<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="E9PK19_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>RING-type E3 ubiquitin transferase </Name>
  <CrossRef>
    <PDBTM id="6vjy">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6vjz">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6vk0">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6vk1">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="5v6p">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <TOPDB id="SYVN1_MOUSE">
      <Alignment>
        <CrossRefSeq>MFRTAVMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMAVLYIQAFVLVFLLGKVMGKVFFGQLRAAEMEHLLERSWYAVTETCLAFTVFRDDFSPRFVALFTLLLFLKCFHWLAEDRVDFMERSPNISWLFHCRIVSLMFLLGILDFLFVSHAYHSILTRGASVQLVFGFEYAILMTMVLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIMIKVHTFPLFAIRPMYLAM</CrossRefSeq>
        <OrigSeq>MFRTAVMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMAVM---------------GKVFFGQLRAAEMEHLLERSWYAVTETCLAFTVFRDDFSPRFVALFTLLLFLKCFHWLAEDRVDFMERSPNISWLFHCRIVSLMFLLGILDFLFVSHAYHSILTRGASVQLVFGFEYAILMTMVLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIMIKVHTFPLFAIRPMYLAM</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SYVN1_HUMAN">
      <Alignment>
        <CrossRefSeq>MFRTAVMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMAVLYIQAFVLVFLLGKVMGKVFFGQLRAAEMEHLLERSWYAVTETCLAFTVFRDDFSPRFVALFTLLLFLKCFHWLAEDRVDFMERSPNISWLFHCRIVSLMFLLGILDFLFVSHAYHSILTRGASVQLVFGFEYAILMTMVLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIMIKVHTFPLFAIRPMYLAM</CrossRefSeq>
        <OrigSeq>MFRTAVMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMAVM---------------GKVFFGQLRAAEMEHLLERSWYAVTETCLAFTVFRDDFSPRFVALFTLLLFLKCFHWLAEDRVDFMERSPNISWLFHCRIVSLMFLLGILDFLFVSHAYHSILTRGASVQLVFGFEYAILMTMVLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIMIKVHTFPLFAIRPMYLAM</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="AMFR_HUMAN">
      <Alignment>
        <CrossRefSeq>LIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLF</CrossRefSeq>
        <OrigSeq>VMGKVFFGQLRAAEMEHLLERSWYAVTETCLAFTVFRDDFSPRFVA----LFTLLLFLKCFHWLAEDRVDFMERSPNISWLFHCRIVSLMFLLGILDFLFVSHAYHSILTRGASVQLVFGFEYAILMTMVLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIMIKV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="AMFR_MOUSE">
      <Alignment>
        <CrossRefSeq>LIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGRVLSLLIAMLLSCCGLAVVCCVTGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELALLSLDLMHHIHMLLF</CrossRefSeq>
        <OrigSeq>VMGKVFFGQLRAAEMEHLLERSWYAVTETCLAFTVFRDDFSPRFVA----LFTLLLFLKCFHWLAEDRVDFMERSPNISWLFHCRIVSLMFLLGILDFLFVSHAYHSILTRGASVQLVFGFEYAILMTMVLTIFIKYVLHSVDLQSENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIMIKV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="HRD1_YEAST">
      <Alignment>
        <CrossRefSeq>SIFILLNSTLLWQLLTKLLFGELRLIEHEHIFERLPFTIINTLFMSSLFHERYFFTVAFFGLL--LLYLKVFHWILKDRLEALLQSINDSTTMKTLIFSRFSFNLVLLAVVDYQIITRCISSIYTNQKSDIESTSLYLIQVMEFTMLLIDLLNLFLQTCLNFWEFYRSQQSLSNENNHIVHGDPTDENTVESDQSQPVLNDDDDDDDDDRQFTGLEGKFMYEKAIDVFTRFLKTALHLSMLI</CrossRefSeq>
        <OrigSeq>TVVYLTKSSPSMAVMGKVFFGQLRAAEMEHLLERSWYAVTETCLAFTVFRDD--FSPRFVALFTLLLFLKCFHWLAEDRVDFMERSPNISWLFHCRIVSL----MFLLGILDFLFVSHAYHSILTRGA------SVQLVFGFEYAILMTMVLTIFIKYVLHSVDLQSENPW--------------------------------------------DNKAVYMLYTELFTGFIKVLLYMAFMT</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="237" CheckSum="32df23851fe5ce6b5f11d95cd50809a0">
    <Seq>
      MFRTAVMMAA SLALTGAVVA HAYYLKHQFY PTVVYLTKSS PSMAVMGKVF
      FGQLRAAEME HLLERSWYAV TETCLAFTVF RDDFSPRFVA LFTLLLFLKC
      FHWLAEDRVD FMERSPNISW LFHCRIVSLM FLLGILDFLF VSHAYHSILT
      RGASVQLVFG FEYAILMTMV LTIFIKYVLH SVDLQSENPW DNKAVYMLYT
      ELFTGFIKVL LYMAFMTIMI KVHTFPLFAI RPMYLAM
    </Seq>
  </Sequence>
  <Topology numTm="5" reliability="72.72">
    <Region from="1" to="3" loc="I"/>
    <Region from="4" to="22" loc="M"/>
    <Region from="23" to="87" loc="O"/>
    <Region from="88" to="104" loc="M"/>
    <Region from="105" to="120" loc="I"/>
    <Region from="121" to="140" loc="M"/>
    <Region from="141" to="156" loc="O"/>
    <Region from="157" to="175" loc="M"/>
    <Region from="176" to="200" loc="I"/>
    <Region from="201" to="222" loc="M"/>
    <Region from="223" to="237" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="3" loc="I"/>
      <Region from="4" to="20" loc="M"/>
      <Region from="21" to="201" loc="O"/>
      <Region from="202" to="220" loc="M"/>
      <Region from="221" to="237" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="16" loc="O"/>
      <Region from="17" to="47" loc="M"/>
      <Region from="48" to="66" loc="I"/>
      <Region from="67" to="82" loc="M"/>
      <Region from="83" to="86" loc="O"/>
