<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="E7EUT2_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>Piezo type mechanosensitive ion channel component 1 </Name>
  <CrossRef>
    <PDBTM id="6lqi">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5z10">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8imz">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7wlt">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="E"/>
    </PDBTM>
    <PDBTM id="6b3r">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="E"/>
    </PDBTM>
    <PDBTM id="3jac">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7wlu">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="E"/>
    </PDBTM>
    <PDBTM id="6bpz">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6kg7">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="4rax">
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="PIEZ1_HUMAN">
      <Alignment>
        <CrossRefSeq>EDIYANIFIIKC-SRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLVRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIIPFTAQAYEELSRQFDPQPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKRELYNGTADITLRFTWNFQRDLAKGGTVEYANEKHMLALAPNSTARRQLASLLEGTSDQSVVIPNLFPKYIRAPNGPEANPVKQLQPNEEADYLGVRIQLRREQGAGATGFLEWWVIELQECRTDCNLLPMVIFSDK</CrossRefSeq>
        <OrigSeq>SSKSSIVLALKFRSLIHFEKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLVRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIIPFTAQAYEELSRQFDPQPLAMQFISQYSPEDIVTAQIEGSSGALWRISPPSRAQMKRELYNGTADITLRFTWNFQRDLAKGGTVEYANEKHMLALAPNSTARRQLASLLEGTSDQSVVIPNLFPKYIRAPNGPEANPVKQLQPNEEADYLGVRIQLRREQGAGATGFLEWWVIELQECRTDCNLLPMVIFSDK</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="373" CheckSum="f22901cb6ade03d2f7722bea9316cc9d">
    <Seq>
      MKICPFSSKS SIVLALKFRS LIHFEKYPQP KGQKKKKIVK YGMGGLIILF
      LIAIIWFPLL FMSLVRSVVG VVNQPIDVTV TLKLGGYEPL FTMSAQQPSI
      IPFTAQAYEE LSRQFDPQPL AMQFISQYSP EDIVTAQIEG SSGALWRISP
      PSRAQMKREL YNGTADITLR FTWNFQRDLA KGGTVEYANE KHMLALAPNS
      TARRQLASLL EGTSDQSVVI PNLFPKYIRA PNGPEANPVK QLQPNEEADY
      LGVRIQLRRE QGAGATGFLE WWVIELQECR TDCNLLPMVI FSDKHHGAVR
      VHRAGHRQVR ARILQRDLAL HYVRGAAVRG PHPQALPGHL PGAGDSGAGA
      GGGVVRQAHL PLPLTGDHDQ VDS
    </Seq>
  </Sequence>
  <Topology numTm="1" reliability="78.53">
    <Region from="1" to="40" loc="I"/>
    <Region from="41" to="60" loc="M"/>
    <Region from="61" to="373" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="2" loc="O"/>
      <Region from="3" to="16" loc="M"/>
      <Region from="17" to="41" loc="I"/>
      <Region from="42" to="55" loc="M"/>
      <Region from="56" to="58" loc="O"/>
      <Region from="59" to="72" loc="M"/>
      <Region from="73" to="373" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="38" loc="O"/>
      <Region from="39" to="64" loc="M"/>
      <Region from="65" to="373" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="41" loc="I"/>
      <Region from="42" to="62" loc="M"/>
      <Region from="63" to="373" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="40" loc="I"/>
      <Region from="41" to="60" loc="M"/>
      <Region from="61" to="373" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="40" loc="I"/>
      <Region from="41" to="65" loc="M"/>
      <Region from="66" to="373" loc="O"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="40" loc="I"/>
      <Region from="41" to="61" loc="M"/>
      <Region from="62" to="373" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="40" loc="I"/>
      <Region from="41" to="62" loc="M"/>
      <Region from="63" to="373" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="40" loc="I"/>
      <Region from="41" to="61" loc="M"/>
      <Region from="62" to="373" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="40" loc="I"/>
      <Region from="41" to="61" loc="M"/>
      <Region from="62" to="373" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="37" loc="I"/>
      <Region from="38" to="60" loc="M"/>
      <Region from="61" to="373" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
