<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A804HJU7_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Chloride voltage-gated channel Kb </Name>
  <CrossRef>
    <PDBTM id="5tr1">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5tqq">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8ta5">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8ta4">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8ta3">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7xf5">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8ta2">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7xja">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8gqu">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6qvd">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6qvc">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6qvu">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6qvb">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6qv6">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6coy">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <TOPDB id="CLCKA_HUMAN">
      <Alignment>
        <CrossRefSeq>MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLMTLGVLMALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKT</CrossRefSeq>
        <OrigSeq>MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLMALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGVPAIQEADA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CLCN2_HUMAN">
      <Alignment>
        <CrossRefSeq>KFLVSRVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRG</CrossRefSeq>
        <OrigSeq>KQKLFRLGEDWYFLMTLGVLMALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPS---SGVPAIQEADAG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CLCN1_HUMAN">
      <Alignment>
        <CrossRefSeq>QDCIHRLGQVVRRKLGEDGIFLVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQMQPSLPLQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRG</CrossRefSeq>
        <OrigSeq>RGGLEWLKQKLFR-LGEDWYFLMTLGVLMALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPS---SGVPAIQEADAG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CICH_TORMA">
      <Alignment>
        <CrossRefSeq>RAVKNCL--YRHLVKVLGEDWIFLLLLGALMALVSWAMDFIGSRGLRFYKYLFALVEGNIGLQYLVWVCYPLALILFSSLFCQIVSPQAVGSGIPELKTIIRGA</CrossRefSeq>
        <OrigSeq>RGIRGGLEWLKQKLFRLGEDWYFLMTLGVLMALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPS---SGVPAIQEADAGG</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="130" CheckSum="e1b278dad65d0027c1b8a260c7fd3d41">
    <Seq>
      MEEFVGLREG SSGNPVTLQE LWGPCPRIRR GIRGGLEWLK QKLFRLGEDW
      YFLMTLGVLM ALVSCAMDLA VESVVRAHQW LYREIGDSHL LRYLSWTVYP
      VALVSFSSGF SQSITPSSGV PAIQEADAGG 
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="80.86">
    <Region from="1" to="49" loc="I"/>
    <Region from="50" to="69" loc="M"/>
    <Region from="70" to="92" loc="O"/>
    <Region from="93" to="111" loc="M"/>
    <Region from="112" to="130" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="51" loc="I"/>
      <Region from="52" to="71" loc="M"/>
      <Region from="72" to="130" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="49" loc="I"/>
      <Region from="50" to="70" loc="M"/>
      <Region from="71" to="90" loc="O"/>
      <Region from="91" to="114" loc="M"/>
      <Region from="115" to="130" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="48" loc="I"/>
      <Region from="49" to="69" loc="M"/>
      <Region from="70" to="92" loc="O"/>
      <Region from="93" to="113" loc="M"/>
