<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A8I5KXV0_HUMAN" transmembrane="yes" evidence="3D">
  <Name>P-type Cu(+) transporter </Name>
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    <PDBTM id="1y3j">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1y3k">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1yju">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1yjv">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3cjk">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5t7l">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="2g9o">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2ga7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1s6o">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1s6u">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1yjr">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1yjt">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1aw0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2aw0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2b8e">
      <Chain id="C"/>
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7lu8">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2rop">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2voy">
      <Chain id="I"/>
      <Chain id="F"/>
    </PDBTM>
    <PDBTM id="2hc8">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2lqb">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4nab">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6a71">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6a72">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2rml">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1p6t">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2yj4">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7nxf">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7ny1">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="E"/>
      <Chain id="F"/>
    </PDBTM>
    <TOPDB id="ATP7A_HUMAN">
      <Alignment>
        <CrossRefSeq>MDPSMGVNSVTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATIIYDPKLQTPKTLQEAIDDMGFDAVIHNPDPLPVLTDTLFLTVTASLTLPWDHIQSTLLKTKGVTDIKIYPQKRTVAVTIIPSIVNANQIKELVPELSLDTGTLEKKSGACEDHSMAQAGEVVLKMKVEGMTCHSCTSTIEGKIGKLQGVQRIKVSLDNQEATIVYQPHLISVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQRSPSYTNDSTATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSDTNEPLVVIAQPSSEMPLLTSTNEFYTKGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENADEGDGVLELVVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVKKDRSASHLDHKREIRQWRRSFLVSLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPGYNRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQISNALNAQQYKVLIGNREWMIRNGLVINNDVNDFMTEHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYESYELPARSQIGQKSPSEISVHVGIDDTSRNSPKLGLLDRIVNYSRASINSLLSDKRSLNSVVTSEPDKHSLLVGDFREDDDTAL</CrossRefSeq>
        <OrigSeq>MDPSMGVNSVTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATIIYDPKLQTPKTLQEAIDDMGFDAVIHNPDPLPVLTDTLFLTVTASLTLPWDHIQSTLLKTKGVTDIKIYPQKRTVAVTIIPSIVNANQIKELVPELSLDTGTLEKKSGACEDHSMAQAGEVVLKMKVEGMTCHSCTSTIEGKIGKLQGVQRIKVSLDNQEATIVYQPHLISVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQRSPSYTNDSTATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSDTNEPLVVIAQPSSEMPLLTSTNEFYTKGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENADEGDGVLELVVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVKKDRSASHLDHKREIRQWRRSFLVSLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYF--------------------PVKVVVFDKTG---------------------------------------------TITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQISNALNAQQYKVLIGNREWMIRNGLVINNDVNDFMTEHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYESYELPARSQIGQKSPSEISVHVGIDDTSRNSPKLGLLDRIVNYSRASINSLLSDKRSLNSVVTSEPDKHSLLVGDFREDDDTAL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ATP7B_HUMAN">
      <Alignment>
        <CrossRefSeq>DYAGSDGNIELTITGMTCASCVHNIESKLTRTNGITYASVALATSKALVKFDPEIIGPRDIIKIIEEIGFHASLAQRNPNAHHLDHKMEIKQW</CrossRefSeq>
        <OrigSeq>DPSMGVNSVTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATIIYDPKLQTPKTLQEAIDDMGFDAVIHNPDPLPVLTDTLFLTVTA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HMA7_ARATH">
      <Alignment>
        <CrossRefSeq>SYHNEANADDILTKIEEGRDVSGLRKIQVGVTGMTCAACSNSVEAALMNVNGVFKASVALLQNRADVVFDPNLVKEEDIKEAIEDAGFEAEILAE-----------EQTQATLVG------------------QFTIGGMTCAACVNSVEGILRDLPGVKRAVVALSTSLGEVEYDPNVINKDDIVNAIEDAGFEGSLVQS--------------------------NQQDKLVLRVDGILNELDAQVLEGILTRLNGVRQFRLDRISGELEVVFDPEVVSSRSLVDGIEEDGFGKFKLRVMSPYERLSSKDTG</CrossRefSeq>
        <OrigSeq>SLDTGTLEKKSGACEDHSMAQAGEVVLKMKVEGMTCHSCTSTIEGKIGKLQGVQRIKVSLDNQEATIVYQPHLISVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQRSPSYTNDSTATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSDTNEPLVVIAQPSSE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ATCS_SYNY3">
      <Alignment>
        <CrossRefSeq>MAQTINLQLEGMRCAACASSIERAIAKVPGVQSCQVNFALEQAVVSYH-GETTPQILTDAVERAGYHARVLKQQVLSSQQTE</CrossRefSeq>
        <OrigSeq>NSSKCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENADEGDGVLE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ATU2_YEAST">
      <Alignment>
        <CrossRefSeq>LSVQGMTCGSCVSTVTKQVEGIEGVESVVVSLVTEECHVIYEPSKTTLETAREMIEDCGFDSNIIMDGNGNADMTEKTVILKVTKAFEDESPLILSSVSERFQFLLDLGVKSIEISDDMHTLTIKYCCNELGIRDLLRHLERTGYKFTVFSNLDNTTQLRLLSKEDE</CrossRefSeq>
        <OrigSeq>ISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATIIYDPKLQTPKTLQEAIDDMGFDAVIHNPDPLPVLTDTLFLTVTASLTLPWDH--IQSTLLKT------KGVTDIKIYPQKRTVAVTIIPSIVNANQIKELVPELSLDTGTLEKKSGACEDHSMAQAGE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="AT1A1_SHEEP">
      <Alignment>
        <CrossRefSeq>VKFCRQLFGGFSMLLWIGAVLCF---LAYGIQAATEEEPQNDNLYL--GVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEK------MSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQDNLPILKRAVAGDASESALLKCIEVCCGSVKEMRERYAKIVE-IPFNSTNKYQLSIHKNANAGEPRHLLVMKGAPERILDRCSSILIHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLMLPDEQFPEGFQFDTDDVNFPVDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDARACVVHGSDLKDMTPEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPQTDKLVNERLISMAYGQIGMIQALGGFFTYFVIMAENGFLPNHLLGIRVTWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAF</CrossRefSeq>
        <OrigSeq>YKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGH-SMVDESLITGEAMPVAKKPG----------STVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVI-------------------------------------------GFLNFEIVETYFPVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYC-KQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMII--DAQISNALNAQQYKVLIGNREWMIRNGL-----VINNDVNDFMTEHERKGRTAVLVAV------------------------DDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITK-----------------------------------------------------VFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIG-TGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNL-----VGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVL----SSLFLKLYRKPT-----YESYELPARSQIGQK-------------------SPSEISVHVGIDDTSRNSPKLGLLDRIVNYSRASINSLLSDKR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="AT1A1_RAT">
      <Alignment>
        <CrossRefSeq>VKFCRQLFGGFSMLLWIGAILCF---LAYGIRSATEEEPPNDDLYL--GVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEK------MSINAEDVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAEEIEHFIHLITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWFALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIEVCCGSVMEMREKYTKIVE-IPFNSTNKYQLSIHKNPNASEPKHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLLLPDEQFPEGFQFDTDEVNFPVDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVNQVNPRDAKACVVHGSDLKDMTSEELDDILRYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIVGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPFHLLGIRETWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAF</CrossRefSeq>
