<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="B7Z317_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>Tetraspanin </Name>
  <CrossRef>
    <PDBTM id="8esv">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6wvg">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7zw1">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6k4j">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5tcx">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7rd5">
      <Chain id="F"/>
      <Chain id="E"/>
    </PDBTM>
    <PDBTM id="7rdb">
      <Chain id="B"/>
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="E"/>
      <Chain id="F"/>
      <Chain id="G"/>
      <Chain id="H"/>
      <Chain id="I"/>
      <Chain id="K"/>
      <Chain id="L"/>
      <Chain id="M"/>
      <Chain id="N"/>
      <Chain id="P"/>
      <Chain id="Q"/>
      <Chain id="R"/>
      <Chain id="S"/>
      <Chain id="X"/>
      <Chain id="D"/>
      <Chain id="T"/>
      <Chain id="W"/>
      <Chain id="J"/>
      <Chain id="O"/>
      <Chain id="U"/>
      <Chain id="V"/>
    </PDBTM>
    <PDBTM id="7jic">
      <Chain id="B"/>
    </PDBTM>
    <TOPDB id="TSN14_HUMAN">
      <Alignment>
        <CrossRefSeq>FTLGFAGCVGALRENICLLNFFCGTIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYRDDIDLQNLIDSLQKANQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVNTQCGYDVRIQLKSKWDESIFTKGCIQALESWLPRNIYIVAGVFIAISLLQIFGIFLARTLISDIEAVKAG</CrossRefSeq>
        <OrigSeq>FILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVRAS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CD82_HUMAN">
      <Alignment>
        <CrossRefSeq>MLMGFLGCIGAVNEVRCLLGLYFAFLLLILIAQVTAGALFYFNMGKLKQEMGGIVTELIRDYNSSREDSLQDAWDYVQAQVKCCGWVSFYNWTDN------AELMNRPEVTYPCSCEVKGEEDNSLSVRKGFCEAPGNRTQSGNHPEDWPVYQEGCMEKVQAWLQENLGIILGVGVGVAIIELLGMVLSICLCRHVHS</CrossRefSeq>
        <OrigSeq>FILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRD--DIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQ-----KPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TSN15_HUMAN">
      <Alignment>
        <CrossRefSeq>MFMVSFIGVLASLRDNLYLLQAFMYILGICLIMELIGGVVALTFRNQTIDFLNDNIRRGIENYYDDLDFKNIMDFVQKKFKCCGGEDYRDWSKNQYHDCSA--PGPLACGVPYTCCIRNTTE-VVNTMCGYKTIDKERFSVQDVIYVRGCTNAVIIWFMDNYTIMAGILLGILLPQFLGVLLTLLYITRVEDI</CrossRefSeq>
        <OrigSeq>MFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CD37_HUMAN">
      <Alignment>
        <CrossRefSeq>MGIALLGCVGALKELRCLLGLYFGMLLLLFATQITLGILISTQRAQLERSLRDVVEKTIQKYGTNPEETAAEESWDYVQFQLRCCGWHYPQDWFQVLILRGNGSEAHRVPCSCYNLSATNDSTILDKVILPQLSRLGHLARSRHSADICAVPAESHIYREGCAQGLQKWLHNNLISIVGICLGVGLLELGFMTLSIFLCRNLDHVYNR</CrossRefSeq>
        <OrigSeq>FILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQ---NLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPA--EDVINTQC--------GYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVRAS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CD63_HUMAN">
      <Alignment>
        <CrossRefSeq>LFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKI---------PSMSKNRVPDSCCIN------VTVGCGINFNEKA-------IHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEVLGIVFACCLVKSIRS</CrossRefSeq>
        <OrigSeq>MFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CD82_MOUSE">
      <Alignment>
        <CrossRefSeq>IVMGFLGCIGAVNEVRCLLGLYFVFLLLILIAQVTVGVLFYFNADKLKKEMGNTVMDIIRNYTANATSSREEAWDYVQAQVKCCGWVSHYNWTEN------EELMGFTKTTYPCSCEKIKEEDNQLIVKKGFCEADNSTVSENNPEDWPVNTEGCMEKAQAWLQENFGILLGVCAGVAVIELLGLFLSICLCRYIHS</CrossRefSeq>
        <OrigSeq>FILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAY--RDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEV----DQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CD63_MOUSE">
      <Alignment>
        <CrossRefSeq>LFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAVAIAGYVFRDQVKSEFNKSFQQQMQNYLKDNKTATILDKLQKENNCCGASNYTDWENI---------PGMAKDRVPDSCCIN------ITVGCGNDFKE-------STIHTQGCVETIAIWLRKNILLVAAAALGIAFVEVLGIIFSCCLVKSIRS</CrossRefSeq>
