<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="E9PR43_HUMAN" transmembrane="yes" evidence="3D">
  <Name>NADPH oxidase 4 </Name>
  <CrossRef>
    <PDBTM id="8wej">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8gz3">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8x2l">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6wxv">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7d3e">
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7d3f">
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6wxr">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8kei">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8cak">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8cb0">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8cal">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5o0x">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8cap">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="E"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8cao">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8u87">
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8u7y">
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="8u85">
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8u86">
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="3a1f">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7u8g">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8qq7">
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="NOX4_HUMAN">
      <Alignment>
        <CrossRefSeq>MVVVLFLMITASTYAIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLPEYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGKTVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS</CrossRefSeq>
        <OrigSeq>MVVVLFLMITASTYAIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLPEYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWFWQ---------------------ENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGKTVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="CY24B_HUMAN">
      <Alignment>
        <CrossRefSeq>ITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAES-----------LAVHNITVCE-----------QKISEWGKIKE-------CPIPQFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEED--FFSIHIRIVGDWTEGLFNAC------GCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCNNATNLKLKKIYFYWLCRDTHAFEWFADLLQLLESQMQERNNAGFLSYNIYLTGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHPNTRIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF</CrossRefSeq>
        <OrigSeq>MVVVLFLMITASTYAIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLPEYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLL----DDWKPYKLRRLYFIWFWQENRPDYVN---------------------IQLYLSQTDGIQKIIG--------EKYHALNSRLFIGRPRWKLLFDEIAKYNRGKTVGVFCCGPNSLSKTLHKLSNQNNSYGTR---FEYNKESF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="NOX1_HUMAN">
      <Alignment>
        <CrossRefSeq>MTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEES--------------MNESHPRKCAESFE--------MWDDRDSH------CRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEED--FFSIHIRAAGDWTENLIRAF------------EQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYKFQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSNIVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF</CrossRefSeq>
        <OrigSeq>MVVVLFLMITASTYAIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLPEYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLDD----WKPYKLRRLYFIWFWQENRPD---------------------YVNIQLYLSQTDGIQ--------KIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGKTVGVFCCGPNSLSKTLHKLSNQNNSYGTR---FEYNKESF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="RBOHB_ORYSI">