        <OrigSeq>YKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGH-SMVDESLITGEAMPVAKKPG----------STVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVI-------------------------------------------GFLNFEIVETYFPVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYC-KQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMII--DAQISNALNAQQYKVLIGNREWMIRNG-----LVINNDVNDFMTEHERKGRTAVLVAV------------------------DDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITK-----------------------------------------------------VFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIG-TGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNL-----VGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVL----SSLFLKLYRKPT-----YESYELPARSQIGQK-------------------SPSEISVHVGIDDTSRNSPKLGLLDRIVNYSRASINSLLSDKR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="AT1A2_PIG">
      <Alignment>
        <CrossRefSeq>VKFCRQLFGGFSILLWIGAILCF---LAYGIQAAMEDEPSNDNLYL--GVVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVVREGEK------MQINAEEVVVGDLVEVKGGDRVPADLRIISSHGCKVDNSSLTGESEPQTRSPEFTHENPLETRNICFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLEVGRTPIAMEIEHFIQLITGVAVFLGVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGATFDKRSPTWTALSRIAGLCNRAVFKAGQENISVSKRDTAGDASESALLKCIELSCGSVRKMRDRNPKVAE-IPFNSTNKYQLSIHEREDNPQSHVLVMKGAPERILDRCSSILV-QGKEIPLDKEMQDAFQNAYLELGGLGERVLGFCQLNLPSGKFPRGFKFDTDELNFPTEKLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPREAKACVVHGSDLKDMTSEQLDEILKNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGIAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPQTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRSMNDLEDSYGQEWTYEQRKVVEFTCHTAF</CrossRefSeq>
        <OrigSeq>YKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGH-SMVDESLITGEAMPVAKKPG----------STVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIG-------------------------------------------FLNFEIVETYFPVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYC-KQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQISN-ALNAQQYKVLIGNREWMIRNGLVINND------VNDFMTEHERKGRTAVLVA------------------------VDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITK-----------------------------------------------------VFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIG-TGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGI-----PIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSS---------LFLKLYRKPTYESYELPARSQIGQK-------------------SPSEISVHVGIDDTSRNSPKLGLLDRIVNYSRASINSLLSDKR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="COPB_ARCFU">
      <Alignment>
        <CrossRefSeq>KMKHSADHGDHHRMMMEDFKKRFYVSTLLTIPILILSPA------------------------IQTFLGFRVEFAGSL----YILFLLSSAVYFYGGYPFLKGIFDELRRRQPGMMTLIAVAISVAYFYSSAVVF-------GLKGKFFFWELATLIDIMLLGHYIEMRSVLGASRALEELVKIMPSEAHLLKDGE------IVEVKVENLKPGDKVLVKPGEKIPVDGIVVEGESFVNEAMLTGESKPVAKKPGDTVIGGAINGEGSLVVEVEKTGKDTYLNQVIELVRQAQESKSRTQDLANRAALLLTVIALTVGSVTLAIWLAYIADFAFAIER--AVTVMVITCPHALGLAIPLVVAVSTSL----AAKSGLLIRDRQAFER-----AKDLQAVIFDKTGTLTEGRFGVTDIVGFNHSEDELLQIAASLEAR----SEHPIAAAIVEEAEKRGFGLTEVEEFRAIPGKGVEGIVNGRRYMVVSPGYIRELGI----KTDESVEKLKQQGKTVVFILKNGEVSGVIALADRIRPESREAISKLKAIGIKCMMLTGDNRFVAKWVAEELGLDDYFAEVLPHEKAEKVKEVQ-QKYVTAMVGDGVNDAPALAQADVGIAIGAGTDVAVETADIVLVRNDPRDVAAIVELSRKTYSKMKQNLLWATGYNAFAIPLAAGVLYSAGILLSPAVGAILMSLSTVIVAINARLLR</CrossRefSeq>
        <OrigSeq>VKKDRSASHLDHKREIRQWRRSFLVSLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQISNALNAQQYKVLIGNREWMIRNGLVINNDVNDFMTEHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLK</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HMA8_ARATH">
      <Alignment>
        <CrossRefSeq>EISTQSFESTESSIESVKSITSDTPILLDVSGMMCGGCVARVKSVLMSDDRVASAVVNMLTETAAVKFKPEVEVTADTAESLAKRLTESGFEAKRR</CrossRefSeq>
        <OrigSeq>RLKNTPVKSSEGSQQRSPSYTNDSTATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASS----VTPESLRKAIEAVSPGLYRV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="KDPB_ECOBW">
      <Alignment>
        <CrossRefSeq>QLALFEPTLVVQA---LKEAVKKLNPQAQWRNPVMFIVWIGSLLTTCISIAMA-SGAMPGNALFSAAISGWLWITVLFANFAEALAEGRSKAQANSLKG-VKKTAFARKLREPKYGAAADKVPADQLRKGDIVLVEAGDIIPCDGEVIEGGASVDESAITGESAPVIRESGGDFASVTGGTRILSDWLVIECSVNPGETFLDRMIAMVEGAQRRKTPNEIALTILLIALTIVFLLATATLWPFSA--------WGGNAVSVTVLVALLVCLIPTTIGGLLSAIGVAGMSRMLGANVIATSGRAVEAAGD-----VDVLLLDKTGTITLGNRQASEFIPAQGVDEKTLADAAQLASLADETPEGRSIVILAKQRFNLRERDVQSLHATFVPFTAQSRMSGINIDNRM------IRKGSVDAI----RRHVEANGGHFPTDVDQKVDQVARQGATPLVVVEGSRVLGVIALKDIVKGGIKERFAQLRKMGIKTVMITGDNRLTAAAIAAEAGVDDFLAEATPEAKLALIRQYQAEGRLVAMTGDGTNDAPALAQADVAVAMNSGTQAAKEAGNMVDLDSNPTKLIEVVHIGKQMLMT-RGSLTTFSIANDVAKYFAIIPAAFAATYPQLNALNIMCLHSPDSAILSAVIFNALIIVFLIPLALKGVSYKPLTASAMLRRNLWIYGLG</CrossRefSeq>
        <OrigSeq>SFLLCVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPG---STVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIK------------------NASLVQIDASNEQSSTSSSMIIDAQISNALNAQQYKVLIGNREWMIRNGLVINNDVNDFMTEHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVF-----MPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYESYELPARSQIGQKSPSEISVHVG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HMA4_ARATH">
      <Alignment>
        <CrossRefSeq>FDVLGICCTSEVPIIENILKSLDGVKEYSVIVPSRTVIVVHDSLLISPFQIAKALNEARLEANVRVNGETS-----------FKNKWPSPFAVVSGLLLLLSFLKFVYSPLRW--------------------------------------LAVAAVAAGIYPILAKAFASIKRPRIDINILVIITVIATLAMQ-----------------DFMEAAAVVFLF-TISDWLETRASYKATSVMQSLMSLAPQKAIIAETGEEVEVDEVKVDT--------VVAVKAGETIPIDGIVVDGNCEVDEKTLTGEAFPVPKQRDSTVWAGTINLNGYICVKTTSLAGDCVVAKMAKLVEEAQSSKTKSQRLIDKCSQYYTPAIILVSACVAIVPVIMKVHNLKHW-FHLALVVLVSGCPCGLILSTP----VATFCALTKAATSGLLIKSADYLD-----TLSKIKIVAFDKTGTITRGEFIVIDFKS---LSRDINLRSLLYWVSSVESKSSHPMAATIVDYAKSVSVEPRPEEVEDYQNFPGEGIYGKIDGNDIFIGNKKIASRAGCSTVPE----IEVDTKGGKTVGYVYVGERLAGFFNLSDACRSGVSQAMAELKSLGIKTAMLTGDNQAAAMHAQEQLGNVLDVVHGDLLPEDKSRIIQEFKKEG-PTAMVGDGVNDAPALATADIGISMGISGSALATQTGNIILMSNDIRRIPQAVKLARRARRKVVENVCLSIILKAGILALAFAGHPLI------WAAVLVDVGTCLLVIFNSMLLLREKKKIGNKKCYRASTSKLNGRKLEG--------DDDYVVDLEAGLLTKSGNGQCKS--SCCGDKKNQENVVMMKPSSKTSSDHSHPGCCGDKKEEKVKPL</CrossRefSeq>
        <OrigSeq>LVVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVKKDRSASHLDHKREIRQWRRSFLVSLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNE---QSSTSSSMIIDAQISNALNAQQYKVLIGNREWMIRNGLVINNDVNDFMTEHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVG--ITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIG-TGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKP--TYESYELPARSQIGQKSPSEISVHVGIDDTSRNSPKLGLLDRIVNYSRASINSLLSDKRSLNSVV-------TSEPDKHSLLVGDFREDDDTAL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CADA_LISMN">
      <Alignment>
        <CrossRefSeq>YRVDGLSCTNCAAKFERNVKEIEGVTEAIVNFGASKITVTGEASIQQVEQ-AGAFEHLKIIPEKESFTDPEHFTDHQSFIRKNWRLLLSGLFIAV------------------GYASQIMNGEDF---------------------YLTNALFIFAIFIGGYSLFKEGFKNLLKFEFTMETLMTIAIIGAAFIGE------------------WAEGSIVVILFAVSEALERYSMDKARQSIRSLMDIAPKEALVRRSGTDR------MVHVDDIQIGDIMIIKPGQKIAMDGHVVKGYSAVNQAAITGESIPVEKNIDDSVFAGTLNEEGLLEVAVTKRVEDTTISKIIHLVEEAQGERAPAQAFVDTFAKYYTPAIIVIAALIATVPPLLFGGNWETW-VYQGLSVLVVGCPCALVVSTP----VAIVTAIGNAAKNGVLVKGGVYLEEIG-----GLKAIAFDKTGTLTKGVPVVTDYIELTEATNIQHNKNYIIMAALEQLSQHPLASAIIKYGETREMDLTSINVNDFTSITGKGIRGTVDGNTYYVGSPVLFKELLASQFTDSIHRQVSDLQLKGKTAMLFGTNQKLISIVAVADEVRSSSQHVIKRLHELGIEKTIMLTGDNQATAQAIGQQVGVSEIEGELMPQDKLDYIKQLKINFGKVAMVGDGINDAPALAAATVGIAMGGAGTDTAIETADVALMGDDLQKLPFTVKLSRKTLQIIKQNITFSLVIKLIA------LLLVIPGWLTLWIAIMADMGATLLVTLNGLRLMKVK</CrossRefSeq>