      <Region from="114" to="130" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="49" loc="I"/>
      <Region from="50" to="71" loc="M"/>
      <Region from="72" to="92" loc="O"/>
      <Region from="93" to="114" loc="M"/>
      <Region from="115" to="130" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="49" loc="O"/>
      <Region from="50" to="70" loc="M"/>
      <Region from="71" to="89" loc="I"/>
      <Region from="90" to="110" loc="M"/>
      <Region from="111" to="130" loc="O"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="49" loc="I"/>
      <Region from="50" to="70" loc="M"/>
      <Region from="71" to="90" loc="O"/>
      <Region from="91" to="111" loc="M"/>
      <Region from="112" to="130" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="49" loc="I"/>
      <Region from="50" to="70" loc="M"/>
      <Region from="71" to="90" loc="O"/>
      <Region from="91" to="111" loc="M"/>
      <Region from="112" to="130" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="49" loc="I"/>
      <Region from="50" to="70" loc="M"/>
      <Region from="71" to="130" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="49" loc="I"/>
      <Region from="50" to="70" loc="M"/>
      <Region from="71" to="130" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="5tr1_A">
      <ConstraintRegion from="36" to="36" loc="I" subId="17328838" subSource="5tr1_A"/>
      <ConstraintRegion from="37" to="46" loc="F" subId="17328839" subSource="5tr1_A"/>
      <ConstraintRegion from="47" to="71" loc="H" subId="17328840" subSource="5tr1_A"/>
      <ConstraintRegion from="72" to="97" loc="O" subId="17328841" subSource="5tr1_A"/>
      <ConstraintRegion from="98" to="112" loc="H" subId="17328842" subSource="5tr1_A"/>
      <ConstraintRegion from="113" to="143" loc="I" subId="17328843" subSource="5tr1_A"/>
      <ConstraintRegion from="144" to="159" loc="H" subId="17328844" subSource="5tr1_A"/>
      <ConstraintRegion from="160" to="160" loc="O" subId="17328845" subSource="5tr1_A"/>
      <ConstraintRegion from="161" to="177" loc="H" subId="17328846" subSource="5tr1_A"/>
      <ConstraintRegion from="178" to="184" loc="F" subId="17328847" subSource="5tr1_A"/>
      <ConstraintRegion from="185" to="185" loc="I" subId="17328848" subSource="5tr1_A"/>
      <ConstraintRegion from="193" to="202" loc="I" subId="17328849" subSource="5tr1_A"/>
      <ConstraintRegion from="203" to="227" loc="L" subId="17328850" subSource="5tr1_A"/>
      <ConstraintRegion from="228" to="233" loc="I" subId="17328852" subSource="5tr1_A"/>
      <ConstraintRegion from="234" to="253" loc="H" subId="17328854" subSource="5tr1_A"/>
      <ConstraintRegion from="254" to="257" loc="O" subId="17328856" subSource="5tr1_A"/>
      <ConstraintRegion from="276" to="279" loc="O" subId="17328858" subSource="5tr1_A"/>
      <ConstraintRegion from="280" to="303" loc="H" subId="17328860" subSource="5tr1_A"/>
      <ConstraintRegion from="304" to="312" loc="F" subId="17328862" subSource="5tr1_A"/>
      <ConstraintRegion from="313" to="313" loc="I" subId="17328863" subSource="5tr1_A"/>
      <ConstraintRegion from="314" to="322" loc="F" subId="17328864" subSource="5tr1_A"/>
      <ConstraintRegion from="323" to="323" loc="I" subId="17328866" subSource="5tr1_A"/>
      <ConstraintRegion from="324" to="339" loc="H" subId="17328868" subSource="5tr1_A"/>
      <ConstraintRegion from="340" to="353" loc="O" subId="17328870" subSource="5tr1_A"/>
      <ConstraintRegion from="354" to="361" loc="F" subId="17328872" subSource="5tr1_A"/>
