<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="E9PE72_HUMAN" transmembrane="yes" evidence="Experiment">
  <Name>Ectonucleotide pyrophosphatase/phosphodiesterase 1 </Name>
  <CrossRef>
    <PDBTM id="6c01">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6g4g">
      <Chain id="D"/>
      <Chain id="C"/>
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6c02">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4b56">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6xkd">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6f2v">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6f2t">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4gtw">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4gtx">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4gty">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4gtz">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6f2y">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6f33">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6ael">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6aek">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6f30">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5ven">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5veo">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4lqy">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="4lr2">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2ys0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3bt1">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3bt2">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4k24">
      <Chain id="B"/>
    </PDBTM>
    <TOPDB id="ENPP1_HUMAN">
      <Alignment>
        <CrossRefSeq>MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDER-PHFYTLYLEEPD</CrossRefSeq>
        <OrigSeq>MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERRTRFFRSFIWTSQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP1_MOUSE">
      <Alignment>
        <CrossRefSeq>MERDG--------DQAGHGPRHGSAGNGRE------LESP----AAASLLAPMDLGEEPLEKAERARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFSNCRCDAACVSLGNCCLDFQETCVEPTHIWTCNKFRCGEKRLSRFVCSCADDCKTHNDCCINYSSVCQDKKSWVEETCESIDTPECPAEFESPPTLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPMYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQPIWVTANHQEVKSGTYFWPGSDVEIDGILPDIYKVYNGSVPFEERILAVLEWLQLPSHER-PHFYTLYLEEPD</CrossRefSeq>
        <OrigSeq>MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERRTRFFRSFIWTSQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP3_HUMAN">
      <Alignment>
        <CrossRefSeq>EQPVKKNTLK---KYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAER-PRFYTMYFEEPD</CrossRefSeq>
        <OrigSeq>EKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFE---RTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERRTRFFRSFIWTSQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP3_RAT">
      <Alignment>
        <CrossRefSeq>EEPIKKDSLK---RYKILCAVLLALLVIVSLGLGLGLGLRKPEEHIGSCRKKCFDSSHRGLEGCRCDSGCTDRGDCCWDFEDTCVKSTQIWTCNSFRCGETRLEAALCSCADDCLQRKDCCTDYKAVCQGEVPWVTEACASSQEPQCPEGFDQPPVILFSMDGFRAEYLQTWSTLLPNINKLKTCGLHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVYLNKNFSLSSVEKSNPAWWSGQPIWLTAMYQGLKAASYYWPGSDVAVNGSFPNIYRNYSNSVPYESRIATLLQWLDLPKAER-PSFYTIYVEEPD</CrossRefSeq>
        <OrigSeq>EKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKE-VKSCKGRCFE---RTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERRTRFFRSFIWTSQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP3_MOUSE">
      <Alignment>
        <CrossRefSeq>EEPIKKDSLK---KYKILCVVLLALLVIVSLGLGLGLGLRKPEEQGSCRKKCFDSSHRGLEGCRCDSGCTGRGDCCWDFEDTCVKSTQIWTCNLFRCGENRLETALCSCADDCLQRKDCCADYKTVCQGESPWVTEACASSQEPQCPPGFDLPPVILFSMDGFRAEYLQTWSTLLPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVHLNKNFSLSSVEKSNPAWWSGQPIWLTAMYQGLKAACYYWPGSDVAVNGSFPTIYRNYSNSVPYERRITTLLQWLDLPKADR-PSFYTIYVEEPD</CrossRefSeq>
        <OrigSeq>EKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFE---RTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERRTRFFRSFIWTSQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP2_HUMAN">
      <Alignment>
        <CrossRefSeq>QIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCKGRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFW------------------SVVIPHERRILTILQWLTLPDHER-PSVYAFYSEQPD</CrossRefSeq>
        <OrigSeq>KVLSLVLSVCVLTTILG----------------CIFGLKPSCAKEVKSCKGRCFERTFGN---CRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERRTRFFRSFIWTSQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP5_MOUSE">
