<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A8Q3SI91_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Aquaporin 7B </Name>
  <CrossRef>
    <PDBTM id="8amw">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="F"/>
      <Chain id="B"/>
      <Chain id="E"/>
      <Chain id="G"/>
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="8c9h">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="E"/>
      <Chain id="F"/>
      <Chain id="G"/>
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="8amx">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="E"/>
      <Chain id="F"/>
      <Chain id="G"/>
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="6kxw">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="6n1g">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="B"/>
      <Chain id="D"/>
      <Chain id="E"/>
      <Chain id="F"/>
      <Chain id="G"/>
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="6qzi">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
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    <PDBTM id="6qzj">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="6f7h">
      <Chain id="B"/>
      <Chain id="D"/>
      <Chain id="C"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1fx8">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="1lda">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="E"/>
      <Chain id="F"/>
      <Chain id="G"/>
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="1ldi">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="1ldf">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="4oj2">
      <Chain id="X"/>
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6qf5">
      <Chain id="B"/>
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="8gcl">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="4nef">
      <Chain id="A"/>
      <Chain id="D"/>
      <Chain id="C"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8ghj">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8oee">
      <Chain id="A"/>
      <Chain id="D"/>
      <Chain id="C"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8jy6">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
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    <PDBTM id="8jy7">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="8jy8">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="2evu">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="2f2b">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="3ne2">
      <Chain id="C"/>
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="D"/>
      <Chain id="F"/>
      <Chain id="G"/>
      <Chain id="H"/>
      <Chain id="E"/>
    </PDBTM>
    <PDBTM id="2w1p">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="2w2e">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="3zoj">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="5bn2">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="3c02">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="8sjx">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="E"/>
      <Chain id="F"/>
      <Chain id="G"/>
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="8sjy">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="E"/>
      <Chain id="F"/>
      <Chain id="G"/>
      <Chain id="H"/>
    </PDBTM>
    <TOPDB id="AQP10_HUMAN">
      <Alignment>
        <CrossRefSeq>QNYTGGNLTVTGP--KETASIFATYPAPYL------SLNNGFLDQVLGTGMLIVGLLAILDRRNKGVPAGLEPVVVGMLILALGLSMGANCGIPLNPARDLGPRLFTYVAGWGPEVFSAGNGWWWVPVVAPLVGATVGTATYQLLVALHHPEGPEPAQDLVSAQHKASEL</CrossRefSeq>
        <OrigSeq>RRSTRGSKMVSWSVIAKIQEIWCEEDERKMVREFLAEFMSTYVMMEWLTRMLQLCLFTITDQENNPALPGTHALVISILVVIIRVSHGINTGYAINPSRDPPPSIFTFIAGWGKQVFSDGENWWWVPVVAPLLGASLGGIIYLVFIGSTIPREPLKLEDSVAYEDHGITV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="FPS1_YEAST">
      <Alignment>
