<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="C9JYT6_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>Semaphorin 3D </Name>
  <CrossRef>
    <PDBTM id="4gza">
      <Chain id="G"/>
    </PDBTM>
    <PDBTM id="7m0r">
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="1olz">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3ol2">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3afc">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6wts">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3oky">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3al8">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3okw">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3nvq">
      <Chain id="A"/>
      <Chain id="E"/>
    </PDBTM>
    <TOPDB id="SEM4C_HUMAN">
      <Alignment>
        <CrossRefSeq>AVWLLAARLWGLGIGAEVWWNLVPRKTVSSGELA---TVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSMEALELQG-AISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYVNM------LTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMG---PHHSMKTEYLAF-WLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMGG</CrossRefSeq>
        <OrigSeq>ALMMLSMTMLFLPVTGTLKQN-IPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNP---DDDKIYFFFRESSQEGSTSDKTILSRVGRVCKENLCF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SEM4D_HUMAN">
      <Alignment>
        <CrossRefSeq>LMALAVMFGTAMAFAPI--------PRITWEHREVHLVQ-----FHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKF-------LGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRN----SSHSPLRTEYAIP-WLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGG</CrossRefSeq>
        <OrigSeq>LFPALMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFI---PDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKENLCF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SEM4D_MOUSE">
      <Alignment>
        <CrossRefSeq>MRMCAPVRGLFLALVVVLRTAVAFAPVPRLTWEHGEVGLVQ-----FHKPGIFNYSALLMSEDKDTLYVGAREAVFAVNALNISEKQHEVYWKVSEDKKSKCAEKGKSKQTECLNYIRVLQPLSSTSLYVCGTNAFQPTCDHLNLTSFKF-------LGKSEDGKGRCPFDPAHSYTSVMVGGELYSGTSYNFLGSEPIISRN----SSHSPLRTEYAIP-WLNEPSFVFADVIQKSPDGPEGEDDKVYFFFTEVSVEYEFVFKLMIPRVARVCKGDQGG</CrossRefSeq>
        <OrigSeq>FHLFPALMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFI---PDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKENLCF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SEM5A_HUMAN">
      <Alignment>
        <CrossRefSeq>IAWLFSSLGLWRLAHPEAQGTTQCQRTEHPVISYKEIGPWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSL-IQAVEWECDEATKKACYSKGKSKE-ECQNYIRVLL-VGGDRLFTCGTNAFTPVCTNRSLSNLTE-------IHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGIL---PPLRTAQYNSKWLNEPNFVSSYDI-------GNFTYFFFRENAVEHD-CGKTVFSRAARVCKNDIGGR</CrossRefSeq>
        <OrigSeq>ALMMLSMTMLFLPVTGTLKQNIP--RLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVM-TDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKENLCFE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SEM6A_HUMAN">
      <Alignment>
        <CrossRefSeq>ALLLYFTLLHFAGAG-FPEDSEPISISHGNY--TKQYPVFVGHKPGRNTTQRHRLDIQMIMI--MNGTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKD-ECHNFIKVLLKKNDDALFVCGTNAFNPSCRNYKMDTL-------EPFGDEFSGMARCPYDAKHANVALFADGKLYSATVTDFLAIDAVIYRSLGES---PTLRTVKHDSKWLKEPYFVQAVD-------YGDYIYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGG</CrossRefSeq>
        <OrigSeq>LMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIPFLG--------SSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNF----KKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKENLCF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SEM4B_HUMAN">
      <Alignment>
        <CrossRefSeq>TWALSPRISLP---LGSEERPFLRFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNV-LLEDGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRS----QSLRPTKTESSLN-WLQDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGE</CrossRefSeq>
        <OrigSeq>LKQNIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVD---LNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPD---TYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKENLCFE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SEM4A_HUMAN">
