Nicastrin MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFSIN MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIFLLEDENETKVIKQ------LDSRSFFWNVAPGAESAVASFVTQLAAAEALQKAPDVTTLPRN FPTPIPTSPTNETIITSKYMMVTARMDSFGMIPEISVGEVSVLTSIISVLAAARSMGTQIEKWQKASNTSN--RNVFFAFFNGESLDYIGSGAAAYQMENGKFPQMIRSDRTHIHPIRPNELDYILEVQQIGVAKGRKYYVHVD--GERYQQNKTQTDRVIDRIER-GLRSHAFDLEKPSGSGDRVPPASWHSFAKADAHVQSVLLAPYGKEYEYQRVNSILDKN--------EWTEDERE-----KAIQEIEAVSTAILAAAADYVGVETDEVVAKVDKKLIT-TIFDCLITS-NFWFDCDFMQKL-----DGGRYHKLFNSYGFNQKSTYISMESHTAFPTVLHWLTIFALGSDKETLNVKSEKSCSHLGQFQAFQ--MYTYTWQPNPYTGNFS-----CLKSAIVKKVMVSPAVDSQTPEEEMNTRYSTWMESVYIIESVNLYLMEDASFEYTMILIA---VISALLSIFAVGRCSETTFIVDEGEPAA FSFPIFLLEDE------NETKVIKQLDSRSFFWNVAPGAESAVASFVTQLAAAEAL-------QKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKF------------PVQLENVDSFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQS-QPLPPSSLQRFLRAR-NISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVTDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQDLRSYLGDGPLQH-------------YIAVSS----PTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYEYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFEL---SQWSSTEYSTWTESRWKDIRARIFLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPR-EPGA GLIRLLSIAFTLVLLSILPLHLSLADEITSIESVPDLQKLMYVAVDG-FPCVRLLNLSGEIGCSNP--GINKVVAPIIKLKDVKDLV-----QPHTILV-----TADEMEDFFTRVSTDLSFASKIGGVLVESGSNFQQKLKGFSPDKRFPQAQFSPYENVEYKWNSAASSIMWRNYNFPVYLLSESGISAVHEILSKKKMKHGTYTSDVAEFNMVMETTKAGTHNSEACLQEGTCLPLGGYSVWSSLP-PISVSSSNNRKPVVLTVASMDTASFFRDKSFGADSPISGLVALLGAVDALSRVDGISNLKKQLVFLVLTGETWGYLGSRRFLHELDLHSDAVAGLSNTSIETVLEIGSVGKGLSGGINTFFAHKTRVS----SVTNMTLDALKIAQDSLASKNIKILSADTANPGIPPSSLMAFMRKNPQTSAVVLEDFDTNFVNKFYHSHLDDLSNINSS--------------SVVAAASVVARTLYILASDNKDTSNSALGSIHVNASFVEELLTCLL--ACEPGLSCNLVKDYISPTNTCPGNYAGVILGEPSSKPYLGY-VGDVSRFLWNFLADKTSVQKGNTTSVCSKGVCSKTDEVCIKAESNKEGTCVVSTTRYVPAYSTRLKYNDGAWTILPQNSSDSMGMVDPVWTESNWDTLRVHVYTVQHSAYDNAVLVAGITVTTLAYIGILA GLLRLLSFC---VLLAGLCRGNSVERK-------------IYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGR-------TSRIAGLAV-------------SLTKPSPASGFSP-------------SVQCPNDGFGVYSNSYGPEFA---------------------------------HC-----REIQWNSLGNGLAYEDFSFPIFLLEDENETKVI---KQLDSRSFFWNVAPGAESAVASFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQ-LEN--VDSFVELGQVALRTSLEL---WMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLRAR-NISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVTDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQDLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYEYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQ--W----------SSTEYSTWTESRWKDIRARIFLIASKELELITLTVGFGILIFSLIVTYC MATAGGGSGA DPGSRGLLRL LSFCVLLAGL CRGNSVERKI YIPLNKTAPC VRLLNATHQI GCQSSISGDT GVIHVVEKEE DLQWVLTDGP NPPYMVLLES KHFTRDLMEK LKGRTSRIAG LAVSLTKPSP ASGFSPSVQC PNDGFGVYSN SYGPEFAHCR EIQWNSLGNG LAYEDFSFPI FLLEDENETK VIKQLDSRSF FWNVAPGAES AVASFVTQLA AAEALQKAPD VTTLPRNVMF VFFQGETFDY IGSSRMVYDM EKGKFPVQLE NVDSFVELGQ VALRTSLELW MHTDPVSQKN ESVRNQVEDL LATLEKSGAG VPAVILRRPN QSQPLPPSSL QRFLRARNIS GVVLADHSGA FHNKYYQSIY DTAENINVSY PEWLSPEEDL NFVTDTAKAL ADVATVLGRA LYELAGGTNF SDTVQADPQT VTRLLYGFLI KANNSWFQSI LRQDLRSYLG DGPLQHYIAV SSPTNTTYVV QYALANLTGT VVNLTREQCQ DPSKVPSENK DLYEYSWVQG PLHSNETDRL PRCVRSTARL ARALSPAFEL SQWSSTEYST WTESRWKDIR ARIFLIASKE LELITLTVGF GILIFSLIVT YCINAKADVL FIAPREPGAV SY