<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="A0A8V8TNG8_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Protein transport protein Sec61 subunit alpha isoform 1 </Name>
  <CrossRef>
    <PDBTM id="2wwb">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8dnz">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8do1">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7kam">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8dny">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7kak">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7kan">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8dnx">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8do0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8do2">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8dnv">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4cg5">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4cg6">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4cg7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8do3">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7kal">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8dnw">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8b6l">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7kao">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7kar">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7kah">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7kat">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7kau">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7kaq">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7kai">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7kaj">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7kap">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6n3q">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7aft">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3jc2">
      <Chain id="1"/>
    </PDBTM>
    <PDBTM id="7kas">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7kb5">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5a6u">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6nd1">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7zl3">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bf9">
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6z3t">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6itc">
      <Chain id="Y"/>
    </PDBTM>
    <PDBTM id="3bo0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3bo1">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7xha">
      <Chain id="Y"/>
    </PDBTM>
    <PDBTM id="7xhb">
      <Chain id="Y"/>
    </PDBTM>
    <PDBTM id="1rhz">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5eul">
      <Chain id="Y"/>
    </PDBTM>
    <PDBTM id="3dkn">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1rh5">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2ww9">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2wwa">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2yxq">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2yxr">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5abb">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5mg3">
      <Chain id="Y"/>
    </PDBTM>
    <PDBTM id="3j46">
      <Chain id="y"/>
    </PDBTM>
    <PDBTM id="3j45">
      <Chain id="y"/>
    </PDBTM>
    <PDBTM id="3mp7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3dl8">
      <Chain id="G"/>
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="5gae">
      <Chain id="g"/>
    </PDBTM>
    <PDBTM id="3din">
      <Chain id="C"/>
      <Chain id="F"/>
    </PDBTM>
    <PDBTM id="6r7l">
      <Chain id="Y"/>
    </PDBTM>
    <PDBTM id="5aww">
      <Chain id="Y"/>
    </PDBTM>
    <PDBTM id="5ch4">
      <Chain id="Y"/>
    </PDBTM>
    <PDBTM id="2zjs">
      <Chain id="Y"/>
    </PDBTM>
    <PDBTM id="2zqp">
      <Chain id="Y"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2akh">
      <Chain id="Y"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="2aki">
      <Chain id="Y"/>
      <Chain id="B"/>
    </PDBTM>
    <TOPDB id="SC61A_YEAST">
      <Alignment>
        <CrossRefSeq>RVLDLFKPFESFLPEVIAPERKVPYNQKLIWTGVSLLIFLILGQIPLYGIVSSETSDPLYWLRAMLASNRGTLLELGVSPIITSSMIFQFLQGTQLLQIRPESKQDRELFQIAQKVCAIILILGQALVVVMTGNYGAPSDLGLPICLLLIFQLMFASLIVMLLDELLSKGYGLGSGISLFTATNIAEQIFWRAFAPTTVNSGRGKEFEGAVIAFFHLLAVRKDKKRALVEAFYRTN</CrossRefSeq>
        <OrigSeq>KFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVG-DTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKWSSISRCVQIQP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SSH1_YEAST">
      <Alignment>
