<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A8I5KUR7_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Solute carrier family 22 member 5 </Name>
  <CrossRef>
    <PDBTM id="8et6">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8et7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8et8">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtz">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8et9">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bvt">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sdu">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sdz">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bvr">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bvs">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bw7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8omu">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sdy">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zh0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zha">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zh6">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jts">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sc4">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sc2">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtt">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtw">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtx">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jty">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sc1">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sc6">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sc3">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtv">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8ju0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6rw3">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8jlf">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jlh">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8js8">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8yf0">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8yf1">
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="OCTN2_HUMAN">
      <Alignment>
        <CrossRefSeq>MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF</CrossRefSeq>
        <OrigSeq>MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSS-YNILYVRSVHILCIWL-----HGAATVCLLHPRLADAAGGADDAGGAMRGTLVGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKSTAF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22A6_HUMAN">
      <Alignment>
        <CrossRefSeq>FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLP---RDRQGQPESCLRFTSPQWGLPFLNGTEAN-----GTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQTRQQQEHQKYMVPLQASA</CrossRefSeq>
        <OrigSeq>YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLS-SAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWL-----HGAATVCLLHPRLADAAGGADDAGGAMRGTLVGRFEEAEVIIRKAAKANGIVVPSTIFDPS----ELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHR------KTPSHTRMLKDGQERPTILKSTA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22A2_RABIT">
      <Alignment>
        <CrossRefSeq>MPTVDDILEQVGHFHFFQKQTFFLLALISAAFTPIYVGIVFLGFTPDHRCRSPGVAELSQRCGWSPGEELNYTVPGLGAADGAFARQCMRYEVDWNQSSPGCVDPLASLAPNRSHLPLGPCQHGWVYDTPG--SSIVTEFNLVCARSWMLDLFQSAVNIGFFIGSVGIGYLADRFGRKLCLLVTILINAAAGVLMAVSPNYTWMLIFRLIQGLVSKAGWLIGYILITEFVGLNYRRTVGILYQVAFTVGLLVLAGVAYALPRWRWLQLTVTLPYFCFLLYYWCIPESPRWLISQNKNAKAMRIMEHIAKKNGKSLPVSLQSLRAAEDV--GEKLNPSFLDLVRTPQIRKHTCILMYNWFTSSVLYQGLIMHLGLAGGDIYLDFFYSALVEFPAAFLIIATIDRVGRRYPWAVSNMVAGAACLASVFVPDDLQGLRITVACLGRMGITMAYEMVCLVNAELYPTFIRNLGVLVCSSLCDVGGIVTPFLVYRLTAIWLQLPLVVFAVVGLVAGGLVLMLPETKGRTLPETIEEAENLQRPRKNREKVIYVHVRKA</CrossRefSeq>
        <OrigSeq>MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLS--SAW-----RNHTVPLRLRDGREVPHSCRRYRLATIANFS-ALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWL-----HGAATVCLLHPRLADAAGGADDAGGAMRGTLVGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVY-LGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22A6_MOUSE">
      <Alignment>
