<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="C9JNU6_HUMAN" transmembrane="yes" evidence="3D">
  <Name>HIG1 hypoxia inducible domain family member 1A </Name>
  <CrossRef>
    <PDBTM id="2lom">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2lon">
      <Chain id="A"/>
    </PDBTM>
  </CrossRef>
  <Sequence Length="96" CheckSum="75af579b9fd9f41a8424b2833baa16a7">
    <Seq>
      MSTDTGVSLP SYEEDQGSKL IRKAKEAPFV PVGIAGFAAI VAYGLYKLKS
      RGNTKMSIHL IHMRVAAQGF VVGAMTVAFF FFRYGLFHVS GILGKT
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="73.82">
    <Region from="1" to="29" loc="I"/>
    <Region from="30" to="46" loc="M"/>
    <Region from="47" to="57" loc="O"/>
    <Region from="58" to="84" loc="M"/>
    <Region from="85" to="96" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="31" loc="O"/>
      <Region from="32" to="45" loc="M"/>
      <Region from="46" to="64" loc="I"/>
      <Region from="65" to="79" loc="M"/>
      <Region from="80" to="96" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="27" loc="O"/>
      <Region from="28" to="43" loc="M"/>
      <Region from="44" to="65" loc="I"/>
      <Region from="66" to="84" loc="M"/>
      <Region from="85" to="96" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="24" loc="I"/>
      <Region from="25" to="45" loc="M"/>
      <Region from="46" to="56" loc="O"/>
      <Region from="57" to="71" loc="M"/>
      <Region from="72" to="72" loc="I"/>
      <Region from="73" to="87" loc="M"/>
      <Region from="88" to="96" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="26" loc="I"/>
      <Region from="27" to="46" loc="M"/>
      <Region from="47" to="64" loc="O"/>
      <Region from="65" to="87" loc="M"/>
      <Region from="88" to="96" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="27" loc="O"/>
      <Region from="28" to="46" loc="M"/>
      <Region from="47" to="66" loc="I"/>
      <Region from="67" to="86" loc="M"/>
      <Region from="87" to="96" loc="O"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="27" loc="I"/>
      <Region from="28" to="48" loc="M"/>
      <Region from="49" to="63" loc="O"/>
      <Region from="64" to="84" loc="M"/>
      <Region from="85" to="96" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="27" loc="I"/>
      <Region from="28" to="48" loc="M"/>
      <Region from="49" to="63" loc="O"/>
      <Region from="64" to="84" loc="M"/>
      <Region from="85" to="96" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="66" loc="I"/>
      <Region from="67" to="87" loc="M"/>
      <Region from="88" to="96" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="27" loc="I"/>
      <Region from="28" to="48" loc="M"/>
      <Region from="49" to="96" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="26" loc="O"/>
      <Region from="27" to="46" loc="M"/>
      <Region from="47" to="64" loc="I"/>
      <Region from="65" to="87" loc="M"/>
      <Region from="88" to="96" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="HIG1A_HUMAN">
      <ConstraintRegion from="1" to="3" loc="I" subId="17172762" subSource="2lom_A"/>
      <ConstraintRegion from="4" to="21" loc="L" subId="17172764" subSource="2lom_A"/>
      <ConstraintRegion from="22" to="31" loc="I" subId="17172766" subSource="2lom_A"/>
      <ConstraintRegion from="32" to="48" loc="H" subId="17172768" subSource="2lom_A"/>
      <ConstraintRegion from="49" to="58" loc="O" subId="17172770" subSource="2lom_A"/>
      <ConstraintRegion from="59" to="85" loc="H" subId="17172772" subSource="2lom_A"/>
      <ConstraintRegion from="86" to="93" loc="I" subId="17172774" subSource="2lom_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="HIG1B_HUMAN">
      <ConstraintRegion from="2" to="15" loc="I" subId="18872194" subSource="2lon_A"/>
      <ConstraintRegion from="17" to="31" loc="I" subId="18872195" subSource="2lon_A"/>
      <ConstraintRegion from="32" to="49" loc="H" subId="18872196" subSource="2lon_A"/>
      <ConstraintRegion from="50" to="62" loc="O" subId="18872197" subSource="2lon_A"/>
      <ConstraintRegion from="63" to="82" loc="H" subId="18872198" subSource="2lon_A"/>
      <ConstraintRegion from="83" to="99" loc="I" subId="18872199" subSource="2lon_A"/>
    </Constraint>
  </Constraints>
</HtpItem>