      <ConstraintRegion from="362" to="403" loc="O" subId="17328874" subSource="5tr1_A"/>
      <ConstraintRegion from="404" to="420" loc="H" subId="17328876" subSource="5tr1_A"/>
      <ConstraintRegion from="421" to="421" loc="I" subId="17328877" subSource="5tr1_A"/>
      <ConstraintRegion from="422" to="437" loc="H" subId="17328878" subSource="5tr1_A"/>
      <ConstraintRegion from="438" to="453" loc="O" subId="17328880" subSource="5tr1_A"/>
      <ConstraintRegion from="459" to="466" loc="O" subId="17328882" subSource="5tr1_A"/>
      <ConstraintRegion from="467" to="480" loc="H" subId="17328884" subSource="5tr1_A"/>
      <ConstraintRegion from="481" to="481" loc="I" subId="17328886" subSource="5tr1_A"/>
      <ConstraintRegion from="482" to="492" loc="H" subId="17328888" subSource="5tr1_A"/>
      <ConstraintRegion from="493" to="497" loc="O" subId="17328890" subSource="5tr1_A"/>
      <ConstraintRegion from="498" to="513" loc="H" subId="17328894" subSource="5tr1_A"/>
      <ConstraintRegion from="514" to="605" loc="I" subId="17328897" subSource="5tr1_A"/>
      <ConstraintRegion from="618" to="683" loc="I" subId="17328900" subSource="5tr1_A"/>
      <ConstraintRegion from="36" to="36" loc="I" subId="17328909" subSource="5tr1_B"/>
      <ConstraintRegion from="37" to="46" loc="F" subId="17328913" subSource="5tr1_B"/>
      <ConstraintRegion from="47" to="71" loc="H" subId="17328917" subSource="5tr1_B"/>
      <ConstraintRegion from="72" to="97" loc="O" subId="17328920" subSource="5tr1_B"/>
      <ConstraintRegion from="98" to="112" loc="H" subId="17328924" subSource="5tr1_B"/>
      <ConstraintRegion from="113" to="143" loc="I" subId="17328928" subSource="5tr1_B"/>
      <ConstraintRegion from="144" to="159" loc="H" subId="17328932" subSource="5tr1_B"/>
      <ConstraintRegion from="160" to="160" loc="O" subId="17328935" subSource="5tr1_B"/>
      <ConstraintRegion from="161" to="177" loc="H" subId="17328938" subSource="5tr1_B"/>
      <ConstraintRegion from="178" to="184" loc="F" subId="17328942" subSource="5tr1_B"/>
      <ConstraintRegion from="185" to="185" loc="I" subId="17328946" subSource="5tr1_B"/>
      <ConstraintRegion from="193" to="202" loc="I" subId="17328950" subSource="5tr1_B"/>
      <ConstraintRegion from="203" to="227" loc="L" subId="17328954" subSource="5tr1_B"/>
      <ConstraintRegion from="228" to="233" loc="I" subId="17328958" subSource="5tr1_B"/>
      <ConstraintRegion from="234" to="253" loc="H" subId="17328962" subSource="5tr1_B"/>
      <ConstraintRegion from="254" to="257" loc="O" subId="17328963" subSource="5tr1_B"/>
      <ConstraintRegion from="276" to="279" loc="O" subId="17328966" subSource="5tr1_B"/>
      <ConstraintRegion from="280" to="303" loc="H" subId="17328969" subSource="5tr1_B"/>
      <ConstraintRegion from="304" to="312" loc="F" subId="17328972" subSource="5tr1_B"/>
      <ConstraintRegion from="313" to="313" loc="I" subId="17328974" subSource="5tr1_B"/>
      <ConstraintRegion from="314" to="322" loc="F" subId="17328977" subSource="5tr1_B"/>
      <ConstraintRegion from="323" to="323" loc="I" subId="17328980" subSource="5tr1_B"/>
      <ConstraintRegion from="324" to="339" loc="H" subId="17328982" subSource="5tr1_B"/>
      <ConstraintRegion from="340" to="353" loc="O" subId="17328985" subSource="5tr1_B"/>
      <ConstraintRegion from="354" to="361" loc="F" subId="17328987" subSource="5tr1_B"/>
      <ConstraintRegion from="362" to="403" loc="O" subId="17328990" subSource="5tr1_B"/>