        <CrossRefSeq>FNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPAHHCRPPANANLSKDGGLEAWLPL---DKQGRPESCLRFPFPHNGT-----------EANGTGVTEPCLDGWVYDNSTFPSTIVTEWNLVCSHRAFRQLAQSLFMVGVLLGAMMFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCIFRLLSGMSLASIAINCMTLNMEWMPIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLAVSVPFFVAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLQTSLQKELTLNKGQASAMELLRCPTLRRLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVCFLVINSMGRRPAQLASLLLAGICILVNGIIPRGHTIIRTSLAVLGKGCLASSFNCIFLYTGELYPTMIRQTGLGMGSTMARVGSIVSPLISMTAEFYPSIPLFIFGAVPVAASAVTALLPETLGQPLPDTVQDLKSRSR</CrossRefSeq>
        <OrigSeq>YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLS-SAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWL-----HGAATVCLLHPRLADAAGGADDAGGAMRGTLVGRFEEAEVIIRKAAKANGIVVPSTIFDPS----ELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22AB_HUMAN">
      <Alignment>
        <CrossRefSeq>FSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAVSTNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNA----TATSWSEADTEPCVDGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVARINGHKEAKNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQKSTAAQGNRQEAVTVESTSL</CrossRefSeq>
        <OrigSeq>YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHT-----VPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWL-----HGAATVCLLHPRLADAAGGADDAGGAMRGTLVGRFEEAEVIIRKAAKANGIVVPSTIFDP---SELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTIL-TAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22A7_HUMAN">
      <Alignment>
        <CrossRefSeq>FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDVWLEAHLP---REPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEEMPM</CrossRefSeq>
        <OrigSeq>YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPD---AANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLE-QESCLDGWEFSQDVYLSTIVTE--WNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVCLLHPRLAD-----AAGGADDAGGAMRGTLVGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQ--QSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ORCT_DROME">
      <Alignment>
        <CrossRefSeq>YDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHLWNLSYPEN--------ERCSYYDVDYTE------EYLNGSIPRSSNETKTC-SSYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPETLNKPMPETIEDGENFGKKPAPQETAEEGGTQE</CrossRefSeq>
        <OrigSeq>YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVP----DAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWL-----HGAATVCLLHPRLADAAGGADDAGGAMRGTLVGRFEEAEVIIRKAAKANGIVVPSTIFD-------PSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKD</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="OCT1_CAEEL">
      <Alignment>
        <CrossRefSeq>PDFDFVLEQVGNYGTYQIVFFFIICLPTSLPSAFSAFNIPFVVGNPPHTCHIPEGKEYLRPLTNDTQIL----------SCKQYNETQI-NVFRAFTSAPVDTYSDRISLVPCQNGWDYDNSTYLDSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRRWRQLTFFCNAPFAFYIIYYFFLPESPRWSVSVGKWADAKKQLKKIAKMNGKSNVDVDELVDSMKNHQNAAEEKETKRSHNVTDLFKTPNLRRKTLIVTYIWVMNAIIYNGLTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPDGYPWLVASASFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVNLGKIVKILPLLIMGLMALSAGILTFFLPETLGAPLPMTIEDAENFGKKPEPDSGMFTQAAKKRESQPLLEPHT</CrossRefSeq>
        <OrigSeq>RDYDEVTAFLGEWGPFQRLIFFLLSAS-IIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRN---SWQVSSYN--ILYVRSVHILCIWLHGAATVCLLHPRLADAAGGADDAGGAMRGTLVGRFEEAEVIIRKAAKANGIV--VPSTIFDPSELQD---LSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRMLKDGQERPTILKST</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="YAAU_ECOLI">
      <Alignment>
        <CrossRefSeq>LAGLFVGTSLFGYISDKVGRRKMFLIDIIAIGVISVATMFVSSPVELLVMRVLIGIVIGADYPIATSMITEFSSTRQRAFSISFIAAMWYVGATCADLVGYWLYDVEGGWRWMLGSAAIPCLLILIGRFELPESPRWLLRKGRVKECEEMMI---KLFGEPVAFD-----------EEQPQQTRFRDLFNRRHFPFVLFVAAIWTCQVIPMFAIYTFGPQIVGLLGLGVGKNAALGNVVISLFFMLGCIPPMLWLNTAGRRPLLIGSFAMMTLALAVLGLIPDMGIWLVVMAFAVYAFFSGGPGNLQWLYPNELFPTDIRASAVGVIMSLSRIGTIVSTWALPIFINNYGISNTMLMGAGISLFGLLISVAFAPETRGMSLAQT</CrossRefSeq>
