<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A8I5KRR9_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>7-dehydrocholesterol reductase </Name>
  <CrossRef>
    <PDBTM id="4quv">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <TOPDB id="LBR_HUMAN">
      <Alignment>
        <CrossRefSeq>LYELWET------RVFGVYLLWFLIQVLFYLL-----------PIGKVVEGTPLIDGRRLKYRLNGFYAFILTSAV--IGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIG-TFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPS-------DPKLAHLKTIHTSTGKN---LLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY</CrossRefSeq>
        <OrigSeq>LSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSH--VTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LBR_CHICK">
      <Alignment>
        <CrossRefSeq>LESLWET------KVFGVFLLWFFFQALFYLL-----------PIGKVVEGLPLSNPRKLQYRINGFYAFLLTAAAIGTLLYFQ--FELHYLYDHFVQFAVSAAAFSMALSIYLYIRSLKAPEEDLAPGGNSGYLVYDFFTGHELNPRIGS-FDLKYFCELRPGLIGWVVINLAMLLAEMKIHNQSMPSLSMILVNSFQLLYVVDALWNEEAVLTTMDITHDGFGFMLAFGDLVWVPFVYSLQAFYLVGHPIAISWPVAAAITILNCIGYYIFRSANSQKNNFRRNPAD----------PKLSYLKVIPTATGKGLLVTGWWGFVRHPNYLGDIIMALAWSLPCGFNHILPYFYVIYFICLLVHREARDEHHCKKKYGLAWERYCQRVPY</CrossRefSeq>
        <OrigSeq>LSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSA-RDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELH--SHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPY</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ERG24_YEAST">
      <Alignment>
        <CrossRefSeq>IVELWNGIKPLRYYLGNRELWTVYCLWYGILAVLDVILP-----------GRVMKGVQLRDGSKLSYKINGIAMSTTLVLVLAIRWKLTDGQLPELQYLYENHVSLCIISILFSFFLATYCYVASFIPLIFKKNGNGKREKILALGGNSGNIIYDWFIGRELNPRLG-PLDIKMFSELRPGMLLWLLINLSCLHHHYLKTGKINDALVLVNFLQGFYIFDGVLNEEGVLTMMDITTDGFGFMLAFGDLSLVPFTYSLQARYLSVSPVELGWVKVVGILAIMFLGFHIFHSANKQKSEFRQG--------------KLENLKSIQTKRGTKLLCDGWWAKSQHINYFGDWLISLSWCLATWFQTPLTYYYSLYFATLLLHRQQRDEHKCRLKYGENWEEYERKVPYKIIPYVY</CrossRefSeq>
        <OrigSeq>LSDIWAKTPPI-----TRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSW--FSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYF---FPTSARD--------CKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ERG4_YEAST">
      <Alignment>
        <CrossRefSeq>HLYQLVLENGIPEKYDWTIFLTFWVFQIIFYYTLPGIWTKGQPLSHLK---------GKQLPYFCNAMWTLYVTTTLVLV-LHFTNLFRLYVIIDRFGRIMTCAIISGFAFSIILYLWTLFI--SHDYHRMTGNHLYDFFMGAPLNPRWG-ILDLKMFFEVRLPWFTLYFITLGACLKQWETYGYVTPQLGVVMLAHWLYANACAKGEELIVPTWDMAYEKFGFMLIFWNIAGVPYTYCHCTLYLYYHDPSEYHWSTLYNVSLYVVLLCAYYFFDTANAQKNAFRKQMSGDKTGRKTFPFLPYQILKNPKYMVTSNGSYLLIDGWYTLARKIHYTADWTQSLVWALSCGFNSVFPWFFPVFFLVVLIHRAFRDQAKCKRKYGKDWDEYCKHCPYVFIPYVF</CrossRefSeq>
        <OrigSeq>RLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPV---QLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIE---CSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="443" CheckSum="dd2481f03ef5fa23150051f7190ade4a">
    <Seq>
      MAAKSQPNIP KAKSLDGVTN DRTASQGQWG RACCALTGPV VDIVTGHARL
      SDIWAKTPPI TRKAAQLYTL WVTFQVLLYT SLPDFCHKFL PGYVGGIQEG
      AVTPAGVVNK YQINGLQAWL LTHLLWFANA HLLSWFSPTI IFDNWIPLLW
      CANILGYAVS TFAMVKGYFF PTSARDCKFT GNFFYNYMMG IEFNPRIGKW
      FDFKLFFNGR PGIVAWTLIN LSFAAKQREL HSHVTNAMVL VNVLQAIYVI
      DFFWNETWYL KTIDICHDHF GWYLGWGDCV WLPYLYTLQG LYLVYHPVQL
      STPHAVGVLL LGLVGYYIFR VANHQKDLFR RTDGRCLIWG RKPKVIECSY
      TSADGQRHHS KLLVSGFWGV ARHFNYVGDL MGSLAYCLAC GGGHLLPYFY
      IIYMAILLTH RCLRDEHRCA SKYGRDWERY TAAVPYRLLP GIF
    </Seq>
  </Sequence>
  <Topology numTm="8" reliability="68.73">
    <Region from="1" to="114" loc="I"/>
    <Region from="115" to="134" loc="M"/>
    <Region from="135" to="144" loc="O"/>
    <Region from="145" to="165" loc="M"/>
    <Region from="166" to="204" loc="I"/>
    <Region from="205" to="224" loc="M"/>
    <Region from="225" to="233" loc="O"/>