        <CrossRefSeq>GFRLIDIVKPILPILPEVELPFEKLPFDDKIVYTIFAGLIYLF-AQFPLVGLPKATTPNVNDPIYFLRGVFGCEPRTLLEFGLFPNISSGLILQLLAGLKVIKVNFKIQSDRELFQSLTKVFAIVQYVILTNIFIFAGYFGD--DLSVVQIGLINFQLVGAGIFTTLLAEVIDKGFGFSSGAMIINTVVIATNLVADTFGVSQIKVGEDDQTEAQGALINLIQGLRSKHKTFIGGIISAFNR</CrossRefSeq>
        <OrigSeq>AIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGI---MSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVG-DTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRG--MEFEGAIIALFHLLATRTDKW-SSISRCVQI</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SECY_ECO57">
      <Alignment>
        <CrossRefSeq>ELKRRLLFVIGALIVFRIGSFIPIPGIDAAVLAKLLEQQRGTIIEMFNMFSGGALSRASIFALGIMPYISASIIIQLLTVVHPTLAEIKKEGESGRRKISQYTRYGTLVLAIFQSIGIATGLPNMPGMQGLVINPGFAFYFTAVVSLVTGTMFLMWLGEQITERG-IGNGISIIIFAGIVAGLP</CrossRefSeq>
        <OrigSeq>QFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPF----------YWMRVILASNRGTLMELGISPIVTSGLIMQLLA---GAKIIEVGDTPKDRALFNGAQKLFGMIITIGQSIVYVMT-----GMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIV</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="246" CheckSum="a6499a6f629850b80e5c634995cbf20a">
    <Seq>
      MAIKFLEVIK PFCVILPEIQ KPERKIQFKE KVLWTAITLF IFLVCCQIPL
      FGIMSSDSAD PFYWMRVILA SNRGTLMELG ISPIVTSGLI MQLLAGAKII
      EVGDTPKDRA LFNGAQKLFG MIITIGQSIV YVMTGMYGDP SEMGAGICLL
      ITIQLFVAGL IVLLLDELLQ KGYGLGSGIS LFIATNICET IVWKAFSPTT
      VNTGRGMEFE GAIIALFHLL ATRTDKWSSI SRCVQIQPQG VSMVWI
    </Seq>
  </Sequence>
  <Topology numTm="5" reliability="84.56">
    <Region from="1" to="31" loc="I"/>
    <Region from="32" to="46" loc="M"/>
    <Region from="47" to="74" loc="O"/>
    <Region from="75" to="90" loc="M"/>
    <Region from="91" to="117" loc="I"/>
    <Region from="118" to="130" loc="M"/>
    <Region from="131" to="149" loc="O"/>
    <Region from="150" to="165" loc="M"/>
    <Region from="166" to="177" loc="I"/>
    <Region from="178" to="192" loc="M"/>
    <Region from="193" to="246" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="31" loc="I"/>
      <Region from="32" to="54" loc="M"/>
      <Region from="55" to="75" loc="O"/>
      <Region from="76" to="97" loc="M"/>
      <Region from="98" to="117" loc="I"/>
      <Region from="118" to="135" loc="M"/>
      <Region from="136" to="144" loc="O"/>
      <Region from="145" to="165" loc="M"/>
      <Region from="166" to="171" loc="I"/>
      <Region from="172" to="192" loc="M"/>
      <Region from="193" to="208" loc="O"/>
      <Region from="209" to="222" loc="M"/>
      <Region from="223" to="246" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="35" loc="I"/>
      <Region from="36" to="51" loc="M"/>
      <Region from="52" to="78" loc="O"/>
      <Region from="79" to="94" loc="M"/>
      <Region from="95" to="115" loc="I"/>
      <Region from="116" to="134" loc="M"/>
      <Region from="135" to="144" loc="O"/>
      <Region from="145" to="168" loc="M"/>
      <Region from="169" to="177" loc="I"/>
      <Region from="178" to="193" loc="M"/>
      <Region from="194" to="246" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="31" loc="I"/>
      <Region from="32" to="52" loc="M"/>
      <Region from="53" to="73" loc="O"/>
      <Region from="74" to="94" loc="M"/>
      <Region from="95" to="114" loc="I"/>
      <Region from="115" to="135" loc="M"/>
      <Region from="136" to="144" loc="O"/>
      <Region from="145" to="165" loc="M"/>
      <Region from="166" to="172" loc="I"/>
      <Region from="173" to="193" loc="M"/>
      <Region from="194" to="204" loc="O"/>
      <Region from="205" to="225" loc="M"/>
      <Region from="226" to="246" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="31" loc="I"/>
      <Region from="32" to="54" loc="M"/>
      <Region from="55" to="74" loc="O"/>
      <Region from="75" to="97" loc="M"/>
      <Region from="98" to="114" loc="I"/>
      <Region from="115" to="135" loc="M"/>
      <Region from="136" to="142" loc="O"/>
      <Region from="143" to="165" loc="M"/>
      <Region from="166" to="172" loc="I"/>
      <Region from="173" to="193" loc="M"/>
      <Region from="194" to="205" loc="O"/>
      <Region from="206" to="222" loc="M"/>
      <Region from="223" to="246" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="31" loc="I"/>
      <Region from="32" to="54" loc="M"/>
      <Region from="55" to="73" loc="O"/>
      <Region from="74" to="97" loc="M"/>
      <Region from="98" to="117" loc="I"/>
      <Region from="118" to="137" loc="M"/>
      <Region from="138" to="142" loc="O"/>
      <Region from="143" to="165" loc="M"/>
      <Region from="166" to="246" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="35" loc="I"/>
      <Region from="36" to="56" loc="M"/>
      <Region from="57" to="76" loc="O"/>
