<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="E9PM00_HUMAN" transmembrane="yes" evidence="Exists">
  <Name>7-dehydrocholesterol reductase </Name>
  <CrossRef>
    <PDBTM id="4quv">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <TOPDB id="LBR_HUMAN">
      <Alignment>
        <CrossRefSeq>CKQKDPSLLNFPPPLPALYELWE------TRVFGVYLLWFLIQVLFYLL-----------PIGKVVEGTPLIDGRRLKYRLNGFYAFILTSAV--IGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIG-TFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPS-------DPKLAHLKTIHTSTGKN---LLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY</CrossRefSeq>
        <OrigSeq>CALTGP-VVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSH--VTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="LBR_CHICK">
      <Alignment>
        <CrossRefSeq>CKQDDPSLMNFPPLPALESLWE------TKVFGVFLLWFFFQALFYLL-----------PIGKVVEGLPLSNPRKLQYRINGFYAFLLTAAAIGTLLYFQ--FELHYLYDHFVQFAVSAAAFSMALSIYLYIRSLKAPEEDLAPGGNSGYLVYDFFTGHELNPRIGS-FDLKYFCELRPGLIGWVVINLAMLLAEMKIHNQSMPSLSMILVNSFQLLYVVDALWNEEAVLTTMDITHDGFGFMLAFGDLVWVPFVYSLQAFYLVGHPIAISWPVAAAITILNCIGYYIFRSANSQKNNFRRNPAD----------PKLSYLKVIPTATGKGLLVTGWWGFVRHPNYLGDIIMALAWSLPCGFNHILPYFYVIYFICLLVHREARDEHHCKKKYGLAWERYCQRVPY</CrossRefSeq>
        <OrigSeq>CALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSA-RDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELH--SHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPY</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ERG24_YEAST">
      <Alignment>
        <CrossRefSeq>IVELWNGIKPLRYYLGNRELWTVYCLWYGILAVLDVILP-----------GRVMKGVQLRDGSKLSYKINGIAMSTTLVLVLAIRWKLTDGQLPELQYLYENHVSLCIISILFSFFLATYCYVASFIPLIFKKNGNGKREKILALGGNSGNIIYDWFIGRELNPRLG-PLDIKMFSELRPGMLLWLLINLSCLHHHYLKTGKINDALVLVNFLQGFYIFDGVLNEEGVLTMMDITTDGFGFMLAFGDLSLVPFTYSLQARYLSVSPVELGWVKVVGILAIMFLGFHIFHSANKQKSEFRQG--------------KLENLKSIQTKRGTKLLCDGWWAKSQHINYFGDWLISLSWCLATWFQTPLTYYYSLYFATLLLHRQQRDEHKCRLKYGENWEEYERKVPYKIIPYVY</CrossRefSeq>
        <OrigSeq>LSDIWAKTPPI-----TRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSW--FSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYF---FPTSARD--------CKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="ERG4_YEAST">
      <Alignment>
        <CrossRefSeq>HLYQLVLENGIPEKYDWTIFLTFWVFQIIFYYTLPGIWTKGQPLSHLK---------GKQLPYFCNAMWTLYVTTTLVLV-LHFTNLFRLYVIIDRFGRIMTCAIISGFAFSIILYLWTLFI--SHDYHRMTGNHLYDFFMGAPLNPRWG-ILDLKMFFEVRLPWFTLYFITLGACLKQWETYGYVTPQLGVVMLAHWLYANACAKGEELIVPTWDMAYEKFGFMLIFWNIAGVPYTYCHCTLYLYYHDPSEYHWSTLYNVSLYVVLLCAYYFFDTANAQKNAFRKQMSGDKTGRKTFPFLPYQILKNPKYMVTSNGSYLLIDGWYTLARKIHYTADWTQSLVWALSCGFNSVFPWFFPVFFLVVLIHRAFRDQAKCKRKYGKDWDEYCKHCPYVFIPYVF</CrossRefSeq>
        <OrigSeq>RLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPV---QLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIE---CSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="417" CheckSum="a17c1bec74732468251612b6ede3d332">
    <Seq>
      MACDQYSCAL TGPVVDIVTG HARLSDIWAK TPPITRKAAQ LYTLWVTFQV
      LLYTSLPDFC HKFLPGYVGG IQEGAVTPAG VVNKYQINGL QAWLLTHLLW
      FANAHLLSWF SPTIIFDNWI PLLWCANILG YAVSTFAMVK GYFFPTSARD
      CKFTGNFFYN YMMGIEFNPR IGKWFDFKLF FNGRPGIVAW TLINLSFAAK
      QRELHSHVTN AMVLVNVLQA IYVIDFFWNE TWYLKTIDIC HDHFGWYLGW
      GDCVWLPYLY TLQGLYLVYH PVQLSTPHAV GVLLLGLVGY YIFRVANHQK
      DLFRRTDGRC LIWGRKPKVI ECSYTSADGQ RHHSKLLVSG FWGVARHFNY
      VGDLMGSLAY CLACGGGHLL PYFYIIYMAI LLTHRCLRDE HRCASKYGRD
      WERYTAAVPY RLLPGIF
    </Seq>
  </Sequence>
  <Topology numTm="8" reliability="72.06">
    <Region from="1" to="88" loc="I"/>
    <Region from="89" to="108" loc="M"/>
    <Region from="109" to="118" loc="O"/>
    <Region from="119" to="138" loc="M"/>
    <Region from="139" to="178" loc="I"/>
    <Region from="179" to="198" loc="M"/>