    <Region from="234" to="253" loc="M"/>
    <Region from="254" to="269" loc="I"/>
    <Region from="270" to="288" loc="M"/>
    <Region from="289" to="299" loc="O"/>
    <Region from="300" to="319" loc="M"/>
    <Region from="320" to="375" loc="I"/>
    <Region from="376" to="392" loc="M"/>
    <Region from="393" to="394" loc="O"/>
    <Region from="395" to="408" loc="M"/>
    <Region from="409" to="443" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="66" loc="I"/>
      <Region from="67" to="78" loc="M"/>
      <Region from="79" to="443" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="64" loc="O"/>
      <Region from="65" to="89" loc="M"/>
      <Region from="90" to="112" loc="I"/>
      <Region from="113" to="136" loc="M"/>
      <Region from="137" to="144" loc="O"/>
      <Region from="145" to="166" loc="M"/>
      <Region from="167" to="205" loc="I"/>
      <Region from="206" to="225" loc="M"/>
      <Region from="226" to="236" loc="O"/>
      <Region from="237" to="253" loc="M"/>
      <Region from="254" to="269" loc="I"/>
      <Region from="270" to="289" loc="M"/>
      <Region from="290" to="302" loc="O"/>
      <Region from="303" to="320" loc="M"/>
      <Region from="321" to="370" loc="I"/>
      <Region from="371" to="392" loc="M"/>
      <Region from="393" to="395" loc="O"/>
      <Region from="396" to="411" loc="M"/>
      <Region from="412" to="443" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="29" loc="I"/>
      <Region from="30" to="50" loc="M"/>
      <Region from="51" to="62" loc="O"/>
      <Region from="63" to="83" loc="M"/>
      <Region from="84" to="94" loc="I"/>
      <Region from="95" to="100" loc="L"/>
      <Region from="101" to="112" loc="I"/>
      <Region from="113" to="143" loc="M"/>
      <Region from="144" to="145" loc="O"/>
      <Region from="146" to="166" loc="M"/>
      <Region from="167" to="203" loc="I"/>
      <Region from="204" to="224" loc="M"/>
      <Region from="225" to="229" loc="O"/>
      <Region from="230" to="250" loc="M"/>
      <Region from="251" to="269" loc="I"/>
      <Region from="270" to="290" loc="M"/>
      <Region from="291" to="296" loc="O"/>
      <Region from="297" to="317" loc="M"/>
      <Region from="318" to="362" loc="I"/>
      <Region from="363" to="383" loc="M"/>
      <Region from="384" to="384" loc="O"/>
      <Region from="385" to="405" loc="M"/>
      <Region from="406" to="443" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="118" loc="I"/>
      <Region from="119" to="139" loc="M"/>
      <Region from="140" to="145" loc="O"/>
      <Region from="146" to="170" loc="M"/>
      <Region from="171" to="205" loc="I"/>
      <Region from="206" to="225" loc="M"/>
      <Region from="226" to="231" loc="O"/>
      <Region from="232" to="254" loc="M"/>
      <Region from="255" to="269" loc="I"/>
      <Region from="270" to="288" loc="M"/>
      <Region from="289" to="299" loc="O"/>
      <Region from="300" to="321" loc="M"/>
      <Region from="322" to="375" loc="I"/>
      <Region from="376" to="392" loc="M"/>
      <Region from="393" to="393" loc="O"/>
      <Region from="394" to="408" loc="M"/>
      <Region from="409" to="443" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="117" loc="I"/>
      <Region from="118" to="138" loc="M"/>
      <Region from="139" to="143" loc="O"/>
      <Region from="144" to="165" loc="M"/>
      <Region from="166" to="233" loc="I"/>
      <Region from="234" to="254" loc="M"/>
      <Region from="255" to="273" loc="O"/>
      <Region from="274" to="295" loc="M"/>
      <Region from="296" to="301" loc="I"/>
      <Region from="302" to="319" loc="M"/>
      <Region from="320" to="382" loc="O"/>
      <Region from="383" to="408" loc="M"/>
