<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="E9PD72_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Transporter </Name>
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    <TOPDB id="SC6A4_RAT">
      <Alignment>
        <CrossRefSeq>AGDEASHSIPAATTT-LVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYA</CrossRefSeq>
        <OrigSeq>PNPGLDARIPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGAS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SC6A4_HUMAN">
      <Alignment>
        <CrossRefSeq>SAVPSPGAGDDTRHSIPATTTT-LVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYA</CrossRefSeq>
        <OrigSeq>VRLVLPNPGLDAR--IPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGAS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SC6A6_HUMAN">
      <Alignment>
        <CrossRefSeq>ILKPSPGKSPG----TRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASV</CrossRefSeq>
        <OrigSeq>LVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGASAL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="INE_DROME">
      <Alignment>
        <CrossRefSeq>MVNPQTPPPLGVDDDDSYLDMSDETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASV</CrossRefSeq>
        <OrigSeq>MVRLVLPNPGLDARIPSLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGASAL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="DAT_DROME">
      <Alignment>
        <CrossRefSeq>DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVL</CrossRefSeq>
        <OrigSeq>SSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGASALE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SC6A1_MOUSE">
      <Alignment>
        <CrossRefSeq>ISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVW-KLAPMFKGVGLAA</CrossRefSeq>
        <OrigSeq>VRLVLPNPGLDARIPSLAELE-TIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGASA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="NAAT1_DROME">
      <Alignment>
        <CrossRefSeq>AASTEKTDAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIWS-VVPGFVGVGYG</CrossRefSeq>
        <OrigSeq>SLAELETIEQEEASSRPKWDNKAQYMLTCLGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVLEGIPLLYLEFAIGQRLRRGSLGVWSSIHPALKGLGAS</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="354" CheckSum="5d9b242d0e0956b54f301c8faaa6a37d">
    <Seq>
      MVRLVLPNPG LDARIPSLAE LETIEQEEAS SRPKWDNKAQ YMLTCLGFCV
      GLGNVWRFPY LCQSHGGGAF MIPFLILLVL EGIPLLYLEF AIGQRLRRGS
      LGVWSSIHPA LKGLGASALE RLPAQREPDR VCGRVRQELP CGLLLVPRDA
      QHLHVHQRLG LHPVVDAAVP GLRMERPVHV HHPRHRDHRE GRVHHLHAAL
      CRPDHLPHPR PDAEGRHQWH RLPLHAQRHG AGPAGHLAGR GRTGLLLLLP
      GLRGPHLLLQ LQLCAQQLRE GLGDCVHHQR LHIGVCGHRG LLRHWVPRHT
      ALRRLLQHVS GCPTILVPWA APPGSLPASL APGGRQPQSD PQEHPDPHQR
      VRPA
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="81.38">
    <Region from="1" to="40" loc="I"/>
    <Region from="41" to="58" loc="M"/>
    <Region from="59" to="68" loc="O"/>
    <Region from="69" to="87" loc="M"/>
    <Region from="88" to="354" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="40" loc="I"/>
      <Region from="41" to="53" loc="M"/>
      <Region from="54" to="73" loc="O"/>
      <Region from="74" to="87" loc="M"/>
      <Region from="88" to="354" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="39" loc="I"/>
      <Region from="40" to="59" loc="M"/>
      <Region from="60" to="70" loc="O"/>
      <Region from="71" to="90" loc="M"/>
      <Region from="91" to="354" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="37" loc="I"/>
      <Region from="38" to="58" loc="M"/>
      <Region from="59" to="67" loc="O"/>
      <Region from="68" to="88" loc="M"/>
      <Region from="89" to="106" loc="I"/>
      <Region from="107" to="127" loc="M"/>
      <Region from="128" to="231" loc="O"/>
      <Region from="232" to="262" loc="M"/>
      <Region from="263" to="273" loc="I"/>
      <Region from="274" to="288" loc="L"/>
      <Region from="289" to="303" loc="I"/>
      <Region from="304" to="324" loc="M"/>
      <Region from="325" to="354" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="38" loc="I"/>
      <Region from="39" to="60" loc="M"/>
      <Region from="61" to="68" loc="O"/>
      <Region from="69" to="88" loc="M"/>
      <Region from="89" to="304" loc="I"/>
      <Region from="305" to="322" loc="M"/>
      <Region from="323" to="354" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="40" loc="I"/>
      <Region from="41" to="58" loc="M"/>
      <Region from="59" to="69" loc="O"/>
      <Region from="70" to="88" loc="M"/>
      <Region from="89" to="354" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="41" loc="I"/>
      <Region from="42" to="62" loc="M"/>
      <Region from="63" to="66" loc="O"/>
