<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="E9PKB0_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>Sortilin related receptor 1 </Name>
  <CrossRef>
    <PDBTM id="2dm4">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1n7d">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6tpv">
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8em4">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4pbx">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="1f5y">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="2lgp">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7qbg">
      <Chain id="B"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="6pok">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7qbe">
      <Chain id="B"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="2fcw">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="4zrp">
      <Chain id="C"/>
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="7qbd">
      <Chain id="D"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7qbf">
      <Chain id="C"/>
    </PDBTM>
    <TOPDB id="SORL_HUMAN">
      <Alignment>
        <CrossRefSeq>RCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETHSNKTNTVLKVLKPDTTYQVKVQVQCLSKAHNTNDFVTLRTPEGLPDAPRNLQLSLPREAEGVIVGHWAPPIHTHGLIREYIVEYSRSGSKMWASQRAASNFTEIKNLLVNTLYTVRVAAVTSRGIGNWSDSKSITTIKGKVIPPPDIHIDSYGENYLSFTLTMESDIKVNGYVVNLFWAFDTHKQERRTLNFRGSILSHKVGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAPSLKAKAINQTAVECTWTGPRNVVYGIFYATSFLDLYRNPKSLTTSLHNKTVIVSKDEQYLFLVRVVVPYQGPSSDYVVVKMIPDSRLPPRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAVAVKDLIRKTDRSYKVKSRNSTVEYTLNKLEPGGKYHIIVQLGNMSKDSSIKITTVSLSAPDALKIITENDHVLLFWKSLALKEKHFNESRGYEIHMFDSAMNITAYLGNTTDNFFKISNLKMGHNYTFTVQARCLFGNQICGEPAILLYDELGSGADASATQAARSTDVAAVVVPILFLILLSLGVGFAILYTKHRRLQSSFTAFANSHYSSRLGSAIFSSGDDLGEDDEDAPMITGFSDDVPMVIA</CrossRefSeq>
        <OrigSeq>RLAAAQSCASHWPPSADSHILPFSTP--------------GPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETHSNKTNTVLKVLKPDTTYQVKVQVQCLSKAHNTNDFVTLRTPEGLPDAPRNLQLSLPREAEGVIVGHWAPPIHTHGLIREYIVEYSRSGSKMWASQRAASNFTEIKNLLVNTLYTVRVAAVTSRGIGNWSDSKSITTIKGKVIPPPDIHIDSYGENYLSFTLTMESDIKVNGYVVNLFWAFDTHKQERRTLNFRGSILSHKVGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAPSLKAKAINQTAVECTWTGPRNVVYGIFYATSFLDLYRNPKSLTTSLHNKTVIVSKDEQYLFLVRVVVPYQGPSSDYVVVKMIPDSRLPPRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAVAVKDLIRKTDRSYKVKSRNSTVEYTLNKLEPGGKYHIIVQLGNMSKDSSIKITTVSLSAPDALKIITENDHVLLFWKSLALKEKHFNESRGYEIHMFDSAMNITAYLGNTTDNFFKISNLKMGHNYTFTVQARCLFGNQICGEPAILLYDELGSGADASATQAARSTDVAAVVVPILFLILLSLGVGFAILYTKHRRLQSSFTAFANSHYSSRLGSAIFSSGDDLGEDDEDAPMITGFSDDVPMVIA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LRP_CAEEL">
      <Alignment>
        <CrossRefSeq>PNPCGDNNGGC-SHLCLIGAGG-NGYTCSCPDQFVLLSDQKTC--------------EPNCTERQFACGGDDAKCIPKLWYCDGEPDCRDGSDEPGESICGQRICPVGEFQCTN-HNCTRPFQICDGNDDCGDSSDEQNCDKACDPWMFKC</CrossRefSeq>
        <OrigSeq>PSTCLPNYYRCSSGTCVMDTWVCDGYR-DCADG----SDEEACPLLANVTAASTPTQLGRCDRFEFECHQPK-TCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQN</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LDLR_HUMAN">
      <Alignment>
        <CrossRefSeq>RCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVL-------------TCGPASFQC-NSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGE-CIHSSWRCDGGPDCKDKSDEENCAVAT--CRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNEC</CrossRefSeq>
        <OrigSeq>QSCASHWPPSADSHILPFST---PGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDE--ANCPT-----HSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNLQWTADFSGDVTLTWMRPKKMPSASC--VYNVYYRVVGESIWKTLETHSNKTNTVLKVLKPDTTYQVKVQVQCLSKAH</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LRP4_HUMAN">
