<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A8I5KXW0_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Solute carrier family 22 member 5 </Name>
  <CrossRef>
    <PDBTM id="8et9">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8et6">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8et7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8et8">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtz">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bvt">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sdu">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sdz">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bvr">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bvs">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bw7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8omu">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sdy">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtv">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zh0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8ju0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zha">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7zh6">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jts">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8jtt">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5eqg">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5eqh">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5eqi">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6tha">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4pyp">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8ex6">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8ex4">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8g92">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6oom">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6oop">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6ooq">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6euq">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4zow">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4zp0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4zp2">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6gv1">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6vrz">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6vs0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6vs1">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6vs2">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8ex5">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8ex7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8ex8">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7yub">
      <Chain id="R"/>
    </PDBTM>
    <PDBTM id="8jhr">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7yud">
      <Chain id="R"/>
    </PDBTM>
    <PDBTM id="7yuf">
      <Chain id="R"/>
    </PDBTM>
    <PDBTM id="8kae">
      <Chain id="R"/>
    </PDBTM>
    <PDBTM id="8jhq">
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="OCTN2_HUMAN">
      <Alignment>
        <CrossRefSeq>MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRML</CrossRefSeq>
        <OrigSeq>MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSS-YNILYVRSVHILCIWLHGAATVCLL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22A6_HUMAN">
      <Alignment>
        <CrossRefSeq>FNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLP---RDRQGQPESCLRFTSPQWGLPFLNGTEAN-----GTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQ</CrossRefSeq>
        <OrigSeq>YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLS-SAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVCLLH</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22A2_RABIT">
      <Alignment>
        <CrossRefSeq>MPTVDDILEQVGHFHFFQKQTFFLLALISAAFTPIYVGIVFLGFTPDHRCRSPGVAELSQRCGWSPGEELNYTVPGLGAADGAFARQCMRYEVDWNQSSPGCVDPLASLAPNRSHLPLGPCQHGWVYDTPG--SSIVTEFNLVCARSWMLDLFQSAVNIGFFIGSVGIGYLADRFGRKLCLLVTILINAAAGVLMAVSPNYTWMLIFRLIQGLVSKAGWLIGYILITEFVGLNYRRTVGILYQVAFTVGLLVLAGVAYALPRWRWLQ</CrossRefSeq>
