<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="C9JYI3_HUMAN" transmembrane="yes" evidence="3D">
  <Name>ATP binding cassette subfamily B member 8 </Name>
  <CrossRef>
    <PDBTM id="3b5x">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7ph3">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6bpl">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6bpp">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7ph4">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7sel">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8dmm">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7bcw">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7mew">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8dmo">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8tsq">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8tss">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3b5w">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="E"/>
      <Chain id="F"/>
      <Chain id="G"/>
      <Chain id="H"/>
    </PDBTM>
    <PDBTM id="5ttp">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5tv4">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6uz2">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7ph2">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7ph7">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6o30">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="3b5y">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="3b5z">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="3b60">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="6bl6">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="6uzl">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8pmd">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6lr0">
      <Chain id="U"/>
    </PDBTM>
    <PDBTM id="7dv5">
      <Chain id="U"/>
    </PDBTM>
    <PDBTM id="7e1a">
      <Chain id="U"/>
    </PDBTM>
    <PDBTM id="8pmj">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6s7p">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7v5d">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7vfi">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7v5c">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5och">
      <Chain id="E"/>
      <Chain id="D"/>
      <Chain id="F"/>
      <Chain id="B"/>
      <Chain id="G"/>
      <Chain id="A"/>
      <Chain id="H"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="4q4j">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3qf4">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4q4h">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4q4a">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4ayw">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4ayx">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3zdq">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4ayt">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7y48">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7ehl">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6quz">
      <Chain id="D"/>
      <Chain id="B"/>
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7y49">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7rit">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7met">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6qv0">
      <Chain id="D"/>
      <Chain id="B"/>
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5u1d">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8pm6">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6qv2">
      <Chain id="B"/>
      <Chain id="D"/>
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6qv1">
      <Chain id="B"/>
      <Chain id="D"/>
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="4a82">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="2hyd">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="2onj">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6ral">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5mkk">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6rag">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6rah">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6raf">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6raj">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6rak">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6ram">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6ran">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6rai">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8chb">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7ow8">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8qoe">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7ocy">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4f4c">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8y6i">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7vr5">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3wmf">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3wmg">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3wme">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7dqv">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6a6n">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6a6m">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7fc9">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6r72">