        <OrigSeq>FVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVH---ILCIWLH---GAATVCLLH---PRLADAAGGADDAGGAMRGTLVGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMV-------TIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILS--PYFVYLGAYDRFLPYILMGSLTILTAIL-TLFLPESFGTPLPDT</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="YGCS_ECOLI">
      <Alignment>
        <CrossRefSeq>FMAGMIGGSALLGLFLGSLVLGWISDHIGRQKIFTFSFLLITLASFLQFFATTPEHLIGLRILIGIGLGGDYSVGHTLLAEFSPRRHRGILLGAFSVVWTVGYVLASIAGHHFISENPEAWRWLLASAALPALLITLLRWGTPESPRWLLRQGRFAEAHAIVHR------------YFGPHVLLGDEVVTATHKHIKTLFSSRYWRRTAFNSVFFVCLVIPWFVI---YTWLPTIAQTIGLEDALTASLMLNALLIVGALLGLVLTHLLAHRKFLLGSFLLLAATLVVMACLPSGSSLTL--LLFVLFSTTISAVSNLVGILPAESFPTDIRSLGVGFATAMSRLGAAVSTGLLPWVLAQWGMQVTLLLLATVLLVGFVVTWLWAPETKALPL</CrossRefSeq>
        <OrigSeq>WKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVCLLHPRLADA----------AGGADDAGGAMRGTLVGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTI------MSIMLWMTISVGYFGLSLDTPNLHGDIFVN--CFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSP-YFVYLGAYDRFLPYILMGSLTILTAILTLFL--PESFGTPL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SV2A_HUMAN">
      <Alignment>
        <CrossRefSeq>VYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESA--MIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVL</CrossRefSeq>
        <OrigSeq>IFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTI-LTAILTLFLPESFGTPL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SV2C_RAT">
      <Alignment>
        <CrossRefSeq>IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSES--MMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLPDTRTQVL</CrossRefSeq>
        <OrigSeq>IFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFV-YLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SV2C_HUMAN">
      <Alignment>
        <CrossRefSeq>IYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSES--MMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGLCLPDTRTQVL</CrossRefSeq>
        <OrigSeq>IFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFV-YLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="GTR12_MOUSE">
      <Alignment>
        <CrossRefSeq>LTCHEQ---EMVVSSLLIGAFLASLTGGVLIDRYGRRLAIILSSCLLGLGSLVLIMSLSYTLLIMGRVAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVTGILFAYISNYAFANISNGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEESAGKVLRKL------RVISDTTEELTLIKSSLKDEYQYSFWDLFRSKDNMRTRILIGLTLVFFVQTTGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPATLLVDHIGSKTFLCIGSSVMSASLLTMGIV</CrossRefSeq>
        <OrigSeq>LVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATV---------CLLHPRLADAAGGADDAGGAMRGTLVGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTW-NIRMVTIM-SIMLWMTISVG------YFGLSLDTPNLHGDIFVNCFLS--AMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLV</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="551" CheckSum="7e7e9149c71502099a9759c57222d820">
    <Seq>
      MRDYDEVTAF LGEWGPFQRL IFFLLSASII PNGFTGLSSV FLIATPEHRC
      RVPDAANLSS AWRNHTVPLR LRDGREVPHS CRRYRLATIA NFSALGLEPG
      RDVDLGQLEQ ESCLDGWEFS QDVYLSTIVT EWNLVCEDDW KAPLTISLFF
      VGVLLGSFIS GQLSDRFGRK NVLFVTMGMQ TGFSFLQIFS KNFEMFVVLF
      VLVGMGQISN YVAAFVLGMA IRLEDRNSWQ VSSYNILYVR SVHILCIWLH
      GAATVCLLHP RLADAAGGAD DAGGAMRGTL VGRFEEAEVI IRKAAKANGI
      VVPSTIFDPS ELQDLSSKKQ QSHNILDLLR TWNIRMVTIM SIMLWMTISV
      GYFGLSLDTP NLHGDIFVNC FLSAMVEVPA YVLAWLLLQY LPRRYSMATA
      LFLGGSVLLF MQLVPPDLYY LATVLVMVGK FGVTAAFSMV YVYTAELYPT
      VVRNMGVGVS STASRLGSIL SPYFVYLGAY DRFLPYILMG SLTILTAILT
      LFLPESFGTP LPDTIDQMLR VKGMKHRKTP SHTRMLKDGQ ERPTILKSTA
      F
    </Seq>
  </Sequence>
  <Topology numTm="12" reliability="83.7">
    <Region from="1" to="19" loc="I"/>
    <Region from="20" to="42" loc="M"/>
    <Region from="43" to="141" loc="O"/>
    <Region from="142" to="161" loc="M"/>
    <Region from="162" to="171" loc="I"/>
    <Region from="172" to="190" loc="M"/>
    <Region from="191" to="195" loc="O"/>
    <Region from="196" to="217" loc="M"/>
    <Region from="218" to="227" loc="I"/>
    <Region from="228" to="247" loc="M"/>
    <Region from="248" to="249" loc="O"/>
