<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="B7Z3R2_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>Two pore segment channel 1 </Name>
  <CrossRef>
    <PDBTM id="8ouo">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8hlp">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8j7f">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="9ayg">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8j7m">
      <Chain id="A"/>
      <Chain id="D"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
  </CrossRef>
  <Sequence Length="748" CheckSum="428547e3b279a335e1eb02391c34f1c2">
    <Seq>
      MNYQEAAIYL QEGENNDKFF THPKDAKALA AYLFAHNHLF YLMELATALL
      LLLLSLCEAP AVPALRLGIY VHATLELFAL MVVVFELCMK LRWLGLHTFI
      RHKRTMVKTS VLVVQFVEAI VVLVRQMSHV RVTRALRCIF LVDCRYCGGV
      RRNLRQIFQS LPPFMDILLL LLFFMIIFAI LGFYLFSPNP SDPYFSTLEN
      SIVSLFVLLT TANFPDVMMP SYSRNPWSCV FFIVYLSIEL YFIMNLLLAV
      VFDTFNDIEK RKFKSLLLHK RTAIQHAYRL LISQRRPAGI SYRQFEGLMR
      FYKPRMSARE RYLTFKALNQ NNTPLLSLKD FYDIYEVAAL KWKAKKNREH
      WFDELPRTAL LIFKGINILV KSKAFQYFMY LVVAVNGVWI LVETFMLKGG
      NFFSKHVPWS YLVFLTIYGV ELFLKVAGLG PVEYLSSGWN LFDFSVTVFA
      FLGLLALALN MEPFYFIVVL RPLQLLRLFK LKERYRNVLD TMFELLPRMA
      SLGLTLLIFY YSFAIVGMEF FCGIVFPNCC NTSTVADAYR WRNHTVGNRT
      VVEEGYYYLN NFDNILNSFV TLFELTVVNN WYIIMEGVTS QTSHWSRLYF
      MTFYIVTMVV MTIIVAFILE AFVFRMNYSR KNQDSEVDGG ITLEKEISKE
      ELVAVLELYR EARGASSDVT RLLETLSQME RYQQHSMVFL GRRSRTKSDL
      SLKMYQEEIQ EWYEEHAREQ EQQRQLSSSA APAAQQPPGS RQRSQTVT
    </Seq>
  </Sequence>
  <Topology numTm="12" reliability="92.03">
    <Region from="1" to="38" loc="I"/>
    <Region from="39" to="61" loc="M"/>
    <Region from="62" to="65" loc="O"/>
    <Region from="66" to="88" loc="M"/>
    <Region from="89" to="108" loc="I"/>
    <Region from="109" to="126" loc="M"/>
    <Region from="127" to="165" loc="O"/>
    <Region from="166" to="185" loc="M"/>
    <Region from="186" to="191" loc="I"/>
    <Region from="192" to="212" loc="M"/>
    <Region from="213" to="229" loc="O"/>
    <Region from="230" to="252" loc="M"/>
    <Region from="253" to="373" loc="I"/>
    <Region from="374" to="396" loc="M"/>
    <Region from="397" to="406" loc="O"/>
    <Region from="407" to="428" loc="M"/>
    <Region from="429" to="437" loc="I"/>
    <Region from="438" to="457" loc="M"/>
    <Region from="458" to="466" loc="O"/>
    <Region from="467" to="480" loc="M"/>
    <Region from="481" to="500" loc="I"/>
    <Region from="501" to="525" loc="M"/>
    <Region from="526" to="596" loc="O"/>
    <Region from="597" to="621" loc="M"/>
    <Region from="622" to="748" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region/>
    </Prediction>
    <Prediction name="Memsat">
      <Region/>
    </Prediction>
    <Prediction name="Octopus">
      <Region/>
    </Prediction>
    <Prediction name="Philius">
      <Region/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="38" loc="I"/>
      <Region from="39" to="61" loc="M"/>
      <Region from="62" to="66" loc="O"/>
      <Region from="67" to="88" loc="M"/>
      <Region from="89" to="108" loc="I"/>
      <Region from="109" to="127" loc="M"/>
      <Region from="128" to="166" loc="O"/>
      <Region from="167" to="186" loc="M"/>
      <Region from="187" to="192" loc="I"/>
      <Region from="193" to="212" loc="M"/>
      <Region from="213" to="231" loc="O"/>
      <Region from="232" to="255" loc="M"/>
      <Region from="256" to="376" loc="I"/>
      <Region from="377" to="397" loc="M"/>
      <Region from="398" to="408" loc="O"/>
      <Region from="409" to="427" loc="M"/>
      <Region from="428" to="438" loc="I"/>
      <Region from="439" to="458" loc="M"/>
      <Region from="459" to="463" loc="O"/>
      <Region from="464" to="481" loc="M"/>
      <Region from="482" to="501" loc="I"/>
      <Region from="502" to="526" loc="M"/>
      <Region from="527" to="597" loc="O"/>
      <Region from="598" to="623" loc="M"/>
      <Region from="624" to="748" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="39" loc="I"/>
      <Region from="40" to="62" loc="M"/>
      <Region from="63" to="66" loc="O"/>
      <Region from="67" to="89" loc="M"/>
      <Region from="90" to="109" loc="I"/>
      <Region from="110" to="127" loc="M"/>
      <Region from="128" to="163" loc="O"/>
      <Region from="164" to="186" loc="M"/>
      <Region from="187" to="192" loc="I"/>
      <Region from="193" to="215" loc="M"/>
      <Region from="216" to="229" loc="O"/>
      <Region from="230" to="252" loc="M"/>
      <Region from="253" to="374" loc="I"/>
      <Region from="375" to="397" loc="M"/>
      <Region from="398" to="406" loc="O"/>
      <Region from="407" to="429" loc="M"/>
      <Region from="430" to="435" loc="I"/>
      <Region from="436" to="458" loc="M"/>
      <Region from="459" to="501" loc="O"/>
      <Region from="502" to="524" loc="M"/>
      <Region from="525" to="565" loc="I"/>
      <Region from="566" to="585" loc="M"/>
      <Region from="586" to="599" loc="O"/>
      <Region from="600" to="622" loc="M"/>
      <Region from="623" to="748" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