      <Region from="67" to="87" loc="M"/>
      <Region from="88" to="354" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="41" loc="I"/>
      <Region from="42" to="62" loc="M"/>
      <Region from="63" to="67" loc="O"/>
      <Region from="68" to="89" loc="M"/>
      <Region from="90" to="130" loc="I"/>
      <Region from="131" to="152" loc="M"/>
      <Region from="153" to="232" loc="O"/>
      <Region from="233" to="261" loc="M"/>
      <Region from="262" to="301" loc="I"/>
      <Region from="302" to="323" loc="M"/>
      <Region from="324" to="354" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="40" loc="I"/>
      <Region from="41" to="61" loc="M"/>
      <Region from="62" to="67" loc="O"/>
      <Region from="68" to="88" loc="M"/>
      <Region from="89" to="354" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="69" loc="O"/>
      <Region from="70" to="90" loc="M"/>
      <Region from="91" to="354" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="38" loc="O"/>
      <Region from="39" to="61" loc="M"/>
      <Region from="62" to="65" loc="I"/>
      <Region from="66" to="88" loc="M"/>
      <Region from="89" to="354" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="8de3_A">
      <ConstraintRegion from="116" to="123" loc="I" subId="17028566" subSource="8de3_A"/>
      <ConstraintRegion from="124" to="142" loc="H" subId="17028568" subSource="8de3_A"/>
      <ConstraintRegion from="143" to="154" loc="O" subId="17028570" subSource="8de3_A"/>
      <ConstraintRegion from="155" to="174" loc="H" subId="17028572" subSource="8de3_A"/>
      <ConstraintRegion from="175" to="197" loc="I" subId="17028574" subSource="8de3_A"/>
      <ConstraintRegion from="198" to="222" loc="H" subId="17028576" subSource="8de3_A"/>
      <ConstraintRegion from="223" to="288" loc="O" subId="17028578" subSource="8de3_A"/>
      <ConstraintRegion from="289" to="308" loc="H" subId="17028580" subSource="8de3_A"/>
      <ConstraintRegion from="309" to="313" loc="I" subId="17028582" subSource="8de3_A"/>
      <ConstraintRegion from="314" to="333" loc="H" subId="17028584" subSource="8de3_A"/>
      <ConstraintRegion from="334" to="360" loc="O" subId="17028587" subSource="8de3_A"/>
      <ConstraintRegion from="361" to="382" loc="H" subId="17028589" subSource="8de3_A"/>
      <ConstraintRegion from="383" to="395" loc="I" subId="17028592" subSource="8de3_A"/>
      <ConstraintRegion from="396" to="413" loc="H" subId="17028595" subSource="8de3_A"/>
      <ConstraintRegion from="414" to="462" loc="O" subId="17028598" subSource="8de3_A"/>
      <ConstraintRegion from="463" to="484" loc="H" subId="17028601" subSource="8de3_A"/>
      <ConstraintRegion from="485" to="503" loc="I" subId="17028604" subSource="8de3_A"/>
      <ConstraintRegion from="504" to="519" loc="H" subId="17028607" subSource="8de3_A"/>
      <ConstraintRegion from="520" to="525" loc="O" subId="17028610" subSource="8de3_A"/>
      <ConstraintRegion from="526" to="548" loc="H" subId="17028613" subSource="8de3_A"/>
      <ConstraintRegion from="549" to="572" loc="I" subId="17028616" subSource="8de3_A"/>
      <ConstraintRegion from="573" to="595" loc="H" subId="17028619" subSource="8de3_A"/>
      <ConstraintRegion from="596" to="612" loc="O" subId="17028622" subSource="8de3_A"/>
      <ConstraintRegion from="613" to="631" loc="H" subId="17028625" subSource="8de3_A"/>
      <ConstraintRegion from="632" to="654" loc="I" subId="17028628" subSource="8de3_A"/>
      <ConstraintRegion from="116" to="123" loc="I" subId="17028648" subSource="8de4_A"/>
      <ConstraintRegion from="124" to="139" loc="H" subId="17028651" subSource="8de4_A"/>
      <ConstraintRegion from="140" to="155" loc="O" subId="17028655" subSource="8de4_A"/>
      <ConstraintRegion from="156" to="173" loc="H" subId="17028660" subSource="8de4_A"/>
      <ConstraintRegion from="174" to="201" loc="I" subId="17028664" subSource="8de4_A"/>
      <ConstraintRegion from="202" to="221" loc="H" subId="17028668" subSource="8de4_A"/>
      <ConstraintRegion from="222" to="288" loc="O" subId="17028673" subSource="8de4_A"/>
      <ConstraintRegion from="289" to="308" loc="H" subId="17028678" subSource="8de4_A"/>
      <ConstraintRegion from="309" to="313" loc="I" subId="17028682" subSource="8de4_A"/>
      <ConstraintRegion from="314" to="330" loc="H" subId="17028685" subSource="8de4_A"/>
      <ConstraintRegion from="331" to="363" loc="O" subId="17028690" subSource="8de4_A"/>
      <ConstraintRegion from="364" to="381" loc="H" subId="17028695" subSource="8de4_A"/>
      <ConstraintRegion from="382" to="395" loc="I" subId="17028699" subSource="8de4_A"/>
