<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="D6RBE5_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Endosomal/lysosomal proton channel TMEM175 </Name>
  <CrossRef>
    <PDBTM id="6w8p">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6w8o">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7lf6">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6w8n">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8fy5">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8fyf">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6wc9">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6wca">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6wcb">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6wcc">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7unl">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8dhm">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7unm">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5vre">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
  </CrossRef>
  <Sequence Length="284" CheckSum="52ed21b0aaf29e97ce59ad2cd3da7d76">
    <Seq>
      MTFLIVTVAW AAHTRLFQVV GKTDDTLALL NLACMMTITF LPYTFSLMVT
      FPDVPLGIFL FCVCVIAIGV VQALIVGYAF HFPHLLSPQI QRSAHRALYR
      RHVLGIVLQG PALCFAAAIF SLFFVPLSYL LMVTVILLPY VSKVTGWCRD
      RLLGHREPSA HPVEVFSFDL HEPLSKERVE AFSDGVYAIV ATLLILDICE
      DNVPDPKDVK ERFSGSLVAA LSATGPRFLA YFGSFATVGL LWFAHHSLFL
      HVRKATRAMG LLNTLSLAFV GGLPLAYQQT SAFA
    </Seq>
  </Sequence>
  <Topology numTm="8" reliability="88.95">
    <Region from="1" to="1" loc="O"/>
    <Region from="2" to="13" loc="M"/>
    <Region from="14" to="25" loc="I"/>
    <Region from="26" to="44" loc="M"/>
    <Region from="45" to="57" loc="O"/>
    <Region from="58" to="76" loc="M"/>
    <Region from="77" to="103" loc="I"/>
    <Region from="104" to="120" loc="M"/>
    <Region from="121" to="126" loc="O"/>
    <Region from="127" to="141" loc="M"/>
    <Region from="142" to="180" loc="I"/>
    <Region from="181" to="195" loc="M"/>
    <Region from="196" to="228" loc="O"/>
    <Region from="229" to="244" loc="M"/>
    <Region from="245" to="257" loc="I"/>
    <Region from="258" to="276" loc="M"/>
    <Region from="277" to="284" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="1" loc="O"/>
      <Region from="2" to="21" loc="M"/>
      <Region from="22" to="26" loc="I"/>
      <Region from="27" to="51" loc="M"/>
      <Region from="52" to="53" loc="O"/>
      <Region from="54" to="80" loc="M"/>
      <Region from="81" to="110" loc="I"/>
      <Region from="111" to="138" loc="M"/>
      <Region from="139" to="216" loc="O"/>
      <Region from="217" to="244" loc="M"/>
      <Region from="245" to="284" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="26" loc="O"/>
      <Region from="27" to="51" loc="M"/>
      <Region from="52" to="54" loc="I"/>
      <Region from="55" to="80" loc="M"/>
      <Region from="81" to="103" loc="O"/>
      <Region from="104" to="120" loc="M"/>
      <Region from="121" to="123" loc="I"/>
      <Region from="124" to="142" loc="M"/>
      <Region from="143" to="181" loc="O"/>
      <Region from="182" to="197" loc="M"/>
      <Region from="198" to="225" loc="I"/>
      <Region from="226" to="244" loc="M"/>
      <Region from="245" to="257" loc="O"/>
      <Region from="258" to="275" loc="M"/>
      <Region from="276" to="284" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="1" loc="O"/>
      <Region from="2" to="22" loc="M"/>
      <Region from="23" to="26" loc="I"/>
      <Region from="27" to="47" loc="M"/>
      <Region from="48" to="50" loc="O"/>
      <Region from="51" to="81" loc="M"/>
      <Region from="82" to="98" loc="I"/>
      <Region from="99" to="119" loc="M"/>
      <Region from="120" to="120" loc="O"/>
      <Region from="121" to="141" loc="M"/>
      <Region from="142" to="180" loc="I"/>
      <Region from="181" to="201" loc="M"/>
      <Region from="202" to="217" loc="O"/>
      <Region from="218" to="248" loc="M"/>
      <Region from="249" to="250" loc="I"/>