        <OrigSeq>LVVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVKKDRSASHLDHKREIRQWRRSFLVSLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNE--QSSTSSSMIIDAQISNALNAQQYKVLIGNREWMIR-NGLVINNDVNDFMTEHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGL-EVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAI-GTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ATZN_SYNY3">
      <Alignment>
        <CrossRefSeq>TQSSPLKTQQMQVGGMDCTSCKLKIEGSLERLKGVAEASVTVATGRLTVTYDPKQVSEITIQERIAALGY</CrossRefSeq>
        <OrigSeq>EEGKNSSKCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="AT2A2_MOUSE">
      <Alignment>
        <CrossRefSeq>WGSNELPAEEGKTLLELVIEQFEDLLVRILLLAA----CISFVLAWFEEGEETITAFVEPFVILLILVA-NAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRK----SVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFSITGSTYAPIGEVQKDDKPVKCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTPGVKQKIMSVIREWGSGSDTLRCLALATHDNPLKREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELSPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFN--------PPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADG-GPRVSFYQLSHFLQCKEDNPDFDGV</CrossRefSeq>
        <OrigSeq>FGGWYFYIQAYKALKHKTAN--MDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSM---VDESLITGEAMPVAKKPG-------------STVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIG-----------------------------------------------------FLNFEIVETYFPVKVVVFDKTGTITHGTPVVNQVKVLT---------------ESNRISHHKIL---------AIVGTAESNSEHPLGT-AITKYCKQELDTETLGTCIDFQVVP-GCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQI-------SNALNAQQYKVLIGNREW-MIRNGLVINNDVNDFMTEH------ERKGRTAVLVAV-----------------------DDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGI-------------------------------TKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYN---LVGIPIAAGVFMPIGLVLQ--PWMGSAAMAASSVSVVLSSLFLKLYRKPTYESYELPARSQIGQKSPSEISVHVGIDDTSRNSPK-----------LGLLDRIVNYSRASINSLLSDKRSLNSV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ATC1_YEAST">
      <Alignment>
        <CrossRefSeq>KFLSNFIEDR---MILLLIGSAVVSLFM--------------GNIDDAVSITLAIFIVVTVGFVQEYRSEKSLEALNKLVPAECHLMRCGQESH------VLASTLVPGDLVHFRIGDRIPADIRIIEAIDLSIDESNLTGENEPVHKTSQTIEKSSFNDQPNSIVPISERSCIAYMGTLVKEGHGKGIVVGTGTNTSFGAVFEMMNNIEKPKTPLQLTMDKLGKDLSLVSFIVIGMICLVGIIQGRSWLEMFQISVSLAVAAIPEGLPIIVTVTLALGVLRMAKRKAIVRRLPSVETLGSVNVICSDKTGTLTSNHMTVSKLWCLDSMS----NKLNVLSLDKNKKTKNSNGNLKNYLTEDVRETLTIGNLCNNASFSQEHAIFLGNPTDVALLE---QLANFEMPDIRNTVQKVQELPFNSKRKLMATKILNPVDNKCTVYVKGAFERILEYSTSYLKSKGKKTEKLTEAQKATINECANSMASEGLRVFGFAKLTLSDSSTPLTEDLIKDLTFTGLIGMNDPPRPNVKFAIEQLLQGGVHIIMITGDSENTAVNIAKQIGIPVIDPKLSVLSGDKLDEMSDDQLANVIDHVNIFARATPEHKLNIVRALRKRGDVVAMTGDGVNDAPALKLSDIGVSMGRIGTDVAKEASDMVLTDDDFSTILTAIEEGKGIFNNIQNFLTFQLSTSVAALSLVALSTAFKLPNPLNAMQILWINILMDGPPAQSLGVEPVDHEVMKKPPRKRTDKILTHDVMKRLLTTAACIIVGTVYIFVKEMAEDGK----VTARDTTMTFTCFVFFDMFNALACRHNTKSI</CrossRefSeq>
        <OrigSeq>KALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEG-HSMVDESLITGEAMPVAKKP---------------------GSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIG-------------------------------------------FLNFEIVETYFPVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTC-------IDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQISNALNAQQYKVLIGNREWMIRNG-------LVINNDVNDFMTEHERKGRTAVLVAV----------------DDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGI-----------------------------TKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGT-GTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAG-----VFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYESYELP-ARSQIGQKSPSEISVHVGIDDTSRNSP-KLGLLDRIVNYSRASINSLLSDKRSLNSVVTSEPDKHSL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="Q42932_NICPL">
      <Alignment>
        <CrossRefSeq>FMWNPLSWVMEAAAIMAIALANGGGKPPDW-QDFVGIITLLVINSTISFIEENNAGNAAAALMARLAPKAKVLRDGK------WDEQDAAILVPGDIISIKLGDIIPADARLLEGDPLKIDQSALTGESLPVTKGPGDGVYSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTN-QVGHFQKVLTAIGNFCICSIAVGMIIEIIVMYPIQHRKYRP-----GIDNLLVLLIGGIPIAMPTVLSVTMAIGSHRLAQQGAITKRMTAIE-----EMAGMDVLCSDKTGTLTLNKLTVDKNLVEVFAKGVDADTVVLMAARASRTENQDAIDTAIVGMLSDPKEARAGIREIHFLPFNPTDKRTALTYLDGEGKMHRVSKGAPEQILNLAHNKSDIERRVHSVIDKFAERGLRSLGVAYQEVPEGRKESTGGPWQFIGLLPLFDPPRHDSAETIRRALNLGVNVKMITGDQLAIGKETGRRLGMGTNMYPSSALLGQTKDESIASLPIDELIEKADGFAGVFPEHKYEIVKRLQARKHICGMTGDGVNDAPALKKADIGIAVDDATDAARSASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSI-TIRIVLGFMLLALIWKFDFPPFMVL------IIAILNDGTIMTISKDRVKPSPLPDSWKLAEIFTTGVVLG</CrossRefSeq>
        <OrigSeq>VLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSM-VDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQISNALN----------AQQYKVLIGNREWMI---RNGLVINNDVNDFMTEHERKGRTAVLVAVDD-------------ELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGI------------------------------TKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYESYELPARSQIGQKSPSEISVH</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ACA2_ARATH">
      <Alignment>
        <CrossRefSeq>LKASPTDGLSTEAAQLSQRQELFGINKFAESEMRGFWVFVWEALQDM--------TLMILG--VCAFVSLIVGIATEGWPKGSHDGLGIAASILLVVFVT------ATSDYRQSLQFRDLDKEKKKITVQVTRNGFR-----QKLSIYDLLPGDIVHLAIGDQVPADGLFLSGFSVVIDESSLTGESEPVMVNAQNPFLMSGTKVQDGSCKMMITTVGMRTQWGKLMATLTEGGDDETPLQVKLNGVATIIGKIGLFFAVVTFAVLVQGMFMRKLSTGTHWVWSGDEALELLEYFAIAVTIVVVAVPEGLPLAVTLSLAFAMKKMMNDKALVRHLAACETMGSATTICSDKTGTLTTNHMTVVKSCICMNVQDVANKGS-SLQSEIPESAVKLLIQSI----FNNTGGEVVVNKHGKTELLGTPTETAILEL-GLSLGGKFQEERKSYKVIKVEPFNSTKKRMGVVIELPEGGRMRAHTKGASEIVLAACDKVVNSSGEVVPLDEESIKYLNVTINEFANEALRTLCLAYMDIEGGFSPDDAIPASGFTCVGIVGIKDPVRPGVKESVELCRRAGITVRMVTGDNINTAKAIARECGILTDDGIAIEGPVFREKNQEELLELIPKIQVMARSSPMDKHTLVKQLRTTFDEVVAVTGDGTNDAPALHEADIGLAMGIAGTEVAKESADVIILDDNFSTIVTVAKWGRSVYINIQKFVQFQLTVNVVALVVNFSSACLTGSAPLTAVQLLWVNMIMDTLGALALATE--------PPNDELMKRLPVGRRGNFITNAMWRNI</CrossRefSeq>
        <OrigSeq>INLHSSMFLERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMV-DESLITGEAMPVAKKP-GSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFAD-------KLSGYFVPFIVFVSI------------------------------------------ATLLVWIVIG------------FLNFEIVETYFPVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQISNALNAQQYKVLIGNREWMIRNGLVINNDVNDF------MTEHERKGRTAVLVAVDD----------------ELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGI---------------------------TKVFAEVLPSHKVAKVKQLQEE-GKRVAMVGDGINDSPALAMANVGIAIG-TGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVF-----MPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYESYELPARSQIGQKSPSEISVHV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="PMA2_YEAST">
      <Alignment>
        <CrossRefSeq>LNQMAEENESLI--VKFLMFFVGPIQFVMEAAAILAAGLSDWVDVGV-ICALLLLNASVGFIQEFQAGSIVDELKKTLANTATVIRDG------QLIEIPANEVVPGEILQLESGTIAPADGRIVTEDCFLQIDQSAITGESLAAEKHYGDEVFSSSTVKTGEAFMVVTATGDNTFVGRAAALVGQASGVEGHFTEVLNGIGIILLVLVI---ATLLLVWTACFYRTVGIVSILRYTLGITII---GVPVGLPAVVTTTMAVGAAYLAKKQAIVQKLSAIES-----LAGVEILCSDKTGTLTKNKLSLHEPYTVEGVSPDDLMLTACLAASRKKKGLDAIDKAFLKSLIEYPKAKDALTKYKVLEFHPFDPVSKKVTAVVESPEGERIVCVKGAPLFVLKTVEEDHPIPEDVHENYENKVAELASRGFRALGVARKRGEGHWEILGVMPCMDPPRDDTAQTINEARNLGLRIKMLTGDAVGIAKETCRQLGLGTNIYNAERLGLGGGGDMPGSELADFVENADGFAEVFPQHKYRVVEILQNRGYLVAMTGDGVNDAPSLKKADTGIAVEGATDAARSAADIVFLAPGLSAIIDALKTSRQIFHRMYSYVVYRIALSLHLEIFLGLWIAILNNSLDINLIVFIAIFADVATLTIAYDNA--------PY---APEPVKWNLPRLWGMSIILGIVLAIGSWITL</CrossRefSeq>
        <OrigSeq>LKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSM--VDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSS------MIIDAQ------ISNALNAQQYKVLIGNREWMIR-------NGLVINNDVNDFMTEHERKGRTAVLVAVD-----DELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGI-----------------------------TKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNL-VGIPIAAGVFM---PIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYESYELPARSQIGQKSPSEISVHVGIDDTSRNSP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="Q97UU7_SACS2">