        <OrigSeq>MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLS--SAW-----RNHTVPLRLRDGREVPHSCRRYRLATIAN-FSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVCLLH</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22A6_MOUSE">
      <Alignment>
        <CrossRefSeq>FNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPAHHCRPPANANLSKDGGLEAWLPL---DKQGRPESCLRFPFP------HNGTEAN-----GTGVTEPCLDGWVYDNSTFPSTIVTEWNLVCSHRAFRQLAQSLFMVGVLLGAMMFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCIFRLLSGMSLASIAINCMTLNMEWMPIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQ</CrossRefSeq>
        <OrigSeq>YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLS-SAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVCLLH</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22A7_HUMAN">
      <Alignment>
        <CrossRefSeq>FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDVWLEAHLP---REPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWL</CrossRefSeq>
        <OrigSeq>YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPD---AANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLE-QESCLDGWEFSQDVYLSTIVTE--WNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVCLL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ORCT_DROME">
      <Alignment>
        <CrossRefSeq>YDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHLWNLSYPEN--------ERCSYYDVDYTEEY------LNGSIPRSSNETKTC-SSYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQ</CrossRefSeq>
        <OrigSeq>YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVP----DAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVCLLH</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="OCT1_CAEEL">
      <Alignment>
        <CrossRefSeq>PDFDFVLEQVGNYGTYQIVFFFIICLPTSLPSAFSAFNIPFVVGNPPHTCHIPEGKEYLRPLTNDTQIL----------SCKQYNETQINVFRAF-TSAPVDTYSDRISLVPCQNGWDYDNSTYLDSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRRWRQL</CrossRefSeq>
        <OrigSeq>RDYDEVTAFLGEWGPFQRLIFFLLSAS-IIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVCLL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="GAL2_YEAST">
      <Alignment>
        <CrossRefSeq>SNVRTGLIVAIFNIGCAFGGIILSKGGDMYGRKKGLSIVVSVYIVGIIIQIASINKWYQYFIGRIISGLGVGGIAVLCPMLISEIAPKHLRGTLVSCYQLMITAGIFLGYCTNYGTKSYSNSVQWRVPLGLCFAWSL--FMIGALTLVP</CrossRefSeq>
        <OrigSeq>DDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKN-FEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVC-LLHPRLADAAGGADDAGGAMRGTLVVHP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HXT4_YEAST">
      <Alignment>
        <CrossRefSeq>SKVRTGLIVSIFNIGCAIGGIILAKLGDMYGRKMGLIVVVVIYIIGIIIQIASINKWYQYFIGRIISGLGVGGIAVLSPMLISEVSPKHIRGTLVSCYQLMITLGIFLGYCTNYGTKTYTNSVQWRVPLGLGFA</CrossRefSeq>
        <OrigSeq>DDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKN-FEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATV-CLLHPRLADAAGGA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HXT8_YEAST">
      <Alignment>
        <CrossRefSeq>SNVRTGLIVSIFNVGSAIGCLFLSKLGDIYGRCMGLIIVIVVYMVGIVIQIASIDKWYQYFIGRIIAGIGAGSISVLAPMLISETAPKHIRGTLLACWQLMVTFAIFLGYCTNYGTKTYSNSVQWRVPLGL</CrossRefSeq>
        <OrigSeq>DDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKN-FEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVC-LLHPRLADAA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SV2C_HUMAN">
      <Alignment>
        <CrossRefSeq>CIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIG----GIYASAMAWAIIPHYGWSFSMGSA</CrossRefSeq>
        <OrigSeq>CEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVCLLHPRLADAAGGA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SV2C_RAT">
      <Alignment>
        <CrossRefSeq>CIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLLCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIG----GIYASAMAWAIIPHYGWSFSMGSA</CrossRefSeq>
        <OrigSeq>CEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVCLLHPRLADAAGGA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HXT3_YEAST">
      <Alignment>