      <Region from="251" to="281" loc="M"/>
      <Region from="282" to="284" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="26" loc="I"/>
      <Region from="27" to="47" loc="M"/>
      <Region from="48" to="56" loc="O"/>
      <Region from="57" to="82" loc="M"/>
      <Region from="83" to="101" loc="I"/>
      <Region from="102" to="124" loc="M"/>
      <Region from="125" to="227" loc="O"/>
      <Region from="228" to="249" loc="M"/>
      <Region from="250" to="257" loc="I"/>
      <Region from="258" to="277" loc="M"/>
      <Region from="278" to="284" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="26" loc="I"/>
      <Region from="27" to="45" loc="M"/>
      <Region from="46" to="56" loc="O"/>
      <Region from="57" to="82" loc="M"/>
      <Region from="83" to="102" loc="I"/>
      <Region from="103" to="123" loc="M"/>
      <Region from="124" to="128" loc="O"/>
      <Region from="129" to="148" loc="M"/>
      <Region from="149" to="227" loc="I"/>
      <Region from="228" to="245" loc="M"/>
      <Region from="246" to="256" loc="O"/>
      <Region from="257" to="277" loc="M"/>
      <Region from="278" to="284" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="20" loc="I"/>
      <Region from="21" to="41" loc="M"/>
      <Region from="42" to="61" loc="O"/>
      <Region from="62" to="82" loc="M"/>
      <Region from="83" to="102" loc="I"/>
      <Region from="103" to="123" loc="M"/>
      <Region from="124" to="227" loc="O"/>
      <Region from="228" to="248" loc="M"/>
      <Region from="249" to="257" loc="I"/>
      <Region from="258" to="278" loc="M"/>
      <Region from="279" to="284" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="24" loc="I"/>
      <Region from="25" to="45" loc="M"/>
      <Region from="46" to="54" loc="O"/>
      <Region from="55" to="75" loc="M"/>
      <Region from="76" to="103" loc="I"/>
      <Region from="104" to="124" loc="M"/>
      <Region from="125" to="228" loc="O"/>
      <Region from="229" to="249" loc="M"/>
      <Region from="250" to="258" loc="I"/>
      <Region from="259" to="279" loc="M"/>
      <Region from="280" to="284" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="24" loc="I"/>
      <Region from="25" to="45" loc="M"/>
      <Region from="46" to="55" loc="O"/>
      <Region from="56" to="75" loc="M"/>
      <Region from="76" to="102" loc="I"/>
      <Region from="103" to="122" loc="M"/>
      <Region from="123" to="124" loc="O"/>
      <Region from="125" to="144" loc="M"/>
      <Region from="145" to="180" loc="I"/>
      <Region from="181" to="200" loc="M"/>
      <Region from="201" to="227" loc="O"/>
      <Region from="228" to="247" loc="M"/>
      <Region from="248" to="256" loc="I"/>
      <Region from="257" to="276" loc="M"/>
      <Region from="277" to="284" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="24" loc="I"/>
      <Region from="25" to="45" loc="M"/>
      <Region from="46" to="55" loc="O"/>
      <Region from="56" to="76" loc="M"/>
      <Region from="77" to="102" loc="I"/>
      <Region from="103" to="123" loc="M"/>
      <Region from="124" to="124" loc="O"/>
      <Region from="125" to="145" loc="M"/>
      <Region from="146" to="180" loc="I"/>
      <Region from="181" to="201" loc="M"/>
      <Region from="202" to="227" loc="O"/>
      <Region from="228" to="248" loc="M"/>
      <Region from="249" to="257" loc="I"/>
      <Region from="258" to="278" loc="M"/>
      <Region from="279" to="284" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="26" loc="O"/>
      <Region from="27" to="49" loc="M"/>
      <Region from="50" to="55" loc="I"/>
      <Region from="56" to="78" loc="M"/>
      <Region from="79" to="118" loc="O"/>
      <Region from="119" to="141" loc="M"/>
      <Region from="142" to="227" loc="I"/>
      <Region from="228" to="250" loc="M"/>
      <Region from="251" to="254" loc="O"/>
      <Region from="255" to="277" loc="M"/>
      <Region from="278" to="284" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
