<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="E5RI04_HUMAN" transmembrane="yes" evidence="Experiment">
  <Name>Ankyrin repeat domain 46 </Name>
  <CrossRef>
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      <Chain id="A"/>
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    <PDBTM id="6moh">
      <Chain id="A"/>
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    <TOPDB id="ANR27_HUMAN">
      <Alignment>
        <CrossRefSeq>ARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQ--NSKIMELL</CrossRefSeq>
        <OrigSeq>NDSSQTNVPLLQACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLCG---HVDTIQFLVSNGLKIDICAMESHSLLNPNLQQGEGVLSSFR</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="175" CheckSum="a4611acda4e3bc86fd63417b999d6506">
    <Seq>
      MSYVFVNDSS QTNVPLLQAC IDGDFNYSKR LLESGFDPNI RDSRGRTGLH
      LAAARGNVDI CQLLHKFGAD LLATDYQGNT ALHLCGHVDT IQFLVSNGLK
      IDICAMESHS LLNPNLQQGE GVLSSFRTTW QEFVEDLGFW RVLLLIFVIA
      LLSLGIAYYV SGVLPFVENQ PELVH
    </Seq>
  </Sequence>
  <Topology numTm="1" reliability="76.81">
    <Region from="1" to="137" loc="I"/>
    <Region from="138" to="158" loc="M"/>
    <Region from="159" to="175" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="141" loc="O"/>
      <Region from="142" to="166" loc="M"/>
      <Region from="167" to="175" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="142" loc="I"/>
      <Region from="143" to="158" loc="M"/>
      <Region from="159" to="175" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="47" loc="I"/>
      <Region from="48" to="68" loc="M"/>
      <Region from="69" to="79" loc="O"/>
      <Region from="80" to="100" loc="M"/>
      <Region from="101" to="136" loc="I"/>
      <Region from="137" to="167" loc="M"/>
      <Region from="168" to="175" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="136" loc="I"/>
      <Region from="137" to="160" loc="M"/>
      <Region from="161" to="175" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="138" loc="I"/>
      <Region from="139" to="160" loc="M"/>
      <Region from="161" to="175" loc="O"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="142" loc="I"/>
      <Region from="143" to="163" loc="M"/>
      <Region from="164" to="175" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="11" loc="I"/>
      <Region from="12" to="32" loc="M"/>
      <Region from="33" to="44" loc="O"/>
      <Region from="45" to="66" loc="M"/>
      <Region from="67" to="77" loc="I"/>
      <Region from="78" to="98" loc="M"/>
      <Region from="99" to="175" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="138" loc="I"/>
      <Region from="139" to="159" loc="M"/>
      <Region from="160" to="175" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="138" loc="I"/>
      <Region from="139" to="159" loc="M"/>
      <Region from="160" to="175" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="136" loc="I"/>
      <Region from="137" to="159" loc="M"/>
      <Region from="160" to="175" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="6zog_D">
      <ConstraintRegion from="11" to="167" loc="O" subId="17474966" subSource="6zog_D"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6q4o_D">
      <ConstraintRegion from="12" to="167" loc="O" subId="17258891" subSource="6q4o_D"/>
      <ConstraintRegion from="12" to="167" loc="O" subId="17235762" subSource="7ouk_D"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="5jmn_D">
      <ConstraintRegion from="11" to="168" loc="O" subId="17138879" subSource="5jmn_D"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="4dx5_D">
      <ConstraintRegion from="11" to="166" loc="O" subId="17040695" subSource="4dx5_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17041047" subSource="4dx6_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17041459" subSource="4dx7_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17131597" subSource="2j8s_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17338144" subSource="4u8v_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17338501" subSource="4u8y_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17339070" subSource="4u95_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17339340" subSource="4u96_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17204388" subSource="5nc5_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17258523" subSource="6q4n_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17259142" subSource="6q4p_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17301989" subSource="6sgr_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17302257" subSource="6sgs_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17302669" subSource="6sgt_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17303098" subSource="6sgu_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17471318" subSource="6zo6_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17472514" subSource="6zo8_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17472778" subSource="6zo9_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17473165" subSource="6zoa_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17474055" subSource="6zoe_B"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17474101" subSource="6zoe_D"/>