        <CrossRefSeq>SKVRTGLIVSIFNIGCAIGGIILAKLGDMYGRKMGLIVVVVIYIIGIIIQIASINKWYQYFIGRIISGLGVGGIAVLSPMLISEVAPKEMRGTLVSCYQLMITLGIFLGYCTNFGTKNYSNSVQWRVPLGLCFAWALFMIGG</CrossRefSeq>
        <OrigSeq>DDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKN-FEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVC-LLHPRL---------ADAAGG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HXT1_YEAST">
      <Alignment>
        <CrossRefSeq>SKVRTGLIVSIFNIGCAIGGIVLAKLGDMYGRRIGLIVVVVIYTIGIIIQIASINKWYQYFIGRIISGLGVGGITVLSPMLISEVAPSEMRGTLVSCYQVMITLGIFLGYCTNFGTKNYSNSVQWRVPLGLCFAWALFMIGG</CrossRefSeq>
        <OrigSeq>DDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKN-FEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVC-LLHPRL---------ADAAGG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SV2A_HUMAN">
      <Alignment>
        <CrossRefSeq>CLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAI----IPHYGWSFQMGSA</CrossRefSeq>
        <OrigSeq>CEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVCLLHPRLADAAGGA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HXT13_YEAST">
      <Alignment>
        <CrossRefSeq>SNVRMGLLVAMFSIGCAIGGLIFARLADTLGRRLAIVIVVLVYMVGAIIQISSNHKWYQYFVGKIIYGLGAGGCSVLCPMLLSEIAPTDLRGGLVSLYQLNMTFGIFLGYCSVYGTRKYDNTAQWRVPLGL</CrossRefSeq>
        <OrigSeq>DDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKN-FEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVC-LLHPRLADAA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HXT7_YEAST">
      <Alignment>
        <CrossRefSeq>SKVRTGLIVSIFNIGCAIGGIILSKLGDMYGRKVGLIVVVVIYIIGIIIQIASINKWYQYFIGRIISGLGVGGIAVLSPMLISEVSPKHLRGTLVSCYQLMITAGIFLGYCTNFGTKNYSNSVQWRVPLGLCFAWALFMIGG</CrossRefSeq>
        <OrigSeq>DDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKN-FEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVC-LLHPRL---------ADAAGG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HXT6_YEAST">
      <Alignment>
        <CrossRefSeq>SKVRTGLIVSIFNIGCAIGGIILSKLGDMYGRKVGLIVVVVIYIIGIIIQIASINKWYQYFIGRIISGLGVGGIAVLSPMLISEVSPKHLRGTLVSCYQLMITAGIFLGYCTNFGTKNYSNSVQWRVPLGLCFAWALFMIGG</CrossRefSeq>
        <OrigSeq>DDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKN-FEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVC-LLHPRL---------ADAAGG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="GTR3_MOUSE">
      <Alignment>
        <CrossRefSeq>TALWSLCVAIFSVGGMIGSFSVGLFVNRFGRRNSMLLVNLLAIIAGCLMGFAKIAESVEMLILGRLLIGIFCGLCTGFVPMYIGEVSPTALRGAFGTLNQLGIVVGILVAQIFG</CrossRefSeq>
        <OrigSeq>DWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSK---NFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="GTR1_RAT">
      <Alignment>
        <CrossRefSeq>YGESIPSTTLTTLW----------SLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIMGNADLWPLLLSVIFIPAL</CrossRefSeq>
        <OrigSeq>FSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSK---NFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVCLLHPRLADAAGGADDA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="YGCS_ECOLI">
      <Alignment>
        <CrossRefSeq>FMAGMIGGSALLGLFLGSLVLGWISDHIGRQKIFTFSFLLITLASFLQFFATTPEHLIGLRILIGIGLGGDYSVGHTLLAEFSPRRHRGILLGAFSVVWTVGYVLASIAGH</CrossRefSeq>
        <OrigSeq>WKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLH</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="YAAU_ECOLI">
      <Alignment>
        <CrossRefSeq>DADWIGLLGAGTLAGLFVGTSLFGYISDKVGRRKMFLIDIIAIGVISVATMFVSSPVELLVMRVLIGIVIGADYPIATSMITEFSSTRQRAFSIS----------FIAAMWYVGATCADLVGYWLYDVEGG</CrossRefSeq>
        <OrigSeq>DDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIWLHGAATVCLLHPRLADAAGG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="MDTM_ECOLI">
      <Alignment>
        <CrossRefSeq>NVVRDFN---ADVSLAPAAVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATMFTTSMTQFLIARAIQGTSICFIATVGYVTVQEAFGQTK----GIKLMAIITSIVLIAPIIGPLSGAALMHFMHWKVLFAI</CrossRefSeq>
        <OrigSeq>TIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHILCIW--LHGAATVCLLHPRLADAA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SHIA_ECOLI">