      <ConstraintRegion from="404" to="420" loc="H" subId="17328993" subSource="5tr1_B"/>
      <ConstraintRegion from="421" to="421" loc="I" subId="17328995" subSource="5tr1_B"/>
      <ConstraintRegion from="422" to="437" loc="H" subId="17328998" subSource="5tr1_B"/>
      <ConstraintRegion from="438" to="453" loc="O" subId="17329001" subSource="5tr1_B"/>
      <ConstraintRegion from="459" to="466" loc="O" subId="17329004" subSource="5tr1_B"/>
      <ConstraintRegion from="467" to="480" loc="H" subId="17329005" subSource="5tr1_B"/>
      <ConstraintRegion from="481" to="481" loc="I" subId="17329007" subSource="5tr1_B"/>
      <ConstraintRegion from="482" to="492" loc="H" subId="17329010" subSource="5tr1_B"/>
      <ConstraintRegion from="493" to="497" loc="O" subId="17329011" subSource="5tr1_B"/>
      <ConstraintRegion from="498" to="513" loc="H" subId="17329012" subSource="5tr1_B"/>
      <ConstraintRegion from="514" to="605" loc="I" subId="17329014" subSource="5tr1_B"/>
      <ConstraintRegion from="618" to="683" loc="I" subId="17329016" subSource="5tr1_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="5tqq_A">
      <ConstraintRegion from="48" to="50" loc="I" subId="17329333" subSource="5tqq_A"/>
      <ConstraintRegion from="51" to="78" loc="H" subId="17329335" subSource="5tqq_A"/>
      <ConstraintRegion from="79" to="93" loc="O" subId="17329337" subSource="5tqq_A"/>
      <ConstraintRegion from="94" to="112" loc="H" subId="17329338" subSource="5tqq_A"/>
      <ConstraintRegion from="113" to="144" loc="I" subId="17329339" subSource="5tqq_A"/>
      <ConstraintRegion from="145" to="159" loc="H" subId="17329341" subSource="5tqq_A"/>
      <ConstraintRegion from="160" to="160" loc="O" subId="17329344" subSource="5tqq_A"/>
      <ConstraintRegion from="161" to="174" loc="H" subId="17329346" subSource="5tqq_A"/>
      <ConstraintRegion from="175" to="203" loc="I" subId="17329348" subSource="5tqq_A"/>
      <ConstraintRegion from="204" to="227" loc="L" subId="17329350" subSource="5tqq_A"/>
      <ConstraintRegion from="228" to="236" loc="I" subId="17329351" subSource="5tqq_A"/>
      <ConstraintRegion from="237" to="257" loc="H" subId="17329354" subSource="5tqq_A"/>
      <ConstraintRegion from="276" to="276" loc="O" subId="17329356" subSource="5tqq_A"/>
      <ConstraintRegion from="277" to="307" loc="H" subId="17329358" subSource="5tqq_A"/>
      <ConstraintRegion from="308" to="313" loc="I" subId="17329360" subSource="5tqq_A"/>
      <ConstraintRegion from="314" to="322" loc="F" subId="17329361" subSource="5tqq_A"/>
      <ConstraintRegion from="323" to="323" loc="I" subId="17329362" subSource="5tqq_A"/>
      <ConstraintRegion from="324" to="341" loc="H" subId="17329364" subSource="5tqq_A"/>
      <ConstraintRegion from="342" to="347" loc="O" subId="17329366" subSource="5tqq_A"/>
      <ConstraintRegion from="348" to="359" loc="L" subId="17329368" subSource="5tqq_A"/>
      <ConstraintRegion from="360" to="400" loc="O" subId="17329370" subSource="5tqq_A"/>
      <ConstraintRegion from="401" to="420" loc="H" subId="17329373" subSource="5tqq_A"/>
      <ConstraintRegion from="421" to="421" loc="I" subId="17329376" subSource="5tqq_A"/>
      <ConstraintRegion from="422" to="441" loc="H" subId="17329378" subSource="5tqq_A"/>
      <ConstraintRegion from="442" to="453" loc="O" subId="17329380" subSource="5tqq_A"/>
      <ConstraintRegion from="457" to="464" loc="O" subId="17329383" subSource="5tqq_A"/>
      <ConstraintRegion from="465" to="480" loc="H" subId="17329386" subSource="5tqq_A"/>