      <Region from="409" to="443" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="71" loc="O"/>
      <Region from="72" to="92" loc="M"/>
      <Region from="93" to="112" loc="I"/>
      <Region from="113" to="133" loc="M"/>
      <Region from="134" to="144" loc="O"/>
      <Region from="145" to="165" loc="M"/>
      <Region from="166" to="204" loc="I"/>
      <Region from="205" to="225" loc="M"/>
      <Region from="226" to="229" loc="O"/>
      <Region from="230" to="250" loc="M"/>
      <Region from="251" to="270" loc="I"/>
      <Region from="271" to="291" loc="M"/>
      <Region from="292" to="301" loc="O"/>
      <Region from="302" to="322" loc="M"/>
      <Region from="323" to="375" loc="I"/>
      <Region from="376" to="396" loc="M"/>
      <Region from="397" to="443" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="25" loc="I"/>
      <Region from="26" to="46" loc="M"/>
      <Region from="47" to="62" loc="O"/>
      <Region from="63" to="83" loc="M"/>
      <Region from="84" to="114" loc="I"/>
      <Region from="115" to="135" loc="M"/>
      <Region from="136" to="144" loc="O"/>
      <Region from="145" to="165" loc="M"/>
      <Region from="166" to="204" loc="I"/>
      <Region from="205" to="225" loc="M"/>
      <Region from="226" to="229" loc="O"/>
      <Region from="230" to="250" loc="M"/>
      <Region from="251" to="270" loc="I"/>
      <Region from="271" to="291" loc="M"/>
      <Region from="292" to="299" loc="O"/>
      <Region from="300" to="320" loc="M"/>
      <Region from="321" to="375" loc="I"/>
      <Region from="376" to="396" loc="M"/>
      <Region from="397" to="443" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="61" loc="O"/>
      <Region from="62" to="81" loc="M"/>
      <Region from="82" to="115" loc="I"/>
      <Region from="116" to="135" loc="M"/>
      <Region from="136" to="144" loc="O"/>
      <Region from="145" to="164" loc="M"/>
      <Region from="165" to="204" loc="I"/>
      <Region from="205" to="224" loc="M"/>
      <Region from="225" to="233" loc="O"/>
      <Region from="234" to="253" loc="M"/>
      <Region from="254" to="268" loc="I"/>
      <Region from="269" to="288" loc="M"/>
      <Region from="289" to="298" loc="O"/>
      <Region from="299" to="318" loc="M"/>
      <Region from="319" to="394" loc="I"/>
      <Region from="395" to="414" loc="M"/>
      <Region from="415" to="443" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="61" loc="O"/>
      <Region from="62" to="82" loc="M"/>
      <Region from="83" to="115" loc="I"/>
      <Region from="116" to="136" loc="M"/>
      <Region from="137" to="144" loc="O"/>
      <Region from="145" to="165" loc="M"/>
      <Region from="166" to="204" loc="I"/>
      <Region from="205" to="225" loc="M"/>
      <Region from="226" to="233" loc="O"/>
      <Region from="234" to="254" loc="M"/>
      <Region from="255" to="269" loc="I"/>
      <Region from="270" to="290" loc="M"/>
      <Region from="291" to="298" loc="O"/>
      <Region from="299" to="319" loc="M"/>
      <Region from="320" to="372" loc="I"/>
      <Region from="373" to="393" loc="M"/>
      <Region from="394" to="394" loc="O"/>
      <Region from="395" to="415" loc="M"/>
      <Region from="416" to="443" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="118" loc="I"/>
      <Region from="119" to="141" loc="M"/>
      <Region from="142" to="145" loc="O"/>
      <Region from="146" to="168" loc="M"/>
      <Region from="169" to="231" loc="I"/>
      <Region from="232" to="254" loc="M"/>
      <Region from="255" to="299" loc="O"/>
      <Region from="300" to="322" loc="M"/>
      <Region from="323" to="381" loc="I"/>
      <Region from="382" to="404" loc="M"/>
      <Region from="405" to="443" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