      <Alignment>
        <CrossRefSeq>ATFGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFSTIGWWAPILLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLL</CrossRefSeq>
        <OrigSeq>SLFFVGVL---LGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEM--------FVVLFVLVGMGQISNYVAAFVLGMAIRLEDRNSWQVSSYNILYVRSVHI</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="MDFA_ECO57">
      <Alignment>
        <CrossRefSeq>WVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLAILLAQNIEQFTLLRFLQGISLCFIGAVGY</CrossRefSeq>
        <OrigSeq>KAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="YDHC_ECOLI">
      <Alignment>
        <CrossRefSeq>VSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLLIGLTIFALGSLGMLWVENAATLLVLRFVQAVGVCAAAVI</CrossRefSeq>
        <OrigSeq>APLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVA</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="284" CheckSum="22a2671dec5a4dc3986d0d4c75bc82a3">
    <Seq>
      MRDYDEVTAF LGEWGPFQRL IFFLLSASII PNGFTGLSSV FLIATPEHRC
      RVPDAANLSS AWRNHTVPLR LRDGREVPHS CRRYRLATIA NFSALGLEPG
      RDVDLGQLEQ ESCLDGWEFS QDVYLSTIVT EWNLVCEDDW KAPLTISLFF
      VGVLLGSFIS GQLSDRFGRK NVLFVTMGMQ TGFSFLQIFS KNFEMFVVLF
      VLVGMGQISN YVAAFVLGMA IRLEDRNSWQ VSSYNILYVR SVHILCIWLH
      GAATVCLLHP RLADAAGGAD DAGGAMRGTL VVHP
    </Seq>
  </Sequence>
  <Topology numTm="5" reliability="79.3">
    <Region from="1" to="19" loc="I"/>
    <Region from="20" to="42" loc="M"/>
    <Region from="43" to="141" loc="O"/>
    <Region from="142" to="161" loc="M"/>
    <Region from="162" to="171" loc="I"/>
    <Region from="172" to="190" loc="M"/>
    <Region from="191" to="194" loc="O"/>
    <Region from="195" to="217" loc="M"/>
    <Region from="218" to="227" loc="I"/>
    <Region from="228" to="252" loc="M"/>
    <Region from="253" to="284" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="19" loc="I"/>
      <Region from="20" to="45" loc="M"/>
      <Region from="46" to="143" loc="O"/>
      <Region from="144" to="164" loc="M"/>
      <Region from="165" to="171" loc="I"/>
      <Region from="172" to="191" loc="M"/>
      <Region from="192" to="195" loc="O"/>
      <Region from="196" to="223" loc="M"/>
      <Region from="224" to="227" loc="I"/>
      <Region from="228" to="252" loc="M"/>
      <Region from="253" to="284" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="16" loc="I"/>
      <Region from="17" to="43" loc="M"/>
      <Region from="44" to="144" loc="O"/>
      <Region from="145" to="163" loc="M"/>
      <Region from="164" to="169" loc="I"/>
      <Region from="170" to="189" loc="M"/>
      <Region from="190" to="192" loc="O"/>
      <Region from="193" to="218" loc="M"/>
      <Region from="219" to="228" loc="I"/>
      <Region from="229" to="256" loc="M"/>
      <Region from="257" to="284" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="46" loc="M"/>
      <Region from="47" to="141" loc="O"/>
      <Region from="142" to="162" loc="M"/>
      <Region from="163" to="172" loc="I"/>
      <Region from="173" to="193" loc="M"/>
      <Region from="194" to="195" loc="O"/>
      <Region from="196" to="216" loc="M"/>
      <Region from="217" to="230" loc="I"/>
      <Region from="231" to="245" loc="M"/>
      <Region from="246" to="246" loc="O"/>
      <Region from="247" to="261" loc="M"/>
      <Region from="262" to="284" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="19" loc="I"/>
      <Region from="20" to="43" loc="M"/>
      <Region from="44" to="141" loc="O"/>
      <Region from="142" to="161" loc="M"/>
      <Region from="162" to="170" loc="I"/>
      <Region from="171" to="189" loc="M"/>
      <Region from="190" to="195" loc="O"/>
      <Region from="196" to="221" loc="M"/>
      <Region from="222" to="235" loc="I"/>
      <Region from="236" to="258" loc="M"/>
      <Region from="259" to="284" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="19" loc="O"/>
      <Region from="20" to="44" loc="M"/>
      <Region from="45" to="141" loc="I"/>