      <Alignment>
        <CrossRefSeq>CQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMC-DSGLCINAGWRCDGDADCDDQSDERNCTTS---MCTAEQFRCHSG-RCVRLSWRCDGEDDCADNSDEENCENTGSPQCALD-QFLCWNGRCIGQRKLCNGVND---CGDNSDESPQQNCRPRTGEENCNVNNGGC</CrossRefSeq>
        <OrigSeq>LAAAQSCASHWPPSADSHILPFST--PGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACP---LLANVTAASTPTQLGR----------------------------CDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNLQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETHSNKTNTVL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ST14_HUMAN">
      <Alignment>
        <CrossRefSeq>DSSD--PCPGQFTC-------RTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCS------CPAQTFRCSNG-KCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC</CrossRefSeq>
        <OrigSeq>DGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQ------------------------PKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACS------DELTVYKVQNLQWTADFSGDVTLTWMRPKKMPSASC</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ST14_MOUSE">
      <Alignment>
        <CrossRefSeq>CKTGRCIRKELRCDGWADCPDYSDERYCRCNATHQFTCKNQFCKPLFWVCDSVNDCGDGSDEEGC----------------SCPAGSFKCSNGK-CLPQSQKCNGKDNCGDGSDEASCDSVNVVSCTKYTYRCQNGLCLSKGNPECDGKTDCSDGSDEKNCDCGLRSFTKQARVVGGTNADEGEWPW</CrossRefSeq>
        <OrigSeq>LAAAQSCASHWPPSADSHILPFSTPGPSTCLP-NYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNLQWTADFSGDVTLTW</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LRP6_HUMAN">
      <Alignment>
        <CrossRefSeq>QCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQAT</CrossRefSeq>
        <OrigSeq>RLAAAQSCASHWPPSADSHILPFSTPGPST--CLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAAST</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LRP8_HUMAN">
      <Alignment>
        <CrossRefSeq>GGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCP-------------LGTCRGDEFQCG-DGTCVLAIKHCNQEQDCPDGSDEAGC-LQGLNECLHNNGGC--SHICTDLKIGFEC----TCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMD</CrossRefSeq>
        <OrigSeq>AAQSCASHWPPSADSHI--------------LPFSTPGPSTCL-PNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEAC--IVLSERCDGFLDCSDE---SDEKAC-SDELTVYKVQNLQWTADFSGDVTLTWMRPKKMP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LRP6_MOUSE">
      <Alignment>
        <CrossRefSeq>QCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCVGKHKKCDHSVDCSDRSDELDCYPTEEPAPQAT</CrossRefSeq>
        <OrigSeq>RLAAAQSCASHWPPSADSHILPFSTPGPST--CLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAAST</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LRAD3_HUMAN">
      <Alignment>
        <CrossRefSeq>RCNGFEDCPD----GSDEENC---TANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSG</CrossRefSeq>
        <OrigSeq>RLAAAQSCASHWPPSADSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LRP1_HUMAN">
      <Alignment>
        <CrossRefSeq>RCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGC-SQDCEDLKIGFKCR----CRPGFRLKDDGRTCAD-VDECSTTFPCSQRCINTHGSYKC----LCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKL</CrossRefSeq>
        <OrigSeq>RLAAAQSCAS-HWPPSADSHILPFSTPGPS---------TCLP-NYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFE--FECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTC--MSREFQCEDGEACIVLSERCDGFLD-CSDESDEKACSDELTVYKVQNL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CD320_HUMAN">
      <Alignment>
        <CrossRefSeq>PLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC</CrossRefSeq>
        <OrigSeq>PLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTH-----------------------------------STLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKAC</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ROBO3_HUMAN">