    <Region from="250" to="267" loc="M"/>
    <Region from="268" to="335" loc="I"/>
    <Region from="336" to="355" loc="M"/>
    <Region from="356" to="365" loc="O"/>
    <Region from="366" to="387" loc="M"/>
    <Region from="388" to="394" loc="I"/>
    <Region from="395" to="413" loc="M"/>
    <Region from="414" to="420" loc="O"/>
    <Region from="421" to="442" loc="M"/>
    <Region from="443" to="455" loc="I"/>
    <Region from="456" to="475" loc="M"/>
    <Region from="476" to="482" loc="O"/>
    <Region from="483" to="502" loc="M"/>
    <Region from="503" to="551" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="19" loc="I"/>
      <Region from="20" to="44" loc="M"/>
      <Region from="45" to="143" loc="O"/>
      <Region from="144" to="164" loc="M"/>
      <Region from="165" to="171" loc="I"/>
      <Region from="172" to="191" loc="M"/>
      <Region from="192" to="197" loc="O"/>
      <Region from="198" to="222" loc="M"/>
      <Region from="223" to="227" loc="I"/>
      <Region from="228" to="249" loc="M"/>
      <Region from="250" to="251" loc="O"/>
      <Region from="252" to="271" loc="M"/>
      <Region from="272" to="335" loc="I"/>
      <Region from="336" to="357" loc="M"/>
      <Region from="358" to="366" loc="O"/>
      <Region from="367" to="388" loc="M"/>
      <Region from="389" to="395" loc="I"/>
      <Region from="396" to="414" loc="M"/>
      <Region from="415" to="420" loc="O"/>
      <Region from="421" to="445" loc="M"/>
      <Region from="446" to="454" loc="I"/>
      <Region from="455" to="475" loc="M"/>
      <Region from="476" to="482" loc="O"/>
      <Region from="483" to="502" loc="M"/>
      <Region from="503" to="551" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="16" loc="I"/>
      <Region from="17" to="43" loc="M"/>
      <Region from="44" to="144" loc="O"/>
      <Region from="145" to="163" loc="M"/>
      <Region from="164" to="169" loc="I"/>
      <Region from="170" to="189" loc="M"/>
      <Region from="190" to="192" loc="O"/>
      <Region from="193" to="219" loc="M"/>
      <Region from="220" to="225" loc="I"/>
      <Region from="226" to="241" loc="M"/>
      <Region from="242" to="244" loc="O"/>
      <Region from="245" to="268" loc="M"/>
      <Region from="269" to="333" loc="I"/>
      <Region from="334" to="357" loc="M"/>
      <Region from="358" to="366" loc="O"/>
      <Region from="367" to="387" loc="M"/>
      <Region from="388" to="395" loc="I"/>
      <Region from="396" to="414" loc="M"/>
      <Region from="415" to="417" loc="O"/>
      <Region from="418" to="448" loc="M"/>
      <Region from="449" to="451" loc="I"/>
      <Region from="452" to="477" loc="M"/>
      <Region from="478" to="483" loc="O"/>
      <Region from="484" to="503" loc="M"/>
      <Region from="504" to="551" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="46" loc="M"/>
      <Region from="47" to="141" loc="O"/>
      <Region from="142" to="162" loc="M"/>
      <Region from="163" to="172" loc="I"/>
      <Region from="173" to="193" loc="M"/>
      <Region from="194" to="197" loc="O"/>
      <Region from="198" to="218" loc="M"/>
      <Region from="219" to="228" loc="I"/>
      <Region from="229" to="243" loc="M"/>
      <Region from="244" to="244" loc="O"/>
      <Region from="245" to="259" loc="M"/>
      <Region from="260" to="263" loc="I"/>
      <Region from="264" to="266" loc="L"/>
      <Region from="267" to="336" loc="I"/>
      <Region from="337" to="357" loc="M"/>
      <Region from="358" to="363" loc="O"/>
      <Region from="364" to="384" loc="M"/>
      <Region from="385" to="394" loc="I"/>
      <Region from="395" to="415" loc="M"/>
      <Region from="416" to="422" loc="O"/>
      <Region from="423" to="443" loc="M"/>
      <Region from="444" to="454" loc="I"/>
      <Region from="455" to="475" loc="M"/>
      <Region from="476" to="481" loc="O"/>
      <Region from="482" to="502" loc="M"/>
      <Region from="503" to="551" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="19" loc="I"/>
      <Region from="20" to="44" loc="M"/>
