<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A7I2V4F4_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>ST3 beta-galactoside alpha-2,3-sialyltransferase 4 </Name>
  <CrossRef>
    <PDBTM id="6apl">
      <Chain id="D"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="A"/>
      <Chain id="F"/>
      <Chain id="E"/>
    </PDBTM>
    <PDBTM id="6apj">
      <Chain id="F"/>
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="B"/>
      <Chain id="E"/>
    </PDBTM>
    <PDBTM id="2wnb">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2wnf">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2wml">
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="SIA10_HUMAN">
      <Alignment>
        <CrossRefSeq>GYLVAIFLSAVFL-YYVLHCILWGTNVYWVAPVEMKRRNKIQPCLSKPAFASLL----RFHQFHPFLCAADFRKIASLYGSDKFDLPYGMRTSAEYFRLALSKLQSCDLFDEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDP-IHNDPNTTVILTAFKPHDLRWLLELLMGDKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDIIEKNL</CrossRefSeq>
        <OrigSeq>KLLAMLALVLVVMVWYSISREDRYIELFYFP-----IPEKKEPCLQGEAESKASKLFGNYSRDQPIFLRLEDYFWVKT--PSAYELPYGTKGSEDLLL-RVLAITSSSIPKNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQPRKIKQFLSCTGPICVLVSSWLVLLDSADGERFR-DCRKFHCRALAEM----MVGGAGLPLTPSCPCSSEAHHGPV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SIAT9_MOUSE">
      <Alignment>
        <CrossRefSeq>TLVAFGVWLLYILILNYTAEECDMKRMHYVDPDRIKRAQSYAQEVLQKECRPRYAKTAMALLFEDRYSINLEPFVQ-KVPTASEAELKYDPPFGFRKFSSKVQSLLDMLPEHDFPEHLRAKACKRCVVVGNGGILHGLELGHALNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLS-DVEYYANDLFVTVLFKSVDFKWLQAMVKNESLPFWVRLFFWKQVAEKVPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGHDKNIPTIGVIAVVLATHLCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMHWQVMHNVTTETKFLLKLLKEGV</CrossRefSeq>
        <OrigSeq>KLLAMLALVLVVMVWYSISRE-----------DRYIELFYFPIPEKKEPCLQGEAESKASKLFG-NYSRDQPIFLRLEDYFWVKTPSAYELPYGTKGSEDLLLRVLAITS-SSIPKNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVENNPDTLLVLVAFKAMDFHWIETILSDKKR---VRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQPRKI--KQFLSCTGPICVLVSSWLVLLDSADGERFR-DCRKFHCRALAEMMVGGAG----LPLTPSCPCSSEAHHGPV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SIA4A_HUMAN">
      <Alignment>
        <CrossRefSeq>TMVATTWFPKQMVLELSENLKRLIKHRPCTCTHCIGQRKLSAWFDERFNQTMQPLLTAQNALLEDDTYRWWLRLQREKKP----NNLNDTIKELFRVVPGNVDPMLEKRSVGCRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFR-----ELGDNVSMILVPFKTIDLEWVVSAITTGT-ISHTYIPVPA-KIRVKQDKILIYHPAFIKYVFDNWLQGHGRY--------PSTGILSVIFSMHVCDEVDLYGFG--ADSKGNWHHYWE</CrossRefSeq>
        <OrigSeq>VLVVMVWYSISREDRYIELFYFPIPEKKEPCLQGEAESKASKLF-GNYSRDQPIFL--------RLEDYFWVKTPSAYELPYGTKGSEDLLLRVLAITSSSIPKNI--QSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQPRKIKQFLSCTGPICVLVSSWLVLLDSADGERFRDCRKFHCRALAE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SIA7B_HUMAN">
      <Alignment>
        <CrossRefSeq>GKGQACRHLLHLAIQRHPHFRGLFNLSIPVLLWGDLFTPALWDRL-SQHKAPYGWRGLSHQVIASTLSLLNGSESAKLFAPPRDTPPKCIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNSLVSYWNLGFTSVPQGQDLQYIFIPSDIRDYVMLRSAILGVPVPEGLDKGDRPHAYFGPEASASKFKLLHPDFISYLTERFLKSKLINTHFGDLYMPSTGALMLLTALHTCDQVSAYGFITSNYWKFSDHYFERKMKPLIFYANHDLSLEAALWRDLHKAGI</CrossRefSeq>
        <OrigSeq>EKKEPCLQGE--AESKASKLFGNYSRDQPIFLR---LEDYFWVKTPSAYELPYGTKG-SEDLLLRVLAITSSSI------PKNIQSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAH---------FDPKVENNPDTLLVLVAFKAMDFHWIETILSD---KKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQPRKIKQFLSCTGPICVLVSSWLVLLDSADGERFRDCRKFHCRALAEMM---VGGAGLPLTPSCPCSSEAHHGPV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SIA4A_PIG">
      <Alignment>
        <CrossRefSeq>TVVTTAWFPKQMVIELSENFKKLMKYPYRPCTCTRCIEEQRVSAWFDERFNRSMQPLLTAKNAHLEEDTYKWWLRLQREKQP----NNLNDTIRELFQVVPGNVDPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFR-----ELAQEVSMILVPFKTTDLEWVISATTTGR-ISHTYVPVPA-KIKVKKEKILIYHPAFIKYVFDRWLQGHGRY--------PSTGILSVIFSLHICDEVDLYGFG--ADSKGNWHHYWE</CrossRefSeq>