      <Alignment>
        <CrossRefSeq>PMPRVRYYAGD---ERRALSFFHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIE---LQDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLG---SQPVLKTDNFLRWLHHDASFVAAI-------PSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGE</CrossRefSeq>
        <OrigSeq>NIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLN--KNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKENLCFE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SEM6A_MOUSE">
      <Alignment>
        <CrossRefSeq>AGAGFPEDSEPISISHGNY--TKQYPVFVGHKPGRNTTQRHRLDIQMIMI--MNRTLYVAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKD-ECHNFIKVLLKKNDDTLFVCGTNAFNPSCRNYRVDTL-------ETFGDEFSGMARCPYDAKHANIALFADGKLYSATVTDFLAIDAVIYRSLG---DSPTLRTVKHDSKWLKEPYFVQAVD-------YGDYIYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGG</CrossRefSeq>
        <OrigSeq>VTGTLKQNIPRLKLTYKDLLLSNSCIPFLG--------SSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNF----KKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKENLCF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SEM4B_MOUSE">
      <Alignment>
        <CrossRefSeq>GPRISVP---LGSEERLIRKFEAENISNYTALLLSQDGKTLYVGAREALFALNSNLSFLPGGEYQELLWSADADRKQQCSFKGKDPKRDCQNYIKILLPLNSSHLLTCGTAAFSPLCAYIHIASFTLAQDEAGNVI-LEDGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRS----QSSRPTKTESSLN-WLQDPAFVASAYVPESLGSPIGDDDKIYFFFSETGQEFEFFENTIVSRVARVCKGDEGGE</CrossRefSeq>
        <OrigSeq>IPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVD---LNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNP---DDDKIYFFFRESSQEGSTSDKTILSRVGRVCKENLCFE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SEM7A_HUMAN">
      <Alignment>
        <CrossRefSeq>RSGPRIFAVWKGHVGQDRVDFGQTEPHTVLFHE----PGSSSVWVGGRGKVYLFDFPEGKN--------ASVRTVNIGSTKGSCLDKRDCENYITLLERRSEG-LLACGTNARHPSCWNLVNGTVVP----------LGEMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESEL-------YTSDTVMQNPQFIKA-TIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGES</CrossRefSeq>
        <OrigSeq>QNIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANT-ECANFIRVLQPYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTAS-DFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKENLCFED</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="294" CheckSum="04cf47b3185d97372272be08d012ad0b">
    <Seq>
      MNANKDERLK ARSQDFHLFP ALMMLSMTML FLPVTGTLKQ NIPRLKLTYK
      DLLLSNSCIP FLGSSEGLDF QTLLLDEERG RLLLGAKDHI FLLSLVDLNK
      NFKKIYWPAA KERVELCKLA GKDANTECAN FIRVLQPYNK THIYVCGTGA
      FHPICGYIDL GVYKEDIIFK LDTHNLESGR LKCPFDPQQP FASVMTDEYL
      YSGTASDFLG KDTAFTRSLG PTHDHHYIRT DISEHYWLNG AKFIGTFFIP
      DTYNPDDDKI YFFFRESSQE GSTSDKTILS RVGRVCKENL CFED
    </Seq>
  </Sequence>
  <Topology numTm="1" reliability="73.94">
    <Region from="1" to="14" loc="I"/>
    <Region from="15" to="35" loc="M"/>
    <Region from="36" to="294" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="35" loc="M"/>
      <Region from="36" to="294" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="192" loc="O"/>
      <Region from="193" to="208" loc="M"/>
      <Region from="209" to="294" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="36" loc="M"/>
      <Region from="37" to="294" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="37" loc="M"/>
      <Region from="38" to="294" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="15" loc="O"/>
      <Region from="16" to="38" loc="M"/>
      <Region from="39" to="294" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="36" loc="M"/>
      <Region from="37" to="294" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="36" loc="M"/>
      <Region from="37" to="294" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="17" loc="O"/>
      <Region from="18" to="37" loc="M"/>
      <Region from="38" to="294" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="36" loc="M"/>
      <Region from="37" to="294" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="38" loc="M"/>
      <Region from="39" to="294" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