    <Region from="199" to="207" loc="O"/>
    <Region from="208" to="227" loc="M"/>
    <Region from="228" to="243" loc="I"/>
    <Region from="244" to="262" loc="M"/>
    <Region from="263" to="273" loc="O"/>
    <Region from="274" to="293" loc="M"/>
    <Region from="294" to="349" loc="I"/>
    <Region from="350" to="366" loc="M"/>
    <Region from="367" to="368" loc="O"/>
    <Region from="369" to="382" loc="M"/>
    <Region from="383" to="417" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="40" loc="I"/>
      <Region from="41" to="52" loc="M"/>
      <Region from="53" to="355" loc="O"/>
      <Region from="356" to="382" loc="M"/>
      <Region from="383" to="417" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="38" loc="O"/>
      <Region from="39" to="63" loc="M"/>
      <Region from="64" to="86" loc="I"/>
      <Region from="87" to="110" loc="M"/>
      <Region from="111" to="118" loc="O"/>
      <Region from="119" to="140" loc="M"/>
      <Region from="141" to="179" loc="I"/>
      <Region from="180" to="199" loc="M"/>
      <Region from="200" to="210" loc="O"/>
      <Region from="211" to="227" loc="M"/>
      <Region from="228" to="243" loc="I"/>
      <Region from="244" to="263" loc="M"/>
      <Region from="264" to="276" loc="O"/>
      <Region from="277" to="294" loc="M"/>
      <Region from="295" to="344" loc="I"/>
      <Region from="345" to="366" loc="M"/>
      <Region from="367" to="369" loc="O"/>
      <Region from="370" to="385" loc="M"/>
      <Region from="386" to="417" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="15" loc="O"/>
      <Region from="16" to="20" loc="L"/>
      <Region from="21" to="35" loc="O"/>
      <Region from="36" to="56" loc="M"/>
      <Region from="57" to="68" loc="I"/>
      <Region from="69" to="74" loc="L"/>
      <Region from="75" to="86" loc="I"/>
      <Region from="87" to="117" loc="M"/>
      <Region from="118" to="119" loc="O"/>
      <Region from="120" to="140" loc="M"/>
      <Region from="141" to="177" loc="I"/>
      <Region from="178" to="198" loc="M"/>
      <Region from="199" to="203" loc="O"/>
      <Region from="204" to="224" loc="M"/>
      <Region from="225" to="243" loc="I"/>
      <Region from="244" to="264" loc="M"/>
      <Region from="265" to="270" loc="O"/>
      <Region from="271" to="291" loc="M"/>
      <Region from="292" to="336" loc="I"/>
      <Region from="337" to="357" loc="M"/>
      <Region from="358" to="358" loc="O"/>
      <Region from="359" to="379" loc="M"/>
      <Region from="380" to="417" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="92" loc="I"/>
      <Region from="93" to="113" loc="M"/>
      <Region from="114" to="119" loc="O"/>
      <Region from="120" to="144" loc="M"/>
      <Region from="145" to="179" loc="I"/>
      <Region from="180" to="199" loc="M"/>
      <Region from="200" to="205" loc="O"/>
      <Region from="206" to="228" loc="M"/>
      <Region from="229" to="243" loc="I"/>
      <Region from="244" to="262" loc="M"/>
      <Region from="263" to="273" loc="O"/>
      <Region from="274" to="295" loc="M"/>
      <Region from="296" to="349" loc="I"/>
      <Region from="350" to="366" loc="M"/>
      <Region from="367" to="367" loc="O"/>
      <Region from="368" to="382" loc="M"/>
      <Region from="383" to="417" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="91" loc="I"/>
      <Region from="92" to="112" loc="M"/>
      <Region from="113" to="117" loc="O"/>
      <Region from="118" to="139" loc="M"/>
      <Region from="140" to="207" loc="I"/>
      <Region from="208" to="228" loc="M"/>
      <Region from="229" to="247" loc="O"/>
      <Region from="248" to="269" loc="M"/>
      <Region from="270" to="275" loc="I"/>
      <Region from="276" to="293" loc="M"/>