        <CrossRefSeq>WWMNESVAGMFCVFPKPYL------SSGRQFFSEFLCGAMLQAGTFALTD-PYTCLSSDVFPLMMFILIFIINASMAYQTGTAMNLARDLGPRLALYAVGFDHKMLWVHHHHFFWVPMVGPFIGALMGGLVYDVCIYQGHESPVN</CrossRefSeq>
        <OrigSeq>WSVIAKIQEIWCEEDERKMVREFLAEFMSTYVMMEWLTRMLQLCLFTITDQENNPALPGTHALVISILVVIIRVSHGINTGYAINPSRDPPPSIFTFIAGWGKQ-VFSDGENWWWVPVVAPLLGASLGGIIYLVFI--GSTIPRE</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="219" CheckSum="27e09d02559ffbdf29957d9407728222">
    <Seq>
      MVQASGHRRS TRGSKMVSWS VIAKIQEIWC EEDERKMVRE FLAEFMSTYV
      MMEWLTRMLQ LCLFTITDQE NNPALPGTHA LVISILVVII RVSHGINTGY
      AINPSRDPPP SIFTFIAGWG KQVFSDGENW WWVPVVAPLL GASLGGIIYL
      VFIGSTIPRE PLKLEDSVAY EDHGITVLPK MGSHEPMISP LTLISVSLAN
      RSSVHSAPPL HESMALEHF
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="70.47">
    <Region from="1" to="79" loc="I"/>
    <Region from="80" to="101" loc="M"/>
    <Region from="102" to="131" loc="O"/>
    <Region from="132" to="152" loc="M"/>
    <Region from="153" to="219" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="14" loc="O"/>
      <Region from="15" to="33" loc="M"/>
      <Region from="34" to="47" loc="I"/>
      <Region from="48" to="67" loc="M"/>
      <Region from="68" to="80" loc="O"/>
      <Region from="81" to="102" loc="M"/>
      <Region from="103" to="111" loc="I"/>
      <Region from="112" to="124" loc="M"/>
      <Region from="125" to="134" loc="O"/>
      <Region from="135" to="153" loc="M"/>
      <Region from="154" to="219" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="41" loc="O"/>
      <Region from="42" to="67" loc="M"/>
      <Region from="68" to="78" loc="I"/>
      <Region from="79" to="95" loc="M"/>
      <Region from="96" to="98" loc="O"/>
      <Region from="99" to="116" loc="L"/>
      <Region from="117" to="131" loc="O"/>
      <Region from="132" to="153" loc="M"/>
      <Region from="154" to="219" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="42" loc="O"/>
      <Region from="43" to="63" loc="M"/>
      <Region from="64" to="75" loc="I"/>
      <Region from="76" to="96" loc="M"/>
      <Region from="97" to="108" loc="O"/>
      <Region from="109" to="118" loc="L"/>
      <Region from="119" to="131" loc="O"/>
      <Region from="132" to="152" loc="M"/>
      <Region from="153" to="219" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="74" loc="I"/>
      <Region from="75" to="95" loc="M"/>
      <Region from="96" to="130" loc="O"/>
      <Region from="131" to="153" loc="M"/>
      <Region from="154" to="219" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="79" loc="I"/>
      <Region from="80" to="102" loc="M"/>
      <Region from="103" to="129" loc="O"/>
      <Region from="130" to="153" loc="M"/>
      <Region from="154" to="219" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="9" loc="I"/>
      <Region from="10" to="30" loc="M"/>
      <Region from="31" to="45" loc="O"/>
      <Region from="46" to="66" loc="M"/>
      <Region from="67" to="75" loc="I"/>
      <Region from="76" to="96" loc="M"/>
      <Region from="97" to="132" loc="O"/>
      <Region from="133" to="153" loc="M"/>
      <Region from="154" to="219" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="9" loc="I"/>
      <Region from="10" to="30" loc="M"/>
      <Region from="31" to="46" loc="O"/>
      <Region from="47" to="67" loc="M"/>
      <Region from="68" to="81" loc="I"/>
      <Region from="82" to="102" loc="M"/>
      <Region from="103" to="132" loc="O"/>
      <Region from="133" to="153" loc="M"/>
      <Region from="154" to="219" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="44" loc="I"/>
      <Region from="45" to="65" loc="M"/>
      <Region from="66" to="79" loc="O"/>
      <Region from="80" to="100" loc="M"/>
      <Region from="101" to="129" loc="I"/>
      <Region from="130" to="150" loc="M"/>
      <Region from="151" to="219" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="79" loc="I"/>
      <Region from="80" to="102" loc="M"/>
      <Region from="103" to="130" loc="O"/>