        <OrigSeq>MFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CD151_HUMAN">
      <Alignment>
        <CrossRefSeq>VMVTGVLGCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYAYYQQLNTELKENLKDTMTKRYHQPGHEAVTSAVDQLQQEFHCCGSNNSQDWRDSEWIRSQEAGGRV----VPDSCCK------TVVALCGQR-----DHASNIYKVEGGCITKLETFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYRSLK</CrossRefSeq>
        <OrigSeq>MFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNI-RAYRDDID--LQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TSN6_MOUSE">
      <Alignment>
        <CrossRefSeq>IILLGTFGCFATCRTSAWMLKLYAMFLTLIFLVELVAAIVGFVFRHEIKNSFKSNYENALKEYNSTGDYRSEAVDKIQSTLHCCGVTNYGDWKGTNYYS---------ETGFPKSCCKLEGCYPQ---------------RDADKVNEEGCFIKVMTTIESEMGVVAGISFGVACFQLIGIFLAYCLSRAITNNQ</CrossRefSeq>
        <OrigSeq>MFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDL-QNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TSN4_HUMAN">
      <Alignment>
        <CrossRefSeq>VMAIGFVGCLGAIKENKCLLLTFFLLLLLVFLLEATIAILFFAYTDKIDRYAQQDLKKGLHLYGTQGNVGLTNAWSIIQTDFRCCGVSNYTDWFEVY-----------NATRVPDSCCLE--------------FSESCGLHAPGTWWKAPCYETVKVWLQENLLAVGIFGLCTALVQILGLTFAMTMYCQV</CrossRefSeq>
        <OrigSeq>MFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAY--RDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDI</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TSN3_HUMAN">
      <Alignment>
        <CrossRefSeq>LFIIGLIGCCATIRESRCGLATFVIILLLVFVTEVVVVVLGYVYRAKVENEVDRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQ------SVPLSCCRETA------------SNCNGSLAHPSDLYAEGCEALVVKKLQEIMMHVIWAALAFAAIQLLGMLCACIVLCR</CrossRefSeq>
        <OrigSeq>MFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDI--DLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSD</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CD53_HUMAN">
      <Alignment>
        <CrossRefSeq>IMVVAFLGCMGSIKENKCLLMSFFILLLIILLAEVTLAILLFVYEQKLNEYVAKGLTDSIHRYHSDNSTKAAWDSIQSFLQCCGINGTSDWTSGP----------------PASC--------------------------PSDRKVEGCYAKARLWFHSNFLYIGIITICVCVIEVLGMSFALTLNCQIDKTSQT</CrossRefSeq>
        <OrigSeq>MFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVRAS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CD81_HUMAN">
      <Alignment>
        <CrossRefSeq>MMFVGFLGCYGAIQESQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVVDDDANNAKAVVKTFHETLDCCG----------------------------------SSTLTALTTSVLKNNLCPSGSNIISNLFKEDCHQKIDDLFSGKLYLIGIAAIVVAVIMIFEMILSMVLCCGIRNSS</CrossRefSeq>
        <OrigSeq>MFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNL---IDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CD9_HUMAN">
      <Alignment>
        <CrossRefSeq>MMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDEVIKEVQEFYKDTYNKLKTKDEPQRETLKAIHYALNCCGLAG--------------------------------GVEQFISDIC-------PKKDVLETFTVKSCPDAIKEVFDNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRNR</CrossRefSeq>
        <OrigSeq>MFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQ-NLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CD81_MOUSE">
      <Alignment>
        <CrossRefSeq>MMFVGFLGCYGAIQESQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVMDDDANNAKAVVKTFHETLNCCGSN----------------------------------ALTTLTTTILRNSLCPSGGNILTPLLQQDCHQKIDELFSGKLYLIGIAAIVVAVIMIFEMILSMVLCCGIRNSS</CrossRefSeq>
        <OrigSeq>MFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNL---IDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TSN8_HUMAN">
      <Alignment>
        <CrossRefSeq>IMILGFLGCCGAIKESRCMLLLFFIGLLLILLLQVATGILGAVFKSKSDRIVNETLYENTKLLSATGESEKQFQEAIIVFQEEFKCCGLVNGAADWGNNFQ-------------HYPELCACLDKQRP-------------CQSYNGKQVYKETCISFIKDFLAKNLIIVIGISFGLAVIEILGLVFSMVLYCQI</CrossRefSeq>