      <Alignment>
        <CrossRefSeq>CHSAPFSLQP---EEQKVLVVSFDGFRWDYLYKVPT--PHFHYIMKNGVHVNQVTNVFITKTYPNHYTLVTGLFAENHGIVANDMFDPILNKSFSLEHMDIYDSKFWEEATPIWITNQRAGHASGAAMWPGADVKIHDSFPTYYLPYNESVSFEDRVAKIIEWFTA----KDPINLGFLYWEEPDD</CrossRefSeq>
        <OrigSeq>CESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFN-PEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERRTRFFRSFIW-TSQQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP4_MOUSE">
      <Alignment>
        <CrossRefSeq>NSSDSSAPRLLLVSFDGFRADYLKSYD--LPHLQNFIKEGVLVEHVKNVFITKTFPNHYSIVTGLYEESHGIVANSMYDSVTKKHFS-ESNDKDPFWWNGAEPIWVTNQLQENRSSAAAMWPGTDVPIHNITASYFMNYSSSVSFKERLGNVTTWLSSSNP--PVTFAALYWEEPD</CrossRefSeq>
        <OrigSeq>CPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQ-GLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERRTRFFRSFIWTSQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP4_HUMAN">
      <Alignment>
        <CrossRefSeq>SSSLPPKLLLVSFDGFRADYLKNYE--FPHLQNFIKEGVLVEHVKNVFITKTFPNHYSIVTGLYEESHGIVANSMYDAVTKKHFS-DSNDKDPFWWNEAVPIWVTNQLQENRSSAAAMWPGTDVPIHDTISSYFMNYNSSVSFEERLNNITMWL---NNSNPPVTFATLYWEEPD</CrossRefSeq>
        <OrigSeq>AGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQ-GLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERRTRFF-RSFIWTSQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP1_CAEEL">
      <Alignment>
        <CrossRefSeq>KARYEW--KGCQNLGKCEL-SGYTKPPLVILSLDGFAREYVDR--NIVQTLNHIADCGVKADKVYPSYPSKTFPNHYSIVTGLWPESHGITDNSVFDPTISPVLESMKSTKYEKFF-EGEPIWSVYKRKTGKKANCLFWVGCAYNNSGYAPDVAPAYNQELPFRNRIDTVVEWLKLPVDER-PGLITAYLHEPD</CrossRefSeq>
        <OrigSeq>QGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIW-VTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERRTRFFRSFIWTSQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ENPP6_BOVIN">
      <Alignment>
        <CrossRefSeq>QPASARRKLLVFLLDGFRADYISDEALESLPGFKEIVSRGVKVDYLTPDFPTLSYPNYYSLMTGRHCEVHQMTGNYMWDPDTNKSFDLGINRDSRLPLWWNGSEPLWVTLTKAKRKVYMYYWPGCEVEILGVRPTYCLEYKSVPTDINFVNAVSGALDVFKSGQADLAAIYY</CrossRefSeq>
        <OrigSeq>PAGFETPPTLLFSLDGFRAEYLHTWG-GLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLK-SKEKFNPEWYKG-EPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNG---SVPFEERILAVLQWLQLPKDERRTRFF</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="378" CheckSum="f07c828c19be434b785c20ab6c95ea1c">
    <Seq>
      MERDGCAGGG SRGGEGGRAP REGPAGNGRD RGRSHAAEAP GDPQAAASLL
      APMDVGEEPL EKAARARTAK DPNTYKVLSL VLSVCVLTTI LGCIFGLKPS
      CAKEVKSCKG RCFERTFGNC RCDAACVELG NCCLDYQETC IEPEHIWTCN
      KFRCGEKRLT RSLCACSDDC KDKGDCCINY SSVCQGEKSW VEEPCESINE
      PQCPAGFETP PTLLFSLDGF RAEYLHTWGG LLPVISKLKK CGTYTKNMRP
      VYPTKTFPNH YSIVTGLYPE SHGIIDNKMY DPKMNASFSL KSKEKFNPEW
      YKGEPIWVTA KYQGLKSGTF FWPGSDVEIN GIFPDIYKMY NGSVPFEERI
      LAVLQWLQLP KDERRTRFFR SFIWTSQQ
    </Seq>
  </Sequence>
  <Topology numTm="1" reliability="91.51">
    <Region from="1" to="76" loc="I"/>
    <Region from="77" to="96" loc="M"/>
    <Region from="97" to="378" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="76" loc="I"/>
      <Region from="77" to="98" loc="M"/>
      <Region from="99" to="378" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="74" loc="I"/>
      <Region from="75" to="97" loc="M"/>
      <Region from="98" to="378" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="77" loc="I"/>
      <Region from="78" to="98" loc="M"/>
      <Region from="99" to="378" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="74" loc="I"/>
      <Region from="75" to="95" loc="M"/>
      <Region from="96" to="378" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="76" loc="I"/>
      <Region from="77" to="97" loc="M"/>
      <Region from="98" to="378" loc="O"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="76" loc="I"/>
      <Region from="77" to="97" loc="M"/>
      <Region from="98" to="378" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="76" loc="I"/>
      <Region from="77" to="97" loc="M"/>
      <Region from="98" to="378" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="76" loc="O"/>
      <Region from="77" to="96" loc="M"/>
      <Region from="97" to="378" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="76" loc="I"/>
      <Region from="77" to="97" loc="M"/>
      <Region from="98" to="378" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="74" loc="I"/>
      <Region from="75" to="97" loc="M"/>
      <Region from="98" to="378" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