      <Region from="45" to="141" loc="O"/>
      <Region from="142" to="163" loc="M"/>
      <Region from="164" to="170" loc="I"/>
      <Region from="171" to="190" loc="M"/>
      <Region from="191" to="195" loc="O"/>
      <Region from="196" to="221" loc="M"/>
      <Region from="222" to="333" loc="I"/>
      <Region from="334" to="355" loc="M"/>
      <Region from="356" to="365" loc="O"/>
      <Region from="366" to="388" loc="M"/>
      <Region from="389" to="394" loc="I"/>
      <Region from="395" to="414" loc="M"/>
      <Region from="415" to="420" loc="O"/>
      <Region from="421" to="443" loc="M"/>
      <Region from="444" to="454" loc="I"/>
      <Region from="455" to="476" loc="M"/>
      <Region from="477" to="482" loc="O"/>
      <Region from="483" to="503" loc="M"/>
      <Region from="504" to="551" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="19" loc="O"/>
      <Region from="20" to="44" loc="M"/>
      <Region from="45" to="141" loc="I"/>
      <Region from="142" to="160" loc="M"/>
      <Region from="161" to="171" loc="O"/>
      <Region from="172" to="189" loc="M"/>
      <Region from="190" to="195" loc="I"/>
      <Region from="196" to="217" loc="M"/>
      <Region from="218" to="236" loc="O"/>
      <Region from="237" to="258" loc="M"/>
      <Region from="259" to="331" loc="I"/>
      <Region from="332" to="354" loc="M"/>
      <Region from="355" to="365" loc="O"/>
      <Region from="366" to="388" loc="M"/>
      <Region from="389" to="394" loc="I"/>
      <Region from="395" to="413" loc="M"/>
      <Region from="414" to="418" loc="O"/>
      <Region from="419" to="443" loc="M"/>
      <Region from="444" to="454" loc="I"/>
      <Region from="455" to="477" loc="M"/>
      <Region from="478" to="482" loc="O"/>
      <Region from="483" to="503" loc="M"/>
      <Region from="504" to="551" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="20" loc="I"/>
      <Region from="21" to="41" loc="M"/>
      <Region from="42" to="140" loc="O"/>
      <Region from="141" to="161" loc="M"/>
      <Region from="162" to="170" loc="I"/>
      <Region from="171" to="191" loc="M"/>
      <Region from="192" to="195" loc="O"/>
      <Region from="196" to="216" loc="M"/>
      <Region from="217" to="227" loc="I"/>
      <Region from="228" to="248" loc="M"/>
      <Region from="249" to="250" loc="O"/>
      <Region from="251" to="271" loc="M"/>
      <Region from="272" to="335" loc="I"/>
      <Region from="336" to="356" loc="M"/>
      <Region from="357" to="365" loc="O"/>
      <Region from="366" to="386" loc="M"/>
      <Region from="387" to="395" loc="I"/>
      <Region from="396" to="416" loc="M"/>
      <Region from="417" to="420" loc="O"/>
      <Region from="421" to="441" loc="M"/>
      <Region from="442" to="456" loc="I"/>
      <Region from="457" to="477" loc="M"/>
      <Region from="478" to="481" loc="O"/>
      <Region from="482" to="502" loc="M"/>
      <Region from="503" to="551" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="20" loc="I"/>
      <Region from="21" to="41" loc="M"/>
      <Region from="42" to="140" loc="O"/>
      <Region from="141" to="161" loc="M"/>
      <Region from="162" to="170" loc="I"/>
      <Region from="171" to="191" loc="M"/>
      <Region from="192" to="195" loc="O"/>
      <Region from="196" to="216" loc="M"/>
      <Region from="217" to="227" loc="I"/>
      <Region from="228" to="248" loc="M"/>
      <Region from="249" to="250" loc="O"/>
      <Region from="251" to="271" loc="M"/>
      <Region from="272" to="336" loc="I"/>
      <Region from="337" to="357" loc="M"/>
      <Region from="358" to="365" loc="O"/>
      <Region from="366" to="386" loc="M"/>
      <Region from="387" to="395" loc="I"/>
      <Region from="396" to="416" loc="M"/>
      <Region from="417" to="420" loc="O"/>
      <Region from="421" to="441" loc="M"/>
      <Region from="442" to="456" loc="I"/>
      <Region from="457" to="477" loc="M"/>
      <Region from="478" to="482" loc="O"/>
      <Region from="483" to="503" loc="M"/>