      <Region from="77" to="97" loc="M"/>
      <Region from="98" to="117" loc="I"/>
      <Region from="118" to="138" loc="M"/>
      <Region from="139" to="142" loc="O"/>
      <Region from="143" to="163" loc="M"/>
      <Region from="164" to="172" loc="I"/>
      <Region from="173" to="193" loc="M"/>
      <Region from="194" to="246" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="32" loc="I"/>
      <Region from="33" to="53" loc="M"/>
      <Region from="54" to="73" loc="O"/>
      <Region from="74" to="94" loc="M"/>
      <Region from="95" to="117" loc="I"/>
      <Region from="118" to="138" loc="M"/>
      <Region from="139" to="142" loc="O"/>
      <Region from="143" to="163" loc="M"/>
      <Region from="164" to="172" loc="I"/>
      <Region from="173" to="193" loc="M"/>
      <Region from="194" to="201" loc="O"/>
      <Region from="202" to="222" loc="M"/>
      <Region from="223" to="246" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="32" loc="I"/>
      <Region from="33" to="53" loc="M"/>
      <Region from="54" to="74" loc="O"/>
      <Region from="75" to="94" loc="M"/>
      <Region from="95" to="117" loc="I"/>
      <Region from="118" to="137" loc="M"/>
      <Region from="138" to="144" loc="O"/>
      <Region from="145" to="165" loc="M"/>
      <Region from="166" to="246" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="31" loc="I"/>
      <Region from="32" to="52" loc="M"/>
      <Region from="53" to="74" loc="O"/>
      <Region from="75" to="95" loc="M"/>
      <Region from="96" to="117" loc="I"/>
      <Region from="118" to="138" loc="M"/>
      <Region from="139" to="144" loc="O"/>
      <Region from="145" to="165" loc="M"/>
      <Region from="166" to="246" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="32" loc="I"/>
      <Region from="33" to="55" loc="M"/>
      <Region from="56" to="74" loc="O"/>
      <Region from="75" to="97" loc="M"/>
      <Region from="98" to="117" loc="I"/>
      <Region from="118" to="138" loc="M"/>
      <Region from="139" to="142" loc="O"/>
      <Region from="143" to="165" loc="M"/>
      <Region from="166" to="246" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="SSH1_YEAST">
      <ConstraintRegion from="1" to="34" loc="I" subId="22886099" subSource="2ww9_A"/>
      <ConstraintRegion from="35" to="50" loc="H" subId="22886100" subSource="2ww9_A"/>
      <ConstraintRegion from="51" to="65" loc="O" subId="22886101" subSource="2ww9_A"/>
      <ConstraintRegion from="66" to="76" loc="L" subId="22886102" subSource="2ww9_A"/>
      <ConstraintRegion from="77" to="90" loc="H" subId="22886103" subSource="2ww9_A"/>
      <ConstraintRegion from="91" to="123" loc="I" subId="22886104" subSource="2ww9_A"/>
      <ConstraintRegion from="124" to="138" loc="H" subId="22886105" subSource="2ww9_A"/>
      <ConstraintRegion from="139" to="150" loc="O" subId="22886106" subSource="2ww9_A"/>
      <ConstraintRegion from="151" to="168" loc="H" subId="22886107" subSource="2ww9_A"/>
      <ConstraintRegion from="169" to="180" loc="I" subId="22886108" subSource="2ww9_A"/>
      <ConstraintRegion from="181" to="195" loc="H" subId="22886109" subSource="2ww9_A"/>
      <ConstraintRegion from="196" to="250" loc="O" subId="22886110" subSource="2ww9_A"/>
      <ConstraintRegion from="251" to="264" loc="H" subId="22886111" subSource="2ww9_A"/>
      <ConstraintRegion from="265" to="296" loc="I" subId="22886112" subSource="2ww9_A"/>
      <ConstraintRegion from="297" to="317" loc="H" subId="22886113" subSource="2ww9_A"/>
      <ConstraintRegion from="318" to="364" loc="O" subId="22886114" subSource="2ww9_A"/>
      <ConstraintRegion from="365" to="378" loc="H" subId="22886115" subSource="2ww9_A"/>
      <ConstraintRegion from="379" to="432" loc="I" subId="22886116" subSource="2ww9_A"/>
      <ConstraintRegion from="433" to="447" loc="H" subId="22886117" subSource="2ww9_A"/>
      <ConstraintRegion from="449" to="460" loc="H" subId="22886118" subSource="2ww9_A"/>
      <ConstraintRegion from="461" to="490" loc="I" subId="22886119" subSource="2ww9_A"/>
      <ConstraintRegion from="1" to="34" loc="I" subId="22886146" subSource="2wwa_A"/>
      <ConstraintRegion from="35" to="48" loc="H" subId="22886147" subSource="2wwa_A"/>
      <ConstraintRegion from="49" to="66" loc="O" subId="22886148" subSource="2wwa_A"/>
      <ConstraintRegion from="67" to="76" loc="L" subId="22886149" subSource="2wwa_A"/>
      <ConstraintRegion from="77" to="78" loc="O" subId="22886150" subSource="2wwa_A"/>
      <ConstraintRegion from="79" to="97" loc="H" subId="22886151" subSource="2wwa_A"/>
      <ConstraintRegion from="98" to="120" loc="I" subId="22886152" subSource="2wwa_A"/>