      <Chain id="D"/>
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6r81">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7bg4">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8hf4">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8hf5">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8k4b">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8hf7">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8hf6">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8k7a">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7t56">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7t55">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7t57">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7t54">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6v9z">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4ry2">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4s0f">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8t1p">
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="8fpf">
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="7m33">
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="8t3k">
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="8fmv">
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="8szc">
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="8fhk">
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="7sgr">
      <Chain id="I"/>
      <Chain id="A"/>
      <Chain id="E"/>
      <Chain id="J"/>
      <Chain id="B"/>
      <Chain id="F"/>
    </PDBTM>
    <PDBTM id="8dck">
      <Chain id="A"/>
      <Chain id="I"/>
      <Chain id="E"/>
      <Chain id="B"/>
      <Chain id="J"/>
      <Chain id="F"/>
    </PDBTM>
    <TOPDB id="MDR1B_MOUSE">
      <Alignment>
        <CrossRefSeq>PAVGVFGMFRYADWLDKLCMILGTLAAIIHGTLLPLLMLVFGNMTDSFTKAEASILPSITNQSGPNSTLIISNSSLEEEMAIYAYYYTGIGAGVLIVAYIQVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINDGIGDKIGMFFQSITTFLAGFIIGFISGWKLTLVILAVSPLIGLSSALWAKVLTSFTNKELQAYAKAGAVAEEVLAAIRTVIAFGGQQKELERYNKNLEEAKNVGIKKAITASISIGIAYLLVYASYALAFWYGTSLVLSNEYSIGEVLTVFFSILLGTFSI</CrossRefSeq>
        <OrigSeq>GSRFNWKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMT-----------------ESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRDV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LMRA_LACLA">
      <Alignment>
        <CrossRefSeq>HFIKLIRAAKPRYLFFIIGILAGIVGTLIQLQVPKMVQPLVNSFGHGVNGGK----------VALVIALYIGSAAVSAIAAIVLGIFGESVVKNLRTRVWDKMIHLPVKYFDEVKTGEMSSRLANDTTQVKNLIANSIPQAFTSILLLVGSIVFMLQMQWRLTLAMIIAVPVVMLIMFPIMTFGQKIGRTRQDSLANFQGIASESLSEIRLVKSSNAEKQASKKAENDVNALYKIGVKEAIFDGLMSPVMMLSMMLMIFGLLAYGIYLISTGVMSLGTLLGMMMYLMNL</CrossRefSeq>
        <OrigSeq>NWKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="MSBA_FRAT1">
      <Alignment>
        <CrossRefSeq>TLYKRLLLQVKHLWHFLLLAAIGSIFFSAADASMIYLINPILNYGFGPGGGITKQSATILMLMGVGMVGLLALRSVGSFVSQYFIGSLGQKVVYKFRKDIYKRLMDLPASFFDKHSTGQIISRLLYNVDQVIEATSTAIITVVQDGTFVIGLIVVMFVSSWQLSLFLIVVGPFLGLFISIINKKFRNLSRNTQSSMGNVTHTAEETIRNYKEIRIFGAQQKQQNKFFKNLDYTYSQQIRTIALDALTSPVIQIIASLVLAFSLFTIAIFGTNEGDGSS</CrossRefSeq>
        <OrigSeq>FNWKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLF-IGGSLVAGQQLTG</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TAP1_RAT">
      <Alignment>
        <CrossRefSeq>RMLGFLDSKKGRLHLVLVLLILSCLGEMAIPFFTGRITDWILQD--KTAPSFARNMW----LMCILTIASTVLEFAGDGIYNITMGHMHSRVHGEVFRAVLHQETGFFLKNPTGSITSRVTEDTSNVCESISDKLNLFLWYLGRGLCLLAFMIWGSFYLTVVTLLSLPLLFLLPRRLGKVYQSLAVKVQESLAKSTQVALEALSAMPTVRSFANEEGEAQKFRQKLEEMKPLNKKEALAYVTEVWTMSVSGMLLKVGILYLGGQLVVRGAVSSGNLVSFVLYQLQFTRAV</CrossRefSeq>
        <OrigSeq>LFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRDV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="TAP1_HUMAN">
      <Alignment>
        <CrossRefSeq>EMAIPFFTGRLTDWILQDGSAD------TFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAV</CrossRefSeq>
        <OrigSeq>NVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRDV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="MDR65_DROME">
      <Alignment>
        <CrossRefSeq>ALPLFGGG--KTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFF</CrossRefSeq>
        <OrigSeq>QIPLLLGQLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLV-LLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVA------GQQLTGGDLM-SFL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HLYBP_ECOLX">
      <Alignment>
        <CrossRefSeq>SSVTGKLAKFDFTWFIPAIIKYRRIFIETLVVSVFLQLFALITPLFFQVVMDKVL------VHRGFSTLNVITVALSVVVVFEIILSGLRTYIFAHSTSRIDVELGAKLFRHLLALPISYFESRRVGDTVARV-RELDQIRNFLTGQALTSVLDLLFSLIFFAVMWYYSPKLTLVILFSLPCYAAWSVFISPILRRRLDDKFSRNADNQSFLVESVTAINTIKAMAVSPQMTNIWDKQLAGYVAAGFKVTVLATIGQQGIQLIQKTVMIINLWLGAHLVISGDLSIGQLIAFNMLAGQIVAPVI</CrossRefSeq>
        <OrigSeq>STPHVVGSRFNWKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRDVL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HLYB3_ECOLX">
      <Alignment>
        <CrossRefSeq>SSVAGKLAKFDFTWFIPAIIKYRRIFIETLVVSVFLQLFALITPLFFQVVMDKVL------VHRGFSTLNVITVALSVVVVFEIILSGLRTYIFAHSTSRIDVELGAKLFRHLLALPISYFESRRVGDTVARV-RELDQIRNFLTGQALTSVLDLLFSFIFFAVMWYYSPKLTLVILFSLPCYAAWSVFISPILRRRLDDKFSRNADNQSFLVESVTAINTIKAMAVSPQMTNIWDKQLAGYVAAGFKVTVLATIGQQGIQLIQKTVMIINLWLGAHLVISGDLSIGQLIAFNMLAGQIVAPVI</CrossRefSeq>