      <Region from="131" to="153" loc="M"/>
      <Region from="154" to="219" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="AQPM_ARCFU">
      <ConstraintRegion from="1" to="9" loc="I" subId="17205390" subSource="3ne2_C"/>
      <ConstraintRegion from="10" to="26" loc="H" subId="17205391" subSource="3ne2_C"/>
      <ConstraintRegion from="27" to="56" loc="O" subId="17205392" subSource="3ne2_C"/>
      <ConstraintRegion from="57" to="75" loc="H" subId="17205394" subSource="3ne2_C"/>
      <ConstraintRegion from="76" to="80" loc="I" subId="17205396" subSource="3ne2_C"/>
      <ConstraintRegion from="81" to="92" loc="L" subId="17205398" subSource="3ne2_C"/>
      <ConstraintRegion from="93" to="101" loc="I" subId="17205400" subSource="3ne2_C"/>
      <ConstraintRegion from="102" to="119" loc="H" subId="17205402" subSource="3ne2_C"/>
      <ConstraintRegion from="120" to="145" loc="O" subId="17205404" subSource="3ne2_C"/>
      <ConstraintRegion from="146" to="165" loc="H" subId="17205406" subSource="3ne2_C"/>
      <ConstraintRegion from="166" to="175" loc="I" subId="17205407" subSource="3ne2_C"/>
      <ConstraintRegion from="176" to="192" loc="H" subId="17205408" subSource="3ne2_C"/>
      <ConstraintRegion from="193" to="195" loc="O" subId="17205409" subSource="3ne2_C"/>
      <ConstraintRegion from="196" to="210" loc="L" subId="17205410" subSource="3ne2_C"/>
      <ConstraintRegion from="211" to="222" loc="O" subId="17205412" subSource="3ne2_C"/>
      <ConstraintRegion from="223" to="240" loc="H" subId="17205414" subSource="3ne2_C"/>
      <ConstraintRegion from="241" to="246" loc="I" subId="17205416" subSource="3ne2_C"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="5bn2_A">
      <ConstraintRegion from="14" to="47" loc="I" subId="16995592" subSource="5bn2_A"/>
      <ConstraintRegion from="48" to="66" loc="H" subId="16995594" subSource="5bn2_A"/>
      <ConstraintRegion from="67" to="86" loc="O" subId="16995596" subSource="5bn2_A"/>
      <ConstraintRegion from="87" to="104" loc="H" subId="16995598" subSource="5bn2_A"/>
      <ConstraintRegion from="105" to="107" loc="I" subId="16995600" subSource="5bn2_A"/>
      <ConstraintRegion from="108" to="121" loc="L" subId="16995602" subSource="5bn2_A"/>
      <ConstraintRegion from="122" to="130" loc="I" subId="16995603" subSource="5bn2_A"/>
      <ConstraintRegion from="131" to="148" loc="H" subId="16995604" subSource="5bn2_A"/>
      <ConstraintRegion from="149" to="169" loc="O" subId="16995605" subSource="5bn2_A"/>
      <ConstraintRegion from="170" to="189" loc="H" subId="16995606" subSource="5bn2_A"/>
      <ConstraintRegion from="190" to="199" loc="I" subId="16995607" subSource="5bn2_A"/>
      <ConstraintRegion from="200" to="216" loc="H" subId="16995608" subSource="5bn2_A"/>
      <ConstraintRegion from="217" to="221" loc="O" subId="16995609" subSource="5bn2_A"/>
      <ConstraintRegion from="222" to="234" loc="L" subId="16995610" subSource="5bn2_A"/>
      <ConstraintRegion from="235" to="242" loc="O" subId="16995611" subSource="5bn2_A"/>
      <ConstraintRegion from="243" to="260" loc="H" subId="16995613" subSource="5bn2_A"/>
      <ConstraintRegion from="261" to="273" loc="I" subId="16995615" subSource="5bn2_A"/>
      <ConstraintRegion from="14" to="47" loc="I" subId="16995618" subSource="5bn2_B"/>
      <ConstraintRegion from="48" to="66" loc="H" subId="16995620" subSource="5bn2_B"/>
      <ConstraintRegion from="67" to="86" loc="O" subId="16995621" subSource="5bn2_B"/>
      <ConstraintRegion from="87" to="104" loc="H" subId="16995623" subSource="5bn2_B"/>
      <ConstraintRegion from="105" to="107" loc="I" subId="16995625" subSource="5bn2_B"/>
      <ConstraintRegion from="108" to="121" loc="L" subId="16995626" subSource="5bn2_B"/>
      <ConstraintRegion from="122" to="130" loc="I" subId="16995628" subSource="5bn2_B"/>
      <ConstraintRegion from="131" to="148" loc="H" subId="16995631" subSource="5bn2_B"/>
