <ConstraintRegion from="124" to="127" loc="I" subId="17205646" subSource="6nf6_B"/>
      <ConstraintRegion from="181" to="193" loc="I" subId="17205654" subSource="6nf6_B"/>
      <ConstraintRegion from="276" to="283" loc="I" subId="17205668" subSource="6nf6_B"/>
      <ConstraintRegion from="304" to="305" loc="I" subId="17205671" subSource="6nf6_B"/>
      <ConstraintRegion from="357" to="366" loc="I" subId="17205683" subSource="6nf6_B"/>
      <ConstraintRegion from="375" to="382" loc="I" subId="17205686" subSource="6nf6_B"/>
      <ConstraintRegion from="432" to="438" loc="I" subId="17205700" subSource="6nf6_B"/>
      <ConstraintRegion from="487" to="498" loc="I" subId="17205703" subSource="6nf6_B"/>
      <ConstraintRegion from="553" to="560" loc="I" subId="17205715" subSource="6nf6_B"/>
      <ConstraintRegion from="78" to="84" loc="O" subId="17205640" subSource="6nf6_B"/>
      <ConstraintRegion from="149" to="161" loc="O" subId="17205650" subSource="6nf6_B"/>
      <ConstraintRegion from="217" to="227" loc="O" subId="17205658" subSource="6nf6_B"/>
      <ConstraintRegion from="246" to="254" loc="O" subId="17205661" subSource="6nf6_B"/>
      <ConstraintRegion from="329" to="335" loc="O" subId="17205677" subSource="6nf6_B"/>
      <ConstraintRegion from="405" to="410" loc="O" subId="17205692" subSource="6nf6_B"/>
      <ConstraintRegion from="520" to="530" loc="O" subId="17205709" subSource="6nf6_B"/>
      <ConstraintRegion from="56" to="77" loc="H" subId="17205638" subSource="6nf6_B"/>
      <ConstraintRegion from="85" to="107" loc="H" subId="17205642" subSource="6nf6_B"/>
      <ConstraintRegion from="128" to="148" loc="H" subId="17205648" subSource="6nf6_B"/>
      <ConstraintRegion from="162" to="180" loc="H" subId="17205652" subSource="6nf6_B"/>
      <ConstraintRegion from="194" to="216" loc="H" subId="17205656" subSource="6nf6_B"/>
      <ConstraintRegion from="255" to="275" loc="H" subId="17205665" subSource="6nf6_B"/>
      <ConstraintRegion from="306" to="328" loc="H" subId="17205674" subSource="6nf6_B"/>
      <ConstraintRegion from="336" to="356" loc="H" subId="17205680" subSource="6nf6_B"/>
      <ConstraintRegion from="383" to="404" loc="H" subId="17205689" subSource="6nf6_B"/>
      <ConstraintRegion from="411" to="431" loc="H" subId="17205695" subSource="6nf6_B"/>
      <ConstraintRegion from="499" to="519" loc="H" subId="17205706" subSource="6nf6_B"/>
      <ConstraintRegion from="531" to="552" loc="H" subId="17205712" subSource="6nf6_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6nf4_A">
      <ConstraintRegion from="46" to="54" loc="I" subId="17205440" subSource="6nf4_A"/>
      <ConstraintRegion from="104" to="113" loc="I" subId="17205444" subSource="6nf4_A"/>
      <ConstraintRegion from="123" to="126" loc="I" subId="17205445" subSource="6nf4_A"/>
      <ConstraintRegion from="180" to="195" loc="I" subId="17205449" subSource="6nf4_A"/>
      <ConstraintRegion from="278" to="283" loc="I" subId="17205454" subSource="6nf4_A"/>
      <ConstraintRegion from="302" to="305" loc="I" subId="17205455" subSource="6nf4_A"/>
      <ConstraintRegion from="359" to="383" loc="I" subId="17205459" subSource="6nf4_A"/>
      <ConstraintRegion from="436" to="443" loc="I" subId="17205463" subSource="6nf4_A"/>
      <ConstraintRegion from="510" to="522" loc="I" subId="17205464" subSource="6nf4_A"/>
      <ConstraintRegion from="578" to="585" loc="I" subId="17205468" subSource="6nf4_A"/>
      <ConstraintRegion from="75" to="83" loc="O" subId="17205442" subSource="6nf4_A"/>
      <ConstraintRegion from="148" to="159" loc="O" subId="17205447" subSource="6nf4_A"/>
      <ConstraintRegion from="217" to="221" loc="O" subId="17205451" subSource="6nf4_A"/>
      <ConstraintRegion from="248" to="256" loc="O" subId="17205452" subSource="6nf4_A"/>
      <ConstraintRegion from="327" to="338" loc="O" subId="17205457" subSource="6nf4_A"/>