        <OrigSeq>STPHVVGSRFNWKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRDVL</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="409" CheckSum="67401f03f4aa8792f5e53710d0ac3a49">
    <Seq>
      MLVHLFRVGI RGGPFPGRLL PPLRFQTFSA VRYSDGYRSS SLLRAVAHLR
      SQLWAHLPRA PLAPRWSPSA WCWVGGALLG PMVLSKHPHL CLVALCEAEE
      APPASSTPHV VGSRFNWKLF WQFLHPHLLV LGVAVVLALG AALVNVQIPL
      LLGQLVEVVA KYTRDHVGSF MTESQNLSTH LLILYGVQGL LTFGYLVLLS
      HVGERMAVDM RRALFSSLLR QDITFFDANK TGQLVSRLTT DVQEFKSSFK
      LVISQGLRSC TQVAGCLVSL SMLSTRLTLL LMVATPALMG VGTLMGSGLR
      KLSRQCQEQI ARAMGVADEA LGNVRTVRAF AMEQREEERY GAELEACRCR
      AEELGRGIAL FQGLSNIAFN CMVLGTLFIG GSLVAGQQLT GGDLMSFLVA
      SQTVQRDVL
    </Seq>
  </Sequence>
  <Topology numTm="5" reliability="77.39">
    <Region from="1" to="126" loc="I"/>
    <Region from="127" to="144" loc="M"/>
    <Region from="145" to="179" loc="O"/>
    <Region from="180" to="199" loc="M"/>
    <Region from="200" to="251" loc="I"/>
    <Region from="252" to="272" loc="M"/>
    <Region from="273" to="276" loc="O"/>
    <Region from="277" to="297" loc="M"/>
    <Region from="298" to="362" loc="I"/>
    <Region from="363" to="384" loc="M"/>
    <Region from="385" to="409" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="127" loc="I"/>
      <Region from="128" to="144" loc="M"/>
      <Region from="145" to="180" loc="O"/>
      <Region from="181" to="200" loc="M"/>
      <Region from="201" to="409" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="127" loc="O"/>
      <Region from="128" to="155" loc="M"/>
      <Region from="156" to="176" loc="I"/>
      <Region from="177" to="199" loc="M"/>
      <Region from="200" to="250" loc="O"/>
      <Region from="251" to="272" loc="M"/>
      <Region from="273" to="275" loc="I"/>
      <Region from="276" to="296" loc="M"/>
      <Region from="297" to="356" loc="O"/>
      <Region from="357" to="380" loc="M"/>
      <Region from="381" to="389" loc="I"/>
      <Region from="390" to="405" loc="M"/>
      <Region from="406" to="409" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="1" loc="I"/>
      <Region from="2" to="22" loc="M"/>
      <Region from="23" to="39" loc="O"/>
      <Region from="40" to="51" loc="L"/>
      <Region from="52" to="67" loc="O"/>
      <Region from="68" to="88" loc="M"/>
      <Region from="89" to="122" loc="I"/>
      <Region from="123" to="153" loc="M"/>
      <Region from="154" to="179" loc="O"/>
      <Region from="180" to="200" loc="M"/>
      <Region from="201" to="252" loc="I"/>
      <Region from="253" to="273" loc="M"/>
      <Region from="274" to="274" loc="O"/>
      <Region from="275" to="295" loc="M"/>
      <Region from="296" to="357" loc="I"/>
      <Region from="358" to="378" loc="M"/>
      <Region from="379" to="382" loc="O"/>
      <Region from="383" to="384" loc="L"/>
      <Region from="385" to="409" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="122" loc="I"/>
      <Region from="123" to="144" loc="M"/>
      <Region from="145" to="180" loc="O"/>
      <Region from="181" to="202" loc="M"/>
      <Region from="203" to="255" loc="I"/>
      <Region from="256" to="273" loc="M"/>
      <Region from="274" to="276" loc="O"/>
      <Region from="277" to="299" loc="M"/>
      <Region from="300" to="365" loc="I"/>
      <Region from="366" to="386" loc="M"/>
      <Region from="387" to="409" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="127" loc="I"/>
      <Region from="128" to="148" loc="M"/>
      <Region from="149" to="181" loc="O"/>
      <Region from="182" to="202" loc="M"/>
      <Region from="203" to="276" loc="I"/>
      <Region from="277" to="299" loc="M"/>
      <Region from="300" to="409" loc="O"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="127" loc="I"/>
      <Region from="128" to="148" loc="M"/>
      <Region from="149" to="178" loc="O"/>
      <Region from="179" to="199" loc="M"/>
      <Region from="200" to="251" loc="I"/>
      <Region from="252" to="272" loc="M"/>
      <Region from="273" to="276" loc="O"/>
      <Region from="277" to="297" loc="M"/>
      <Region from="298" to="363" loc="I"/>
      <Region from="364" to="384" loc="M"/>
      <Region from="385" to="409" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="123" loc="I"/>
      <Region from="124" to="144" loc="M"/>
      <Region from="145" to="179" loc="O"/>
      <Region from="180" to="200" loc="M"/>
      <Region from="201" to="252" loc="I"/>
      <Region from="253" to="273" loc="M"/>
      <Region from="274" to="277" loc="O"/>
      <Region from="278" to="299" loc="M"/>
      <Region from="300" to="363" loc="I"/>
      <Region from="364" to="386" loc="M"/>
      <Region from="387" to="409" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="122" loc="I"/>
      <Region from="123" to="143" loc="M"/>
      <Region from="144" to="179" loc="O"/>
      <Region from="180" to="199" loc="M"/>
      <Region from="200" to="256" loc="I"/>
      <Region from="257" to="276" loc="M"/>
      <Region from="277" to="278" loc="O"/>
      <Region from="279" to="298" loc="M"/>