      <Region from="504" to="551" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="16" loc="O"/>
      <Region from="17" to="36" loc="M"/>
      <Region from="37" to="80" loc="I"/>
      <Region from="81" to="100" loc="M"/>
      <Region from="101" to="139" loc="O"/>
      <Region from="140" to="159" loc="M"/>
      <Region from="160" to="192" loc="I"/>
      <Region from="193" to="212" loc="M"/>
      <Region from="213" to="237" loc="O"/>
      <Region from="238" to="257" loc="M"/>
      <Region from="258" to="327" loc="I"/>
      <Region from="328" to="347" loc="M"/>
      <Region from="348" to="370" loc="O"/>
      <Region from="371" to="390" loc="M"/>
      <Region from="391" to="394" loc="I"/>
      <Region from="395" to="414" loc="M"/>
      <Region from="415" to="416" loc="O"/>
      <Region from="417" to="436" loc="M"/>
      <Region from="437" to="482" loc="I"/>
      <Region from="483" to="502" loc="M"/>
      <Region from="503" to="551" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="16" loc="I"/>
      <Region from="17" to="37" loc="M"/>
      <Region from="38" to="143" loc="O"/>
      <Region from="144" to="164" loc="M"/>
      <Region from="165" to="170" loc="I"/>
      <Region from="171" to="191" loc="M"/>
      <Region from="192" to="192" loc="O"/>
      <Region from="193" to="213" loc="M"/>
      <Region from="214" to="236" loc="I"/>
      <Region from="237" to="257" loc="M"/>
      <Region from="258" to="260" loc="O"/>
      <Region from="261" to="281" loc="M"/>
      <Region from="282" to="336" loc="I"/>
      <Region from="337" to="357" loc="M"/>
      <Region from="358" to="365" loc="O"/>
      <Region from="366" to="386" loc="M"/>
      <Region from="387" to="395" loc="I"/>
      <Region from="396" to="416" loc="M"/>
      <Region from="417" to="422" loc="O"/>
      <Region from="423" to="443" loc="M"/>
      <Region from="444" to="482" loc="I"/>
      <Region from="483" to="503" loc="M"/>
      <Region from="504" to="551" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="20" loc="I"/>
      <Region from="21" to="43" loc="M"/>
      <Region from="44" to="141" loc="O"/>
      <Region from="142" to="164" loc="M"/>
      <Region from="165" to="170" loc="I"/>
      <Region from="171" to="190" loc="M"/>
      <Region from="191" to="194" loc="O"/>
      <Region from="195" to="217" loc="M"/>
      <Region from="218" to="333" loc="I"/>
      <Region from="334" to="356" loc="M"/>
      <Region from="357" to="365" loc="O"/>
      <Region from="366" to="388" loc="M"/>
      <Region from="389" to="394" loc="I"/>
      <Region from="395" to="414" loc="M"/>
      <Region from="415" to="418" loc="O"/>
      <Region from="419" to="441" loc="M"/>
      <Region from="442" to="453" loc="I"/>
      <Region from="454" to="476" loc="M"/>
      <Region from="477" to="485" loc="O"/>
      <Region from="486" to="508" loc="M"/>
      <Region from="509" to="551" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="8et6_A">
      <ConstraintRegion from="2" to="22" loc="I" subId="17063776" subSource="8et6_A"/>
      <ConstraintRegion from="23" to="39" loc="H" subId="17063778" subSource="8et6_A"/>
      <ConstraintRegion from="40" to="150" loc="O" subId="17063780" subSource="8et6_A"/>
      <ConstraintRegion from="151" to="167" loc="H" subId="17063782" subSource="8et6_A"/>
      <ConstraintRegion from="168" to="178" loc="I" subId="17063784" subSource="8et6_A"/>
      <ConstraintRegion from="179" to="196" loc="H" subId="17063786" subSource="8et6_A"/>
      <ConstraintRegion from="197" to="200" loc="O" subId="17063788" subSource="8et6_A"/>
      <ConstraintRegion from="201" to="221" loc="H" subId="17063790" subSource="8et6_A"/>
      <ConstraintRegion from="222" to="234" loc="I" subId="17063792" subSource="8et6_A"/>
      <ConstraintRegion from="235" to="254" loc="H" subId="17063794" subSource="8et6_A"/>
      <ConstraintRegion from="255" to="264" loc="O" subId="17063796" subSource="8et6_A"/>
      <ConstraintRegion from="265" to="279" loc="H" subId="17063798" subSource="8et6_A"/>