      <Region from="87" to="103" loc="M"/>
      <Region from="104" to="122" loc="I"/>
      <Region from="123" to="145" loc="M"/>
      <Region from="146" to="154" loc="O"/>
      <Region from="155" to="179" loc="M"/>
      <Region from="180" to="198" loc="I"/>
      <Region from="199" to="229" loc="M"/>
      <Region from="230" to="237" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="2" loc="I"/>
      <Region from="3" to="23" loc="M"/>
      <Region from="24" to="46" loc="O"/>
      <Region from="47" to="51" loc="L"/>
      <Region from="52" to="65" loc="O"/>
      <Region from="66" to="75" loc="L"/>
      <Region from="76" to="80" loc="O"/>
      <Region from="81" to="101" loc="M"/>
      <Region from="102" to="121" loc="I"/>
      <Region from="122" to="142" loc="M"/>
      <Region from="143" to="148" loc="O"/>
      <Region from="149" to="179" loc="M"/>
      <Region from="180" to="197" loc="I"/>
      <Region from="198" to="212" loc="M"/>
      <Region from="213" to="213" loc="O"/>
      <Region from="214" to="228" loc="M"/>
      <Region from="229" to="237" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="24" to="87" loc="O"/>
      <Region from="88" to="105" loc="M"/>
      <Region from="106" to="120" loc="I"/>
      <Region from="121" to="144" loc="M"/>
      <Region from="145" to="156" loc="O"/>
      <Region from="157" to="179" loc="M"/>
      <Region from="180" to="198" loc="I"/>
      <Region from="199" to="225" loc="M"/>
      <Region from="226" to="237" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="3" loc="O"/>
      <Region from="4" to="14" loc="O"/>
      <Region from="15" to="22" loc="O"/>
      <Region from="23" to="31" loc="O"/>
      <Region from="32" to="51" loc="M"/>
      <Region from="52" to="87" loc="I"/>
      <Region from="88" to="105" loc="M"/>
      <Region from="106" to="124" loc="O"/>
      <Region from="125" to="145" loc="M"/>
      <Region from="146" to="156" loc="I"/>
      <Region from="157" to="179" loc="M"/>
      <Region from="180" to="208" loc="O"/>
      <Region from="209" to="230" loc="M"/>
      <Region from="231" to="237" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="5" loc="I"/>
      <Region from="6" to="26" loc="M"/>
      <Region from="27" to="83" loc="O"/>
      <Region from="84" to="104" loc="M"/>
      <Region from="105" to="119" loc="I"/>
      <Region from="120" to="140" loc="M"/>
      <Region from="141" to="160" loc="O"/>
      <Region from="161" to="181" loc="M"/>
      <Region from="182" to="201" loc="I"/>
      <Region from="202" to="222" loc="M"/>
      <Region from="223" to="237" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="5" loc="I"/>
      <Region from="6" to="26" loc="M"/>
      <Region from="27" to="83" loc="O"/>
      <Region from="84" to="104" loc="M"/>
      <Region from="105" to="119" loc="I"/>
      <Region from="120" to="140" loc="M"/>
      <Region from="141" to="160" loc="O"/>
      <Region from="161" to="181" loc="M"/>
      <Region from="182" to="201" loc="I"/>
      <Region from="202" to="222" loc="M"/>
      <Region from="223" to="237" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="4" loc="I"/>
      <Region from="5" to="25" loc="M"/>
      <Region from="26" to="83" loc="O"/>
      <Region from="84" to="103" loc="M"/>
      <Region from="104" to="119" loc="I"/>
      <Region from="120" to="139" loc="M"/>
      <Region from="140" to="154" loc="O"/>
      <Region from="155" to="174" loc="M"/>
      <Region from="175" to="201" loc="I"/>
      <Region from="202" to="221" loc="M"/>
      <Region from="222" to="237" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="4" loc="O"/>
      <Region from="5" to="25" loc="M"/>
      <Region from="26" to="64" loc="I"/>
      <Region from="65" to="85" loc="M"/>
      <Region from="86" to="86" loc="O"/>
      <Region from="87" to="107" loc="M"/>
      <Region from="108" to="125" loc="I"/>
      <Region from="126" to="146" loc="M"/>
      <Region from="147" to="154" loc="O"/>
      <Region from="155" to="175" loc="M"/>
      <Region from="176" to="201" loc="I"/>
      <Region from="202" to="222" loc="M"/>
      <Region from="223" to="237" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="4" loc="I"/>
      <Region from="5" to="24" loc="M"/>
      <Region from="25" to="87" loc="O"/>
      <Region from="88" to="105" loc="M"/>
      <Region from="106" to="117" loc="I"/>
      <Region from="118" to="140" loc="M"/>
      <Region from="141" to="154" loc="O"/>
      <Region from="155" to="177" loc="M"/>
      <Region from="178" to="197" loc="I"/>
      <Region from="198" to="220" loc="M"/>
      <Region from="221" to="237" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