      <ConstraintRegion from="407" to="416" loc="O" subId="17205461" subSource="6nf4_A"/>
      <ConstraintRegion from="544" to="556" loc="O" subId="17205466" subSource="6nf4_A"/>
      <ConstraintRegion from="55" to="74" loc="H" subId="17205441" subSource="6nf4_A"/>
      <ConstraintRegion from="84" to="103" loc="H" subId="17205443" subSource="6nf4_A"/>
      <ConstraintRegion from="127" to="147" loc="H" subId="17205446" subSource="6nf4_A"/>
      <ConstraintRegion from="160" to="179" loc="H" subId="17205448" subSource="6nf4_A"/>
      <ConstraintRegion from="196" to="216" loc="H" subId="17205450" subSource="6nf4_A"/>
      <ConstraintRegion from="257" to="277" loc="H" subId="17205453" subSource="6nf4_A"/>
      <ConstraintRegion from="306" to="326" loc="H" subId="17205456" subSource="6nf4_A"/>
      <ConstraintRegion from="339" to="358" loc="H" subId="17205458" subSource="6nf4_A"/>
      <ConstraintRegion from="384" to="406" loc="H" subId="17205460" subSource="6nf4_A"/>
      <ConstraintRegion from="417" to="435" loc="H" subId="17205462" subSource="6nf4_A"/>
      <ConstraintRegion from="523" to="543" loc="H" subId="17205465" subSource="6nf4_A"/>
      <ConstraintRegion from="557" to="577" loc="H" subId="17205467" subSource="6nf4_A"/>
      <ConstraintRegion from="46" to="54" loc="I" subId="17205469" subSource="6nf4_B"/>
      <ConstraintRegion from="104" to="113" loc="I" subId="17205473" subSource="6nf4_B"/>
      <ConstraintRegion from="123" to="126" loc="I" subId="17205474" subSource="6nf4_B"/>
      <ConstraintRegion from="180" to="195" loc="I" subId="17205483" subSource="6nf4_B"/>
      <ConstraintRegion from="278" to="283" loc="I" subId="17205496" subSource="6nf4_B"/>
      <ConstraintRegion from="302" to="305" loc="I" subId="17205499" subSource="6nf4_B"/>
      <ConstraintRegion from="359" to="383" loc="I" subId="17205511" subSource="6nf4_B"/>
      <ConstraintRegion from="436" to="443" loc="I" subId="17205524" subSource="6nf4_B"/>
      <ConstraintRegion from="510" to="522" loc="I" subId="17205527" subSource="6nf4_B"/>
      <ConstraintRegion from="578" to="585" loc="I" subId="17205539" subSource="6nf4_B"/>
      <ConstraintRegion from="75" to="83" loc="O" subId="17205471" subSource="6nf4_B"/>
      <ConstraintRegion from="148" to="159" loc="O" subId="17205478" subSource="6nf4_B"/>
      <ConstraintRegion from="217" to="221" loc="O" subId="17205489" subSource="6nf4_B"/>
      <ConstraintRegion from="248" to="256" loc="O" subId="17205491" subSource="6nf4_B"/>
      <ConstraintRegion from="327" to="338" loc="O" subId="17205505" subSource="6nf4_B"/>
      <ConstraintRegion from="407" to="416" loc="O" subId="17205518" subSource="6nf4_B"/>
      <ConstraintRegion from="544" to="556" loc="O" subId="17205533" subSource="6nf4_B"/>
      <ConstraintRegion from="55" to="74" loc="H" subId="17205470" subSource="6nf4_B"/>
      <ConstraintRegion from="84" to="103" loc="H" subId="17205472" subSource="6nf4_B"/>
      <ConstraintRegion from="127" to="147" loc="H" subId="17205476" subSource="6nf4_B"/>
      <ConstraintRegion from="160" to="179" loc="H" subId="17205480" subSource="6nf4_B"/>
      <ConstraintRegion from="196" to="216" loc="H" subId="17205486" subSource="6nf4_B"/>
      <ConstraintRegion from="257" to="277" loc="H" subId="17205493" subSource="6nf4_B"/>
      <ConstraintRegion from="306" to="326" loc="H" subId="17205502" subSource="6nf4_B"/>
      <ConstraintRegion from="339" to="358" loc="H" subId="17205508" subSource="6nf4_B"/>
      <ConstraintRegion from="384" to="406" loc="H" subId="17205515" subSource="6nf4_B"/>
      <ConstraintRegion from="417" to="435" loc="H" subId="17205521" subSource="6nf4_B"/>
      <ConstraintRegion from="523" to="543" loc="H" subId="17205530" subSource="6nf4_B"/>
      <ConstraintRegion from="557" to="577" loc="H" subId="17205536" subSource="6nf4_B"/>
    </Constraint>
  </Constraints>
</HtpItem>