      <ConstraintRegion from="396" to="412" loc="H" subId="17028706" subSource="8de4_A"/>
      <ConstraintRegion from="413" to="465" loc="O" subId="17028710" subSource="8de4_A"/>
      <ConstraintRegion from="466" to="483" loc="H" subId="17028713" subSource="8de4_A"/>
      <ConstraintRegion from="484" to="503" loc="I" subId="17028717" subSource="8de4_A"/>
      <ConstraintRegion from="504" to="519" loc="H" subId="17028720" subSource="8de4_A"/>
      <ConstraintRegion from="520" to="525" loc="O" subId="17028721" subSource="8de4_A"/>
      <ConstraintRegion from="526" to="546" loc="H" subId="17028722" subSource="8de4_A"/>
      <ConstraintRegion from="547" to="576" loc="I" subId="17028723" subSource="8de4_A"/>
      <ConstraintRegion from="577" to="598" loc="H" subId="17028725" subSource="8de4_A"/>
      <ConstraintRegion from="599" to="610" loc="O" subId="17028727" subSource="8de4_A"/>
      <ConstraintRegion from="611" to="625" loc="H" subId="17028729" subSource="8de4_A"/>
      <ConstraintRegion from="626" to="654" loc="I" subId="17028731" subSource="8de4_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6yu2_A">
      <ConstraintRegion from="8" to="19" loc="I" subId="17447217" subSource="6yu2_A"/>
      <ConstraintRegion from="20" to="36" loc="H" subId="17447218" subSource="6yu2_A"/>
      <ConstraintRegion from="37" to="48" loc="O" subId="17447219" subSource="6yu2_A"/>
      <ConstraintRegion from="49" to="67" loc="H" subId="17447220" subSource="6yu2_A"/>
      <ConstraintRegion from="68" to="88" loc="I" subId="17447221" subSource="6yu2_A"/>
      <ConstraintRegion from="89" to="125" loc="H" subId="17447222" subSource="6yu2_A"/>
      <ConstraintRegion from="126" to="133" loc="O" subId="17447223" subSource="6yu2_A"/>
      <ConstraintRegion from="134" to="143" loc="F" subId="17447224" subSource="6yu2_A"/>
      <ConstraintRegion from="144" to="147" loc="O" subId="17447225" subSource="6yu2_A"/>
      <ConstraintRegion from="148" to="165" loc="H" subId="17447226" subSource="6yu2_A"/>
      <ConstraintRegion from="166" to="175" loc="I" subId="17447227" subSource="6yu2_A"/>
      <ConstraintRegion from="176" to="193" loc="H" subId="17447228" subSource="6yu2_A"/>
      <ConstraintRegion from="194" to="199" loc="O" subId="17447229" subSource="6yu2_A"/>
      <ConstraintRegion from="200" to="208" loc="F" subId="17447230" subSource="6yu2_A"/>
      <ConstraintRegion from="209" to="221" loc="O" subId="17447231" subSource="6yu2_A"/>
      <ConstraintRegion from="222" to="242" loc="H" subId="17447232" subSource="6yu2_A"/>
      <ConstraintRegion from="243" to="253" loc="I" subId="17447233" subSource="6yu2_A"/>
      <ConstraintRegion from="254" to="273" loc="H" subId="17447234" subSource="6yu2_A"/>
      <ConstraintRegion from="274" to="291" loc="O" subId="17447235" subSource="6yu2_A"/>
      <ConstraintRegion from="292" to="300" loc="F" subId="17447236" subSource="6yu2_A"/>
      <ConstraintRegion from="301" to="305" loc="O" subId="17447237" subSource="6yu2_A"/>
      <ConstraintRegion from="306" to="333" loc="H" subId="17447238" subSource="6yu2_A"/>
      <ConstraintRegion from="334" to="347" loc="I" subId="17447239" subSource="6yu2_A"/>
      <ConstraintRegion from="348" to="363" loc="H" subId="17447240" subSource="6yu2_A"/>
      <ConstraintRegion from="364" to="383" loc="O" subId="17447241" subSource="6yu2_A"/>
      <ConstraintRegion from="384" to="407" loc="H" subId="17447242" subSource="6yu2_A"/>
      <ConstraintRegion from="408" to="409" loc="I" subId="17447243" subSource="6yu2_A"/>
      <ConstraintRegion from="410" to="416" loc="F" subId="17447244" subSource="6yu2_A"/>
      <ConstraintRegion from="417" to="423" loc="I" subId="17447245" subSource="6yu2_A"/>
      <ConstraintRegion from="424" to="445" loc="H" subId="17447246" subSource="6yu2_A"/>
      <ConstraintRegion from="446" to="448" loc="O" subId="17447247" subSource="6yu2_A"/>
      <ConstraintRegion from="8" to="19" loc="I" subId="17447248" subSource="6yu2_B"/>
      <ConstraintRegion from="20" to="36" loc="H" subId="17447249" subSource="6yu2_B"/>
      <ConstraintRegion from="37" to="48" loc="O" subId="17447250" subSource="6yu2_B"/>
      <ConstraintRegion from="49" to="67" loc="H" subId="17447251" subSource="6yu2_B"/>
      <ConstraintRegion from="68" to="88" loc="I" subId="17447252" subSource="6yu2_B"/>
      <ConstraintRegion from="89" to="125" loc="H" subId="17447253" subSource="6yu2_B"/>
      <ConstraintRegion from="126" to="133" loc="O" subId="17447254" subSource="6yu2_B"/>
      <ConstraintRegion from="134" to="144" loc="F" subId="17447255" subSource="6yu2_B"/>
      <ConstraintRegion from="145" to="147" loc="O" subId="17447256" subSource="6yu2_B"/>