      <ConstraintRegion from="121" to="135" loc="H" subId="22886153" subSource="2wwa_A"/>
      <ConstraintRegion from="136" to="152" loc="O" subId="22886154" subSource="2wwa_A"/>
      <ConstraintRegion from="153" to="170" loc="H" subId="22886155" subSource="2wwa_A"/>
      <ConstraintRegion from="171" to="179" loc="I" subId="22886156" subSource="2wwa_A"/>
      <ConstraintRegion from="180" to="198" loc="H" subId="22886157" subSource="2wwa_A"/>
      <ConstraintRegion from="199" to="249" loc="O" subId="22886158" subSource="2wwa_A"/>
      <ConstraintRegion from="250" to="264" loc="H" subId="22886159" subSource="2wwa_A"/>
      <ConstraintRegion from="265" to="292" loc="I" subId="22886160" subSource="2wwa_A"/>
      <ConstraintRegion from="293" to="314" loc="H" subId="22886161" subSource="2wwa_A"/>
      <ConstraintRegion from="315" to="364" loc="O" subId="22886162" subSource="2wwa_A"/>
      <ConstraintRegion from="365" to="381" loc="H" subId="22886163" subSource="2wwa_A"/>
      <ConstraintRegion from="382" to="431" loc="I" subId="22886164" subSource="2wwa_A"/>
      <ConstraintRegion from="432" to="447" loc="H" subId="22886165" subSource="2wwa_A"/>
      <ConstraintRegion from="449" to="461" loc="H" subId="22886166" subSource="2wwa_A"/>
      <ConstraintRegion from="462" to="490" loc="I" subId="22886167" subSource="2wwa_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="SECY_ECO57">
      <ConstraintRegion from="1" to="22" loc="I" subId="16964902" subSource="5abb_A"/>
      <ConstraintRegion from="23" to="36" loc="H" subId="16964903" subSource="5abb_A"/>
      <ConstraintRegion from="37" to="76" loc="O" subId="16964904" subSource="5abb_A"/>
      <ConstraintRegion from="77" to="95" loc="H" subId="16964905" subSource="5abb_A"/>
      <ConstraintRegion from="96" to="118" loc="I" subId="16964906" subSource="5abb_A"/>
      <ConstraintRegion from="119" to="132" loc="H" subId="16964907" subSource="5abb_A"/>
      <ConstraintRegion from="133" to="163" loc="O" subId="16964908" subSource="5abb_A"/>
      <ConstraintRegion from="164" to="178" loc="H" subId="16964909" subSource="5abb_A"/>
      <ConstraintRegion from="179" to="184" loc="I" subId="16964910" subSource="5abb_A"/>
      <ConstraintRegion from="185" to="200" loc="H" subId="16964911" subSource="5abb_A"/>
      <ConstraintRegion from="201" to="220" loc="O" subId="16964912" subSource="5abb_A"/>
      <ConstraintRegion from="221" to="234" loc="H" subId="16964913" subSource="5abb_A"/>
      <ConstraintRegion from="235" to="272" loc="I" subId="16964914" subSource="5abb_A"/>
      <ConstraintRegion from="273" to="287" loc="H" subId="16964915" subSource="5abb_A"/>
      <ConstraintRegion from="288" to="317" loc="O" subId="16964916" subSource="5abb_A"/>
      <ConstraintRegion from="318" to="330" loc="H" subId="16964917" subSource="5abb_A"/>
      <ConstraintRegion from="331" to="376" loc="I" subId="16964918" subSource="5abb_A"/>
      <ConstraintRegion from="377" to="391" loc="H" subId="16964919" subSource="5abb_A"/>
      <ConstraintRegion from="392" to="399" loc="O" subId="16964920" subSource="5abb_A"/>
      <ConstraintRegion from="400" to="414" loc="H" subId="16964921" subSource="5abb_A"/>
      <ConstraintRegion from="415" to="443" loc="I" subId="16964922" subSource="5abb_A"/>
      <ConstraintRegion from="1" to="28" loc="I" subId="17188244" subSource="5mg3_Y"/>
      <ConstraintRegion from="29" to="42" loc="H" subId="17188246" subSource="5mg3_Y"/>
      <ConstraintRegion from="43" to="59" loc="O" subId="17188248" subSource="5mg3_Y"/>
      <ConstraintRegion from="60" to="74" loc="L" subId="17188250" subSource="5mg3_Y"/>
      <ConstraintRegion from="75" to="75" loc="O" subId="17188252" subSource="5mg3_Y"/>
      <ConstraintRegion from="76" to="91" loc="H" subId="17188254" subSource="5mg3_Y"/>
      <ConstraintRegion from="92" to="121" loc="I" subId="17188256" subSource="5mg3_Y"/>
      <ConstraintRegion from="122" to="139" loc="H" subId="17188258" subSource="5mg3_Y"/>
      <ConstraintRegion from="140" to="157" loc="O" subId="17188259" subSource="5mg3_Y"/>
      <ConstraintRegion from="158" to="174" loc="H" subId="17188261" subSource="5mg3_Y"/>
      <ConstraintRegion from="175" to="190" loc="I" subId="17188263" subSource="5mg3_Y"/>
      <ConstraintRegion from="191" to="212" loc="H" subId="17188265" subSource="5mg3_Y"/>
      <ConstraintRegion from="213" to="218" loc="O" subId="17188267" subSource="5mg3_Y"/>
      <ConstraintRegion from="219" to="234" loc="H" subId="17188268" subSource="5mg3_Y"/>
      <ConstraintRegion from="235" to="281" loc="I" subId="17188269" subSource="5mg3_Y"/>
      <ConstraintRegion from="282" to="296" loc="H" subId="17188270" subSource="5mg3_Y"/>