      <Region from="299" to="366" loc="I"/>
      <Region from="367" to="386" loc="M"/>
      <Region from="387" to="409" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="122" loc="I"/>
      <Region from="123" to="143" loc="M"/>
      <Region from="144" to="179" loc="O"/>
      <Region from="180" to="200" loc="M"/>
      <Region from="201" to="252" loc="I"/>
      <Region from="253" to="273" loc="M"/>
      <Region from="274" to="275" loc="O"/>
      <Region from="276" to="296" loc="M"/>
      <Region from="297" to="358" loc="I"/>
      <Region from="359" to="379" loc="M"/>
      <Region from="380" to="409" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="123" loc="O"/>
      <Region from="124" to="146" loc="M"/>
      <Region from="147" to="180" loc="I"/>
      <Region from="181" to="203" loc="M"/>
      <Region from="204" to="276" loc="O"/>
      <Region from="277" to="299" loc="M"/>
      <Region from="300" to="363" loc="I"/>
      <Region from="364" to="386" loc="M"/>
      <Region from="387" to="409" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="Y2003_STAA8">
      <ConstraintRegion from="1" to="19" loc="I" subId="16964279" subSource="4a82_A"/>
      <ConstraintRegion from="20" to="34" loc="H" subId="16964280" subSource="4a82_A"/>
      <ConstraintRegion from="35" to="62" loc="O" subId="16964281" subSource="4a82_A"/>
      <ConstraintRegion from="63" to="78" loc="H" subId="16964282" subSource="4a82_A"/>
      <ConstraintRegion from="79" to="141" loc="I" subId="16964283" subSource="4a82_A"/>
      <ConstraintRegion from="142" to="156" loc="H" subId="16964284" subSource="4a82_A"/>
      <ConstraintRegion from="157" to="163" loc="O" subId="16964285" subSource="4a82_A"/>
      <ConstraintRegion from="164" to="177" loc="H" subId="16964286" subSource="4a82_A"/>
      <ConstraintRegion from="178" to="247" loc="I" subId="16964287" subSource="4a82_A"/>
      <ConstraintRegion from="248" to="261" loc="H" subId="16964288" subSource="4a82_A"/>
      <ConstraintRegion from="262" to="285" loc="O" subId="16964289" subSource="4a82_A"/>
      <ConstraintRegion from="286" to="298" loc="H" subId="16964290" subSource="4a82_A"/>
      <ConstraintRegion from="299" to="578" loc="I" subId="16964291" subSource="4a82_A"/>
      <ConstraintRegion from="1" to="16" loc="I" subId="16964292" subSource="4a82_B"/>
      <ConstraintRegion from="17" to="33" loc="H" subId="16964293" subSource="4a82_B"/>
      <ConstraintRegion from="34" to="65" loc="O" subId="16964294" subSource="4a82_B"/>
      <ConstraintRegion from="66" to="81" loc="H" subId="16964295" subSource="4a82_B"/>
      <ConstraintRegion from="82" to="140" loc="I" subId="16964296" subSource="4a82_B"/>
      <ConstraintRegion from="141" to="154" loc="H" subId="16964297" subSource="4a82_B"/>
      <ConstraintRegion from="155" to="163" loc="O" subId="16964298" subSource="4a82_B"/>
      <ConstraintRegion from="164" to="177" loc="H" subId="16964299" subSource="4a82_B"/>
      <ConstraintRegion from="178" to="248" loc="I" subId="16964300" subSource="4a82_B"/>
      <ConstraintRegion from="249" to="262" loc="H" subId="16964301" subSource="4a82_B"/>
      <ConstraintRegion from="263" to="285" loc="O" subId="16964302" subSource="4a82_B"/>
      <ConstraintRegion from="286" to="298" loc="H" subId="16964303" subSource="4a82_B"/>
      <ConstraintRegion from="299" to="578" loc="I" subId="16964304" subSource="4a82_B"/>
      <ConstraintRegion from="1" to="1" loc="I" subId="17114821" subSource="2hyd_A"/>
      <ConstraintRegion from="2" to="9" loc="F" subId="17114823" subSource="2hyd_A"/>
      <ConstraintRegion from="10" to="35" loc="H" subId="17114825" subSource="2hyd_A"/>
      <ConstraintRegion from="36" to="63" loc="O" subId="17114827" subSource="2hyd_A"/>
      <ConstraintRegion from="64" to="89" loc="H" subId="17114829" subSource="2hyd_A"/>
      <ConstraintRegion from="90" to="132" loc="I" subId="17114832" subSource="2hyd_A"/>
      <ConstraintRegion from="133" to="157" loc="H" subId="17114834" subSource="2hyd_A"/>
      <ConstraintRegion from="158" to="163" loc="O" subId="17114837" subSource="2hyd_A"/>
      <ConstraintRegion from="164" to="186" loc="H" subId="17114839" subSource="2hyd_A"/>
      <ConstraintRegion from="187" to="240" loc="I" subId="17114841" subSource="2hyd_A"/>
      <ConstraintRegion from="241" to="262" loc="H" subId="17114842" subSource="2hyd_A"/>
      <ConstraintRegion from="263" to="285" loc="O" subId="17114845" subSource="2hyd_A"/>
      <ConstraintRegion from="286" to="308" loc="H" subId="17114847" subSource="2hyd_A"/>
      <ConstraintRegion from="309" to="578" loc="I" subId="17114850" subSource="2hyd_A"/>
      <ConstraintRegion from="1" to="1" loc="I" subId="17114855" subSource="2hyd_B"/>
      <ConstraintRegion from="2" to="9" loc="F" subId="17114857" subSource="2hyd_B"/>
      <ConstraintRegion from="10" to="34" loc="H" subId="17114859" subSource="2hyd_B"/>
      <ConstraintRegion from="35" to="63" loc="O" subId="17114862" subSource="2hyd_B"/>
      <ConstraintRegion from="64" to="89" loc="H" subId="17114864" subSource="2hyd_B"/>
      <ConstraintRegion from="90" to="132" loc="I" subId="17114866" subSource="2hyd_B"/>
      <ConstraintRegion from="133" to="157" loc="H" subId="17114869" subSource="2hyd_B"/>