      <ConstraintRegion from="11" to="166" loc="O" subId="17474132" subSource="6zoe_F"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6zo5_D">
      <ConstraintRegion from="12" to="166" loc="O" subId="17470573" subSource="6zo5_D"/>
      <ConstraintRegion from="12" to="166" loc="O" subId="17474692" subSource="6zof_D"/>
      <ConstraintRegion from="12" to="166" loc="O" subId="17236148" subSource="7oul_D"/>
      <ConstraintRegion from="12" to="166" loc="O" subId="17236421" subSource="7oum_D"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="3noc_D">
      <ConstraintRegion from="13" to="166" loc="O" subId="17212226" subSource="3noc_D"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6zoc_D">
      <ConstraintRegion from="11" to="165" loc="O" subId="17473610" subSource="6zoc_D"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="4dx5_E">
      <ConstraintRegion from="15" to="166" loc="O" subId="17040698" subSource="4dx5_E"/>
      <ConstraintRegion from="15" to="166" loc="O" subId="17041053" subSource="4dx6_E"/>
      <ConstraintRegion from="15" to="166" loc="O" subId="17041462" subSource="4dx7_E"/>
      <ConstraintRegion from="15" to="166" loc="O" subId="17004697" subSource="4c48_B"/>
      <ConstraintRegion from="15" to="166" loc="O" subId="17338147" subSource="4u8v_E"/>
      <ConstraintRegion from="15" to="166" loc="O" subId="17338505" subSource="4u8y_E"/>
      <ConstraintRegion from="15" to="166" loc="O" subId="17339073" subSource="4u95_E"/>
      <ConstraintRegion from="15" to="166" loc="O" subId="17339341" subSource="4u96_E"/>
      <ConstraintRegion from="15" to="166" loc="O" subId="17204389" subSource="5nc5_E"/>
      <ConstraintRegion from="15" to="166" loc="O" subId="17301995" subSource="6sgr_E"/>
      <ConstraintRegion from="15" to="166" loc="O" subId="17302258" subSource="6sgs_E"/>
      <ConstraintRegion from="15" to="166" loc="O" subId="17302675" subSource="6sgt_E"/>
      <ConstraintRegion from="15" to="166" loc="O" subId="17303101" subSource="6sgu_E"/>
      <ConstraintRegion from="15" to="166" loc="O" subId="17004768" subSource="4c48_E"/>
      <ConstraintRegion from="15" to="166" loc="O" subId="17004823" subSource="4c48_H"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="5jmn_E">
      <ConstraintRegion from="13" to="166" loc="O" subId="17138884" subSource="5jmn_E"/>
      <ConstraintRegion from="13" to="166" loc="O" subId="17258527" subSource="6q4n_E"/>
      <ConstraintRegion from="13" to="166" loc="O" subId="17258897" subSource="6q4o_E"/>
      <ConstraintRegion from="13" to="166" loc="O" subId="17259145" subSource="6q4p_E"/>
      <ConstraintRegion from="13" to="166" loc="O" subId="17471326" subSource="6zo6_E"/>
      <ConstraintRegion from="13" to="166" loc="O" subId="17471923" subSource="6zo7_E"/>
      <ConstraintRegion from="13" to="166" loc="O" subId="17472519" subSource="6zo8_E"/>
      <ConstraintRegion from="13" to="166" loc="O" subId="17472782" subSource="6zo9_E"/>
      <ConstraintRegion from="13" to="166" loc="O" subId="17473166" subSource="6zoa_E"/>
      <ConstraintRegion from="13" to="166" loc="O" subId="17473387" subSource="6zob_D"/>
      <ConstraintRegion from="13" to="166" loc="O" subId="17473391" subSource="6zob_E"/>
      <ConstraintRegion from="13" to="166" loc="O" subId="17473612" subSource="6zoc_E"/>
      <ConstraintRegion from="13" to="166" loc="O" subId="17473955" subSource="6zod_D"/>
      <ConstraintRegion from="13" to="166" loc="O" subId="17474698" subSource="6zof_E"/>
      <ConstraintRegion from="13" to="166" loc="O" subId="17474969" subSource="6zog_E"/>
      <ConstraintRegion from="13" to="166" loc="O" subId="17475287" subSource="6zoh_D"/>
      <ConstraintRegion from="13" to="166" loc="O" subId="17236155" subSource="7oul_E"/>
      <ConstraintRegion from="13" to="166" loc="O" subId="17236424" subSource="7oum_E"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="2j8s_E">
      <ConstraintRegion from="14" to="166" loc="O" subId="17131614" subSource="2j8s_E"/>
      <ConstraintRegion from="14" to="166" loc="O" subId="17470583" subSource="6zo5_E"/>
      <ConstraintRegion from="14" to="166" loc="O" subId="17475290" subSource="6zoh_E"/>
      <ConstraintRegion from="14" to="166" loc="O" subId="17235777" subSource="7ouk_E"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="3noc_E">
      <ConstraintRegion from="14" to="165" loc="O" subId="17212236" subSource="3noc_E"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6zo7_D">
      <ConstraintRegion from="13" to="165" loc="O" subId="17471920" subSource="6zo7_D"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6zod_E">
      <ConstraintRegion from="14" to="165" loc="O" subId="17473957" subSource="6zod_E"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="3nog_D">
      <ConstraintRegion from="13" to="166" loc="O" subId="17212902" subSource="3nog_D"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="3nog_E">
      <ConstraintRegion from="13" to="147" loc="O" subId="17212926" subSource="3nog_E"/>
      <ConstraintRegion from="151" to="166" loc="O" subId="17212936" subSource="3nog_E"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="7pd8_B">
      <ConstraintRegion from="9" to="136" loc="I" subId="17244751" subSource="7pd8_B"/>
      <ConstraintRegion from="9" to="136" loc="I" subId="17245033" subSource="7pdg_C"/>
    </Constraint>
  </Constraints>
</HtpItem>