      <ConstraintRegion from="280" to="348" loc="I" subId="17063800" subSource="8et6_A"/>
      <ConstraintRegion from="349" to="366" loc="H" subId="17063802" subSource="8et6_A"/>
      <ConstraintRegion from="367" to="379" loc="O" subId="17063804" subSource="8et6_A"/>
      <ConstraintRegion from="380" to="397" loc="H" subId="17063805" subSource="8et6_A"/>
      <ConstraintRegion from="398" to="402" loc="I" subId="17063806" subSource="8et6_A"/>
      <ConstraintRegion from="403" to="422" loc="H" subId="17063807" subSource="8et6_A"/>
      <ConstraintRegion from="423" to="433" loc="O" subId="17063808" subSource="8et6_A"/>
      <ConstraintRegion from="434" to="453" loc="H" subId="17063809" subSource="8et6_A"/>
      <ConstraintRegion from="454" to="466" loc="I" subId="17063810" subSource="8et6_A"/>
      <ConstraintRegion from="467" to="484" loc="H" subId="17063811" subSource="8et6_A"/>
      <ConstraintRegion from="485" to="494" loc="O" subId="17063812" subSource="8et6_A"/>
      <ConstraintRegion from="495" to="511" loc="H" subId="17063813" subSource="8et6_A"/>
      <ConstraintRegion from="512" to="533" loc="I" subId="17063814" subSource="8et6_A"/>
      <ConstraintRegion from="2" to="22" loc="I" subId="17063817" subSource="8et7_A"/>
      <ConstraintRegion from="23" to="39" loc="H" subId="17063818" subSource="8et7_A"/>
      <ConstraintRegion from="40" to="151" loc="O" subId="17063819" subSource="8et7_A"/>
      <ConstraintRegion from="152" to="167" loc="H" subId="17063820" subSource="8et7_A"/>
      <ConstraintRegion from="168" to="178" loc="I" subId="17063821" subSource="8et7_A"/>
      <ConstraintRegion from="179" to="196" loc="H" subId="17063822" subSource="8et7_A"/>
      <ConstraintRegion from="197" to="200" loc="O" subId="17063823" subSource="8et7_A"/>
      <ConstraintRegion from="201" to="221" loc="H" subId="17063824" subSource="8et7_A"/>
      <ConstraintRegion from="222" to="235" loc="I" subId="17063825" subSource="8et7_A"/>
      <ConstraintRegion from="236" to="254" loc="H" subId="17063826" subSource="8et7_A"/>
      <ConstraintRegion from="255" to="264" loc="O" subId="17063827" subSource="8et7_A"/>
      <ConstraintRegion from="265" to="279" loc="H" subId="17063828" subSource="8et7_A"/>
      <ConstraintRegion from="280" to="348" loc="I" subId="17063829" subSource="8et7_A"/>
      <ConstraintRegion from="349" to="365" loc="H" subId="17063830" subSource="8et7_A"/>
      <ConstraintRegion from="366" to="380" loc="O" subId="17063831" subSource="8et7_A"/>
      <ConstraintRegion from="381" to="397" loc="H" subId="17063832" subSource="8et7_A"/>
      <ConstraintRegion from="398" to="402" loc="I" subId="17063833" subSource="8et7_A"/>
      <ConstraintRegion from="403" to="419" loc="H" subId="17063834" subSource="8et7_A"/>
      <ConstraintRegion from="420" to="434" loc="O" subId="17063835" subSource="8et7_A"/>
      <ConstraintRegion from="435" to="453" loc="H" subId="17063836" subSource="8et7_A"/>
      <ConstraintRegion from="454" to="466" loc="I" subId="17063837" subSource="8et7_A"/>
      <ConstraintRegion from="467" to="483" loc="H" subId="17063838" subSource="8et7_A"/>
      <ConstraintRegion from="484" to="495" loc="O" subId="17063839" subSource="8et7_A"/>
      <ConstraintRegion from="496" to="511" loc="H" subId="17063840" subSource="8et7_A"/>
      <ConstraintRegion from="512" to="533" loc="I" subId="17063841" subSource="8et7_A"/>
      <ConstraintRegion from="2" to="20" loc="I" subId="17063877" subSource="8et8_A"/>
      <ConstraintRegion from="21" to="41" loc="H" subId="17063878" subSource="8et8_A"/>
      <ConstraintRegion from="42" to="150" loc="O" subId="17063879" subSource="8et8_A"/>
      <ConstraintRegion from="151" to="170" loc="H" subId="17063880" subSource="8et8_A"/>
      <ConstraintRegion from="171" to="175" loc="I" subId="17063881" subSource="8et8_A"/>
      <ConstraintRegion from="176" to="196" loc="H" subId="17063882" subSource="8et8_A"/>
      <ConstraintRegion from="197" to="200" loc="O" subId="17063883" subSource="8et8_A"/>
      <ConstraintRegion from="201" to="222" loc="H" subId="17063884" subSource="8et8_A"/>