      <ConstraintRegion from="148" to="165" loc="H" subId="17447257" subSource="6yu2_B"/>
      <ConstraintRegion from="166" to="175" loc="I" subId="17447258" subSource="6yu2_B"/>
      <ConstraintRegion from="176" to="193" loc="H" subId="17447259" subSource="6yu2_B"/>
      <ConstraintRegion from="194" to="199" loc="O" subId="17447260" subSource="6yu2_B"/>
      <ConstraintRegion from="200" to="208" loc="F" subId="17447261" subSource="6yu2_B"/>
      <ConstraintRegion from="209" to="221" loc="O" subId="17447262" subSource="6yu2_B"/>
      <ConstraintRegion from="222" to="242" loc="H" subId="17447263" subSource="6yu2_B"/>
      <ConstraintRegion from="243" to="253" loc="I" subId="17447264" subSource="6yu2_B"/>
      <ConstraintRegion from="254" to="273" loc="H" subId="17447265" subSource="6yu2_B"/>
      <ConstraintRegion from="274" to="290" loc="O" subId="17447266" subSource="6yu2_B"/>
      <ConstraintRegion from="291" to="302" loc="F" subId="17447267" subSource="6yu2_B"/>
      <ConstraintRegion from="303" to="305" loc="O" subId="17447268" subSource="6yu2_B"/>
      <ConstraintRegion from="306" to="333" loc="H" subId="17447269" subSource="6yu2_B"/>
      <ConstraintRegion from="334" to="347" loc="I" subId="17447270" subSource="6yu2_B"/>
      <ConstraintRegion from="348" to="363" loc="H" subId="17447271" subSource="6yu2_B"/>
      <ConstraintRegion from="364" to="383" loc="O" subId="17447272" subSource="6yu2_B"/>
      <ConstraintRegion from="384" to="407" loc="H" subId="17447273" subSource="6yu2_B"/>
      <ConstraintRegion from="408" to="409" loc="I" subId="17447274" subSource="6yu2_B"/>
      <ConstraintRegion from="410" to="415" loc="F" subId="17447275" subSource="6yu2_B"/>
      <ConstraintRegion from="416" to="423" loc="I" subId="17447276" subSource="6yu2_B"/>
      <ConstraintRegion from="424" to="445" loc="H" subId="17447277" subSource="6yu2_B"/>
      <ConstraintRegion from="446" to="448" loc="O" subId="17447278" subSource="6yu2_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6yu3_A">
      <ConstraintRegion from="8" to="19" loc="I" subId="17447283" subSource="6yu3_A"/>
      <ConstraintRegion from="20" to="39" loc="H" subId="17447285" subSource="6yu3_A"/>
      <ConstraintRegion from="40" to="44" loc="O" subId="17447287" subSource="6yu3_A"/>
      <ConstraintRegion from="45" to="67" loc="H" subId="17447289" subSource="6yu3_A"/>
      <ConstraintRegion from="68" to="89" loc="I" subId="17447291" subSource="6yu3_A"/>
      <ConstraintRegion from="90" to="120" loc="H" subId="17447293" subSource="6yu3_A"/>
      <ConstraintRegion from="121" to="133" loc="O" subId="17447295" subSource="6yu3_A"/>
      <ConstraintRegion from="134" to="144" loc="F" subId="17447297" subSource="6yu3_A"/>
      <ConstraintRegion from="145" to="149" loc="O" subId="17447299" subSource="6yu3_A"/>
      <ConstraintRegion from="150" to="168" loc="H" subId="17447301" subSource="6yu3_A"/>
      <ConstraintRegion from="169" to="171" loc="I" subId="17447303" subSource="6yu3_A"/>
      <ConstraintRegion from="172" to="193" loc="H" subId="17447305" subSource="6yu3_A"/>
      <ConstraintRegion from="194" to="218" loc="O" subId="17447307" subSource="6yu3_A"/>
      <ConstraintRegion from="219" to="242" loc="H" subId="17447309" subSource="6yu3_A"/>
      <ConstraintRegion from="243" to="254" loc="I" subId="17447311" subSource="6yu3_A"/>
      <ConstraintRegion from="255" to="274" loc="H" subId="17447313" subSource="6yu3_A"/>
      <ConstraintRegion from="275" to="290" loc="O" subId="17447315" subSource="6yu3_A"/>
      <ConstraintRegion from="291" to="302" loc="F" subId="17447317" subSource="6yu3_A"/>
      <ConstraintRegion from="303" to="307" loc="O" subId="17447319" subSource="6yu3_A"/>
      <ConstraintRegion from="308" to="337" loc="H" subId="17447321" subSource="6yu3_A"/>
      <ConstraintRegion from="338" to="344" loc="I" subId="17447323" subSource="6yu3_A"/>
      <ConstraintRegion from="345" to="363" loc="H" subId="17447325" subSource="6yu3_A"/>
      <ConstraintRegion from="364" to="380" loc="O" subId="17447327" subSource="6yu3_A"/>
      <ConstraintRegion from="381" to="403" loc="H" subId="17447329" subSource="6yu3_A"/>
      <ConstraintRegion from="404" to="409" loc="I" subId="17447331" subSource="6yu3_A"/>
      <ConstraintRegion from="410" to="416" loc="F" subId="17447333" subSource="6yu3_A"/>
      <ConstraintRegion from="417" to="427" loc="I" subId="17447335" subSource="6yu3_A"/>
      <ConstraintRegion from="428" to="448" loc="H" subId="17447337" subSource="6yu3_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6yu4_A">
      <ConstraintRegion from="8" to="19" loc="I" subId="17447354" subSource="6yu4_A"/>