      <ConstraintRegion from="149" to="169" loc="O" subId="16995636" subSource="5bn2_B"/>
      <ConstraintRegion from="170" to="189" loc="H" subId="16995639" subSource="5bn2_B"/>
      <ConstraintRegion from="190" to="199" loc="I" subId="16995643" subSource="5bn2_B"/>
      <ConstraintRegion from="200" to="216" loc="H" subId="16995647" subSource="5bn2_B"/>
      <ConstraintRegion from="217" to="221" loc="O" subId="16995650" subSource="5bn2_B"/>
      <ConstraintRegion from="222" to="234" loc="L" subId="16995654" subSource="5bn2_B"/>
      <ConstraintRegion from="235" to="242" loc="O" subId="16995657" subSource="5bn2_B"/>
      <ConstraintRegion from="243" to="260" loc="H" subId="16995660" subSource="5bn2_B"/>
      <ConstraintRegion from="261" to="273" loc="I" subId="16995663" subSource="5bn2_B"/>
      <ConstraintRegion from="14" to="47" loc="I" subId="16995673" subSource="5bn2_C"/>
      <ConstraintRegion from="48" to="66" loc="H" subId="16995675" subSource="5bn2_C"/>
      <ConstraintRegion from="67" to="86" loc="O" subId="16995679" subSource="5bn2_C"/>
      <ConstraintRegion from="87" to="104" loc="H" subId="16995682" subSource="5bn2_C"/>
      <ConstraintRegion from="105" to="107" loc="I" subId="16995685" subSource="5bn2_C"/>
      <ConstraintRegion from="108" to="121" loc="L" subId="16995688" subSource="5bn2_C"/>
      <ConstraintRegion from="122" to="130" loc="I" subId="16995692" subSource="5bn2_C"/>
      <ConstraintRegion from="131" to="148" loc="H" subId="16995696" subSource="5bn2_C"/>
      <ConstraintRegion from="149" to="169" loc="O" subId="16995699" subSource="5bn2_C"/>
      <ConstraintRegion from="170" to="189" loc="H" subId="16995702" subSource="5bn2_C"/>
      <ConstraintRegion from="190" to="199" loc="I" subId="16995705" subSource="5bn2_C"/>
      <ConstraintRegion from="200" to="216" loc="H" subId="16995708" subSource="5bn2_C"/>
      <ConstraintRegion from="217" to="221" loc="O" subId="16995712" subSource="5bn2_C"/>
      <ConstraintRegion from="222" to="234" loc="L" subId="16995716" subSource="5bn2_C"/>
      <ConstraintRegion from="235" to="242" loc="O" subId="16995720" subSource="5bn2_C"/>
      <ConstraintRegion from="243" to="260" loc="H" subId="16995723" subSource="5bn2_C"/>
      <ConstraintRegion from="261" to="273" loc="I" subId="16995725" subSource="5bn2_C"/>
      <ConstraintRegion from="14" to="47" loc="I" subId="16995734" subSource="5bn2_D"/>
      <ConstraintRegion from="48" to="66" loc="H" subId="16995736" subSource="5bn2_D"/>
      <ConstraintRegion from="67" to="86" loc="O" subId="16995738" subSource="5bn2_D"/>
      <ConstraintRegion from="87" to="104" loc="H" subId="16995740" subSource="5bn2_D"/>
      <ConstraintRegion from="105" to="107" loc="I" subId="16995743" subSource="5bn2_D"/>
      <ConstraintRegion from="108" to="121" loc="L" subId="16995745" subSource="5bn2_D"/>
      <ConstraintRegion from="122" to="130" loc="I" subId="16995746" subSource="5bn2_D"/>
      <ConstraintRegion from="131" to="148" loc="H" subId="16995747" subSource="5bn2_D"/>
      <ConstraintRegion from="149" to="169" loc="O" subId="16995750" subSource="5bn2_D"/>
      <ConstraintRegion from="170" to="189" loc="H" subId="16995752" subSource="5bn2_D"/>
      <ConstraintRegion from="190" to="199" loc="I" subId="16995754" subSource="5bn2_D"/>
      <ConstraintRegion from="200" to="216" loc="H" subId="16995756" subSource="5bn2_D"/>
      <ConstraintRegion from="217" to="221" loc="O" subId="16995758" subSource="5bn2_D"/>
      <ConstraintRegion from="222" to="234" loc="L" subId="16995760" subSource="5bn2_D"/>
      <ConstraintRegion from="235" to="242" loc="O" subId="16995762" subSource="5bn2_D"/>
      <ConstraintRegion from="243" to="260" loc="H" subId="16995764" subSource="5bn2_D"/>
      <ConstraintRegion from="261" to="273" loc="I" subId="16995766" subSource="5bn2_D"/>
    </Constraint>
  </Constraints>
</HtpItem>