      <Alignment>
        <CrossRefSeq>SQEQNNITKFYVGGMACAFCASTIEKGLKKIEGVNEVKVVLESSEVFVKYDNSLVSSEIIKKEIEKLGY</CrossRefSeq>
        <OrigSeq>PLPVLTDTLFLTVTASLTLPWDHIQSTLLKTKGVTDIKIYPQKRTVAVTIIPSIVNANQIKELVPELSL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ZNTA_ECOLI">
      <Alignment>
        <CrossRefSeq>KVSGMDCAACARKVENAVRQLAGVNQVQVLFATEKLVVDAD------NDIRAQVESALQKAGYSLRDEQAAEEPQASRLKEN-----LPLITLIVMMAISWGLEQFNHPFGQ-------------------------------------LAFIATTLVGLYPIARQALRLIKSGSYFAIETLMSVAAIGALFIGATA------------------EAAMVLLLFLIGERLEGWAASRARQGVSALMALKPETATRLRKGE------REEVAINSLRPGDVIEVAAGGRLPADGKLLSPFASFDESALTGESIPVERATGDKVPAGATSVDRLVTLEVLSEPGASAIDRILKLIEEAEERRAPIERFIDRFSRIYTPAIMAVALLVTLVPPLLFAASWQEWIYKGLTLLLIGCPCALVISTPAAITSGLAAAARRGALIKGGAALEQLGRVTQVAFDKTGTLTVGKPRVTAIH---PATGISESELLTLAAAVEQGATHPLAQAIVREAQ--VAELAIPTAESQRALVGSGIEAQVNGERVLICAAGKHPADAFTGLINELESAGQTVVLVVRNDDVLG---------------------VIALQDTLRADAATAISELNALG-------------------------------------VKGVILTGDNPRAAAAIAGELGL-EFKAGLLPEDKVKAVTELN-QHAPLAMVGDGINDAPAMKAAAIGIAMGSGTDVALETADAALTHNHLRGLVQMIELARATHANIRQNITIALGLK--GIFLVTTLLGMTGL----WLAVLADTGATVLVTANALRLLRRR</CrossRefSeq>
        <OrigSeq>VVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVKKDRSASHLDHKREIRQWRRSFLVSLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHK-TANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVS-----------IATLLVWIVIGF---------------------------------LNFEIVETYFPVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQISNALNAQQYKVLIGNREWMIRNGLVINNDVNDFMTEHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="PMA1_NEUCR">
      <Alignment>
        <CrossRefSeq>IQFVMEGAAVLAAGLEDWVDFGVICGLLLLNAVVG----FVQEFQAGSIVDELKKTLALKAVVLRDG------TLKEIEAPEVVPGDILQVEEGTIIPADGRIVTDDAFLQVDQSALTGESLAVDKHKGDQVFASSAVKRGEAFVVITATGDNTFVGRAAALVNAASGGSG---HFTEVLNGIGTILLILVIFTLLIVWVSSFYRSNPIVQILEFTLAITII---GVPVGLPAVVTTTMAVGAAYLAKKKAIVQKLSAIES-----LAGVEILCSDKTGTLTKNKLSLHDPYTVAGVDPEDLMLTACLAASRKKKGIDAIDKAFLKSLKYYPRAKSVLSKYKVLQFHPFDPVSKKVVAVVESPQGERITCVKGAPLFVLKTVEEDHPIPEEVDQAYKNKVAEFATRGFRSLGVARKRGEGSWEILGIMPCMDPPRHDTYKTVCEAKTLGLSIKMLTGDAVGIARETSRQLGLGTNIYNAERLGLGGGGDMPGSEVYDFVEAADGFAEVFPQHKYNVVEILQQRGYLVAMTGDGVNDAPSLKKADTGIAVEGSSDAARSAADIVFLAPGLGAIIDALKTSRQIFHRMYAYVVYRIALSIHLEIFLGLWIAILNRSLNIELVVFIAIFADVATLAIAYDNA</CrossRefSeq>
        <OrigSeq>YSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVI--EGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSS------MIIDAQ------ISNALNAQQYKVLIGNREWMI---RNGLVINNDVNDFMT----EHERKGRTAVLVAVDD-----ELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGI-----------------------------TKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNL-VGIPIAAGVFMP---IGLVLQPWMGSAAMAASSVSVVLSS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HMCT_HELPY">
      <Alignment>
        <CrossRefSeq>MQEYHIHNLDCPDCASKLERDLNELDYVKKAQINFSTSKLFLDTSD---------------------FEKVKAFIKQNEPHLSLSFKEATEKPLSFTPLIITIMVFL----------------GAILILHLNPSPLIEKAM-----------FFVLALVYLVSGKDVILGAFRGLRKGQFFDENALMLIATIAAFFVGAY------------------EESVSIMVFYSAGEFLQKLAVSRSKKSLKALVDVAPNLAYLKKGDELV------SVAPEDLRVNDIVVVKVGEKVPVDGVVVKGESLLDERALSGESMPVNVSENSKVLGGSLNLKAVLEIQVEKMYKDSSIAKVVDLVQQATNEKSETEKFITKFSRYYTPSVLFIALMIAVLPPLFSMGSFDEWIYRGLVALMVSCPCALVISVPLGYFGGVGAASRKGILMKGVHVLEVLTQAKSIAFDKTGTLTKGVFKVTDI---VPQNGHSKEEVLHYASCSQLLSTHPIALSIQKACEEMLKDDKHQHDIKNYEEVSGMGVKAQCHT--DLIIAGNEKMLDQFHIAHSPSKENGTIVHVAFNQTYVGYIVISDEIKDDAIECLRDLKVQGIENFCILSGDRKSATESIA-------------QTLGCEYHASLLPEEKTSVFKTFKERYKAPAIFVGDGINDAPTLAS---------------------------------------------ADVGIGMGKGSELSKQSADIVITNDSLNSLVKVLAIAKKTKSIIWQNILFALGIKAVFI------VLGLMGVASLWEAVFGDVGVTLLALANSMR</CrossRefSeq>
        <OrigSeq>VLELVVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIESLGFEASLVKKDRSASHLDHKREIRQWRRSFLVSLFFCIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALKHKTA-NMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLV-----------WIVIGFLNF---------------------------------EIVETYFPVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLG-TCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNASLVQIDASNEQSSTSSSMIIDAQISNALNAQQYKVLIGNREWMIRNGLVINNDVNDFMTEHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ATMA_ECO57">
      <Alignment>
        <CrossRefSeq>AAGVIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRVINDKGENGWLEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKAATTRQPEHSNPLECDTLCFMGTTVVSGTAQAMVIATGANTWFGQLAGRVSEQESEPNAFQQGISRVSMLLIRFMLVMAPVVLLIN---GYTKGDWWEAALFALSVA---VGLTPEMLPMIVTSTLARGAVKLSKQKVIVKHLDAIQNFGAMDILCTDKTGTLTQDKIVLENHTDISGKTSERVLHSAWLNSHYQTGLKNLLDTAVLEGTDEESARSLASRWQKIDEIPFDFERRRMSVVVAENTEHHQLVCKGALQEILNVCSQVRHNGEIVPLDDIMLRKIKRVTDTLNRQGLRVVAVATKYLPAREGDYQRADESDLILEGYIAFLDPPKETTAPALKALKASGITVKILTGDSELVAAKVCHEVGLDAGEVVIGSDIETLSDDELANLAQRTTLFARLTPMHKERIVTLLKREGHVVGFMGDGINDAPALRAADIGISVDGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYIKMTASSNFGNVFSVLVASAFLPFLPMLP</CrossRefSeq>
        <OrigSeq>TPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIEGHSM-VDESLITGEAMPVAK-------------KPGSTVIAGSINQNGSLLICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFPVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGI-------SCKVTNIEGLLHKNNWNIEDNNIKNA------SLVQIDASNEQSSTSSSMIIDAQISNALNAQQYKVLIGNREWMIRNGLVINND------VNDFMTEHERKGRTAVLVAV----------------DDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGIT-------------------------KVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYN--LVGIPIAAGVFMPIGLVLQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ATN2_YEAST">
      <Alignment>
        <CrossRefSeq>FLGLIGIYDPPRNETAGAVKKFHQAGINVHMLTGDFVGTAKAIAQEVGILPTNLYHYSQEIVDSMVMTGSQFDGLSEEEVDDLPVLPLVIARCSPQTKVRMIEALHRRKKFCAMTGDGVNDSPSLKMANVGIAMGINGSDVSKEASDIVLSDDNFASILNAVEEGRRMTDNIQ-----KFVLQLLAENVAQALYLIIGLVFRDENGKSVFPLSPVEVL</CrossRefSeq>
        <OrigSeq>LCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITK-------------------------------------VFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIG-TGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ATN5_YEAST">
      <Alignment>
        <CrossRefSeq>FLGLIGIYDPPRNETAGAVKKFHQAGINVHMLTGDFVGTAKAIAQEVGILPTNLYHYSQEIVDSMVMTGSQFDGLSEEEVDDLPVLPLVIARCSPQTKVRMIEALHRRKKFCAMTGDGVNDSPSLKMANVGIAMGINGSDVSKEASDIVLSDDNFASILNAVEEGRRMTDNIQ-----KFVLQLLAENVAQALYLIIGLVFRDENGKSVFPLSPVEVL</CrossRefSeq>
        <OrigSeq>LCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITK-------------------------------------VFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIG-TGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ATN1_YEAST">
      <Alignment>
        <CrossRefSeq>FLGLIGIYDPPRNETAGAVKKFHQAGINVHMLTGDFVGTAKAIAQEVGILPTNLYHYSQEIVDSMVMTGSQFDGLSEEEVDDLPVLPLVIARCSPQTKVRMIEALHRRKKFCTMTGDGVNDSPSLKMANVGIAMGINGSDVSKEASDIVLSDDNFASILNAVEEGRRMTDNIQ-----KFVLQLLAENVAQALYLIIGLVFRDENGKSVFPLSPVEVL</CrossRefSeq>
        <OrigSeq>LCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGITK-------------------------------------VFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIG-TGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="AT2B4_HUMAN">
      <Alignment>
        <CrossRefSeq>AVVGIEDPVRPEVPDAIAKCKQAGITVRMVTGDNINTARAIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTLVKGIIDSTVGEHRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA</CrossRefSeq>
        <OrigSeq>GLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGIT-------------------------------------KVFAEVLPSHKVAKVKQL-----QEEGKRVAMVGDGINDSPALAMANVGIAIG-TGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ACA8_ARATH">
      <Alignment>
        <CrossRefSeq>LLAIVGIKDPCRPGVKDSVVLCQNAGVKVRMVTGDNVQTARAIALECGILSSDADLSEPTLIEGKSFREMTDAERDKISDKISVMGRSSPNDKLLLVQSLRRQGHVVAVTGDGTNDAPALHEADIGLAMGIAGTEVAKESSDIIILDDNFASVVKVVRWGRSVYANIQKFIQFQLTVNVAALVINVVAAISSGDVPLTAVQLLWVNLIMDT-LGALALA</CrossRefSeq>