      <ConstraintRegion from="20" to="39" loc="H" subId="17447356" subSource="6yu4_A"/>
      <ConstraintRegion from="40" to="44" loc="O" subId="17447358" subSource="6yu4_A"/>
      <ConstraintRegion from="45" to="64" loc="H" subId="17447360" subSource="6yu4_A"/>
      <ConstraintRegion from="65" to="92" loc="I" subId="17447362" subSource="6yu4_A"/>
      <ConstraintRegion from="93" to="120" loc="H" subId="17447364" subSource="6yu4_A"/>
      <ConstraintRegion from="121" to="133" loc="O" subId="17447366" subSource="6yu4_A"/>
      <ConstraintRegion from="134" to="144" loc="F" subId="17447368" subSource="6yu4_A"/>
      <ConstraintRegion from="145" to="149" loc="O" subId="17447370" subSource="6yu4_A"/>
      <ConstraintRegion from="150" to="167" loc="H" subId="17447372" subSource="6yu4_A"/>
      <ConstraintRegion from="168" to="171" loc="I" subId="17447374" subSource="6yu4_A"/>
      <ConstraintRegion from="172" to="192" loc="H" subId="17447376" subSource="6yu4_A"/>
      <ConstraintRegion from="193" to="215" loc="O" subId="17447378" subSource="6yu4_A"/>
      <ConstraintRegion from="216" to="242" loc="H" subId="17447380" subSource="6yu4_A"/>
      <ConstraintRegion from="243" to="255" loc="I" subId="17447382" subSource="6yu4_A"/>
      <ConstraintRegion from="256" to="273" loc="H" subId="17447384" subSource="6yu4_A"/>
      <ConstraintRegion from="274" to="290" loc="O" subId="17447386" subSource="6yu4_A"/>
      <ConstraintRegion from="291" to="301" loc="F" subId="17447388" subSource="6yu4_A"/>
      <ConstraintRegion from="302" to="308" loc="O" subId="17447390" subSource="6yu4_A"/>
      <ConstraintRegion from="309" to="336" loc="H" subId="17447392" subSource="6yu4_A"/>
      <ConstraintRegion from="337" to="344" loc="I" subId="17447394" subSource="6yu4_A"/>
      <ConstraintRegion from="345" to="363" loc="H" subId="17447396" subSource="6yu4_A"/>
      <ConstraintRegion from="364" to="380" loc="O" subId="17447398" subSource="6yu4_A"/>
      <ConstraintRegion from="381" to="402" loc="H" subId="17447400" subSource="6yu4_A"/>
      <ConstraintRegion from="403" to="422" loc="I" subId="17447401" subSource="6yu4_A"/>
      <ConstraintRegion from="423" to="430" loc="F" subId="17447402" subSource="6yu4_A"/>
      <ConstraintRegion from="431" to="449" loc="H" subId="17447403" subSource="6yu4_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6yu5_A">
      <ConstraintRegion from="8" to="18" loc="I" subId="17447419" subSource="6yu5_A"/>
      <ConstraintRegion from="19" to="39" loc="H" subId="17447421" subSource="6yu5_A"/>
      <ConstraintRegion from="40" to="44" loc="O" subId="17447423" subSource="6yu5_A"/>
      <ConstraintRegion from="45" to="67" loc="H" subId="17447425" subSource="6yu5_A"/>
      <ConstraintRegion from="68" to="90" loc="I" subId="17447427" subSource="6yu5_A"/>
      <ConstraintRegion from="91" to="124" loc="H" subId="17447429" subSource="6yu5_A"/>
      <ConstraintRegion from="125" to="147" loc="O" subId="17447431" subSource="6yu5_A"/>
      <ConstraintRegion from="148" to="166" loc="H" subId="17447433" subSource="6yu5_A"/>
      <ConstraintRegion from="167" to="171" loc="I" subId="17447435" subSource="6yu5_A"/>
      <ConstraintRegion from="172" to="192" loc="H" subId="17447437" subSource="6yu5_A"/>
      <ConstraintRegion from="193" to="215" loc="O" subId="17447439" subSource="6yu5_A"/>
      <ConstraintRegion from="216" to="242" loc="H" subId="17447441" subSource="6yu5_A"/>
      <ConstraintRegion from="243" to="253" loc="I" subId="17447443" subSource="6yu5_A"/>
      <ConstraintRegion from="254" to="273" loc="H" subId="17447445" subSource="6yu5_A"/>
      <ConstraintRegion from="274" to="290" loc="O" subId="17447447" subSource="6yu5_A"/>
      <ConstraintRegion from="291" to="301" loc="F" subId="17447449" subSource="6yu5_A"/>
      <ConstraintRegion from="302" to="308" loc="O" subId="17447451" subSource="6yu5_A"/>
      <ConstraintRegion from="309" to="336" loc="H" subId="17447453" subSource="6yu5_A"/>
      <ConstraintRegion from="337" to="345" loc="I" subId="17447455" subSource="6yu5_A"/>
      <ConstraintRegion from="346" to="364" loc="H" subId="17447457" subSource="6yu5_A"/>
      <ConstraintRegion from="365" to="378" loc="O" subId="17447459" subSource="6yu5_A"/>
      <ConstraintRegion from="379" to="403" loc="H" subId="17447460" subSource="6yu5_A"/>
      <ConstraintRegion from="404" to="409" loc="I" subId="17447461" subSource="6yu5_A"/>
      <ConstraintRegion from="410" to="416" loc="F" subId="17447463" subSource="6yu5_A"/>
      <ConstraintRegion from="417" to="427" loc="I" subId="17447465" subSource="6yu5_A"/>
      <ConstraintRegion from="428" to="448" loc="H" subId="17447467" subSource="6yu5_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6yu6_A">