        <OrigSeq>VLVVMVWYSISREDRYIELFYFPIPEKKEPCLQ-----------GEAESKASKLFGNYSRDQPIFLRLEDYFWVKTPSAYELPYGTKGSEDLLLRVLAITSSSIPKNI--QSLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQPRKIKQFLSCTGPICVLVSSWLVLLDSADGERFRDCRKFHCRALAE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SIA4B_HUMAN">
      <Alignment>
        <CrossRefSeq>NISPVWTRENMDLPPDV---QRWWMML----QPQFKSHNTNEVLEKLFQIVPGENPYRFRDPHQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLP-----ANVSFVLVPFKVLDLLWIASALSTGQ-IRFTYAPVKSF-LRVDKEKVQIYNPAFFKYIHDRWTEHHGRY--------PSTGMLVLFFALHVCDEVNVYGFG--ADSRGNWHHYWE</CrossRefSeq>
        <OrigSeq>KASKLFGNYSRDQPIFLRLEDYFWVKTPSAYELPYGTKGSEDLLLRVLAITSSSIPKNIQ-SLRCRRCVVVGNGHRLRNSSLGDAINKYDVVIRLNNAPVAGYEGDVGSKTTMRLFYPESAHFDPKVENNPDTLLVLVAFKAMDFHWIETILSDKKRVRKGFWKQPPLIWDVNPKQIRILNPFFMEIAADKLLSLPMQQPRKIKQFLSCTGPICVLVSSWLVLLDSADGERFRDCRKFHCRALAE</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="331" CheckSum="507bfb212e69a7b8f6cdb016ad6bf3b1">
    <Seq>
      MVSKSRWKLL AMLALVLVVM VWYSISREDR YIELFYFPIP EKKEPCLQGE
      AESKASKLFG NYSRDQPIFL RLEDYFWVKT PSAYELPYGT KGSEDLLLRV
      LAITSSSIPK NIQSLRCRRC VVVGNGHRLR NSSLGDAINK YDVVIRLNNA
      PVAGYEGDVG SKTTMRLFYP ESAHFDPKVE NNPDTLLVLV AFKAMDFHWI
      ETILSDKKRV RKGFWKQPPL IWDVNPKQIR ILNPFFMEIA ADKLLSLPMQ
      QPRKIKQFLS CTGPICVLVS SWLVLLDSAD GERFRDCRKF HCRALAEMMV
      GGAGLPLTPS CPCSSEAHHG PVGHHAGPPP L
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="63.41">
    <Region from="1" to="8" loc="I"/>
    <Region from="9" to="25" loc="M"/>
    <Region from="26" to="262" loc="O"/>
    <Region from="263" to="277" loc="M"/>
    <Region from="278" to="331" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="8" loc="I"/>
      <Region from="9" to="25" loc="M"/>
      <Region from="26" to="263" loc="O"/>
      <Region from="264" to="283" loc="M"/>
      <Region from="284" to="331" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="261" loc="O"/>
      <Region from="262" to="277" loc="M"/>
      <Region from="278" to="331" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="9" loc="I"/>
      <Region from="10" to="11" loc="L"/>
      <Region from="12" to="22" loc="I"/>
      <Region from="23" to="24" loc="L"/>
      <Region from="25" to="31" loc="I"/>
      <Region from="32" to="33" loc="L"/>
      <Region from="34" to="186" loc="I"/>
      <Region from="187" to="191" loc="L"/>
      <Region from="192" to="235" loc="I"/>
      <Region from="236" to="241" loc="L"/>
      <Region from="242" to="258" loc="I"/>
      <Region from="259" to="279" loc="M"/>
      <Region from="280" to="291" loc="O"/>
      <Region from="292" to="305" loc="L"/>
      <Region from="306" to="331" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region/>
    </Prediction>
    <Prediction name="Phobius">
      <Region/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="6" loc="I"/>
      <Region from="7" to="27" loc="M"/>
      <Region from="28" to="331" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="6" loc="I"/>
      <Region from="7" to="27" loc="M"/>
      <Region from="28" to="258" loc="O"/>
      <Region from="259" to="279" loc="M"/>
      <Region from="280" to="331" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="6" loc="I"/>
      <Region from="7" to="27" loc="M"/>
      <Region from="28" to="183" loc="O"/>
      <Region from="184" to="203" loc="M"/>
      <Region from="204" to="256" loc="I"/>
      <Region from="257" to="276" loc="M"/>
      <Region from="277" to="331" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="5" loc="O"/>
      <Region from="6" to="26" loc="M"/>
      <Region from="27" to="331" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="6" loc="I"/>
      <Region from="7" to="26" loc="M"/>
      <Region from="27" to="331" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