        <OrigSeq>LCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGI--------------TKVFAEVL------------------PSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIG-TGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIR--INF-----VFALIYNLVG------IPIAAGVFMPIGLVLQPWMGSAAMA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="AT2B2_HUMAN">
      <Alignment>
        <CrossRefSeq>VVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA</CrossRefSeq>
        <OrigSeq>LIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGIT-------------------------------------KVFAEVLPSHKVAKVKQL-----QEEGKRVAMVGDGINDSPALAMANVGIAIG-TGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="AT2B1_HUMAN">
      <Alignment>
        <CrossRefSeq>VVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA</CrossRefSeq>
        <OrigSeq>LIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTARSIASQVGIT-------------------------------------KVFAEVLPSHKVAKVKQL-----QEEGKRVAMVGDGINDSPALAMANVGIAIG-TGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIA</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="1435" CheckSum="3e8f5072db5269f2a89a035a92f29ab9">
    <Seq>
      MDPSMGVNSV TISVEGMTCN SCVWTIEQQI GKVNGVHHIK VSLEEKNATI
      IYDPKLQTPK TLQEAIDDMG FDAVIHNPDP LPVLTDTLFL TVTASLTLPW
      DHIQSTLLKT KGVTDIKIYP QKRTVAVTII PSIVNANQIK ELVPELSLDT
      GTLEKKSGAC EDHSMAQAGE VVLKMKVEGM TCHSCTSTIE GKIGKLQGVQ
      RIKVSLDNQE ATIVYQPHLI SVEEMKKQIE AMGFPAFVKK QPKYLKLGAI
      DVERLKNTPV KSSEGSQQRS PSYTNDSTAT FIIDGMHCKS CVSNIESTLS
      ALQYVSSIVV SLENRSAIVK YNASSVTPES LRKAIEAVSP GLYRVSITSE
      VESTSNSPSS SSLQKIPLNV VSQPLTQETV INIDGMTCNS CVQSIEGVIS
      KKPGVKSIRV SLANSNGTVE YDPLLTSPET LRGAIEDMGF DATLSDTNEP
      LVVIAQPSSE MPLLTSTNEF YTKGMTPVQD KEEGKNSSKC YIQVTGMTCA
      SCVANIERNL RREEGIYSIL VALMAGKAEV RYNPAVIQPP MIAEFIRELG
      FGATVIENAD EGDGVLELVV RGMTCASCVH KIESSLTKHR GILYCSVALA
      TNKAHIKYDP EIIGPRDIIH TIESLGFEAS LVKKDRSASH LDHKREIRQW
      RRSFLVSLFF CIPVMGLMIY MMVMDHHFAT LHHNQNMSKE EMINLHSSMF
      LERQILPGLS VMNLLSFLLC VPVQFFGGWY FYIQAYKALK HKTANMDVLI
      VLATTIAFAY SLIILLVAMY ERAKVNPITF FDTPPMLFVF IALGRWLEHI
      AKGKTSEALA KLISLQATEA TIVTLDSDNI LLSEEQVDVE LVQRGDIIKV
      VPGGKFPVDG RVIEGHSMVD ESLITGEAMP VAKKPGSTVI AGSINQNGSL
      LICATHVGAD TTLSQIVKLV EEAQTSKAPI QQFADKLSGY FVPFIVFVSI
      ATLLVWIVIG FLNFEIVETY FPVKVVVFDK TGTITHGTPV VNQVKVLTES
      NRISHHKILA IVGTAESNSE HPLGTAITKY CKQELDTETL GTCIDFQVVP
      GCGISCKVTN IEGLLHKNNW NIEDNNIKNA SLVQIDASNE QSSTSSSMII
      DAQISNALNA QQYKVLIGNR EWMIRNGLVI NNDVNDFMTE HERKGRTAVL
      VAVDDELCGL IAIADTVKPE AELAIHILKS MGLEVVLMTG DNSKTARSIA
      SQVGITKVFA EVLPSHKVAK VKQLQEEGKR VAMVGDGIND SPALAMANVG
      IAIGTGTDVA IEAADVVLIR NDLLDVVASI DLSRKTVKRI RINFVFALIY
      NLVGIPIAAG VFMPIGLVLQ PWMGSAAMAA SSVSVVLSSL FLKLYRKPTY
      ESYELPARSQ IGQKSPSEIS VHVGIDDTSR NSPKLGLLDR IVNYSRASIN
      SLLSDKRSLN SVVTSEPDKH SLLVGDFRED DDTAL
    </Seq>
  </Sequence>
  <Topology numTm="8" reliability="95.06">
    <Region from="1" to="652" loc="I"/>
    <Region from="653" to="674" loc="M"/>
    <Region from="675" to="704" loc="O"/>
    <Region from="705" to="728" loc="M"/>
    <Region from="729" to="747" loc="I"/>
    <Region from="748" to="767" loc="M"/>
    <Region from="768" to="776" loc="O"/>
    <Region from="777" to="794" loc="M"/>
    <Region from="795" to="938" loc="I"/>
    <Region from="939" to="960" loc="M"/>
    <Region from="961" to="970" loc="O"/>
    <Region from="971" to="982" loc="M"/>
    <Region from="983" to="1291" loc="I"/>
    <Region from="1292" to="1313" loc="M"/>
    <Region from="1314" to="1322" loc="O"/>
    <Region from="1323" to="1341" loc="M"/>
    <Region from="1342" to="1435" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="653" loc="I"/>
      <Region from="654" to="674" loc="M"/>
      <Region from="675" to="704" loc="O"/>
      <Region from="705" to="731" loc="M"/>
      <Region from="732" to="747" loc="I"/>
      <Region from="748" to="769" loc="M"/>
      <Region from="770" to="776" loc="O"/>
      <Region from="777" to="794" loc="M"/>
      <Region from="795" to="1291" loc="I"/>
      <Region from="1292" to="1319" loc="M"/>
      <Region from="1320" to="1324" loc="O"/>
      <Region from="1325" to="1342" loc="M"/>
      <Region from="1343" to="1435" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="652" loc="I"/>
      <Region from="653" to="675" loc="M"/>
      <Region from="676" to="709" loc="O"/>
      <Region from="710" to="732" loc="M"/>
      <Region from="733" to="744" loc="I"/>
      <Region from="745" to="767" loc="M"/>
      <Region from="768" to="779" loc="O"/>
      <Region from="780" to="798" loc="M"/>
      <Region from="799" to="940" loc="I"/>
      <Region from="941" to="967" loc="M"/>
      <Region from="968" to="972" loc="O"/>
      <Region from="973" to="990" loc="M"/>
      <Region from="991" to="1292" loc="I"/>
      <Region from="1293" to="1318" loc="M"/>
      <Region from="1319" to="1321" loc="O"/>
      <Region from="1322" to="1339" loc="M"/>
      <Region from="1340" to="1435" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="654" loc="I"/>
      <Region from="655" to="675" loc="M"/>
      <Region from="676" to="700" loc="O"/>
      <Region from="701" to="731" loc="M"/>
      <Region from="732" to="744" loc="I"/>
      <Region from="745" to="765" loc="M"/>
      <Region from="766" to="777" loc="O"/>
      <Region from="778" to="798" loc="M"/>
      <Region from="799" to="937" loc="I"/>
      <Region from="938" to="952" loc="M"/>
      <Region from="953" to="953" loc="O"/>
      <Region from="954" to="968" loc="M"/>
      <Region from="969" to="1295" loc="I"/>
      <Region from="1296" to="1316" loc="M"/>
      <Region from="1317" to="1318" loc="O"/>
      <Region from="1319" to="1339" loc="M"/>
      <Region from="1340" to="1435" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="653" loc="I"/>
      <Region from="654" to="674" loc="M"/>
      <Region from="675" to="708" loc="O"/>
      <Region from="709" to="733" loc="M"/>
      <Region from="734" to="747" loc="I"/>
      <Region from="748" to="770" loc="M"/>
      <Region from="771" to="777" loc="O"/>
      <Region from="778" to="797" loc="M"/>
      <Region from="798" to="888" loc="I"/>
      <Region from="889" to="909" loc="M"/>
      <Region from="910" to="939" loc="O"/>
      <Region from="940" to="962" loc="M"/>
      <Region from="963" to="1291" loc="I"/>
      <Region from="1292" to="1315" loc="M"/>
      <Region from="1316" to="1321" loc="O"/>
      <Region from="1322" to="1342" loc="M"/>
      <Region from="1343" to="1435" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="653" loc="I"/>
      <Region from="654" to="673" loc="M"/>
      <Region from="674" to="704" loc="O"/>
      <Region from="705" to="732" loc="M"/>
      <Region from="733" to="743" loc="I"/>
      <Region from="744" to="770" loc="M"/>
      <Region from="771" to="939" loc="O"/>
      <Region from="940" to="964" loc="M"/>
      <Region from="965" to="1293" loc="I"/>
      <Region from="1294" to="1316" loc="M"/>
      <Region from="1317" to="1321" loc="O"/>
      <Region from="1322" to="1342" loc="M"/>
      <Region from="1343" to="1435" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="653" loc="I"/>
      <Region from="654" to="674" loc="M"/>
      <Region from="675" to="708" loc="O"/>
      <Region from="709" to="729" loc="M"/>
      <Region from="730" to="749" loc="I"/>
      <Region from="750" to="770" loc="M"/>
      <Region from="771" to="940" loc="O"/>
      <Region from="941" to="961" loc="M"/>