      <ConstraintRegion from="8" to="20" loc="I" subId="17447493" subSource="6yu6_A"/>
      <ConstraintRegion from="21" to="36" loc="H" subId="17447495" subSource="6yu6_A"/>
      <ConstraintRegion from="37" to="45" loc="O" subId="17447497" subSource="6yu6_A"/>
      <ConstraintRegion from="46" to="63" loc="H" subId="17447499" subSource="6yu6_A"/>
      <ConstraintRegion from="64" to="89" loc="I" subId="17447501" subSource="6yu6_A"/>
      <ConstraintRegion from="90" to="113" loc="H" subId="17447503" subSource="6yu6_A"/>
      <ConstraintRegion from="114" to="123" loc="F" subId="17447505" subSource="6yu6_A"/>
      <ConstraintRegion from="124" to="151" loc="O" subId="17447507" subSource="6yu6_A"/>
      <ConstraintRegion from="152" to="167" loc="H" subId="17447508" subSource="6yu6_A"/>
      <ConstraintRegion from="168" to="174" loc="I" subId="17447509" subSource="6yu6_A"/>
      <ConstraintRegion from="175" to="193" loc="H" subId="17447510" subSource="6yu6_A"/>
      <ConstraintRegion from="194" to="218" loc="O" subId="17447511" subSource="6yu6_A"/>
      <ConstraintRegion from="219" to="242" loc="H" subId="17447512" subSource="6yu6_A"/>
      <ConstraintRegion from="243" to="256" loc="I" subId="17447513" subSource="6yu6_A"/>
      <ConstraintRegion from="257" to="273" loc="H" subId="17447514" subSource="6yu6_A"/>
      <ConstraintRegion from="274" to="290" loc="O" subId="17447515" subSource="6yu6_A"/>
      <ConstraintRegion from="291" to="302" loc="F" subId="17447516" subSource="6yu6_A"/>
      <ConstraintRegion from="303" to="308" loc="O" subId="17447517" subSource="6yu6_A"/>
      <ConstraintRegion from="309" to="337" loc="H" subId="17447518" subSource="6yu6_A"/>
      <ConstraintRegion from="338" to="342" loc="I" subId="17447519" subSource="6yu6_A"/>
      <ConstraintRegion from="343" to="360" loc="H" subId="17447520" subSource="6yu6_A"/>
      <ConstraintRegion from="361" to="383" loc="O" subId="17447521" subSource="6yu6_A"/>
      <ConstraintRegion from="384" to="402" loc="H" subId="17447522" subSource="6yu6_A"/>
      <ConstraintRegion from="403" to="431" loc="I" subId="17447523" subSource="6yu6_A"/>
      <ConstraintRegion from="432" to="448" loc="H" subId="17447524" subSource="6yu6_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6yu7_A">
      <ConstraintRegion from="8" to="17" loc="I" subId="17447525" subSource="6yu7_A"/>
      <ConstraintRegion from="18" to="39" loc="H" subId="17447526" subSource="6yu7_A"/>
      <ConstraintRegion from="40" to="44" loc="O" subId="17447527" subSource="6yu7_A"/>
      <ConstraintRegion from="45" to="67" loc="H" subId="17447528" subSource="6yu7_A"/>
      <ConstraintRegion from="68" to="89" loc="I" subId="17447529" subSource="6yu7_A"/>
      <ConstraintRegion from="90" to="125" loc="H" subId="17447530" subSource="6yu7_A"/>
      <ConstraintRegion from="126" to="146" loc="O" subId="17447531" subSource="6yu7_A"/>
      <ConstraintRegion from="147" to="166" loc="H" subId="17447532" subSource="6yu7_A"/>
      <ConstraintRegion from="167" to="171" loc="I" subId="17447533" subSource="6yu7_A"/>
      <ConstraintRegion from="172" to="192" loc="H" subId="17447534" subSource="6yu7_A"/>
      <ConstraintRegion from="193" to="217" loc="O" subId="17447535" subSource="6yu7_A"/>
      <ConstraintRegion from="218" to="242" loc="H" subId="17447536" subSource="6yu7_A"/>
      <ConstraintRegion from="243" to="253" loc="I" subId="17447537" subSource="6yu7_A"/>
      <ConstraintRegion from="254" to="274" loc="H" subId="17447538" subSource="6yu7_A"/>
      <ConstraintRegion from="275" to="290" loc="O" subId="17447539" subSource="6yu7_A"/>
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      <ConstraintRegion from="302" to="307" loc="O" subId="17447541" subSource="6yu7_A"/>
      <ConstraintRegion from="308" to="336" loc="H" subId="17447542" subSource="6yu7_A"/>
      <ConstraintRegion from="337" to="345" loc="I" subId="17447543" subSource="6yu7_A"/>
      <ConstraintRegion from="346" to="366" loc="H" subId="17447544" subSource="6yu7_A"/>
      <ConstraintRegion from="367" to="378" loc="O" subId="17447545" subSource="6yu7_A"/>
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      <ConstraintRegion from="407" to="409" loc="I" subId="17447547" subSource="6yu7_A"/>
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      <ConstraintRegion from="417" to="423" loc="I" subId="17447549" subSource="6yu7_A"/>
      <ConstraintRegion from="424" to="449" loc="H" subId="17447550" subSource="6yu7_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="5jae_A">
