<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="F5GWV3_HUMAN" transmembrane="yes" evidence="3D">
  <Name>[histone H3]-trimethyl-L-lysine(27) demethylase </Name>
  <CrossRef>
    <PDBTM id="6vfi">
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6vfk">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6vfh">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6b85">
      <Chain id="J"/>
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
      <Chain id="D"/>
      <Chain id="E"/>
      <Chain id="F"/>
      <Chain id="G"/>
      <Chain id="H"/>
      <Chain id="I"/>
      <Chain id="K"/>
      <Chain id="L"/>
      <Chain id="M"/>
      <Chain id="N"/>
      <Chain id="O"/>
      <Chain id="P"/>
    </PDBTM>
    <PDBTM id="4eqf">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="3fp3">
      <Chain id="A"/>
    </PDBTM>
  </CrossRef>
  <Sequence Length="1389" CheckSum="de5b5346017b8c68990a4168fbc09d2e">
    <Seq>
      MKSCAVSLTT AAVAFGDEAK KMAEGKASRE SEEESVSLTV EEREALGGMD
      SRLFGFVRLH EDGARTKTLL GKAVRCYESL ILKAEGKVES DFFCQLGHFN
      LLLEDYSKAL SAYQRYYSLQ ADYWKNAAFL YGLGLVYFYY NAFHWAIKAF
      QDVLYVDPSF CRAKEIHLRL GLMFKVNTDY KSSLKHFQLA LIDCNPCTLS
      NAEIQFHIAH LYETQRKYHS AKEAYEQLLQ TENLPAQVKA TVLQQLGWMH
      HNMDLVGDKA TKESYAIQYL QKSLEADPNS GQSWYFLGSV LYQQQNQPMD
      ALQAYICAVQ LDHGHAAAWM DLGTLYESCN QPQDAIKCYL NAARSKRCSN
      TSTLAARIKF LQAQLCNLPQ SSLQNKTKLL PSIEEAWSLP IPAELTSRQG
      AMNTAQQQSL SLHMITSSQV EGLSSPAKKK RTSSPTKNGS DNWNGGQSLS
      HHPVQQVYSL CLTPQKLQHL EQLRANRDNL NPAQKHQLEQ LESQFVLMQQ
      MRHKEVAQVR TTGIHNGAIT DSSLPTNSVS NRQPHGALTR VSSVSQPGVR
      PACVEKLLSS GAFSAGCIPC GTSKILGSTD TILLGSNCIA GSESNGNVPY
      LQQNTHTLPH NHTDLNSSTE EPWRKQLSNS AQGLHKSQSS CLSGPNEEQP
      LFSTGSAQYH QATSTGIKKA NEHLTLPSNS VPQGDADSHL SCHTATSGGQ
      QGIMFTKESK PSKNRSLVPE TSRHTGDTSN GCADVKGLSN HVHQLIADAV
      SSPNHGDSPN LLIADNPQLS ALLIGKANGN VGTGTCDKVN NIHPAVHTKT
      DHSVASSPSS AISTATPSPK STEQRSINSV TSLNSPHSGL HTVNGEGLGK
      SQSSTKVDLP LASHRSTSQI LPSMSVSICP SSTEVLKACR NPGKNGLSNS
      CILLDKCPPP RPPTSPYPPL PKDKLNPPTP SIYLENKRDA FFPPLHQFCT
      NPKNPVTVIR GLAGALKLDL GLFSTKTLVE ANNEHMVEVR TQLLQPADEN
      WDPTGTKKIW RCESNRSHTT IAKYAQYQAS SFQESLREEN EKRTQHKDHS
      DNESTSSENS GRRRKGPFKT IKFGTNIDLS DNKKWKLQLH ELTKLPAFAR
      VVSAGNLLTH VGHTILGMNT VQLYMKVPGS RTPGHQENNN FCSVNINIGP
      GDCEWFVVPE DYWGVLNDFC EKNNLNFLMS SWWPNLEDLY EANVPVYRFI
      QRPGDLVWIN AGTVHWVQAV GWCNNIAWNV GPLTACQYKL AVERYEWNKL
      KSVKSPVPMV HLSWNMARNI KVSDPKLFEM IKYCLLKILK QYQTLREALV
      AAGKEVIWHG RTNDEPAHYC SICEVEVFNL LFVTNESNTQ KTYIVHCHDC
      ARKTSKSLEN FVVLEQYKME DLIQVYDQFT LALSLSSSS
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="66.99">
    <Region from="1" to="953" loc="I"/>
    <Region from="954" to="965" loc="M"/>
    <Region from="966" to="1094" loc="O"/>
    <Region from="1095" to="1106" loc="M"/>
    <Region from="1107" to="1389" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="126" loc="I"/>
      <Region from="127" to="138" loc="M"/>