      <ConstraintRegion from="158" to="164" loc="O" subId="17114871" subSource="2hyd_B"/>
      <ConstraintRegion from="165" to="186" loc="H" subId="17114873" subSource="2hyd_B"/>
      <ConstraintRegion from="187" to="240" loc="I" subId="17114875" subSource="2hyd_B"/>
      <ConstraintRegion from="241" to="263" loc="H" subId="17114877" subSource="2hyd_B"/>
      <ConstraintRegion from="264" to="285" loc="O" subId="17114879" subSource="2hyd_B"/>
      <ConstraintRegion from="286" to="308" loc="H" subId="17114881" subSource="2hyd_B"/>
      <ConstraintRegion from="309" to="578" loc="I" subId="17114883" subSource="2hyd_B"/>
      <ConstraintRegion from="1" to="1" loc="I" subId="17230901" subSource="2onj_A"/>
      <ConstraintRegion from="2" to="9" loc="F" subId="17230902" subSource="2onj_A"/>
      <ConstraintRegion from="10" to="35" loc="H" subId="17230904" subSource="2onj_A"/>
      <ConstraintRegion from="36" to="63" loc="O" subId="17230906" subSource="2onj_A"/>
      <ConstraintRegion from="64" to="89" loc="H" subId="17230908" subSource="2onj_A"/>
      <ConstraintRegion from="90" to="132" loc="I" subId="17230910" subSource="2onj_A"/>
      <ConstraintRegion from="133" to="157" loc="H" subId="17230912" subSource="2onj_A"/>
      <ConstraintRegion from="158" to="163" loc="O" subId="17230914" subSource="2onj_A"/>
      <ConstraintRegion from="164" to="186" loc="H" subId="17230916" subSource="2onj_A"/>
      <ConstraintRegion from="187" to="240" loc="I" subId="17230918" subSource="2onj_A"/>
      <ConstraintRegion from="241" to="262" loc="H" subId="17230921" subSource="2onj_A"/>
      <ConstraintRegion from="263" to="285" loc="O" subId="17230924" subSource="2onj_A"/>
      <ConstraintRegion from="286" to="308" loc="H" subId="17230927" subSource="2onj_A"/>
      <ConstraintRegion from="309" to="578" loc="I" subId="17230930" subSource="2onj_A"/>
      <ConstraintRegion from="1" to="1" loc="I" subId="17230935" subSource="2onj_B"/>
      <ConstraintRegion from="2" to="9" loc="F" subId="17230938" subSource="2onj_B"/>
      <ConstraintRegion from="10" to="35" loc="H" subId="17230940" subSource="2onj_B"/>
      <ConstraintRegion from="36" to="63" loc="O" subId="17230942" subSource="2onj_B"/>
      <ConstraintRegion from="64" to="89" loc="H" subId="17230945" subSource="2onj_B"/>
      <ConstraintRegion from="90" to="132" loc="I" subId="17230948" subSource="2onj_B"/>
      <ConstraintRegion from="133" to="157" loc="H" subId="17230950" subSource="2onj_B"/>
      <ConstraintRegion from="158" to="164" loc="O" subId="17230953" subSource="2onj_B"/>
      <ConstraintRegion from="165" to="186" loc="H" subId="17230956" subSource="2onj_B"/>
      <ConstraintRegion from="187" to="240" loc="I" subId="17230958" subSource="2onj_B"/>
      <ConstraintRegion from="241" to="263" loc="H" subId="17230961" subSource="2onj_B"/>
      <ConstraintRegion from="264" to="285" loc="O" subId="17230964" subSource="2onj_B"/>
      <ConstraintRegion from="286" to="308" loc="H" subId="17230966" subSource="2onj_B"/>
      <ConstraintRegion from="309" to="578" loc="I" subId="17230969" subSource="2onj_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6quz_A">
      <ConstraintRegion from="2" to="13" loc="I" subId="17270724" subSource="6quz_A"/>
      <ConstraintRegion from="14" to="36" loc="H" subId="17270726" subSource="6quz_A"/>
      <ConstraintRegion from="37" to="55" loc="O" subId="17270728" subSource="6quz_A"/>
      <ConstraintRegion from="56" to="77" loc="H" subId="17270729" subSource="6quz_A"/>
      <ConstraintRegion from="78" to="128" loc="I" subId="17270730" subSource="6quz_A"/>
      <ConstraintRegion from="129" to="149" loc="H" subId="17270732" subSource="6quz_A"/>
      <ConstraintRegion from="150" to="156" loc="O" subId="17270734" subSource="6quz_A"/>
      <ConstraintRegion from="157" to="174" loc="H" subId="17270736" subSource="6quz_A"/>
      <ConstraintRegion from="175" to="234" loc="I" subId="17270738" subSource="6quz_A"/>
      <ConstraintRegion from="235" to="254" loc="H" subId="17270740" subSource="6quz_A"/>
      <ConstraintRegion from="255" to="275" loc="O" subId="17270742" subSource="6quz_A"/>
      <ConstraintRegion from="276" to="295" loc="H" subId="17270744" subSource="6quz_A"/>
      <ConstraintRegion from="296" to="569" loc="I" subId="17270746" subSource="6quz_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6ral_A">
      <ConstraintRegion from="11" to="13" loc="I" subId="17278739" subSource="6ral_A"/>
      <ConstraintRegion from="14" to="26" loc="F" subId="17278740" subSource="6ral_A"/>
      <ConstraintRegion from="27" to="47" loc="H" subId="17278741" subSource="6ral_A"/>
      <ConstraintRegion from="48" to="80" loc="O" subId="17278743" subSource="6ral_A"/>
      <ConstraintRegion from="81" to="100" loc="H" subId="17278745" subSource="6ral_A"/>
      <ConstraintRegion from="101" to="148" loc="I" subId="17278747" subSource="6ral_A"/>
      <ConstraintRegion from="149" to="171" loc="H" subId="17278748" subSource="6ral_A"/>
      <ConstraintRegion from="172" to="177" loc="O" subId="17278750" subSource="6ral_A"/>
      <ConstraintRegion from="178" to="195" loc="H" subId="17278752" subSource="6ral_A"/>