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      <ConstraintRegion from="14" to="32" loc="H" subId="17131556" subSource="5jae_A"/>
      <ConstraintRegion from="33" to="43" loc="O" subId="17131559" subSource="5jae_A"/>
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      <ConstraintRegion from="64" to="89" loc="I" subId="17131565" subSource="5jae_A"/>
      <ConstraintRegion from="90" to="120" loc="H" subId="17131569" subSource="5jae_A"/>
      <ConstraintRegion from="121" to="131" loc="O" subId="17131573" subSource="5jae_A"/>
      <ConstraintRegion from="134" to="166" loc="O" subId="17131577" subSource="5jae_A"/>
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      <ConstraintRegion from="185" to="190" loc="I" subId="17131584" subSource="5jae_A"/>
      <ConstraintRegion from="191" to="212" loc="H" subId="17131587" subSource="5jae_A"/>
      <ConstraintRegion from="213" to="222" loc="O" subId="17131590" subSource="5jae_A"/>
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      <ConstraintRegion from="266" to="278" loc="I" subId="17131602" subSource="5jae_A"/>
      <ConstraintRegion from="279" to="297" loc="H" subId="17131605" subSource="5jae_A"/>
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      <ConstraintRegion from="378" to="394" loc="H" subId="17131632" subSource="5jae_A"/>
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      <ConstraintRegion from="502" to="512" loc="I" subId="17131659" subSource="5jae_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="5jae_B">
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      <ConstraintRegion from="14" to="32" loc="H" subId="17131668" subSource="5jae_B"/>
      <ConstraintRegion from="33" to="41" loc="O" subId="17131671" subSource="5jae_B"/>
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      <ConstraintRegion from="64" to="89" loc="I" subId="17131677" subSource="5jae_B"/>
      <ConstraintRegion from="90" to="120" loc="H" subId="17131681" subSource="5jae_B"/>
      <ConstraintRegion from="121" to="166" loc="O" subId="17131684" subSource="5jae_B"/>
      <ConstraintRegion from="167" to="184" loc="H" subId="17131687" subSource="5jae_B"/>
      <ConstraintRegion from="185" to="190" loc="I" subId="17131690" subSource="5jae_B"/>
      <ConstraintRegion from="191" to="212" loc="H" subId="17131694" subSource="5jae_B"/>
      <ConstraintRegion from="213" to="222" loc="O" subId="17131697" subSource="5jae_B"/>
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      <ConstraintRegion from="244" to="265" loc="H" subId="17131706" subSource="5jae_B"/>
      <ConstraintRegion from="266" to="278" loc="I" subId="17131709" subSource="5jae_B"/>
      <ConstraintRegion from="279" to="297" loc="H" subId="17131712" subSource="5jae_B"/>
      <ConstraintRegion from="298" to="325" loc="O" subId="17131714" subSource="5jae_B"/>
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    </Constraint>
    <Constraint source="TOPDB" sourceId="5jaf_A">
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      <ConstraintRegion from="185" to="190" loc="I" subId="17131780" subSource="5jaf_A"/>
      <ConstraintRegion from="191" to="211" loc="H" subId="17131782" subSource="5jaf_A"/>
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      <ConstraintRegion from="266" to="278" loc="I" subId="17131792" subSource="5jaf_A"/>
      <ConstraintRegion from="279" to="296" loc="H" subId="17131794" subSource="5jaf_A"/>
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    </Constraint>
    <Constraint source="TOPDB" sourceId="5jag_A">
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      <ConstraintRegion from="186" to="190" loc="I" subId="17131873" subSource="5jag_A"/>
      <ConstraintRegion from="191" to="214" loc="H" subId="17131876" subSource="5jag_A"/>
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      <ConstraintRegion from="280" to="298" loc="H" subId="17131896" subSource="5jag_A"/>
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    </Constraint>
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      <ConstraintRegion from="60" to="92" loc="I" subId="17031799" subSource="7dii_A"/>
      <ConstraintRegion from="93" to="120" loc="H" subId="17031801" subSource="7dii_A"/>
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    </Constraint>
    <Constraint source="TOPDB" sourceId="7dii_B">
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      <ConstraintRegion from="93" to="120" loc="H" subId="17031864" subSource="7dii_B"/>
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      <ConstraintRegion from="195" to="211" loc="H" subId="17031872" subSource="7dii_B"/>
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      <ConstraintRegion from="266" to="279" loc="I" subId="17033352" subSource="7djc_A"/>
