<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="E5RJ49_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>Ectonucleotide pyrophosphatase/phosphodiesterase 2 </Name>
  <CrossRef>
    <PDBTM id="6g4g">
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6c01">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6c02">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4b56">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6xkd">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4gtw">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4gtx">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4gty">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4gtz">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6f2v">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6f2t">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6ael">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6aek">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6f2y">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6f33">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6f30">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5ven">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5veo">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4lqy">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4lr2">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2ys0">
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="ENPP2_HUMAN">
      <Alignment>
        <CrossRefSeq>MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCKGRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPL</CrossRefSeq>
        <OrigSeq>MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCKGRCFELQEAGPPDCRCDNLS------------------RGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP3_HUMAN">
      <Alignment>
        <CrossRefSeq>QGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPM</CrossRefSeq>
        <OrigSeq>SGSCKGRCFELQEAGPPDCRCDNLS------------------RGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP3_RAT">
      <Alignment>
        <CrossRefSeq>GSCRKKCFDSSHRGLEGCRCDSGCTDRGDCCWDFEDTCVKSTQIWTCNSFRCGETRLEAALCSCADDCLQRKDCCTDYKAVCQGEVPWVTEACASSQEPQCPEGFDQPPVILFSMDGFRAEYLQTWSTLLPNINKLKTCGLHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVYLNKNFSLSSVEKSNPAWWSGQPI</CrossRefSeq>
        <OrigSeq>GSCKGRCFELQEAGPPDCRCDNLS------------------RGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP3_MOUSE">
      <Alignment>
        <CrossRefSeq>QGSCRKKCFDSSHRGLEGCRCDSGCTGRGDCCWDFEDTCVKSTQIWTCNLFRCGENRLETALCSCADDCLQRKDCCADYKTVCQGESPWVTEACASSQEPQCPPGFDLPPVILFSMDGFRAEYLQTWSTLLPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVHLNKNFSLSSVEKSNPAWWSGQPI</CrossRefSeq>
        <OrigSeq>SGSCKGRCFELQEAGPPDCRCDNLS------------------RGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP1_HUMAN">
      <Alignment>
        <CrossRefSeq>SCKGRCFERTFG---NCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPI</CrossRefSeq>
        <OrigSeq>SCKGRCFELQEAGPPDCRCDNLS------------------RGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP1_MOUSE">
      <Alignment>
        <CrossRefSeq>SCKGRCFERTF---SNCRCDAACVSLGNCCLDFQETCVEPTHIWTCNKFRCGEKRLSRFVCSCADDCKTHNDCCINYSSVCQDKKSWVEETCESIDTPECPAEFESPPTLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPMYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPI</CrossRefSeq>
        <OrigSeq>SCKGRCFELQEAGPPDCRCDNLS------------------RGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP5_MOUSE">
      <Alignment>
        <CrossRefSeq>CHSAPFSLQPEE---QKVLVVSFDGFRWDYLYKVPT--PHFHYIMKNGVHVNQVTNVFITKTYPNHYTLVTGLFAENHGIVANDMFDPILNKSFSLEHMDIYDSKFWEEATPI</CrossRefSeq>
        <OrigSeq>CEEIKAAECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWW-GGQPV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP4_MOUSE">
      <Alignment>
        <CrossRefSeq>NSSDSSAPRLLLVSFDGFRADYLKSYD--LPHLQNFIKEGVLVEHVKNVFITKTFPNHYSIVTGLYEESHGIVANSMYDSVTKKHFS--ESNDKDPFWWNGAEPI</CrossRefSeq>
        <OrigSeq>CPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGG-QPV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP4_HUMAN">
      <Alignment>
        <CrossRefSeq>DSSSSLPPKLLLVSFDGFRADYLKNYE--FPHLQNFIKEGVLVEHVKNVFITKTFPNHYSIVTGLYEESHGIVANSMYDAVTKKHFS--DSNDKDPFWWNEAVPI</CrossRefSeq>
        <OrigSeq>CPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWG-GQPV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP6_BOVIN">
      <Alignment>
        <CrossRefSeq>PASARRKLLVFLLDGFRADYISDEALESLPGFKEIVSRGVKVDYLTPDFPTLSYPNYYSLMTGRHCEVHQMTGNYMWDPDTNKSFDLGINRDSRLPLWWNGSEPL</CrossRefSeq>
        <OrigSeq>AGFVRPPLIIFSVDGFRASYM-KKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLR-GREKFNHRWWGG-QPV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP1_CAEEL">
      <Alignment>
        <CrossRefSeq>KARYEW--KGCQNLGKCEL-SGYTKPPLVILSLDGFAREYVDR--NIVQTLNHIADCGVKADKVYPSYPSKTFPNHYSIVTGLWPESHGITDNSVFDPTISPVLESMKSTKY-EKFFEGEPI</CrossRefSeq>
        <OrigSeq>KGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPV</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="245" CheckSum="42f70f70e5f48c6f91978947980f13a7">
    <Seq>
      MARRSSFQSC QIISLFTFAV GVNICLGFTA HRIKRAEGWE EGPPTVLSDS
      PWTNISGSCK GRCFELQEAG PPDCRCDNLS RGWECTKDRC GEVRNEENAC
      HCSEDCLARG DCCTNYQVVC KGESHWVDDD CEEIKAAECP AGFVRPPLII
      FSVDGFRASY MKKGSKVMPN IEKLRSCGTH SPYMRPVYPT KTFPNLYTLA
      TGLYPESHGI VGNSMYDPVF DATFHLRGRE KFNHRWWGGQ PVSFA
    </Seq>
  </Sequence>
  <Topology numTm="1" reliability="75.07">
    <Region from="1" to="10" loc="I"/>
    <Region from="11" to="30" loc="M"/>
    <Region from="31" to="245" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="11" loc="I"/>
      <Region from="12" to="30" loc="M"/>
      <Region from="31" to="245" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="17" loc="O"/>
      <Region from="18" to="33" loc="M"/>
      <Region from="34" to="245" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="9" loc="I"/>
      <Region from="10" to="30" loc="M"/>
      <Region from="31" to="245" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="11" loc="I"/>
      <Region from="12" to="30" loc="M"/>
      <Region from="31" to="245" loc="O"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="11" loc="I"/>
      <Region from="12" to="32" loc="M"/>
      <Region from="33" to="245" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="11" loc="I"/>
      <Region from="12" to="32" loc="M"/>
      <Region from="33" to="245" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="9" loc="O"/>
      <Region from="10" to="29" loc="M"/>
      <Region from="30" to="245" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="9" loc="O"/>
      <Region from="10" to="30" loc="M"/>
      <Region from="31" to="245" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="11" loc="I"/>
      <Region from="12" to="31" loc="M"/>
      <Region from="32" to="245" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