      <ConstraintRegion from="223" to="234" loc="I" subId="17063885" subSource="8et8_A"/>
      <ConstraintRegion from="235" to="255" loc="H" subId="17063886" subSource="8et8_A"/>
      <ConstraintRegion from="256" to="262" loc="O" subId="17063887" subSource="8et8_A"/>
      <ConstraintRegion from="263" to="281" loc="H" subId="17063888" subSource="8et8_A"/>
      <ConstraintRegion from="282" to="347" loc="I" subId="17063889" subSource="8et8_A"/>
      <ConstraintRegion from="348" to="368" loc="H" subId="17063890" subSource="8et8_A"/>
      <ConstraintRegion from="369" to="377" loc="O" subId="17063891" subSource="8et8_A"/>
      <ConstraintRegion from="378" to="397" loc="H" subId="17063892" subSource="8et8_A"/>
      <ConstraintRegion from="398" to="402" loc="I" subId="17063893" subSource="8et8_A"/>
      <ConstraintRegion from="403" to="423" loc="H" subId="17063894" subSource="8et8_A"/>
      <ConstraintRegion from="424" to="430" loc="O" subId="17063895" subSource="8et8_A"/>
      <ConstraintRegion from="431" to="454" loc="H" subId="17063896" subSource="8et8_A"/>
      <ConstraintRegion from="455" to="463" loc="I" subId="17063897" subSource="8et8_A"/>
      <ConstraintRegion from="464" to="484" loc="H" subId="17063898" subSource="8et8_A"/>
      <ConstraintRegion from="485" to="493" loc="O" subId="17063899" subSource="8et8_A"/>
      <ConstraintRegion from="494" to="511" loc="H" subId="17063900" subSource="8et8_A"/>
      <ConstraintRegion from="512" to="533" loc="I" subId="17063901" subSource="8et8_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="8et9_A">
      <ConstraintRegion from="3" to="23" loc="I" subId="17063953" subSource="8et9_A"/>
      <ConstraintRegion from="24" to="40" loc="H" subId="17063955" subSource="8et9_A"/>
      <ConstraintRegion from="41" to="151" loc="O" subId="17063957" subSource="8et9_A"/>
      <ConstraintRegion from="152" to="168" loc="H" subId="17063959" subSource="8et9_A"/>
      <ConstraintRegion from="169" to="179" loc="I" subId="17063961" subSource="8et9_A"/>
      <ConstraintRegion from="180" to="197" loc="H" subId="17063962" subSource="8et9_A"/>
      <ConstraintRegion from="198" to="201" loc="O" subId="17063964" subSource="8et9_A"/>
      <ConstraintRegion from="202" to="222" loc="H" subId="17063966" subSource="8et9_A"/>
      <ConstraintRegion from="223" to="236" loc="I" subId="17063968" subSource="8et9_A"/>
      <ConstraintRegion from="237" to="255" loc="H" subId="17063969" subSource="8et9_A"/>
      <ConstraintRegion from="256" to="265" loc="O" subId="17063971" subSource="8et9_A"/>
      <ConstraintRegion from="266" to="280" loc="H" subId="17063973" subSource="8et9_A"/>
      <ConstraintRegion from="281" to="317" loc="I" subId="17063975" subSource="8et9_A"/>
      <ConstraintRegion from="329" to="349" loc="I" subId="17063979" subSource="8et9_A"/>
      <ConstraintRegion from="350" to="367" loc="H" subId="17063981" subSource="8et9_A"/>
      <ConstraintRegion from="368" to="380" loc="O" subId="17063983" subSource="8et9_A"/>
      <ConstraintRegion from="381" to="398" loc="H" subId="17063985" subSource="8et9_A"/>
      <ConstraintRegion from="399" to="403" loc="I" subId="17063987" subSource="8et9_A"/>
      <ConstraintRegion from="404" to="421" loc="H" subId="17063989" subSource="8et9_A"/>
      <ConstraintRegion from="422" to="423" loc="O" subId="17063991" subSource="8et9_A"/>
      <ConstraintRegion from="428" to="434" loc="O" subId="17063995" subSource="8et9_A"/>
      <ConstraintRegion from="435" to="454" loc="H" subId="17063997" subSource="8et9_A"/>
      <ConstraintRegion from="455" to="467" loc="I" subId="17063999" subSource="8et9_A"/>
      <ConstraintRegion from="468" to="485" loc="H" subId="17064001" subSource="8et9_A"/>
      <ConstraintRegion from="486" to="496" loc="O" subId="17064002" subSource="8et9_A"/>
      <ConstraintRegion from="497" to="512" loc="H" subId="17064003" subSource="8et9_A"/>
      <ConstraintRegion from="513" to="534" loc="I" subId="17064004" subSource="8et9_A"/>
    </Constraint>
  </Constraints>
</HtpItem>