      <ConstraintRegion from="280" to="298" loc="H" subId="17033353" subSource="7djc_A"/>
      <ConstraintRegion from="299" to="318" loc="O" subId="17033354" subSource="7djc_A"/>
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      <ConstraintRegion from="368" to="376" loc="I" subId="17033360" subSource="7djc_A"/>
      <ConstraintRegion from="377" to="394" loc="H" subId="17033361" subSource="7djc_A"/>
      <ConstraintRegion from="395" to="399" loc="O" subId="17033362" subSource="7djc_A"/>
      <ConstraintRegion from="400" to="425" loc="H" subId="17033363" subSource="7djc_A"/>
      <ConstraintRegion from="426" to="428" loc="I" subId="17033364" subSource="7djc_A"/>
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      <ConstraintRegion from="470" to="473" loc="O" subId="17033368" subSource="7djc_A"/>
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      <ConstraintRegion from="504" to="508" loc="I" subId="17033371" subSource="7djc_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6xwm_A">
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      <ConstraintRegion from="16" to="35" loc="H" subId="17430179" subSource="6xwm_A"/>
      <ConstraintRegion from="36" to="43" loc="O" subId="17430180" subSource="6xwm_A"/>
      <ConstraintRegion from="44" to="62" loc="H" subId="17430181" subSource="6xwm_A"/>
      <ConstraintRegion from="63" to="92" loc="I" subId="17430182" subSource="6xwm_A"/>
      <ConstraintRegion from="93" to="124" loc="H" subId="17430183" subSource="6xwm_A"/>
      <ConstraintRegion from="125" to="166" loc="O" subId="17430184" subSource="6xwm_A"/>
      <ConstraintRegion from="167" to="183" loc="H" subId="17430185" subSource="6xwm_A"/>
      <ConstraintRegion from="184" to="190" loc="I" subId="17430186" subSource="6xwm_A"/>
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      <ConstraintRegion from="380" to="396" loc="H" subId="17430199" subSource="6xwm_A"/>
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      <ConstraintRegion from="501" to="510" loc="I" subId="17430209" subSource="6xwm_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6xwm_B">
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      <ConstraintRegion from="16" to="35" loc="H" subId="17430211" subSource="6xwm_B"/>
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      <ConstraintRegion from="44" to="62" loc="H" subId="17430213" subSource="6xwm_B"/>
      <ConstraintRegion from="63" to="92" loc="I" subId="17430214" subSource="6xwm_B"/>
      <ConstraintRegion from="93" to="124" loc="H" subId="17430215" subSource="6xwm_B"/>
      <ConstraintRegion from="125" to="166" loc="O" subId="17430216" subSource="6xwm_B"/>
      <ConstraintRegion from="167" to="183" loc="H" subId="17430217" subSource="6xwm_B"/>
      <ConstraintRegion from="184" to="190" loc="I" subId="17430218" subSource="6xwm_B"/>
      <ConstraintRegion from="191" to="211" loc="H" subId="17430219" subSource="6xwm_B"/>
      <ConstraintRegion from="212" to="241" loc="O" subId="17430220" subSource="6xwm_B"/>
      <ConstraintRegion from="242" to="262" loc="H" subId="17430221" subSource="6xwm_B"/>
      <ConstraintRegion from="263" to="279" loc="I" subId="17430222" subSource="6xwm_B"/>
      <ConstraintRegion from="280" to="297" loc="H" subId="17430223" subSource="6xwm_B"/>
      <ConstraintRegion from="298" to="320" loc="O" subId="17430224" subSource="6xwm_B"/>
      <ConstraintRegion from="321" to="333" loc="F" subId="17430225" subSource="6xwm_B"/>
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      <ConstraintRegion from="364" to="379" loc="I" subId="17430228" subSource="6xwm_B"/>
      <ConstraintRegion from="380" to="396" loc="H" subId="17430229" subSource="6xwm_B"/>
      <ConstraintRegion from="397" to="399" loc="O" subId="17430230" subSource="6xwm_B"/>
      <ConstraintRegion from="400" to="421" loc="H" subId="17430231" subSource="6xwm_B"/>
      <ConstraintRegion from="422" to="428" loc="I" subId="17430232" subSource="6xwm_B"/>
      <ConstraintRegion from="429" to="436" loc="F" subId="17430233" subSource="6xwm_B"/>
      <ConstraintRegion from="437" to="447" loc="I" subId="17430234" subSource="6xwm_B"/>
      <ConstraintRegion from="448" to="469" loc="H" subId="17430235" subSource="6xwm_B"/>
      <ConstraintRegion from="470" to="476" loc="F" subId="17430236" subSource="6xwm_B"/>
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      <ConstraintRegion from="484" to="500" loc="H" subId="17430238" subSource="6xwm_B"/>
      <ConstraintRegion from="501" to="507" loc="I" subId="17430239" subSource="6xwm_B"/>
    </Constraint>
  </Constraints>
</HtpItem>