      <ConstraintRegion from="196" to="255" loc="I" subId="17278754" subSource="6ral_A"/>
      <ConstraintRegion from="256" to="275" loc="H" subId="17278756" subSource="6ral_A"/>
      <ConstraintRegion from="276" to="296" loc="O" subId="17278758" subSource="6ral_A"/>
      <ConstraintRegion from="297" to="314" loc="H" subId="17278760" subSource="6ral_A"/>
      <ConstraintRegion from="315" to="593" loc="I" subId="17278763" subSource="6ral_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6rag_A">
      <ConstraintRegion from="11" to="30" loc="I" subId="17277789" subSource="6rag_A"/>
      <ConstraintRegion from="31" to="50" loc="H" subId="17277790" subSource="6rag_A"/>
      <ConstraintRegion from="51" to="76" loc="O" subId="17277791" subSource="6rag_A"/>
      <ConstraintRegion from="77" to="96" loc="H" subId="17277792" subSource="6rag_A"/>
      <ConstraintRegion from="97" to="153" loc="I" subId="17277793" subSource="6rag_A"/>
      <ConstraintRegion from="154" to="175" loc="H" subId="17277794" subSource="6rag_A"/>
      <ConstraintRegion from="176" to="176" loc="O" subId="17277795" subSource="6rag_A"/>
      <ConstraintRegion from="177" to="195" loc="H" subId="17277796" subSource="6rag_A"/>
      <ConstraintRegion from="196" to="255" loc="I" subId="17277797" subSource="6rag_A"/>
      <ConstraintRegion from="256" to="276" loc="H" subId="17277798" subSource="6rag_A"/>
      <ConstraintRegion from="277" to="294" loc="O" subId="17277799" subSource="6rag_A"/>
      <ConstraintRegion from="295" to="312" loc="H" subId="17277800" subSource="6rag_A"/>
      <ConstraintRegion from="313" to="596" loc="I" subId="17277801" subSource="6rag_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6rah_A">
      <ConstraintRegion from="11" to="12" loc="I" subId="17277943" subSource="6rah_A"/>
      <ConstraintRegion from="13" to="26" loc="F" subId="17277946" subSource="6rah_A"/>
      <ConstraintRegion from="27" to="47" loc="H" subId="17277948" subSource="6rah_A"/>
      <ConstraintRegion from="48" to="74" loc="O" subId="17277950" subSource="6rah_A"/>
      <ConstraintRegion from="75" to="98" loc="H" subId="17277952" subSource="6rah_A"/>
      <ConstraintRegion from="99" to="149" loc="I" subId="17277954" subSource="6rah_A"/>
      <ConstraintRegion from="150" to="168" loc="H" subId="17277955" subSource="6rah_A"/>
      <ConstraintRegion from="169" to="180" loc="O" subId="17277957" subSource="6rah_A"/>
      <ConstraintRegion from="181" to="198" loc="H" subId="17277959" subSource="6rah_A"/>
      <ConstraintRegion from="199" to="254" loc="I" subId="17277961" subSource="6rah_A"/>
      <ConstraintRegion from="255" to="272" loc="H" subId="17277963" subSource="6rah_A"/>
      <ConstraintRegion from="273" to="299" loc="O" subId="17277965" subSource="6rah_A"/>
      <ConstraintRegion from="300" to="317" loc="H" subId="17277968" subSource="6rah_A"/>
      <ConstraintRegion from="318" to="596" loc="I" subId="17277969" subSource="6rah_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6raf_A">
      <ConstraintRegion from="11" to="22" loc="I" subId="17277596" subSource="6raf_A"/>
      <ConstraintRegion from="23" to="46" loc="H" subId="17277599" subSource="6raf_A"/>
      <ConstraintRegion from="47" to="81" loc="O" subId="17277602" subSource="6raf_A"/>
      <ConstraintRegion from="82" to="104" loc="H" subId="17277604" subSource="6raf_A"/>
      <ConstraintRegion from="105" to="146" loc="I" subId="17277605" subSource="6raf_A"/>
      <ConstraintRegion from="147" to="169" loc="H" subId="17277606" subSource="6raf_A"/>
      <ConstraintRegion from="170" to="180" loc="O" subId="17277608" subSource="6raf_A"/>
      <ConstraintRegion from="181" to="200" loc="H" subId="17277611" subSource="6raf_A"/>
      <ConstraintRegion from="201" to="252" loc="I" subId="17277613" subSource="6raf_A"/>
      <ConstraintRegion from="253" to="273" loc="H" subId="17277616" subSource="6raf_A"/>
      <ConstraintRegion from="274" to="297" loc="O" subId="17277618" subSource="6raf_A"/>
      <ConstraintRegion from="298" to="317" loc="H" subId="17277622" subSource="6raf_A"/>
      <ConstraintRegion from="318" to="598" loc="I" subId="17277626" subSource="6raf_A"/>
      <ConstraintRegion from="11" to="11" loc="I" subId="17278284" subSource="6raj_A"/>
      <ConstraintRegion from="12" to="25" loc="F" subId="17278287" subSource="6raj_A"/>
      <ConstraintRegion from="26" to="46" loc="H" subId="17278290" subSource="6raj_A"/>
      <ConstraintRegion from="47" to="77" loc="O" subId="17278293" subSource="6raj_A"/>
      <ConstraintRegion from="78" to="99" loc="H" subId="17278297" subSource="6raj_A"/>
      <ConstraintRegion from="100" to="147" loc="I" subId="17278301" subSource="6raj_A"/>
      <ConstraintRegion from="148" to="170" loc="H" subId="17278306" subSource="6raj_A"/>
      <ConstraintRegion from="171" to="177" loc="O" subId="17278314" subSource="6raj_A"/>
      <ConstraintRegion from="178" to="196" loc="H" subId="17278317" subSource="6raj_A"/>
      <ConstraintRegion from="197" to="255" loc="I" subId="17278322" subSource="6raj_A"/>
      <ConstraintRegion from="256" to="274" loc="H" subId="17278326" subSource="6raj_A"/>
      <ConstraintRegion from="275" to="298" loc="O" subId="17278329" subSource="6raj_A"/>