      <Region from="142" to="160" loc="M"/>
      <Region from="161" to="171" loc="O"/>
      <Region from="172" to="189" loc="M"/>
      <Region from="190" to="195" loc="I"/>
      <Region from="196" to="217" loc="M"/>
      <Region from="218" to="236" loc="O"/>
      <Region from="237" to="258" loc="M"/>
      <Region from="259" to="284" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="20" loc="I"/>
      <Region from="21" to="41" loc="M"/>
      <Region from="42" to="140" loc="O"/>
      <Region from="141" to="161" loc="M"/>
      <Region from="162" to="170" loc="I"/>
      <Region from="171" to="191" loc="M"/>
      <Region from="192" to="195" loc="O"/>
      <Region from="196" to="216" loc="M"/>
      <Region from="217" to="227" loc="I"/>
      <Region from="228" to="248" loc="M"/>
      <Region from="249" to="284" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="21" loc="I"/>
      <Region from="22" to="42" loc="M"/>
      <Region from="43" to="140" loc="O"/>
      <Region from="141" to="161" loc="M"/>
      <Region from="162" to="170" loc="I"/>
      <Region from="171" to="191" loc="M"/>
      <Region from="192" to="196" loc="O"/>
      <Region from="197" to="217" loc="M"/>
      <Region from="218" to="228" loc="I"/>
      <Region from="229" to="249" loc="M"/>
      <Region from="250" to="284" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="16" loc="O"/>
      <Region from="17" to="36" loc="M"/>
      <Region from="37" to="80" loc="I"/>
      <Region from="81" to="100" loc="M"/>
      <Region from="101" to="139" loc="O"/>
      <Region from="140" to="159" loc="M"/>
      <Region from="160" to="192" loc="I"/>
      <Region from="193" to="212" loc="M"/>
      <Region from="213" to="237" loc="O"/>
      <Region from="238" to="258" loc="M"/>
      <Region from="259" to="284" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="16" loc="I"/>
      <Region from="17" to="37" loc="M"/>
      <Region from="38" to="143" loc="O"/>
      <Region from="144" to="164" loc="M"/>
      <Region from="165" to="170" loc="I"/>
      <Region from="171" to="191" loc="M"/>
      <Region from="192" to="194" loc="O"/>
      <Region from="195" to="215" loc="M"/>
      <Region from="216" to="237" loc="I"/>
      <Region from="238" to="258" loc="M"/>
      <Region from="259" to="284" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="20" loc="I"/>
      <Region from="21" to="43" loc="M"/>
      <Region from="44" to="141" loc="O"/>
      <Region from="142" to="164" loc="M"/>
      <Region from="165" to="170" loc="I"/>
      <Region from="171" to="190" loc="M"/>
      <Region from="191" to="194" loc="O"/>
      <Region from="195" to="217" loc="M"/>
      <Region from="218" to="284" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="8et9_A">
      <ConstraintRegion from="3" to="23" loc="I" subId="17063953" subSource="8et9_A"/>
      <ConstraintRegion from="24" to="40" loc="H" subId="17063955" subSource="8et9_A"/>
      <ConstraintRegion from="41" to="151" loc="O" subId="17063957" subSource="8et9_A"/>
      <ConstraintRegion from="152" to="168" loc="H" subId="17063959" subSource="8et9_A"/>
      <ConstraintRegion from="169" to="179" loc="I" subId="17063961" subSource="8et9_A"/>
      <ConstraintRegion from="180" to="197" loc="H" subId="17063962" subSource="8et9_A"/>
      <ConstraintRegion from="198" to="201" loc="O" subId="17063964" subSource="8et9_A"/>
      <ConstraintRegion from="202" to="222" loc="H" subId="17063966" subSource="8et9_A"/>
      <ConstraintRegion from="223" to="236" loc="I" subId="17063968" subSource="8et9_A"/>
      <ConstraintRegion from="237" to="255" loc="H" subId="17063969" subSource="8et9_A"/>
      <ConstraintRegion from="256" to="265" loc="O" subId="17063971" subSource="8et9_A"/>
      <ConstraintRegion from="266" to="280" loc="H" subId="17063973" subSource="8et9_A"/>
      <ConstraintRegion from="281" to="317" loc="I" subId="17063975" subSource="8et9_A"/>
      <ConstraintRegion from="329" to="349" loc="I" subId="17063979" subSource="8et9_A"/>