      <ConstraintRegion from="297" to="301" loc="O" subId="17188271" subSource="5mg3_Y"/>
      <ConstraintRegion from="302" to="321" loc="H" subId="17188272" subSource="5mg3_Y"/>
      <ConstraintRegion from="322" to="389" loc="I" subId="17188273" subSource="5mg3_Y"/>
      <ConstraintRegion from="390" to="407" loc="L" subId="17188274" subSource="5mg3_Y"/>
      <ConstraintRegion from="408" to="443" loc="I" subId="17188275" subSource="5mg3_Y"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="S61A1_CANLF">
      <ConstraintRegion from="1" to="37" loc="I" subId="22886194" subSource="2wwb_A"/>
      <ConstraintRegion from="38" to="50" loc="H" subId="22886195" subSource="2wwb_A"/>
      <ConstraintRegion from="51" to="63" loc="O" subId="22886196" subSource="2wwb_A"/>
      <ConstraintRegion from="64" to="76" loc="L" subId="22886197" subSource="2wwb_A"/>
      <ConstraintRegion from="78" to="91" loc="H" subId="22886198" subSource="2wwb_A"/>
      <ConstraintRegion from="92" to="118" loc="I" subId="22886199" subSource="2wwb_A"/>
      <ConstraintRegion from="119" to="131" loc="H" subId="22886200" subSource="2wwb_A"/>
      <ConstraintRegion from="132" to="151" loc="O" subId="22886201" subSource="2wwb_A"/>
      <ConstraintRegion from="152" to="164" loc="H" subId="22886202" subSource="2wwb_A"/>
      <ConstraintRegion from="165" to="178" loc="I" subId="22886203" subSource="2wwb_A"/>
      <ConstraintRegion from="179" to="196" loc="H" subId="22886204" subSource="2wwb_A"/>
      <ConstraintRegion from="197" to="242" loc="O" subId="22886205" subSource="2wwb_A"/>
      <ConstraintRegion from="243" to="255" loc="H" subId="22886206" subSource="2wwb_A"/>
      <ConstraintRegion from="256" to="290" loc="I" subId="22886207" subSource="2wwb_A"/>
      <ConstraintRegion from="291" to="305" loc="H" subId="22886208" subSource="2wwb_A"/>
      <ConstraintRegion from="306" to="360" loc="O" subId="22886209" subSource="2wwb_A"/>
      <ConstraintRegion from="361" to="375" loc="H" subId="22886210" subSource="2wwb_A"/>
      <ConstraintRegion from="376" to="425" loc="I" subId="22886211" subSource="2wwb_A"/>
      <ConstraintRegion from="426" to="439" loc="H" subId="22886212" subSource="2wwb_A"/>
      <ConstraintRegion from="441" to="454" loc="H" subId="22886213" subSource="2wwb_A"/>
      <ConstraintRegion from="455" to="476" loc="I" subId="22886214" subSource="2wwb_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="7kam_A">
      <ConstraintRegion from="9" to="34" loc="I" subId="17150611" subSource="7kam_A"/>
      <ConstraintRegion from="35" to="51" loc="H" subId="17150614" subSource="7kam_A"/>
      <ConstraintRegion from="52" to="62" loc="O" subId="17150617" subSource="7kam_A"/>
      <ConstraintRegion from="63" to="75" loc="L" subId="17150620" subSource="7kam_A"/>
      <ConstraintRegion from="76" to="76" loc="O" subId="17150624" subSource="7kam_A"/>
      <ConstraintRegion from="77" to="95" loc="H" subId="17150628" subSource="7kam_A"/>
      <ConstraintRegion from="96" to="117" loc="I" subId="17150633" subSource="7kam_A"/>
      <ConstraintRegion from="118" to="134" loc="H" subId="17150637" subSource="7kam_A"/>
      <ConstraintRegion from="135" to="151" loc="O" subId="17150640" subSource="7kam_A"/>
      <ConstraintRegion from="152" to="171" loc="H" subId="17150642" subSource="7kam_A"/>
      <ConstraintRegion from="172" to="179" loc="I" subId="17150644" subSource="7kam_A"/>
      <ConstraintRegion from="180" to="199" loc="H" subId="17150647" subSource="7kam_A"/>
      <ConstraintRegion from="200" to="242" loc="O" subId="17150651" subSource="7kam_A"/>
      <ConstraintRegion from="243" to="261" loc="H" subId="17150654" subSource="7kam_A"/>
      <ConstraintRegion from="262" to="289" loc="I" subId="17150657" subSource="7kam_A"/>
      <ConstraintRegion from="290" to="309" loc="H" subId="17150659" subSource="7kam_A"/>
      <ConstraintRegion from="310" to="317" loc="O" subId="17150662" subSource="7kam_A"/>
      <ConstraintRegion from="318" to="323" loc="F" subId="17150665" subSource="7kam_A"/>
      <ConstraintRegion from="324" to="328" loc="O" subId="17150667" subSource="7kam_A"/>
      <ConstraintRegion from="335" to="358" loc="O" subId="17150670" subSource="7kam_A"/>
      <ConstraintRegion from="359" to="376" loc="H" subId="17150673" subSource="7kam_A"/>
      <ConstraintRegion from="377" to="423" loc="I" subId="17150676" subSource="7kam_A"/>
      <ConstraintRegion from="424" to="440" loc="H" subId="17150679" subSource="7kam_A"/>
      <ConstraintRegion from="441" to="441" loc="O" subId="17150682" subSource="7kam_A"/>
      <ConstraintRegion from="442" to="455" loc="H" subId="17150684" subSource="7kam_A"/>