      <Region from="962" to="1296" loc="I"/>
      <Region from="1297" to="1317" loc="M"/>
      <Region from="1318" to="1321" loc="O"/>
      <Region from="1322" to="1342" loc="M"/>
      <Region from="1343" to="1435" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="653" loc="I"/>
      <Region from="654" to="674" loc="M"/>
      <Region from="675" to="706" loc="O"/>
      <Region from="707" to="727" loc="M"/>
      <Region from="728" to="747" loc="I"/>
      <Region from="748" to="768" loc="M"/>
      <Region from="769" to="776" loc="O"/>
      <Region from="777" to="797" loc="M"/>
      <Region from="798" to="940" loc="I"/>
      <Region from="941" to="961" loc="M"/>
      <Region from="962" to="969" loc="O"/>
      <Region from="970" to="990" loc="M"/>
      <Region from="991" to="1292" loc="I"/>
      <Region from="1293" to="1313" loc="M"/>
      <Region from="1314" to="1321" loc="O"/>
      <Region from="1322" to="1342" loc="M"/>
      <Region from="1343" to="1435" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="653" loc="I"/>
      <Region from="654" to="674" loc="M"/>
      <Region from="675" to="712" loc="O"/>
      <Region from="713" to="732" loc="M"/>
      <Region from="733" to="748" loc="I"/>
      <Region from="749" to="768" loc="M"/>
      <Region from="769" to="777" loc="O"/>
      <Region from="778" to="797" loc="M"/>
      <Region from="798" to="938" loc="I"/>
      <Region from="939" to="958" loc="M"/>
      <Region from="959" to="1240" loc="O"/>
      <Region from="1241" to="1260" loc="M"/>
      <Region from="1261" to="1293" loc="I"/>
      <Region from="1294" to="1313" loc="M"/>
      <Region from="1314" to="1325" loc="O"/>
      <Region from="1326" to="1346" loc="M"/>
      <Region from="1347" to="1435" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="653" loc="I"/>
      <Region from="654" to="674" loc="M"/>
      <Region from="675" to="705" loc="O"/>
      <Region from="706" to="726" loc="M"/>
      <Region from="727" to="749" loc="I"/>
      <Region from="750" to="770" loc="M"/>
      <Region from="771" to="777" loc="O"/>
      <Region from="778" to="798" loc="M"/>
      <Region from="799" to="936" loc="I"/>
      <Region from="937" to="957" loc="M"/>
      <Region from="958" to="1146" loc="O"/>
      <Region from="1147" to="1167" loc="M"/>
      <Region from="1168" to="1293" loc="I"/>
      <Region from="1294" to="1314" loc="M"/>
      <Region from="1315" to="1321" loc="O"/>
      <Region from="1322" to="1342" loc="M"/>
      <Region from="1343" to="1435" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="653" loc="I"/>
      <Region from="654" to="673" loc="M"/>
      <Region from="674" to="704" loc="O"/>
      <Region from="705" to="727" loc="M"/>
      <Region from="728" to="747" loc="I"/>
      <Region from="748" to="770" loc="M"/>
      <Region from="771" to="939" loc="O"/>
      <Region from="940" to="962" loc="M"/>
      <Region from="963" to="1293" loc="I"/>
      <Region from="1294" to="1316" loc="M"/>
      <Region from="1317" to="1319" loc="O"/>
      <Region from="1320" to="1342" loc="M"/>
      <Region from="1343" to="1435" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="PMA1_NEUCR">
      <ConstraintRegion from="1" to="112" loc="I" subId="17188472" subSource="1mhs_A"/>
      <ConstraintRegion from="113" to="134" loc="H" subId="17188475" subSource="1mhs_A"/>
      <ConstraintRegion from="135" to="143" loc="O" subId="17188478" subSource="1mhs_A"/>
      <ConstraintRegion from="144" to="164" loc="H" subId="17188481" subSource="1mhs_A"/>
      <ConstraintRegion from="165" to="293" loc="I" subId="17188483" subSource="1mhs_A"/>
      <ConstraintRegion from="294" to="313" loc="H" subId="17188485" subSource="1mhs_A"/>
      <ConstraintRegion from="314" to="319" loc="O" subId="17188488" subSource="1mhs_A"/>
      <ConstraintRegion from="320" to="341" loc="H" subId="17188491" subSource="1mhs_A"/>
      <ConstraintRegion from="342" to="689" loc="I" subId="17188494" subSource="1mhs_A"/>
      <ConstraintRegion from="690" to="713" loc="H" subId="17188497" subSource="1mhs_A"/>
      <ConstraintRegion from="714" to="716" loc="O" subId="17188500" subSource="1mhs_A"/>
      <ConstraintRegion from="717" to="737" loc="H" subId="17188504" subSource="1mhs_A"/>
      <ConstraintRegion from="738" to="759" loc="I" subId="17188507" subSource="1mhs_A"/>
      <ConstraintRegion from="760" to="783" loc="H" subId="17188510" subSource="1mhs_A"/>
      <ConstraintRegion from="784" to="794" loc="O" subId="17188513" subSource="1mhs_A"/>
      <ConstraintRegion from="795" to="813" loc="H" subId="17188516" subSource="1mhs_A"/>
      <ConstraintRegion from="814" to="826" loc="I" subId="17188519" subSource="1mhs_A"/>
      <ConstraintRegion from="827" to="843" loc="H" subId="17188522" subSource="1mhs_A"/>
      <ConstraintRegion from="844" to="853" loc="O" subId="17188525" subSource="1mhs_A"/>
      <ConstraintRegion from="854" to="875" loc="H" subId="17188528" subSource="1mhs_A"/>
      <ConstraintRegion from="876" to="920" loc="I" subId="17188531" subSource="1mhs_A"/>
      <ConstraintRegion from="1" to="112" loc="I" subId="17188536" subSource="1mhs_B"/>
      <ConstraintRegion from="113" to="134" loc="H" subId="17188539" subSource="1mhs_B"/>
      <ConstraintRegion from="135" to="143" loc="O" subId="17188542" subSource="1mhs_B"/>
      <ConstraintRegion from="144" to="164" loc="H" subId="17188544" subSource="1mhs_B"/>
      <ConstraintRegion from="165" to="293" loc="I" subId="17188548" subSource="1mhs_B"/>
      <ConstraintRegion from="294" to="313" loc="H" subId="17188551" subSource="1mhs_B"/>
      <ConstraintRegion from="314" to="319" loc="O" subId="17188554" subSource="1mhs_B"/>
      <ConstraintRegion from="320" to="341" loc="H" subId="17188557" subSource="1mhs_B"/>
      <ConstraintRegion from="342" to="689" loc="I" subId="17188559" subSource="1mhs_B"/>
      <ConstraintRegion from="690" to="713" loc="H" subId="17188561" subSource="1mhs_B"/>
      <ConstraintRegion from="714" to="716" loc="O" subId="17188564" subSource="1mhs_B"/>
      <ConstraintRegion from="717" to="737" loc="H" subId="17188567" subSource="1mhs_B"/>
      <ConstraintRegion from="738" to="759" loc="I" subId="17188570" subSource="1mhs_B"/>
      <ConstraintRegion from="760" to="783" loc="H" subId="17188573" subSource="1mhs_B"/>
      <ConstraintRegion from="784" to="794" loc="O" subId="17188576" subSource="1mhs_B"/>
      <ConstraintRegion from="795" to="813" loc="H" subId="17188581" subSource="1mhs_B"/>
      <ConstraintRegion from="814" to="826" loc="I" subId="17188583" subSource="1mhs_B"/>
      <ConstraintRegion from="827" to="843" loc="H" subId="17188585" subSource="1mhs_B"/>
      <ConstraintRegion from="844" to="853" loc="O" subId="17188588" subSource="1mhs_B"/>
      <ConstraintRegion from="854" to="875" loc="H" subId="17188591" subSource="1mhs_B"/>
      <ConstraintRegion from="876" to="920" loc="I" subId="17188594" subSource="1mhs_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="7si3_A">
      <ConstraintRegion from="483" to="554" loc="I" subId="17301796" subSource="7si3_A"/>
      <ConstraintRegion from="561" to="575" loc="I" subId="17301800" subSource="7si3_A"/>
      <ConstraintRegion from="577" to="629" loc="I" subId="17301804" subSource="7si3_A"/>
      <ConstraintRegion from="640" to="647" loc="I" subId="17301807" subSource="7si3_A"/>
      <ConstraintRegion from="648" to="671" loc="H" subId="17301809" subSource="7si3_A"/>
      <ConstraintRegion from="678" to="689" loc="O" subId="17301812" subSource="7si3_A"/>
      <ConstraintRegion from="690" to="716" loc="H" subId="17301815" subSource="7si3_A"/>