      <Alignment>
        <CrossRefSeq>FRVSWRVAGPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGWARSAMLRGLVPGLLYRTLVAAATSAGVG</CrossRefSeq>
        <OrigSeq>YNVYYRVVGE--SIWKTLETHS-NKTNTVLKVLKPDTTYQVKVQVQCLSKAHNTNDFVTLRTPEGLPDA-PRNLQLSLPREAEGVIVGHWAPPI--HTHGLIREYIVEYSRSGSKMWASQRAA--SNFTEIKNLLVNTLYTVRVAAVTSRGIG</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="829" CheckSum="c1c188859933d3ffccaf3ef004d9f17f">
    <Seq>
      MISRLAAAQS CASHWPPSAD SHILPFSTPG PSTCLPNYYR CSSGTCVMDT
      WVCDGYRDCA DGSDEEACPL LANVTAASTP TQLGRCDRFE FECHQPKTCI
      PNWKRCDGHQ DCQDGRDEAN CPTHSTLTCM SREFQCEDGE ACIVLSERCD
      GFLDCSDESD EKACSDELTV YKVQNLQWTA DFSGDVTLTW MRPKKMPSAS
      CVYNVYYRVV GESIWKTLET HSNKTNTVLK VLKPDTTYQV KVQVQCLSKA
      HNTNDFVTLR TPEGLPDAPR NLQLSLPREA EGVIVGHWAP PIHTHGLIRE
      YIVEYSRSGS KMWASQRAAS NFTEIKNLLV NTLYTVRVAA VTSRGIGNWS
      DSKSITTIKG KVIPPPDIHI DSYGENYLSF TLTMESDIKV NGYVVNLFWA
      FDTHKQERRT LNFRGSILSH KVGNLTAHTS YEISAWAKTD LGDSPLAFEH
      VMTRGVRPPA PSLKAKAINQ TAVECTWTGP RNVVYGIFYA TSFLDLYRNP
      KSLTTSLHNK TVIVSKDEQY LFLVRVVVPY QGPSSDYVVV KMIPDSRLPP
      RHLHVVHTGK TSVVIKWESP YDSPDQDLLY AVAVKDLIRK TDRSYKVKSR
      NSTVEYTLNK LEPGGKYHII VQLGNMSKDS SIKITTVSLS APDALKIITE
      NDHVLLFWKS LALKEKHFNE SRGYEIHMFD SAMNITAYLG NTTDNFFKIS
      NLKMGHNYTF TVQARCLFGN QICGEPAILL YDELGSGADA SATQAARSTD
      VAAVVVPILF LILLSLGVGF AILYTKHRRL QSSFTAFANS HYSSRLGSAI
      FSSGDDLGED DEDAPMITGF SDDVPMVIA
    </Seq>
  </Sequence>
  <Topology numTm="1" reliability="69.42">
    <Region from="1" to="750" loc="O"/>
    <Region from="751" to="773" loc="M"/>
    <Region from="774" to="829" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="750" loc="O"/>
      <Region from="751" to="775" loc="M"/>
      <Region from="776" to="829" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="749" loc="I"/>
      <Region from="750" to="774" loc="M"/>
      <Region from="775" to="829" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="326" loc="O"/>
      <Region from="327" to="347" loc="M"/>
      <Region from="348" to="701" loc="I"/>
      <Region from="702" to="722" loc="M"/>
      <Region from="723" to="750" loc="O"/>
      <Region from="751" to="771" loc="M"/>
      <Region from="772" to="782" loc="I"/>
      <Region from="783" to="788" loc="L"/>
      <Region from="789" to="829" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="23" to="750" loc="O"/>
      <Region from="751" to="774" loc="M"/>
      <Region from="775" to="829" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="4" loc="O"/>
      <Region from="5" to="13" loc="O"/>
      <Region from="14" to="21" loc="O"/>
      <Region from="22" to="750" loc="O"/>
      <Region from="751" to="774" loc="M"/>
      <Region from="775" to="829" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="753" loc="I"/>
      <Region from="754" to="774" loc="M"/>
      <Region from="775" to="829" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="709" loc="I"/>
      <Region from="710" to="730" loc="M"/>
      <Region from="731" to="750" loc="O"/>
      <Region from="751" to="772" loc="M"/>
      <Region from="773" to="829" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="754" loc="O"/>
      <Region from="755" to="774" loc="M"/>
      <Region from="775" to="829" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="754" loc="O"/>
      <Region from="755" to="775" loc="M"/>
      <Region from="776" to="829" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="750" loc="O"/>
      <Region from="751" to="773" loc="M"/>
      <Region from="774" to="829" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