      <ConstraintRegion from="299" to="317" loc="H" subId="17278333" subSource="6raj_A"/>
      <ConstraintRegion from="318" to="598" loc="I" subId="17278335" subSource="6raj_A"/>
      <ConstraintRegion from="11" to="30" loc="I" subId="17278499" subSource="6rak_A"/>
      <ConstraintRegion from="31" to="47" loc="H" subId="17278502" subSource="6rak_A"/>
      <ConstraintRegion from="48" to="78" loc="O" subId="17278504" subSource="6rak_A"/>
      <ConstraintRegion from="79" to="94" loc="H" subId="17278506" subSource="6rak_A"/>
      <ConstraintRegion from="95" to="153" loc="I" subId="17278509" subSource="6rak_A"/>
      <ConstraintRegion from="154" to="170" loc="H" subId="17278512" subSource="6rak_A"/>
      <ConstraintRegion from="171" to="180" loc="O" subId="17278515" subSource="6rak_A"/>
      <ConstraintRegion from="181" to="194" loc="H" subId="17278518" subSource="6rak_A"/>
      <ConstraintRegion from="195" to="258" loc="I" subId="17278521" subSource="6rak_A"/>
      <ConstraintRegion from="259" to="273" loc="H" subId="17278524" subSource="6rak_A"/>
      <ConstraintRegion from="274" to="296" loc="O" subId="17278527" subSource="6rak_A"/>
      <ConstraintRegion from="297" to="312" loc="H" subId="17278530" subSource="6rak_A"/>
      <ConstraintRegion from="313" to="598" loc="I" subId="17278533" subSource="6rak_A"/>
      <ConstraintRegion from="11" to="11" loc="I" subId="17278944" subSource="6ram_A"/>
      <ConstraintRegion from="12" to="19" loc="F" subId="17278946" subSource="6ram_A"/>
      <ConstraintRegion from="20" to="27" loc="I" subId="17278948" subSource="6ram_A"/>
      <ConstraintRegion from="28" to="48" loc="H" subId="17278950" subSource="6ram_A"/>
      <ConstraintRegion from="49" to="77" loc="O" subId="17278952" subSource="6ram_A"/>
      <ConstraintRegion from="78" to="98" loc="H" subId="17278954" subSource="6ram_A"/>
      <ConstraintRegion from="99" to="150" loc="I" subId="17278956" subSource="6ram_A"/>
      <ConstraintRegion from="151" to="171" loc="H" subId="17278958" subSource="6ram_A"/>
      <ConstraintRegion from="172" to="177" loc="O" subId="17278960" subSource="6ram_A"/>
      <ConstraintRegion from="178" to="197" loc="H" subId="17278961" subSource="6ram_A"/>
      <ConstraintRegion from="198" to="254" loc="I" subId="17278962" subSource="6ram_A"/>
      <ConstraintRegion from="255" to="274" loc="H" subId="17278964" subSource="6ram_A"/>
      <ConstraintRegion from="275" to="296" loc="O" subId="17278966" subSource="6ram_A"/>
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      <ConstraintRegion from="315" to="598" loc="I" subId="17278970" subSource="6ram_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6ran_A">
      <ConstraintRegion from="11" to="30" loc="I" subId="17279068" subSource="6ran_A"/>
      <ConstraintRegion from="31" to="48" loc="H" subId="17279070" subSource="6ran_A"/>
      <ConstraintRegion from="49" to="78" loc="O" subId="17279072" subSource="6ran_A"/>
      <ConstraintRegion from="79" to="95" loc="H" subId="17279074" subSource="6ran_A"/>
      <ConstraintRegion from="96" to="153" loc="I" subId="17279076" subSource="6ran_A"/>
      <ConstraintRegion from="154" to="171" loc="H" subId="17279078" subSource="6ran_A"/>
      <ConstraintRegion from="172" to="177" loc="O" subId="17279079" subSource="6ran_A"/>
      <ConstraintRegion from="178" to="195" loc="H" subId="17279080" subSource="6ran_A"/>
      <ConstraintRegion from="196" to="255" loc="I" subId="17279081" subSource="6ran_A"/>
      <ConstraintRegion from="256" to="274" loc="H" subId="17279082" subSource="6ran_A"/>
      <ConstraintRegion from="275" to="296" loc="O" subId="17279083" subSource="6ran_A"/>
      <ConstraintRegion from="297" to="312" loc="H" subId="17279084" subSource="6ran_A"/>
      <ConstraintRegion from="313" to="602" loc="I" subId="17279085" subSource="6ran_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6rai_A">
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      <ConstraintRegion from="14" to="23" loc="F" subId="17278104" subSource="6rai_A"/>
      <ConstraintRegion from="24" to="27" loc="I" subId="17278105" subSource="6rai_A"/>
      <ConstraintRegion from="28" to="47" loc="H" subId="17278107" subSource="6rai_A"/>
      <ConstraintRegion from="48" to="80" loc="O" subId="17278108" subSource="6rai_A"/>
      <ConstraintRegion from="81" to="98" loc="H" subId="17278110" subSource="6rai_A"/>
      <ConstraintRegion from="99" to="151" loc="I" subId="17278112" subSource="6rai_A"/>
      <ConstraintRegion from="152" to="170" loc="H" subId="17278113" subSource="6rai_A"/>
      <ConstraintRegion from="171" to="177" loc="O" subId="17278114" subSource="6rai_A"/>
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      <ConstraintRegion from="195" to="258" loc="I" subId="17278118" subSource="6rai_A"/>
      <ConstraintRegion from="259" to="275" loc="H" subId="17278120" subSource="6rai_A"/>
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      <ConstraintRegion from="315" to="597" loc="I" subId="17278124" subSource="6rai_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="4q4j_A">
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      <ConstraintRegion from="13" to="35" loc="H" subId="17258899" subSource="4q4j_A"/>