      <ConstraintRegion from="456" to="466" loc="I" subId="17150686" subSource="7kam_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="7kak_A">
      <ConstraintRegion from="9" to="37" loc="I" subId="17150192" subSource="7kak_A"/>
      <ConstraintRegion from="38" to="52" loc="H" subId="17150195" subSource="7kak_A"/>
      <ConstraintRegion from="53" to="76" loc="O" subId="17150198" subSource="7kak_A"/>
      <ConstraintRegion from="77" to="92" loc="H" subId="17150201" subSource="7kak_A"/>
      <ConstraintRegion from="93" to="99" loc="I" subId="17150203" subSource="7kak_A"/>
      <ConstraintRegion from="106" to="117" loc="I" subId="17150204" subSource="7kak_A"/>
      <ConstraintRegion from="118" to="134" loc="H" subId="17150205" subSource="7kak_A"/>
      <ConstraintRegion from="135" to="151" loc="O" subId="17150208" subSource="7kak_A"/>
      <ConstraintRegion from="152" to="168" loc="H" subId="17150212" subSource="7kak_A"/>
      <ConstraintRegion from="169" to="180" loc="I" subId="17150215" subSource="7kak_A"/>
      <ConstraintRegion from="181" to="200" loc="H" subId="17150218" subSource="7kak_A"/>
      <ConstraintRegion from="201" to="227" loc="O" subId="17150221" subSource="7kak_A"/>
      <ConstraintRegion from="228" to="235" loc="F" subId="17150224" subSource="7kak_A"/>
      <ConstraintRegion from="236" to="242" loc="O" subId="17150227" subSource="7kak_A"/>
      <ConstraintRegion from="243" to="258" loc="H" subId="17150230" subSource="7kak_A"/>
      <ConstraintRegion from="259" to="290" loc="I" subId="17150235" subSource="7kak_A"/>
      <ConstraintRegion from="291" to="307" loc="H" subId="17150242" subSource="7kak_A"/>
      <ConstraintRegion from="308" to="317" loc="O" subId="17150245" subSource="7kak_A"/>
      <ConstraintRegion from="318" to="323" loc="F" subId="17150248" subSource="7kak_A"/>
      <ConstraintRegion from="324" to="328" loc="O" subId="17150253" subSource="7kak_A"/>
      <ConstraintRegion from="335" to="358" loc="O" subId="17150258" subSource="7kak_A"/>
      <ConstraintRegion from="359" to="376" loc="H" subId="17150263" subSource="7kak_A"/>
      <ConstraintRegion from="377" to="425" loc="I" subId="17150268" subSource="7kak_A"/>
      <ConstraintRegion from="426" to="438" loc="H" subId="17150273" subSource="7kak_A"/>
      <ConstraintRegion from="439" to="439" loc="O" subId="17150278" subSource="7kak_A"/>
      <ConstraintRegion from="440" to="454" loc="H" subId="17150283" subSource="7kak_A"/>
      <ConstraintRegion from="455" to="466" loc="I" subId="17150287" subSource="7kak_A"/>
      <ConstraintRegion from="9" to="36" loc="I" subId="17150736" subSource="7kan_A"/>
      <ConstraintRegion from="37" to="53" loc="H" subId="17150737" subSource="7kan_A"/>
      <ConstraintRegion from="54" to="76" loc="O" subId="17150738" subSource="7kan_A"/>
      <ConstraintRegion from="77" to="91" loc="H" subId="17150739" subSource="7kan_A"/>
      <ConstraintRegion from="92" to="99" loc="I" subId="17150740" subSource="7kan_A"/>
      <ConstraintRegion from="106" to="119" loc="I" subId="17150741" subSource="7kan_A"/>
      <ConstraintRegion from="120" to="136" loc="H" subId="17150742" subSource="7kan_A"/>
      <ConstraintRegion from="137" to="148" loc="O" subId="17150743" subSource="7kan_A"/>
      <ConstraintRegion from="149" to="168" loc="H" subId="17150744" subSource="7kan_A"/>
      <ConstraintRegion from="169" to="180" loc="I" subId="17150745" subSource="7kan_A"/>
      <ConstraintRegion from="181" to="199" loc="H" subId="17150746" subSource="7kan_A"/>
      <ConstraintRegion from="200" to="227" loc="O" subId="17150747" subSource="7kan_A"/>
      <ConstraintRegion from="228" to="235" loc="F" subId="17150748" subSource="7kan_A"/>
      <ConstraintRegion from="236" to="242" loc="O" subId="17150749" subSource="7kan_A"/>
      <ConstraintRegion from="243" to="261" loc="H" subId="17150750" subSource="7kan_A"/>
      <ConstraintRegion from="262" to="289" loc="I" subId="17150751" subSource="7kan_A"/>
      <ConstraintRegion from="290" to="310" loc="H" subId="17150752" subSource="7kan_A"/>
      <ConstraintRegion from="311" to="317" loc="O" subId="17150753" subSource="7kan_A"/>
      <ConstraintRegion from="318" to="323" loc="F" subId="17150754" subSource="7kan_A"/>
      <ConstraintRegion from="324" to="328" loc="O" subId="17150755" subSource="7kan_A"/>
      <ConstraintRegion from="335" to="358" loc="O" subId="17150756" subSource="7kan_A"/>
      <ConstraintRegion from="359" to="378" loc="H" subId="17150757" subSource="7kan_A"/>
      <ConstraintRegion from="379" to="422" loc="I" subId="17150758" subSource="7kan_A"/>
      <ConstraintRegion from="423" to="439" loc="H" subId="17150759" subSource="7kan_A"/>