      <ConstraintRegion from="481" to="481" loc="I" subId="17329389" subSource="5tqq_A"/>
      <ConstraintRegion from="482" to="495" loc="H" subId="17329391" subSource="5tqq_A"/>
      <ConstraintRegion from="496" to="496" loc="O" subId="17329393" subSource="5tqq_A"/>
      <ConstraintRegion from="497" to="516" loc="H" subId="17329396" subSource="5tqq_A"/>
      <ConstraintRegion from="517" to="605" loc="I" subId="17329399" subSource="5tqq_A"/>
      <ConstraintRegion from="618" to="683" loc="I" subId="17329402" subSource="5tqq_A"/>
      <ConstraintRegion from="48" to="50" loc="I" subId="17329407" subSource="5tqq_B"/>
      <ConstraintRegion from="51" to="78" loc="H" subId="17329410" subSource="5tqq_B"/>
      <ConstraintRegion from="79" to="93" loc="O" subId="17329413" subSource="5tqq_B"/>
      <ConstraintRegion from="94" to="112" loc="H" subId="17329416" subSource="5tqq_B"/>
      <ConstraintRegion from="113" to="144" loc="I" subId="17329419" subSource="5tqq_B"/>
      <ConstraintRegion from="145" to="159" loc="H" subId="17329421" subSource="5tqq_B"/>
      <ConstraintRegion from="160" to="160" loc="O" subId="17329423" subSource="5tqq_B"/>
      <ConstraintRegion from="161" to="174" loc="H" subId="17329424" subSource="5tqq_B"/>
      <ConstraintRegion from="175" to="203" loc="I" subId="17329425" subSource="5tqq_B"/>
      <ConstraintRegion from="204" to="227" loc="L" subId="17329427" subSource="5tqq_B"/>
      <ConstraintRegion from="228" to="236" loc="I" subId="17329428" subSource="5tqq_B"/>
      <ConstraintRegion from="237" to="257" loc="H" subId="17329430" subSource="5tqq_B"/>
      <ConstraintRegion from="276" to="276" loc="O" subId="17329432" subSource="5tqq_B"/>
      <ConstraintRegion from="277" to="307" loc="H" subId="17329433" subSource="5tqq_B"/>
      <ConstraintRegion from="308" to="313" loc="I" subId="17329435" subSource="5tqq_B"/>
      <ConstraintRegion from="314" to="322" loc="F" subId="17329437" subSource="5tqq_B"/>
      <ConstraintRegion from="323" to="323" loc="I" subId="17329438" subSource="5tqq_B"/>
      <ConstraintRegion from="324" to="341" loc="H" subId="17329439" subSource="5tqq_B"/>
      <ConstraintRegion from="342" to="347" loc="O" subId="17329440" subSource="5tqq_B"/>
      <ConstraintRegion from="348" to="359" loc="L" subId="17329442" subSource="5tqq_B"/>
      <ConstraintRegion from="360" to="400" loc="O" subId="17329445" subSource="5tqq_B"/>
      <ConstraintRegion from="401" to="420" loc="H" subId="17329447" subSource="5tqq_B"/>
      <ConstraintRegion from="421" to="421" loc="I" subId="17329449" subSource="5tqq_B"/>
      <ConstraintRegion from="422" to="441" loc="H" subId="17329452" subSource="5tqq_B"/>
      <ConstraintRegion from="442" to="453" loc="O" subId="17329455" subSource="5tqq_B"/>
      <ConstraintRegion from="457" to="464" loc="O" subId="17329458" subSource="5tqq_B"/>
      <ConstraintRegion from="465" to="480" loc="H" subId="17329461" subSource="5tqq_B"/>
      <ConstraintRegion from="481" to="481" loc="I" subId="17329463" subSource="5tqq_B"/>
      <ConstraintRegion from="482" to="495" loc="H" subId="17329465" subSource="5tqq_B"/>
      <ConstraintRegion from="496" to="496" loc="O" subId="17329467" subSource="5tqq_B"/>
      <ConstraintRegion from="497" to="516" loc="H" subId="17329470" subSource="5tqq_B"/>
      <ConstraintRegion from="517" to="605" loc="I" subId="17329472" subSource="5tqq_B"/>
      <ConstraintRegion from="618" to="683" loc="I" subId="17329474" subSource="5tqq_B"/>
    </Constraint>
  </Constraints>
</HtpItem>