      <Alignment>
        <CrossRefSeq>PPNYWWFVKGTEGWTGVVMVVLMAIAFTLAQPWFRRNKLKDSNPLKKMTGFNAFWFTHHLFVIVYTLLFVHGTCLYLSRKWYKKTTWMYLAVPVVLYVSERILRLFRSHDAVGIQKVAVYPGNVLALYMSKPPGFRYRSGQYIFIKCTAVSPYEWHPFSITSAPGDD--YLSVHIRTRGDWTSRLRTVFSEACRPPTEGESGLLRADLSKGITDEKARFPKLLVDGPYGAPAQDYREYDVLLLIGLGIGATPLISIVKDVLNHIQGEGSVGTTEPESSSKAKKKPFMTKRAYFYWVTREEGSFEWFRGVMNEVSEKDKDGVIELHNHCSSVYQEGDARSALIVMLQELQHAKKGVDILSGTSVKTHFARPNWRSVFKKVAVSHENQRVGVFYCGEPVLVPQLRQLSADFTHKTNTRFDFHKENF</CrossRefSeq>
        <OrigSeq>GGLLKYQTNLDTHPPGCISLNRTSSQN-ISLPEYFSEHFHEPFPEG---FSKPAEFTQHKFVKICMEEPRFQANFP--------QTWLWISGPLCLYCAERLYRYIRSNKPVTIISVMSHPSDVMEIRMVKE-NFKARPGQYITLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPF-----------IQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLD-------------------DWKPYKLRRLYFIWFWQENRPDYV-----------------NIQLYLS----------------QTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGKTVGVFCCGPNSLSKTLHKLSNQN-NSYGTRFEYNKESF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="NOX5_HUMAN">
      <Alignment>
        <CrossRefSeq>FWELLLTTRPGI--GWVHGSASPTGVALLLLLLLMFICSSSCIRRSGHFEVF----------YWTHLSYLLVWLLLIFHG--PNFWKWLLVPGILFFLEKAIGLAVSRMAAVCIMEVNLLPSKVTHLLIKRPPFFHYRPGDYLYLNIPTIARYEWHPFTISSAP-EQKDTIWLHIRSQGQWTNRLYESFKASDPLGRGSKRLSRSVTMRKSQRSSKGSEILLEKHKFCNIKCYIDGPYGTPTRRIFASEHAVLIGAGIGITPFASILQSIMYRHQKRKHTCPSCQHSWIEGVQDNMKLHKVDFIWINRDQRSFEWFVSLLTKLEMDQAEEAQYGRFLELHMYMTSALGKNDMKAIGLQMALDLLANKEKKDSITGLQTRTQPGRPDWSKVFQKVAAEKKGK-VQVFFCGSPALAKVLKGHCEKFG-----FRFFQENF</CrossRefSeq>
        <OrigSeq>YMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNI--SLPEYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLYRYIRSNKP-VTIISVMSHPSDVMEIRMVKENF-KARPGQYITLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQD---------------------SEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLDD-------------------WKPYKLRRLYFIWFWQENRPD----------------------YVNIQLYLSQTDGIQKIIG----------------EKYHALNSRLFIGRPRWKLLFDEIAKYNRGKTVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="DUOX1_CAEEL">
      <Alignment>
        <CrossRefSeq>SAIAFHKIVALFAAFWATLHTVGHCVNFYHVGTQSQEGLACLFQEAFFGSNFLPSISYWFFSTITGLTGIALVAVMCIIYVFALPCFIKRAYHAFR---------LTHLLNIAFYALTLLHGLPKLLDSPKFGYYVVGPIVLFVIDRIIGLMQYYKKLEIVNAEILPSDIIYIEYRRPREFKYKSGQWVTVSSPSISCTFNESHAFSIASSPQDENMKL--YIKAVGPWTWKLRSELIRSLNTGS---------PFPLIHMKGPYGDGNQEWMDYEVAIMVGAGIGVTPYASTLVDLVQRTSSDSFHRVRCRKVYFLWVCSTHKNYEWFVDVLKNVEDQARSGILETHIFVTQTFHKFDLRTTMLYICEKHFRATNSGISMFTGLHAKNHFGRPNFKAFFQFIQSEHKEQSKIGVFSCGPVNLNESIAEGCADANRQRDAPSFAHRFETF</CrossRefSeq>
        <OrigSeq>TASTYAIRVSNYDIFWYT-----HNLFFVFYML--------------LTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLPEYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANF-----PQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVMSHPSDVMEIRMVKE-NFKARPGQYITLHCPSVS--ALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLL-----DDWKPYKLRRLYFIWFWQENRPDYVNI-----------------QLYLSQTDGIQKIIG-----------------EKYHALNSRLFIGRPRWKLLFDEIAKYN-RGKTVGVFCCGPNSLSKTLHKLSNQNNSY--GTRFEYNKESF</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="391" CheckSum="c80e04a3e4a2cb27d07ccd5610161a01">
    <Seq>
      MVVVLFLMIT ASTYAIRVSN YDIFWYTHNL FFVFYMLLTL HVSGGLLKYQ
      TNLDTHPPGC ISLNRTSSQN ISLPEYFSEH FHEPFPEGFS KPAEFTQHKF
      VKICMEEPRF QANFPQTWLW ISGPLCLYCA ERLYRYIRSN KPVTIISVMS
      HPSDVMEIRM VKENFKARPG QYITLHCPSV SALENHPFTL TMCPTETKAT
      FGVHLKIVGD WTERFRDLLL PPSSQDSEIL PFIQSRNYPK LYIDGPFGSP