      <ConstraintRegion from="440" to="440" loc="O" subId="17150760" subSource="7kan_A"/>
      <ConstraintRegion from="441" to="455" loc="H" subId="17150761" subSource="7kan_A"/>
      <ConstraintRegion from="456" to="466" loc="I" subId="17150762" subSource="7kan_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="7kal_A">
      <ConstraintRegion from="9" to="33" loc="I" subId="17150398" subSource="7kal_A"/>
      <ConstraintRegion from="34" to="51" loc="H" subId="17150400" subSource="7kal_A"/>
      <ConstraintRegion from="52" to="58" loc="O" subId="17150402" subSource="7kal_A"/>
      <ConstraintRegion from="71" to="75" loc="O" subId="17150404" subSource="7kal_A"/>
      <ConstraintRegion from="76" to="95" loc="H" subId="17150406" subSource="7kal_A"/>
      <ConstraintRegion from="96" to="99" loc="I" subId="17150408" subSource="7kal_A"/>
      <ConstraintRegion from="103" to="117" loc="I" subId="17150410" subSource="7kal_A"/>
      <ConstraintRegion from="118" to="134" loc="H" subId="17150412" subSource="7kal_A"/>
      <ConstraintRegion from="135" to="151" loc="O" subId="17150414" subSource="7kal_A"/>
      <ConstraintRegion from="152" to="171" loc="H" subId="17150416" subSource="7kal_A"/>
      <ConstraintRegion from="172" to="178" loc="I" subId="17150418" subSource="7kal_A"/>
      <ConstraintRegion from="179" to="198" loc="H" subId="17150419" subSource="7kal_A"/>
      <ConstraintRegion from="199" to="227" loc="O" subId="17150420" subSource="7kal_A"/>
      <ConstraintRegion from="228" to="236" loc="F" subId="17150421" subSource="7kal_A"/>
      <ConstraintRegion from="237" to="244" loc="O" subId="17150422" subSource="7kal_A"/>
      <ConstraintRegion from="245" to="261" loc="H" subId="17150423" subSource="7kal_A"/>
      <ConstraintRegion from="262" to="288" loc="I" subId="17150424" subSource="7kal_A"/>
      <ConstraintRegion from="289" to="307" loc="H" subId="17150425" subSource="7kal_A"/>
      <ConstraintRegion from="308" to="328" loc="O" subId="17150426" subSource="7kal_A"/>
      <ConstraintRegion from="335" to="359" loc="O" subId="17150427" subSource="7kal_A"/>
      <ConstraintRegion from="360" to="379" loc="H" subId="17150428" subSource="7kal_A"/>
      <ConstraintRegion from="380" to="422" loc="I" subId="17150429" subSource="7kal_A"/>
      <ConstraintRegion from="423" to="439" loc="H" subId="17150430" subSource="7kal_A"/>
      <ConstraintRegion from="440" to="440" loc="O" subId="17150431" subSource="7kal_A"/>
      <ConstraintRegion from="441" to="457" loc="H" subId="17150432" subSource="7kal_A"/>
      <ConstraintRegion from="458" to="466" loc="I" subId="17150433" subSource="7kal_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="8bf9_C">
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      <ConstraintRegion from="31" to="43" loc="H" subId="19158261" subSource="8bf9_C"/>
      <ConstraintRegion from="44" to="46" loc="O" subId="19158262" subSource="8bf9_C"/>
      <ConstraintRegion from="62" to="73" loc="O" subId="19158264" subSource="8bf9_C"/>
      <ConstraintRegion from="75" to="77" loc="O" subId="19158265" subSource="8bf9_C"/>
      <ConstraintRegion from="78" to="90" loc="H" subId="19158266" subSource="8bf9_C"/>
      <ConstraintRegion from="91" to="96" loc="I" subId="19158267" subSource="8bf9_C"/>
      <ConstraintRegion from="106" to="114" loc="I" subId="19158269" subSource="8bf9_C"/>
      <ConstraintRegion from="115" to="127" loc="H" subId="19158270" subSource="8bf9_C"/>
      <ConstraintRegion from="128" to="135" loc="O" subId="19158271" subSource="8bf9_C"/>
      <ConstraintRegion from="148" to="159" loc="O" subId="19158273" subSource="8bf9_C"/>
      <ConstraintRegion from="160" to="171" loc="H" subId="19158274" subSource="8bf9_C"/>
      <ConstraintRegion from="172" to="176" loc="I" subId="19158275" subSource="8bf9_C"/>
      <ConstraintRegion from="177" to="193" loc="H" subId="19158276" subSource="8bf9_C"/>
      <ConstraintRegion from="194" to="221" loc="O" subId="19158277" subSource="8bf9_C"/>
      <ConstraintRegion from="230" to="245" loc="O" subId="19158279" subSource="8bf9_C"/>
      <ConstraintRegion from="246" to="257" loc="H" subId="19158280" subSource="8bf9_C"/>
      <ConstraintRegion from="258" to="289" loc="I" subId="19158281" subSource="8bf9_C"/>
      <ConstraintRegion from="290" to="306" loc="H" subId="19158282" subSource="8bf9_C"/>
      <ConstraintRegion from="307" to="310" loc="O" subId="19158283" subSource="8bf9_C"/>
      <ConstraintRegion from="338" to="359" loc="O" subId="19158285" subSource="8bf9_C"/>
      <ConstraintRegion from="360" to="376" loc="H" subId="19158286" subSource="8bf9_C"/>
      <ConstraintRegion from="377" to="426" loc="I" subId="19158287" subSource="8bf9_C"/>