      <ConstraintRegion from="717" to="722" loc="I" subId="17301818" subSource="7si3_A"/>
      <ConstraintRegion from="723" to="750" loc="H" subId="17301821" subSource="7si3_A"/>
      <ConstraintRegion from="751" to="757" loc="O" subId="17301824" subSource="7si3_A"/>
      <ConstraintRegion from="758" to="777" loc="H" subId="17301826" subSource="7si3_A"/>
      <ConstraintRegion from="778" to="913" loc="I" subId="17301828" subSource="7si3_A"/>
      <ConstraintRegion from="914" to="938" loc="H" subId="17301831" subSource="7si3_A"/>
      <ConstraintRegion from="939" to="965" loc="O" subId="17301834" subSource="7si3_A"/>
      <ConstraintRegion from="966" to="991" loc="H" subId="17301837" subSource="7si3_A"/>
      <ConstraintRegion from="992" to="1042" loc="I" subId="17301840" subSource="7si3_A"/>
      <ConstraintRegion from="1046" to="1112" loc="I" subId="17301846" subSource="7si3_A"/>
      <ConstraintRegion from="1150" to="1325" loc="I" subId="17301852" subSource="7si3_A"/>
      <ConstraintRegion from="1326" to="1349" loc="H" subId="17301855" subSource="7si3_A"/>
      <ConstraintRegion from="1350" to="1354" loc="O" subId="17301858" subSource="7si3_A"/>
      <ConstraintRegion from="1355" to="1381" loc="H" subId="17301861" subSource="7si3_A"/>
      <ConstraintRegion from="1382" to="1417" loc="I" subId="17301863" subSource="7si3_A"/>
      <ConstraintRegion from="483" to="554" loc="I" subId="17301951" subSource="7si6_A"/>
      <ConstraintRegion from="561" to="629" loc="I" subId="17301958" subSource="7si6_A"/>
      <ConstraintRegion from="640" to="647" loc="I" subId="17301963" subSource="7si6_A"/>
      <ConstraintRegion from="648" to="671" loc="H" subId="17301966" subSource="7si6_A"/>
      <ConstraintRegion from="678" to="691" loc="O" subId="17301971" subSource="7si6_A"/>
      <ConstraintRegion from="692" to="716" loc="H" subId="17301974" subSource="7si6_A"/>
      <ConstraintRegion from="717" to="722" loc="I" subId="17301977" subSource="7si6_A"/>
      <ConstraintRegion from="723" to="746" loc="H" subId="17301980" subSource="7si6_A"/>
      <ConstraintRegion from="747" to="758" loc="O" subId="17301983" subSource="7si6_A"/>
      <ConstraintRegion from="759" to="774" loc="H" subId="17301986" subSource="7si6_A"/>
      <ConstraintRegion from="775" to="914" loc="I" subId="17301988" subSource="7si6_A"/>
      <ConstraintRegion from="915" to="936" loc="H" subId="17301991" subSource="7si6_A"/>
      <ConstraintRegion from="937" to="968" loc="O" subId="17301993" subSource="7si6_A"/>
      <ConstraintRegion from="969" to="987" loc="H" subId="17301996" subSource="7si6_A"/>
      <ConstraintRegion from="988" to="1042" loc="I" subId="17301999" subSource="7si6_A"/>
      <ConstraintRegion from="1046" to="1112" loc="I" subId="17302006" subSource="7si6_A"/>
      <ConstraintRegion from="1150" to="1328" loc="I" subId="17302012" subSource="7si6_A"/>
      <ConstraintRegion from="1329" to="1350" loc="H" subId="17302016" subSource="7si6_A"/>
      <ConstraintRegion from="1351" to="1354" loc="O" subId="17302019" subSource="7si6_A"/>
      <ConstraintRegion from="1355" to="1375" loc="H" subId="17302023" subSource="7si6_A"/>
      <ConstraintRegion from="1376" to="1417" loc="I" subId="17302026" subSource="7si6_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="8jbk_A">
      <ConstraintRegion from="22" to="81" loc="I" subId="17134439" subSource="8jbk_A"/>
      <ConstraintRegion from="82" to="107" loc="H" subId="17134442" subSource="8jbk_A"/>
      <ConstraintRegion from="108" to="122" loc="O" subId="17134444" subSource="8jbk_A"/>
      <ConstraintRegion from="123" to="144" loc="H" subId="17134446" subSource="8jbk_A"/>
      <ConstraintRegion from="145" to="283" loc="I" subId="17134449" subSource="8jbk_A"/>
      <ConstraintRegion from="284" to="304" loc="H" subId="17134452" subSource="8jbk_A"/>
      <ConstraintRegion from="305" to="310" loc="O" subId="17134455" subSource="8jbk_A"/>
      <ConstraintRegion from="311" to="332" loc="H" subId="17134457" subSource="8jbk_A"/>
      <ConstraintRegion from="333" to="767" loc="I" subId="17134459" subSource="8jbk_A"/>
      <ConstraintRegion from="768" to="788" loc="H" subId="17134462" subSource="8jbk_A"/>
      <ConstraintRegion from="789" to="793" loc="O" subId="17134465" subSource="8jbk_A"/>
      <ConstraintRegion from="794" to="815" loc="H" subId="17134468" subSource="8jbk_A"/>
      <ConstraintRegion from="816" to="838" loc="I" subId="17134470" subSource="8jbk_A"/>
      <ConstraintRegion from="839" to="862" loc="H" subId="17134473" subSource="8jbk_A"/>
      <ConstraintRegion from="863" to="911" loc="O" subId="17134476" subSource="8jbk_A"/>
      <ConstraintRegion from="912" to="933" loc="H" subId="17134479" subSource="8jbk_A"/>
      <ConstraintRegion from="934" to="941" loc="I" subId="17134482" subSource="8jbk_A"/>
      <ConstraintRegion from="942" to="964" loc="H" subId="17134485" subSource="8jbk_A"/>
      <ConstraintRegion from="965" to="978" loc="O" subId="17134488" subSource="8jbk_A"/>
      <ConstraintRegion from="979" to="1001" loc="H" subId="17134492" subSource="8jbk_A"/>
      <ConstraintRegion from="1002" to="1012" loc="I" subId="17134495" subSource="8jbk_A"/>
      <ConstraintRegion from="1013" to="1016" loc="I" subId="17134498" subSource="8jbk_A"/>
      <ConstraintRegion from="22" to="81" loc="I" subId="17134545" subSource="8jbl_A"/>
      <ConstraintRegion from="82" to="106" loc="H" subId="17134547" subSource="8jbl_A"/>
      <ConstraintRegion from="107" to="123" loc="O" subId="17134549" subSource="8jbl_A"/>
      <ConstraintRegion from="124" to="143" loc="H" subId="17134551" subSource="8jbl_A"/>
      <ConstraintRegion from="144" to="284" loc="I" subId="17134553" subSource="8jbl_A"/>
      <ConstraintRegion from="285" to="304" loc="H" subId="17134555" subSource="8jbl_A"/>
      <ConstraintRegion from="305" to="310" loc="O" subId="17134557" subSource="8jbl_A"/>
      <ConstraintRegion from="311" to="332" loc="H" subId="17134559" subSource="8jbl_A"/>
      <ConstraintRegion from="333" to="767" loc="I" subId="17134561" subSource="8jbl_A"/>
      <ConstraintRegion from="768" to="788" loc="H" subId="17134563" subSource="8jbl_A"/>
      <ConstraintRegion from="789" to="794" loc="O" subId="17134565" subSource="8jbl_A"/>
      <ConstraintRegion from="795" to="815" loc="H" subId="17134567" subSource="8jbl_A"/>
      <ConstraintRegion from="816" to="838" loc="I" subId="17134569" subSource="8jbl_A"/>
      <ConstraintRegion from="839" to="862" loc="H" subId="17134571" subSource="8jbl_A"/>
      <ConstraintRegion from="863" to="912" loc="O" subId="17134573" subSource="8jbl_A"/>
      <ConstraintRegion from="913" to="933" loc="H" subId="17134575" subSource="8jbl_A"/>
      <ConstraintRegion from="934" to="944" loc="I" subId="17134577" subSource="8jbl_A"/>
      <ConstraintRegion from="945" to="965" loc="H" subId="17134579" subSource="8jbl_A"/>
      <ConstraintRegion from="966" to="980" loc="O" subId="17134581" subSource="8jbl_A"/>
      <ConstraintRegion from="981" to="1001" loc="H" subId="17134583" subSource="8jbl_A"/>
      <ConstraintRegion from="1002" to="1015" loc="I" subId="17134585" subSource="8jbl_A"/>
      <ConstraintRegion from="1016" to="1016" loc="I" subId="17134587" subSource="8jbl_A"/>
      <ConstraintRegion from="22" to="81" loc="I" subId="17134605" subSource="8jbm_A"/>
      <ConstraintRegion from="82" to="106" loc="H" subId="17134606" subSource="8jbm_A"/>
      <ConstraintRegion from="107" to="123" loc="O" subId="17134607" subSource="8jbm_A"/>
      <ConstraintRegion from="124" to="144" loc="H" subId="17134608" subSource="8jbm_A"/>