      <ConstraintRegion from="350" to="367" loc="H" subId="17063981" subSource="8et9_A"/>
      <ConstraintRegion from="368" to="380" loc="O" subId="17063983" subSource="8et9_A"/>
      <ConstraintRegion from="381" to="398" loc="H" subId="17063985" subSource="8et9_A"/>
      <ConstraintRegion from="399" to="403" loc="I" subId="17063987" subSource="8et9_A"/>
      <ConstraintRegion from="404" to="421" loc="H" subId="17063989" subSource="8et9_A"/>
      <ConstraintRegion from="422" to="423" loc="O" subId="17063991" subSource="8et9_A"/>
      <ConstraintRegion from="428" to="434" loc="O" subId="17063995" subSource="8et9_A"/>
      <ConstraintRegion from="435" to="454" loc="H" subId="17063997" subSource="8et9_A"/>
      <ConstraintRegion from="455" to="467" loc="I" subId="17063999" subSource="8et9_A"/>
      <ConstraintRegion from="468" to="485" loc="H" subId="17064001" subSource="8et9_A"/>
      <ConstraintRegion from="486" to="496" loc="O" subId="17064002" subSource="8et9_A"/>
      <ConstraintRegion from="497" to="512" loc="H" subId="17064003" subSource="8et9_A"/>
      <ConstraintRegion from="513" to="534" loc="I" subId="17064004" subSource="8et9_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="8et6_A">
      <ConstraintRegion from="2" to="22" loc="I" subId="17063776" subSource="8et6_A"/>
      <ConstraintRegion from="23" to="39" loc="H" subId="17063778" subSource="8et6_A"/>
      <ConstraintRegion from="40" to="150" loc="O" subId="17063780" subSource="8et6_A"/>
      <ConstraintRegion from="151" to="167" loc="H" subId="17063782" subSource="8et6_A"/>
      <ConstraintRegion from="168" to="178" loc="I" subId="17063784" subSource="8et6_A"/>
      <ConstraintRegion from="179" to="196" loc="H" subId="17063786" subSource="8et6_A"/>
      <ConstraintRegion from="197" to="200" loc="O" subId="17063788" subSource="8et6_A"/>
      <ConstraintRegion from="201" to="221" loc="H" subId="17063790" subSource="8et6_A"/>
      <ConstraintRegion from="222" to="234" loc="I" subId="17063792" subSource="8et6_A"/>
      <ConstraintRegion from="235" to="254" loc="H" subId="17063794" subSource="8et6_A"/>
      <ConstraintRegion from="255" to="264" loc="O" subId="17063796" subSource="8et6_A"/>
      <ConstraintRegion from="265" to="279" loc="H" subId="17063798" subSource="8et6_A"/>
      <ConstraintRegion from="280" to="348" loc="I" subId="17063800" subSource="8et6_A"/>
      <ConstraintRegion from="349" to="366" loc="H" subId="17063802" subSource="8et6_A"/>
      <ConstraintRegion from="367" to="379" loc="O" subId="17063804" subSource="8et6_A"/>
      <ConstraintRegion from="380" to="397" loc="H" subId="17063805" subSource="8et6_A"/>
      <ConstraintRegion from="398" to="402" loc="I" subId="17063806" subSource="8et6_A"/>
      <ConstraintRegion from="403" to="422" loc="H" subId="17063807" subSource="8et6_A"/>
      <ConstraintRegion from="423" to="433" loc="O" subId="17063808" subSource="8et6_A"/>
      <ConstraintRegion from="434" to="453" loc="H" subId="17063809" subSource="8et6_A"/>
      <ConstraintRegion from="454" to="466" loc="I" subId="17063810" subSource="8et6_A"/>
      <ConstraintRegion from="467" to="484" loc="H" subId="17063811" subSource="8et6_A"/>
      <ConstraintRegion from="485" to="494" loc="O" subId="17063812" subSource="8et6_A"/>
      <ConstraintRegion from="495" to="511" loc="H" subId="17063813" subSource="8et6_A"/>
      <ConstraintRegion from="512" to="533" loc="I" subId="17063814" subSource="8et6_A"/>
      <ConstraintRegion from="2" to="22" loc="I" subId="17063817" subSource="8et7_A"/>
      <ConstraintRegion from="23" to="39" loc="H" subId="17063818" subSource="8et7_A"/>
      <ConstraintRegion from="40" to="151" loc="O" subId="17063819" subSource="8et7_A"/>
      <ConstraintRegion from="152" to="167" loc="H" subId="17063820" subSource="8et7_A"/>
      <ConstraintRegion from="168" to="178" loc="I" subId="17063821" subSource="8et7_A"/>
      <ConstraintRegion from="179" to="196" loc="H" subId="17063822" subSource="8et7_A"/>