      <ConstraintRegion from="427" to="442" loc="H" subId="19158288" subSource="8bf9_C"/>
      <ConstraintRegion from="444" to="456" loc="H" subId="19158289" subSource="8bf9_C"/>
      <ConstraintRegion from="457" to="467" loc="I" subId="19158290" subSource="8bf9_C"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6itc_Y">
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      <ConstraintRegion from="395" to="409" loc="H" subId="17124180" subSource="6itc_Y"/>
      <ConstraintRegion from="410" to="430" loc="I" subId="17124181" subSource="6itc_Y"/>
      <ConstraintRegion from="196" to="202" loc="O" subId="19156507" subSource="6itc_Y"/>
      <ConstraintRegion from="212" to="215" loc="O" subId="19156509" subSource="6itc_Y"/>
      <ConstraintRegion from="387" to="394" loc="O" subId="19156517" subSource="6itc_Y"/>
      <ConstraintRegion from="20" to="38" loc="H" subId="19158098" subSource="6itc_Y"/>
      <ConstraintRegion from="39" to="57" loc="O" subId="19158099" subSource="6itc_Y"/>
      <ConstraintRegion from="58" to="83" loc="H" subId="19158100" subSource="6itc_Y"/>
      <ConstraintRegion from="84" to="114" loc="I" subId="19158101" subSource="6itc_Y"/>
      <ConstraintRegion from="115" to="132" loc="H" subId="19158102" subSource="6itc_Y"/>
      <ConstraintRegion from="133" to="146" loc="O" subId="19158103" subSource="6itc_Y"/>
      <ConstraintRegion from="147" to="167" loc="H" subId="19158104" subSource="6itc_Y"/>
      <ConstraintRegion from="168" to="178" loc="I" subId="19158105" subSource="6itc_Y"/>
      <ConstraintRegion from="179" to="195" loc="H" subId="19158106" subSource="6itc_Y"/>
      <ConstraintRegion from="216" to="234" loc="H" subId="19158107" subSource="6itc_Y"/>
      <ConstraintRegion from="235" to="270" loc="I" subId="19158108" subSource="6itc_Y"/>
      <ConstraintRegion from="271" to="288" loc="H" subId="19158109" subSource="6itc_Y"/>
      <ConstraintRegion from="289" to="303" loc="O" subId="19158110" subSource="6itc_Y"/>
      <ConstraintRegion from="304" to="324" loc="H" subId="19158111" subSource="6itc_Y"/>
      <ConstraintRegion from="325" to="369" loc="I" subId="19158112" subSource="6itc_Y"/>
      <ConstraintRegion from="370" to="386" loc="H" subId="19158113" subSource="6itc_Y"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="5eul_Y">
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      <ConstraintRegion from="22" to="34" loc="H" subId="17062897" subSource="5eul_Y"/>
      <ConstraintRegion from="35" to="62" loc="O" subId="17062898" subSource="5eul_Y"/>
      <ConstraintRegion from="63" to="83" loc="H" subId="17062899" subSource="5eul_Y"/>
      <ConstraintRegion from="84" to="114" loc="I" subId="17062900" subSource="5eul_Y"/>
      <ConstraintRegion from="115" to="126" loc="H" subId="17062901" subSource="5eul_Y"/>
      <ConstraintRegion from="127" to="144" loc="O" subId="17062902" subSource="5eul_Y"/>
      <ConstraintRegion from="146" to="149" loc="O" subId="17062904" subSource="5eul_Y"/>
      <ConstraintRegion from="150" to="166" loc="H" subId="17062905" subSource="5eul_Y"/>
      <ConstraintRegion from="167" to="180" loc="I" subId="17062906" subSource="5eul_Y"/>
      <ConstraintRegion from="181" to="194" loc="H" subId="17062907" subSource="5eul_Y"/>
      <ConstraintRegion from="195" to="200" loc="O" subId="17062908" subSource="5eul_Y"/>
      <ConstraintRegion from="214" to="215" loc="O" subId="17062910" subSource="5eul_Y"/>
      <ConstraintRegion from="216" to="231" loc="H" subId="17062911" subSource="5eul_Y"/>
      <ConstraintRegion from="232" to="244" loc="I" subId="17062912" subSource="5eul_Y"/>
      <ConstraintRegion from="259" to="267" loc="I" subId="17062914" subSource="5eul_Y"/>
      <ConstraintRegion from="273" to="274" loc="I" subId="17062916" subSource="5eul_Y"/>
      <ConstraintRegion from="275" to="288" loc="H" subId="17062917" subSource="5eul_Y"/>
      <ConstraintRegion from="289" to="295" loc="O" subId="17062918" subSource="5eul_Y"/>
      <ConstraintRegion from="301" to="309" loc="O" subId="17062920" subSource="5eul_Y"/>
      <ConstraintRegion from="310" to="323" loc="H" subId="17062921" subSource="5eul_Y"/>
      <ConstraintRegion from="324" to="371" loc="I" subId="17062922" subSource="5eul_Y"/>
      <ConstraintRegion from="372" to="385" loc="H" subId="17062923" subSource="5eul_Y"/>
      <ConstraintRegion from="386" to="394" loc="O" subId="17062924" subSource="5eul_Y"/>
      <ConstraintRegion from="395" to="406" loc="H" subId="17062925" subSource="5eul_Y"/>
      <ConstraintRegion from="407" to="430" loc="I" subId="17062926" subSource="5eul_Y"/>
    </Constraint>
  </Constraints>
</HtpItem>