      <ConstraintRegion from="145" to="284" loc="I" subId="17134609" subSource="8jbm_A"/>
      <ConstraintRegion from="285" to="304" loc="H" subId="17134610" subSource="8jbm_A"/>
      <ConstraintRegion from="305" to="310" loc="O" subId="17134611" subSource="8jbm_A"/>
      <ConstraintRegion from="311" to="332" loc="H" subId="17134612" subSource="8jbm_A"/>
      <ConstraintRegion from="333" to="767" loc="I" subId="17134613" subSource="8jbm_A"/>
      <ConstraintRegion from="768" to="789" loc="H" subId="17134614" subSource="8jbm_A"/>
      <ConstraintRegion from="790" to="793" loc="O" subId="17134615" subSource="8jbm_A"/>
      <ConstraintRegion from="794" to="815" loc="H" subId="17134616" subSource="8jbm_A"/>
      <ConstraintRegion from="816" to="838" loc="I" subId="17134617" subSource="8jbm_A"/>
      <ConstraintRegion from="839" to="862" loc="H" subId="17134618" subSource="8jbm_A"/>
      <ConstraintRegion from="863" to="911" loc="O" subId="17134619" subSource="8jbm_A"/>
      <ConstraintRegion from="912" to="932" loc="H" subId="17134620" subSource="8jbm_A"/>
      <ConstraintRegion from="933" to="944" loc="I" subId="17134621" subSource="8jbm_A"/>
      <ConstraintRegion from="945" to="965" loc="H" subId="17134622" subSource="8jbm_A"/>
      <ConstraintRegion from="966" to="978" loc="O" subId="17134623" subSource="8jbm_A"/>
      <ConstraintRegion from="979" to="1001" loc="H" subId="17134624" subSource="8jbm_A"/>
      <ConstraintRegion from="1002" to="1016" loc="I" subId="17134625" subSource="8jbm_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="7wyu_A">
      <ConstraintRegion from="31" to="100" loc="I" subId="17410015" subSource="7wyu_A"/>
      <ConstraintRegion from="101" to="118" loc="H" subId="17410016" subSource="7wyu_A"/>
      <ConstraintRegion from="119" to="127" loc="O" subId="17410017" subSource="7wyu_A"/>
      <ConstraintRegion from="128" to="145" loc="H" subId="17410018" subSource="7wyu_A"/>
      <ConstraintRegion from="146" to="291" loc="I" subId="17410019" subSource="7wyu_A"/>
      <ConstraintRegion from="292" to="312" loc="H" subId="17410020" subSource="7wyu_A"/>
      <ConstraintRegion from="313" to="317" loc="O" subId="17410021" subSource="7wyu_A"/>
      <ConstraintRegion from="318" to="339" loc="H" subId="17410022" subSource="7wyu_A"/>
      <ConstraintRegion from="340" to="775" loc="I" subId="17410023" subSource="7wyu_A"/>
      <ConstraintRegion from="776" to="795" loc="H" subId="17410024" subSource="7wyu_A"/>
      <ConstraintRegion from="796" to="801" loc="O" subId="17410025" subSource="7wyu_A"/>
      <ConstraintRegion from="802" to="822" loc="H" subId="17410026" subSource="7wyu_A"/>
      <ConstraintRegion from="823" to="847" loc="I" subId="17410027" subSource="7wyu_A"/>
      <ConstraintRegion from="848" to="868" loc="H" subId="17410028" subSource="7wyu_A"/>
      <ConstraintRegion from="869" to="919" loc="O" subId="17410029" subSource="7wyu_A"/>
      <ConstraintRegion from="920" to="938" loc="H" subId="17410030" subSource="7wyu_A"/>
      <ConstraintRegion from="939" to="952" loc="I" subId="17410031" subSource="7wyu_A"/>
      <ConstraintRegion from="953" to="971" loc="H" subId="17410032" subSource="7wyu_A"/>
      <ConstraintRegion from="972" to="987" loc="O" subId="17410033" subSource="7wyu_A"/>
      <ConstraintRegion from="988" to="1006" loc="H" subId="17410034" subSource="7wyu_A"/>
      <ConstraintRegion from="1007" to="1023" loc="I" subId="17410035" subSource="7wyu_A"/>
      <ConstraintRegion from="31" to="99" loc="I" subId="17410147" subSource="7wyv_C"/>
      <ConstraintRegion from="100" to="118" loc="H" subId="17410150" subSource="7wyv_C"/>
      <ConstraintRegion from="119" to="127" loc="O" subId="17410155" subSource="7wyv_C"/>
      <ConstraintRegion from="128" to="146" loc="H" subId="17410159" subSource="7wyv_C"/>
      <ConstraintRegion from="147" to="291" loc="I" subId="17410163" subSource="7wyv_C"/>
      <ConstraintRegion from="292" to="311" loc="H" subId="17410167" subSource="7wyv_C"/>
      <ConstraintRegion from="312" to="317" loc="O" subId="17410170" subSource="7wyv_C"/>
      <ConstraintRegion from="318" to="340" loc="H" subId="17410173" subSource="7wyv_C"/>
      <ConstraintRegion from="341" to="774" loc="I" subId="17410176" subSource="7wyv_C"/>
      <ConstraintRegion from="775" to="792" loc="H" subId="17410180" subSource="7wyv_C"/>
      <ConstraintRegion from="793" to="801" loc="O" subId="17410183" subSource="7wyv_C"/>
      <ConstraintRegion from="802" to="822" loc="H" subId="17410186" subSource="7wyv_C"/>
      <ConstraintRegion from="823" to="847" loc="I" subId="17410189" subSource="7wyv_C"/>
      <ConstraintRegion from="848" to="868" loc="H" subId="17410192" subSource="7wyv_C"/>
      <ConstraintRegion from="869" to="919" loc="O" subId="17410195" subSource="7wyv_C"/>
      <ConstraintRegion from="920" to="938" loc="H" subId="17410198" subSource="7wyv_C"/>
      <ConstraintRegion from="939" to="952" loc="I" subId="17410200" subSource="7wyv_C"/>
      <ConstraintRegion from="953" to="971" loc="H" subId="17410202" subSource="7wyv_C"/>
      <ConstraintRegion from="972" to="988" loc="O" subId="17410205" subSource="7wyv_C"/>
      <ConstraintRegion from="989" to="1008" loc="H" subId="17410207" subSource="7wyv_C"/>
      <ConstraintRegion from="1009" to="1023" loc="I" subId="17410209" subSource="7wyv_C"/>
      <ConstraintRegion from="31" to="100" loc="I" subId="17410318" subSource="7wyw_A"/>
      <ConstraintRegion from="101" to="120" loc="H" subId="17410320" subSource="7wyw_A"/>
      <ConstraintRegion from="121" to="126" loc="O" subId="17410322" subSource="7wyw_A"/>
      <ConstraintRegion from="127" to="145" loc="H" subId="17410324" subSource="7wyw_A"/>
      <ConstraintRegion from="146" to="292" loc="I" subId="17410326" subSource="7wyw_A"/>
      <ConstraintRegion from="293" to="312" loc="H" subId="17410328" subSource="7wyw_A"/>
      <ConstraintRegion from="313" to="317" loc="O" subId="17410330" subSource="7wyw_A"/>
      <ConstraintRegion from="318" to="339" loc="H" subId="17410331" subSource="7wyw_A"/>
      <ConstraintRegion from="340" to="774" loc="I" subId="17410332" subSource="7wyw_A"/>
      <ConstraintRegion from="775" to="795" loc="H" subId="17410334" subSource="7wyw_A"/>
      <ConstraintRegion from="796" to="801" loc="O" subId="17410336" subSource="7wyw_A"/>
      <ConstraintRegion from="802" to="822" loc="H" subId="17410339" subSource="7wyw_A"/>
      <ConstraintRegion from="823" to="847" loc="I" subId="17410341" subSource="7wyw_A"/>
      <ConstraintRegion from="848" to="868" loc="H" subId="17410342" subSource="7wyw_A"/>
      <ConstraintRegion from="869" to="919" loc="O" subId="17410344" subSource="7wyw_A"/>
      <ConstraintRegion from="920" to="938" loc="H" subId="17410347" subSource="7wyw_A"/>
      <ConstraintRegion from="939" to="951" loc="I" subId="17410349" subSource="7wyw_A"/>
      <ConstraintRegion from="952" to="971" loc="H" subId="17410351" subSource="7wyw_A"/>
      <ConstraintRegion from="972" to="988" loc="O" subId="17410353" subSource="7wyw_A"/>
      <ConstraintRegion from="989" to="1007" loc="H" subId="17410354" subSource="7wyw_A"/>
      <ConstraintRegion from="1008" to="1023" loc="I" subId="17410356" subSource="7wyw_A"/>
      <ConstraintRegion from="31" to="92" loc="I" subId="17410475" subSource="7wyx_A"/>
      <ConstraintRegion from="93" to="119" loc="H" subId="17410476" subSource="7wyx_A"/>
      <ConstraintRegion from="120" to="126" loc="O" subId="17410478" subSource="7wyx_A"/>
      <ConstraintRegion from="127" to="146" loc="H" subId="17410480" subSource="7wyx_A"/>
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  </Constraints>
</HtpItem>