      <ConstraintRegion from="36" to="57" loc="O" subId="17258901" subSource="4q4j_A"/>
      <ConstraintRegion from="58" to="78" loc="H" subId="17258903" subSource="4q4j_A"/>
      <ConstraintRegion from="79" to="128" loc="I" subId="17258905" subSource="4q4j_A"/>
      <ConstraintRegion from="129" to="150" loc="H" subId="17258907" subSource="4q4j_A"/>
      <ConstraintRegion from="151" to="156" loc="O" subId="17258908" subSource="4q4j_A"/>
      <ConstraintRegion from="157" to="177" loc="H" subId="17258909" subSource="4q4j_A"/>
      <ConstraintRegion from="178" to="230" loc="I" subId="17258910" subSource="4q4j_A"/>
      <ConstraintRegion from="231" to="254" loc="H" subId="17258912" subSource="4q4j_A"/>
      <ConstraintRegion from="255" to="274" loc="O" subId="17258914" subSource="4q4j_A"/>
      <ConstraintRegion from="275" to="295" loc="H" subId="17258916" subSource="4q4j_A"/>
      <ConstraintRegion from="296" to="569" loc="I" subId="17258918" subSource="4q4j_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6qv1_A">
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      <ConstraintRegion from="13" to="36" loc="H" subId="17270768" subSource="6qv1_A"/>
      <ConstraintRegion from="37" to="53" loc="O" subId="17270769" subSource="6qv1_A"/>
      <ConstraintRegion from="54" to="78" loc="H" subId="17270770" subSource="6qv1_A"/>
      <ConstraintRegion from="79" to="126" loc="I" subId="17270771" subSource="6qv1_A"/>
      <ConstraintRegion from="127" to="149" loc="H" subId="17270772" subSource="6qv1_A"/>
      <ConstraintRegion from="150" to="155" loc="O" subId="17270773" subSource="6qv1_A"/>
      <ConstraintRegion from="156" to="177" loc="H" subId="17270774" subSource="6qv1_A"/>
      <ConstraintRegion from="178" to="233" loc="I" subId="17270775" subSource="6qv1_A"/>
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      <ConstraintRegion from="255" to="275" loc="O" subId="17270777" subSource="6qv1_A"/>
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      <ConstraintRegion from="298" to="570" loc="I" subId="17270779" subSource="6qv1_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6qv0_A">
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      <ConstraintRegion from="3" to="9" loc="F" subId="17270712" subSource="6qv0_A"/>
      <ConstraintRegion from="10" to="12" loc="I" subId="17270713" subSource="6qv0_A"/>
      <ConstraintRegion from="13" to="33" loc="H" subId="17270714" subSource="6qv0_A"/>
      <ConstraintRegion from="34" to="56" loc="O" subId="17270715" subSource="6qv0_A"/>
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      <ConstraintRegion from="80" to="126" loc="I" subId="17270717" subSource="6qv0_A"/>
      <ConstraintRegion from="127" to="149" loc="H" subId="17270718" subSource="6qv0_A"/>
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      <ConstraintRegion from="176" to="234" loc="I" subId="17270721" subSource="6qv0_A"/>
      <ConstraintRegion from="235" to="254" loc="H" subId="17270722" subSource="6qv0_A"/>
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      <ConstraintRegion from="297" to="569" loc="I" subId="17270727" subSource="6qv0_A"/>
      <ConstraintRegion from="2" to="11" loc="I" subId="17270795" subSource="6qv2_A"/>
      <ConstraintRegion from="12" to="33" loc="H" subId="17270796" subSource="6qv2_A"/>
      <ConstraintRegion from="34" to="57" loc="O" subId="17270797" subSource="6qv2_A"/>
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      <ConstraintRegion from="82" to="125" loc="I" subId="17270799" subSource="6qv2_A"/>
      <ConstraintRegion from="126" to="149" loc="H" subId="17270800" subSource="6qv2_A"/>
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      <ConstraintRegion from="235" to="254" loc="H" subId="17270804" subSource="6qv2_A"/>
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      <ConstraintRegion from="298" to="569" loc="I" subId="17270807" subSource="6qv2_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="7vr5_A">
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      <ConstraintRegion from="190" to="233" loc="I" subId="17369778" subSource="7vr5_A"/>
      <ConstraintRegion from="234" to="256" loc="H" subId="17369782" subSource="7vr5_A"/>
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      <ConstraintRegion from="101" to="117" loc="I" subId="17369812" subSource="7vr5_B"/>
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      <ConstraintRegion from="190" to="233" loc="I" subId="17369824" subSource="7vr5_B"/>
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    </Constraint>
    <Constraint source="TOPDB" sourceId="3wmg_A">
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      <ConstraintRegion from="103" to="116" loc="F" subId="17399874" subSource="3wmg_A"/>
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    </Constraint>
    <Constraint source="TOPDB" sourceId="7dqv_A">
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    </Constraint>
    <Constraint source="TOPDB" sourceId="6a6n_A">
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      <ConstraintRegion from="404" to="688" loc="I" subId="16963867" subSource="6a6n_B"/>
    </Constraint>
  </Constraints>
</HtpItem>