        <OrigSeq>MFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDID----LQNLIDFTQEYWQCCG-AFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDI</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TSN1_HUMAN">
      <Alignment>
        <CrossRefSeq>VFALGFLGCYGAKTESKCALVTFFFILLLIFIAEVAAAVVALVYTTMAEHFLTLLVVPAIKKDYGSQEDFTQVWNTTMKGLKCCGFTNYTDFEDSPYFKENSA--------FPPFCC-NDNVTNTANETCTKQKAHDQK--------VEGCFNQLLYDIRTNAVTVGGVAAGIGGLELAAMIVSMYLYCNLQ</CrossRefSeq>
        <OrigSeq>MFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNI-RAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIE</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="197" CheckSum="bb475cae445969b32177845015ec4eca">
    <Seq>
      MFILGFAGCI GALRENTFLL KFFSVFLGII FFLELTAGVL AFVFKDWIKD
      QLYFFINNNI RAYRDDIDLQ NLIDFTQEYW QCCGAFGADD WNLNIYFNCT
      DSNASRERCG VPFSCCTKDP AEDVINTQCG YDARQKPEVD QQIVIYTKGC
      VPQFEKWLQD NLTIVAGIFI GIALLQIFGI CLAQNLVSDI EAVRASW
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="61.52">
    <Region from="1" to="15" loc="O"/>
    <Region from="16" to="43" loc="M"/>
    <Region from="44" to="160" loc="I"/>
    <Region from="161" to="183" loc="M"/>
    <Region from="184" to="197" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="1" loc="O"/>
      <Region from="2" to="20" loc="M"/>
      <Region from="21" to="22" loc="I"/>
      <Region from="23" to="43" loc="M"/>
      <Region from="44" to="161" loc="O"/>
      <Region from="162" to="183" loc="M"/>
      <Region from="184" to="197" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="18" loc="I"/>
      <Region from="19" to="44" loc="M"/>
      <Region from="45" to="159" loc="O"/>
      <Region from="160" to="185" loc="M"/>
      <Region from="186" to="197" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="1" loc="I"/>
      <Region from="2" to="22" loc="M"/>
      <Region from="23" to="23" loc="O"/>
      <Region from="24" to="44" loc="M"/>
      <Region from="45" to="161" loc="I"/>
      <Region from="162" to="182" loc="M"/>
      <Region from="183" to="197" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="18" loc="I"/>
      <Region from="19" to="44" loc="M"/>
      <Region from="45" to="161" loc="O"/>
      <Region from="162" to="187" loc="M"/>
      <Region from="188" to="197" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="1" loc="O"/>
      <Region from="2" to="10" loc="O"/>
      <Region from="11" to="14" loc="O"/>
      <Region from="15" to="23" loc="O"/>
      <Region from="24" to="44" loc="M"/>
      <Region from="45" to="161" loc="I"/>
      <Region from="162" to="187" loc="M"/>
      <Region from="188" to="197" loc="O"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="20" loc="I"/>
      <Region from="21" to="41" loc="M"/>
      <Region from="42" to="166" loc="O"/>
      <Region from="167" to="187" loc="M"/>
      <Region from="188" to="197" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="20" loc="I"/>
      <Region from="21" to="41" loc="M"/>
      <Region from="42" to="162" loc="O"/>
      <Region from="163" to="183" loc="M"/>
      <Region from="184" to="197" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="16" loc="O"/>
      <Region from="17" to="36" loc="M"/>
      <Region from="37" to="161" loc="I"/>
      <Region from="162" to="181" loc="M"/>
      <Region from="182" to="197" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="21" loc="O"/>
      <Region from="22" to="42" loc="M"/>
      <Region from="43" to="161" loc="I"/>
      <Region from="162" to="182" loc="M"/>
      <Region from="183" to="197" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="21" loc="O"/>
      <Region from="22" to="44" loc="M"/>
      <Region from="45" to="164" loc="I"/>
      <Region from="165" to="187" loc="M"/>
      <Region from="188" to="197" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