      <Region from="294" to="356" loc="O"/>
      <Region from="357" to="382" loc="M"/>
      <Region from="383" to="417" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="86" loc="I"/>
      <Region from="87" to="107" loc="M"/>
      <Region from="108" to="118" loc="O"/>
      <Region from="119" to="139" loc="M"/>
      <Region from="140" to="178" loc="I"/>
      <Region from="179" to="199" loc="M"/>
      <Region from="200" to="203" loc="O"/>
      <Region from="204" to="224" loc="M"/>
      <Region from="225" to="244" loc="I"/>
      <Region from="245" to="265" loc="M"/>
      <Region from="266" to="275" loc="O"/>
      <Region from="276" to="296" loc="M"/>
      <Region from="297" to="349" loc="I"/>
      <Region from="350" to="370" loc="M"/>
      <Region from="371" to="417" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="36" loc="O"/>
      <Region from="37" to="57" loc="M"/>
      <Region from="58" to="88" loc="I"/>
      <Region from="89" to="109" loc="M"/>
      <Region from="110" to="117" loc="O"/>
      <Region from="118" to="138" loc="M"/>
      <Region from="139" to="178" loc="I"/>
      <Region from="179" to="199" loc="M"/>
      <Region from="200" to="203" loc="O"/>
      <Region from="204" to="224" loc="M"/>
      <Region from="225" to="244" loc="I"/>
      <Region from="245" to="265" loc="M"/>
      <Region from="266" to="273" loc="O"/>
      <Region from="274" to="294" loc="M"/>
      <Region from="295" to="349" loc="I"/>
      <Region from="350" to="370" loc="M"/>
      <Region from="371" to="417" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="35" loc="O"/>
      <Region from="36" to="55" loc="M"/>
      <Region from="56" to="89" loc="I"/>
      <Region from="90" to="109" loc="M"/>
      <Region from="110" to="118" loc="O"/>
      <Region from="119" to="138" loc="M"/>
      <Region from="139" to="178" loc="I"/>
      <Region from="179" to="198" loc="M"/>
      <Region from="199" to="207" loc="O"/>
      <Region from="208" to="227" loc="M"/>
      <Region from="228" to="242" loc="I"/>
      <Region from="243" to="262" loc="M"/>
      <Region from="263" to="272" loc="O"/>
      <Region from="273" to="292" loc="M"/>
      <Region from="293" to="368" loc="I"/>
      <Region from="369" to="388" loc="M"/>
      <Region from="389" to="417" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="35" loc="O"/>
      <Region from="36" to="56" loc="M"/>
      <Region from="57" to="89" loc="I"/>
      <Region from="90" to="110" loc="M"/>
      <Region from="111" to="118" loc="O"/>
      <Region from="119" to="139" loc="M"/>
      <Region from="140" to="178" loc="I"/>
      <Region from="179" to="199" loc="M"/>
      <Region from="200" to="207" loc="O"/>
      <Region from="208" to="228" loc="M"/>
      <Region from="229" to="243" loc="I"/>
      <Region from="244" to="264" loc="M"/>
      <Region from="265" to="272" loc="O"/>
      <Region from="273" to="293" loc="M"/>
      <Region from="294" to="346" loc="I"/>
      <Region from="347" to="367" loc="M"/>
      <Region from="368" to="368" loc="O"/>
      <Region from="369" to="389" loc="M"/>
      <Region from="390" to="417" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="92" loc="I"/>
      <Region from="93" to="115" loc="M"/>
      <Region from="116" to="119" loc="O"/>
      <Region from="120" to="142" loc="M"/>
      <Region from="143" to="205" loc="I"/>
      <Region from="206" to="228" loc="M"/>
      <Region from="229" to="273" loc="O"/>
      <Region from="274" to="296" loc="M"/>
      <Region from="297" to="355" loc="I"/>
      <Region from="356" to="378" loc="M"/>
      <Region from="379" to="417" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints/>
</HtpItem>
