Single Ig and TIR domain containing LTDKPPKLLYPMESKLTIQETQLGDSANLTCRAFFGYSGDVS-PLIYWMKGEKFIEDLDENRVWESDIRILKEHLGEQEVSISLIVDSVEEGDLGNYSCYVENGNGRRHASVLLHKRELMYTVELAGGLGAILLLLVCLVTIYKCYKIEIMLFYRNHFGAEELDGDNKDYDAYLSYTKVDPDQWNQETGEEERFALEILPDMLEKHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYVVRRGWSIFELETRLRNMLVTGEIKVILIECSELRGIMNYQEVEALKHTIKLLTVIKWHGPKCNKLNSKFWKRLQYEMPFKRIEP--ITHEQALDVSEQGPFGELQTVSAISMAAATSTALATAHPDLRSTFHNTYHSQ-MRQKHYYRSYEYDVPPT--GTLPLTSIGNQH VCDRAPDFLSPSEDQ--VLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLGIGGHYSLHE--YSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISF---SSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVEIN-DGKLYDAYVSYSD---------CPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAF-LSRAWCSHSFREGLCRLLELTR-RPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWR-PGSVTPSSDFWKEVQLALPRKVQYRPVEGDPQTQLQDDKDP--MLILRGRVPEGRALDSEVD---PDPEGDLGMPAQPHSPTGEAQHRAEWGQAQGTGPGGAPGVEDSSRH LTDKPPKLLYPMESKLTVQETQLGGSANLTCRAFFGYSGDVS-PLIYWMKGEKFIEDLDENRVWESDIRILKEHLGEQEVSISLIVDSVEEGDLGNYSCYVENGNGRRHASVLLHKRELMYTVELAGGLGAILLLLICSVTIYKCYKIEIMLFYRNHFGAEELDGDNKDYDAYLSYTKVDPDQWNQETGEEERFALEILPDMLEKHYGYKLFIPDRDLIPTGNI-EDVARCVDQSKRLIIVMTPNYVVRRGWSIFELETRLRNMLVTGEIKVILIECSELRGIMNYQEVEALKHTIKLLTVIKWHGPKCNKLNSKFWKRLQYEMPFKRIEP--ITHEQALDVSEQGPFGELQTVSAISMAAATSTALATAHPDLRSTFHNTYHSQ-MRQKHYYRSYEYDVPPT--GTLPLTSIGNQH VCDRAPDFLSPSEDQ--VLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLGIGGHYSLHE--YSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISF---SSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVEIN-DGKLYDAYVSYSD---------CPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAF-LSRAWCSHSFREGLCRLLELTR-RPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWR-PGSVTPSSDFWKEVQLALPRKVQYRPVEGDPQTQLQDDKDP--MLILRGRVPEGRALDSEVD---PDPEGDLGMPAQPHSPTGEAQHRAEWGQAQGTGPGGAPGVEDSSRH VPPVIHSPNDHVVYEKEPGEELLIPCTVYF-SFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKE----TKVKELKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPVKKSPRRSSSDEQ RAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLGIGG-HYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFS-----SFTLQRAGPTSHVAAVLASLLVLLALLLAALLYVKCRLNVLLWYQDAYG-EVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAF-LSRAWCSHSFREGLCRLLEL-TRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWR-PGSVTPSSDFWKEVQLALPRKVQYRPVEGDPQ PPQIYSPNDRVVYEKEPGEELVIPCKVYF-SFIMDSHNEVWWTIDGKKPDDVTVDITINESVSYSSTEDETRTQILSIKKVTPEDLRRNYVCHARNTKGEAEQAAKVKQKVIPPRYTVELACGFGATVFLVVVLIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNVEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKD----MKVKELKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPVKKSPRWSSNDKQ APDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLGIGG-HYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFS-----SFTLQRAGPTSHVAAVLASLLVLLALLLAALLYVKCRLNVLLWYQDAYG-EVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAF-LSRAWCSHSFREGLCRLLEL-TRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWR-PGSVTPSSDFWKEVQLALPRKVQYRPVEGDPQ PVIVSPA-NETMEVDLGSQIQLICNV---TGQLSDIAYWKW--NGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHMIGICVTLTVIIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCDIFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLGGSSEEQIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQKHGA---IRWSGDFTQGPQSAKTRFWKNVRYHMPVQ---RRSPSSKHQLLSPATKEKLQREAHVPLG PDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLGIGGHYSLHEYSWVK--ANLSEVLVSSVLGVNVTSTEVYGA-FTCSIQNISFSSF-TLQRAGPTSHVAAVLASLL--VLLALLLAALLYVKCRLNVLLWYQDA---YGEVEINDGKLYDAYVSYSDCPED------RKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAWCSHSFREGL---CRLLELTRRPIFITFEGQRRDPAHP-ALRLLRQHRHLVTLLLW----RPGSVTPSSDFWKEVQLALPRKVQYRPVEGDPQTQLQDDKDPMLILRGRVPEG FPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQF-LAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPIDHHSIYCIIAVCSVFLMLINVLVIILKMFWIEATLLWRDIAKPYKTRNDGKLYDAYVVYPRNYKSSTDGASRVEHFVHQILPDVLENKCGYTLCIYGRDMLPGEDVVTAVETNIRKSRRHIFILTPQITHNKEFAYEQEVALHCALIQNDAKVILIEMEALSELDMLQAEALQDSLQHLMKVQGTIKWREDHIANKRSLNSKFWKHVRYQMPVPSKIPRKASSLTPLAAQKQ APDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLGIGGHYSLHEYSWVKANLSE---VLVSSVLGVNVTSTEVYGAFTCSIQNISF---SSFTLQRAGPTSHVAAVLA----SLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVEINDGKLYDAYVSYSDCPE--------DRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAWCSHSFREGLCR-LLELTRRPIFITFEGQRRDPAHPALRL---LRQHRHLVTLLLWRPG----SVTPSSDFWKEVQLALPRKVQYRPVEGDPQTQLQDDK IVGDTKLKPDILDPVED-TLEVELGKPLTISCKARFG-FERVFNPVIKWYIKDS--DLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYVNGP-SIFELQAAVNLALDDQTLKLILIKFCYFQEPESLP--HLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNS MPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLGIGGHYSLHEYSWVKANLSEVLVSS-VLGVNVTSTEVYGAFTCSIQNI---SFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYVKCRLNVLLWYQ-DAYGEVEINDGKLYDAYVSYSDCPE----------DRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAWCSHSFREGLC-RLLELTRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWRP-GSVTPSSDFWKEVQLALPRKVQ VEDRSNIVPVLLGPKLNHV-AVELGKNVRLNCSALLNEED-----VIYWMF-GEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNE-VRYELESGLHEALVERKIKIILIEFTPVTDFTFLPQSLKL---LKSHRVLKWKADKSLSYNSRFWKNLLYLMPAK-TVKPGRDEPEVLPV MPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLGIGGHYSLHEYSWVKANLSEVLVSSVLGV-NVTSTEVYGAFTCSIQ---NISFSSFTLQRAGPTSHVAAVLAS------LLVLLALLLAALLYVKCRLNVLLWYQD-AYGEVEINDGKLYDAYVSY-----SDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAWCSHSFREGLC-RLLELTRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWR-PGSVTPSSDFWKEVQLALPRKVQYRPVEGDPQTQLQ AGYGGSVPKIIYPK-NHSIEVQLGTTLIVDCNV---TDTKDNTNLRCWRVNNTLVDDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHA-GVSTAYIILQLPAPDFRAYLIGGLIALVAVAVSVVYIYNIFKIDIVLWYRSAFHSTETIVDGKLYDAYVLYPKPHKESQRHAVDALVLNILPEVLERQCGYKLFIFGRDEFPGQAVANVIDENVKLCRRLIVIVVPESLGFGLLKNLSEEQIAVYSALIQDGMKVILIELEKIEDYTVMPESIQYIKQKHGAIRWHGDFTEQSQCMKTKFWKTVRYHM PGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLGIGGH--YSLHEYSWVKANLSEVLVSSVLGV--NVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYVKCRLNVLLWYQDAYGE-VEINDGKLYDAYVSYSDCPEDRK------FVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAWCSHSFREGL---CRLLELTRRPIFITFEGQRRDPAHP-ALRLLRQHRHLVTLL-LWRPGSVTPSSDFWKEVQLAL LTIYNVSKSDINVYF-CXVYGVYGNDTLLARENFTLSNIESNTQCNTTIRSIMANDNVKIIIVVTTSFVMLILLIAIVLLLKKMKKRKFRKKEKTYDVNICYA--PEDREWVINTLVFEVERA-GIKTFVNIRDDTPGNFFAENIMDAIENSNRTIVVMSPDFFKNNICDKTLQIGLSH------QIIPILYRP----------CEVPYFLNHMTYLDWCDKDVRP--VFWRNL VLGVNVTSTEVYGAFTCSIQNISFSSFTLQR-----------AGPTSHVAAVLAS-LLVLLALLLAALLYVKCRLNVLLWYQDAYGEVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAWCSHSFREGLCRLLELTRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWRPGSVTPSSDFWKEV ETIPVIISPL--KTISASLGSRLTIPCKVFLGTGTPLTTMLW-WTANDTHIESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQTLRTTVKEASSTFSWGIVLAPLSLAFLVLGGIWMHRR DRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLGI---GGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNI-SFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYVKCR VKGTTTEPIPVIISPL--ETIPASLGSRLIVPCKVFLGTGT-SSNTIVWWLANSTFISAAYPRGRVTEGLHHQYSENDENYVEVSLIFDPVTREDLHTDFKCVASNPRSSQSLHTTVKEVSSTFSWSIALAPLSLIILVVGAIWMRRR MPGVCDRA-PDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLG---IGGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQN-ISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYVKCR MPGVCDRAPD FLSPSEDQVL RPALGSSVAL NCTAWVVSGP HCSLPSVQWL KDGLPLGIGG HYSLHEYSWV KANLSEVLVS SVLGVNVTST EVYGAFTCSI QNISFSSFTL QRAGPTSHVA AVLASLLVLL ALLLAALLYV KCRLNVLLWY QDAYGEVEIN DGKLYDAYVS YSDCPEDRKF VNFILKPQLE RRRGYKLFLD DRDLLPRAEP SADLLVNLSR CRRLIVVLSD AFLSRAWCSH SFREGLCRLL ELTRRPIFIT FEGQRRDPAH PALRLLRQHR HLVTLLLWRP GSVTPSSDFW KEVQLALPRK VQYRPVEGDP QTQLQDDKDP MLILRGRVPE GRALDSEVDP DPEGDLGMPA QPHSPTGEAQ HRAEWGQAQG TGPGGAPGVE DSSRHREPLH GLCPGGARPS VCLGTSWASQ AITAGGEQGQ PLAVGLGQGC GWPPQASRSP HPRCPGACLW RAISSTAHQW GLAGREPEQR SGRLGSRLAK LQCPHRLLLP GVQG