      FEESLNYEVS LCVAGGIGVT PFASILNTLL DDWKPYKLRR LYFIWFWQEN
      RPDYVNIQLY LSQTDGIQKI IGEKYHALNS RLFIGRPRWK LLFDEIAKYN
      RGKTVGVFCC GPNSLSKTLH KLSNQNNSYG TRFEYNKESF S
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="64.21">
    <Region from="1" to="22" loc="I"/>
    <Region from="23" to="42" loc="M"/>
    <Region from="43" to="258" loc="O"/>
    <Region from="259" to="276" loc="M"/>
    <Region from="277" to="391" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="1" loc="O"/>
      <Region from="2" to="16" loc="M"/>
      <Region from="17" to="29" loc="I"/>
      <Region from="30" to="46" loc="M"/>
      <Region from="47" to="391" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="25" loc="O"/>
      <Region from="26" to="43" loc="M"/>
      <Region from="44" to="117" loc="I"/>
      <Region from="118" to="133" loc="M"/>
      <Region from="134" to="259" loc="O"/>
      <Region from="260" to="275" loc="M"/>
      <Region from="276" to="391" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="4" loc="O"/>
      <Region from="5" to="12" loc="L"/>
      <Region from="13" to="22" loc="O"/>
      <Region from="23" to="43" loc="M"/>
      <Region from="44" to="114" loc="I"/>
      <Region from="115" to="135" loc="M"/>
      <Region from="136" to="257" loc="O"/>
      <Region from="258" to="278" loc="M"/>
      <Region from="279" to="391" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="1" loc="O"/>
      <Region from="2" to="10" loc="O"/>
      <Region from="11" to="15" loc="O"/>
      <Region from="16" to="24" loc="O"/>
      <Region from="25" to="47" loc="M"/>
      <Region from="48" to="391" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="20" loc="I"/>
      <Region from="21" to="41" loc="M"/>
      <Region from="42" to="259" loc="O"/>
      <Region from="260" to="280" loc="M"/>
      <Region from="281" to="391" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="20" loc="I"/>
      <Region from="21" to="41" loc="M"/>
      <Region from="42" to="253" loc="O"/>
      <Region from="254" to="274" loc="M"/>
      <Region from="275" to="391" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="22" loc="I"/>
      <Region from="23" to="43" loc="M"/>
      <Region from="44" to="116" loc="O"/>
      <Region from="117" to="137" loc="M"/>
      <Region from="138" to="256" loc="I"/>
      <Region from="257" to="277" loc="M"/>
      <Region from="278" to="391" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="20" loc="I"/>
      <Region from="21" to="43" loc="M"/>
      <Region from="44" to="391" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="6wxv_A">
      <ConstraintRegion from="22" to="349" loc="O" subId="17408986" subSource="6wxv_A"/>
      <ConstraintRegion from="358" to="592" loc="O" subId="17408987" subSource="6wxv_A"/>
      <ConstraintRegion from="593" to="613" loc="H" subId="17408988" subSource="6wxv_A"/>
      <ConstraintRegion from="614" to="623" loc="I" subId="17408989" subSource="6wxv_A"/>
      <ConstraintRegion from="1028" to="1029" loc="I" subId="17408990" subSource="6wxv_A"/>
      <ConstraintRegion from="1030" to="1040" loc="F" subId="17408992" subSource="6wxv_A"/>
      <ConstraintRegion from="1041" to="1043" loc="I" subId="17408994" subSource="6wxv_A"/>
      <ConstraintRegion from="1044" to="1064" loc="H" subId="17408996" subSource="6wxv_A"/>
      <ConstraintRegion from="1065" to="1081" loc="O" subId="17408998" subSource="6wxv_A"/>
      <ConstraintRegion from="1082" to="1105" loc="H" subId="17409000" subSource="6wxv_A"/>