      <ConstraintRegion from="197" to="200" loc="O" subId="17063823" subSource="8et7_A"/>
      <ConstraintRegion from="201" to="221" loc="H" subId="17063824" subSource="8et7_A"/>
      <ConstraintRegion from="222" to="235" loc="I" subId="17063825" subSource="8et7_A"/>
      <ConstraintRegion from="236" to="254" loc="H" subId="17063826" subSource="8et7_A"/>
      <ConstraintRegion from="255" to="264" loc="O" subId="17063827" subSource="8et7_A"/>
      <ConstraintRegion from="265" to="279" loc="H" subId="17063828" subSource="8et7_A"/>
      <ConstraintRegion from="280" to="348" loc="I" subId="17063829" subSource="8et7_A"/>
      <ConstraintRegion from="349" to="365" loc="H" subId="17063830" subSource="8et7_A"/>
      <ConstraintRegion from="366" to="380" loc="O" subId="17063831" subSource="8et7_A"/>
      <ConstraintRegion from="381" to="397" loc="H" subId="17063832" subSource="8et7_A"/>
      <ConstraintRegion from="398" to="402" loc="I" subId="17063833" subSource="8et7_A"/>
      <ConstraintRegion from="403" to="419" loc="H" subId="17063834" subSource="8et7_A"/>
      <ConstraintRegion from="420" to="434" loc="O" subId="17063835" subSource="8et7_A"/>
      <ConstraintRegion from="435" to="453" loc="H" subId="17063836" subSource="8et7_A"/>
      <ConstraintRegion from="454" to="466" loc="I" subId="17063837" subSource="8et7_A"/>
      <ConstraintRegion from="467" to="483" loc="H" subId="17063838" subSource="8et7_A"/>
      <ConstraintRegion from="484" to="495" loc="O" subId="17063839" subSource="8et7_A"/>
      <ConstraintRegion from="496" to="511" loc="H" subId="17063840" subSource="8et7_A"/>
      <ConstraintRegion from="512" to="533" loc="I" subId="17063841" subSource="8et7_A"/>
      <ConstraintRegion from="2" to="20" loc="I" subId="17063877" subSource="8et8_A"/>
      <ConstraintRegion from="21" to="41" loc="H" subId="17063878" subSource="8et8_A"/>
      <ConstraintRegion from="42" to="150" loc="O" subId="17063879" subSource="8et8_A"/>
      <ConstraintRegion from="151" to="170" loc="H" subId="17063880" subSource="8et8_A"/>
      <ConstraintRegion from="171" to="175" loc="I" subId="17063881" subSource="8et8_A"/>
      <ConstraintRegion from="176" to="196" loc="H" subId="17063882" subSource="8et8_A"/>
      <ConstraintRegion from="197" to="200" loc="O" subId="17063883" subSource="8et8_A"/>
      <ConstraintRegion from="201" to="222" loc="H" subId="17063884" subSource="8et8_A"/>
      <ConstraintRegion from="223" to="234" loc="I" subId="17063885" subSource="8et8_A"/>
      <ConstraintRegion from="235" to="255" loc="H" subId="17063886" subSource="8et8_A"/>
      <ConstraintRegion from="256" to="262" loc="O" subId="17063887" subSource="8et8_A"/>
      <ConstraintRegion from="263" to="281" loc="H" subId="17063888" subSource="8et8_A"/>
      <ConstraintRegion from="282" to="347" loc="I" subId="17063889" subSource="8et8_A"/>
      <ConstraintRegion from="348" to="368" loc="H" subId="17063890" subSource="8et8_A"/>
      <ConstraintRegion from="369" to="377" loc="O" subId="17063891" subSource="8et8_A"/>
      <ConstraintRegion from="378" to="397" loc="H" subId="17063892" subSource="8et8_A"/>
      <ConstraintRegion from="398" to="402" loc="I" subId="17063893" subSource="8et8_A"/>
      <ConstraintRegion from="403" to="423" loc="H" subId="17063894" subSource="8et8_A"/>
      <ConstraintRegion from="424" to="430" loc="O" subId="17063895" subSource="8et8_A"/>
      <ConstraintRegion from="431" to="454" loc="H" subId="17063896" subSource="8et8_A"/>
      <ConstraintRegion from="455" to="463" loc="I" subId="17063897" subSource="8et8_A"/>
      <ConstraintRegion from="464" to="484" loc="H" subId="17063898" subSource="8et8_A"/>
      <ConstraintRegion from="485" to="493" loc="O" subId="17063899" subSource="8et8_A"/>
      <ConstraintRegion from="494" to="511" loc="H" subId="17063900" subSource="8et8_A"/>
      <ConstraintRegion from="512" to="533" loc="I" subId="17063901" subSource="8et8_A"/>
    </Constraint>
  </Constraints>
</HtpItem>