      <ConstraintRegion from="1106" to="1112" loc="F" subId="17409003" subSource="6wxv_A"/>
      <ConstraintRegion from="1113" to="1129" loc="I" subId="17409005" subSource="6wxv_A"/>
      <ConstraintRegion from="1130" to="1152" loc="H" subId="17409007" subSource="6wxv_A"/>
      <ConstraintRegion from="1153" to="1185" loc="O" subId="17409009" subSource="6wxv_A"/>
      <ConstraintRegion from="1186" to="1210" loc="H" subId="17409010" subSource="6wxv_A"/>
      <ConstraintRegion from="1211" to="1223" loc="I" subId="17409011" subSource="6wxv_A"/>
      <ConstraintRegion from="1224" to="1241" loc="H" subId="17409014" subSource="6wxv_A"/>
      <ConstraintRegion from="1242" to="1246" loc="O" subId="17409015" subSource="6wxv_A"/>
      <ConstraintRegion from="1247" to="1265" loc="H" subId="17409016" subSource="6wxv_A"/>
      <ConstraintRegion from="1266" to="1353" loc="I" subId="17409018" subSource="6wxv_A"/>
      <ConstraintRegion from="1360" to="1410" loc="I" subId="17409020" subSource="6wxv_A"/>
      <ConstraintRegion from="1414" to="1464" loc="I" subId="17409022" subSource="6wxv_A"/>
      <ConstraintRegion from="1478" to="1511" loc="I" subId="17409023" subSource="6wxv_A"/>
      <ConstraintRegion from="1514" to="1540" loc="I" subId="17409025" subSource="6wxv_A"/>
      <ConstraintRegion from="1544" to="1551" loc="I" subId="17409027" subSource="6wxv_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6wxr_A">
      <ConstraintRegion from="22" to="349" loc="O" subId="17408826" subSource="6wxr_A"/>
      <ConstraintRegion from="358" to="595" loc="O" subId="17408828" subSource="6wxr_A"/>
      <ConstraintRegion from="596" to="613" loc="H" subId="17408829" subSource="6wxr_A"/>
      <ConstraintRegion from="614" to="622" loc="I" subId="17408830" subSource="6wxr_A"/>
      <ConstraintRegion from="1028" to="1045" loc="I" subId="17408832" subSource="6wxr_A"/>
      <ConstraintRegion from="1046" to="1064" loc="H" subId="17408834" subSource="6wxr_A"/>
      <ConstraintRegion from="1065" to="1083" loc="O" subId="17408836" subSource="6wxr_A"/>
      <ConstraintRegion from="1084" to="1103" loc="H" subId="17408838" subSource="6wxr_A"/>
      <ConstraintRegion from="1104" to="1129" loc="I" subId="17408841" subSource="6wxr_A"/>
      <ConstraintRegion from="1130" to="1149" loc="H" subId="17408843" subSource="6wxr_A"/>
      <ConstraintRegion from="1150" to="1189" loc="O" subId="17408845" subSource="6wxr_A"/>
      <ConstraintRegion from="1190" to="1208" loc="H" subId="17408847" subSource="6wxr_A"/>
      <ConstraintRegion from="1209" to="1223" loc="I" subId="17408849" subSource="6wxr_A"/>
      <ConstraintRegion from="1224" to="1240" loc="H" subId="17408851" subSource="6wxr_A"/>
      <ConstraintRegion from="1241" to="1245" loc="O" subId="17408853" subSource="6wxr_A"/>
      <ConstraintRegion from="1246" to="1262" loc="H" subId="17408855" subSource="6wxr_A"/>
      <ConstraintRegion from="1263" to="1353" loc="I" subId="17408857" subSource="6wxr_A"/>
      <ConstraintRegion from="1360" to="1410" loc="I" subId="17408859" subSource="6wxr_A"/>
      <ConstraintRegion from="1414" to="1464" loc="I" subId="17408861" subSource="6wxr_A"/>
      <ConstraintRegion from="1494" to="1511" loc="I" subId="17408863" subSource="6wxr_A"/>
      <ConstraintRegion from="1514" to="1539" loc="I" subId="17408865" subSource="6wxr_A"/>
      <ConstraintRegion from="1542" to="1551" loc="I" subId="17408867" subSource="6wxr_A"/>
    </Constraint>
  </Constraints>
</HtpItem>