      <Region from="139" to="1389" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="948" loc="I"/>
      <Region from="949" to="964" loc="M"/>
      <Region from="965" to="1389" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="3" loc="O"/>
      <Region from="4" to="24" loc="M"/>
      <Region from="25" to="55" loc="I"/>
      <Region from="56" to="76" loc="M"/>
      <Region from="77" to="92" loc="O"/>
      <Region from="93" to="97" loc="L"/>
      <Region from="98" to="124" loc="O"/>
      <Region from="125" to="145" loc="M"/>
      <Region from="146" to="356" loc="I"/>
      <Region from="357" to="358" loc="L"/>
      <Region from="359" to="953" loc="I"/>
      <Region from="954" to="974" loc="M"/>
      <Region from="975" to="1096" loc="O"/>
      <Region from="1097" to="1102" loc="L"/>
      <Region from="1103" to="1207" loc="O"/>
      <Region from="1208" to="1238" loc="M"/>
      <Region from="1239" to="1298" loc="I"/>
      <Region from="1299" to="1304" loc="L"/>
      <Region from="1305" to="1389" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region/>
    </Prediction>
    <Prediction name="Phobius">
      <Region/>
    </Prediction>
    <Prediction name="Pro">
      <Region/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="125" loc="O"/>
      <Region from="126" to="146" loc="M"/>
      <Region from="147" to="1095" loc="I"/>
      <Region from="1096" to="1116" loc="M"/>
      <Region from="1117" to="1212" loc="O"/>
      <Region from="1213" to="1232" loc="M"/>
      <Region from="1233" to="1389" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="122" loc="I"/>
      <Region from="123" to="145" loc="M"/>
      <Region from="146" to="1389" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="6b85_J">
      <ConstraintRegion from="1" to="8" loc="I" subId="16988111" subSource="6b85_J"/>
      <ConstraintRegion from="9" to="31" loc="H" subId="16988112" subSource="6b85_J"/>
      <ConstraintRegion from="32" to="42" loc="O" subId="16988113" subSource="6b85_J"/>
      <ConstraintRegion from="43" to="65" loc="H" subId="16988115" subSource="6b85_J"/>
      <ConstraintRegion from="66" to="215" loc="I" subId="16988117" subSource="6b85_J"/>
      <ConstraintRegion from="1" to="8" loc="I" subId="16988121" subSource="6b85_D"/>
      <ConstraintRegion from="9" to="31" loc="H" subId="16988123" subSource="6b85_D"/>
      <ConstraintRegion from="32" to="42" loc="O" subId="16988125" subSource="6b85_D"/>
      <ConstraintRegion from="43" to="65" loc="H" subId="16988127" subSource="6b85_D"/>
      <ConstraintRegion from="66" to="215" loc="I" subId="16988129" subSource="6b85_D"/>
      <ConstraintRegion from="1" to="8" loc="I" subId="16988134" subSource="6b85_E"/>
      <ConstraintRegion from="9" to="31" loc="H" subId="16988135" subSource="6b85_E"/>
      <ConstraintRegion from="32" to="42" loc="O" subId="16988137" subSource="6b85_E"/>
      <ConstraintRegion from="43" to="65" loc="H" subId="16988139" subSource="6b85_E"/>
      <ConstraintRegion from="66" to="215" loc="I" subId="16988141" subSource="6b85_E"/>
      <ConstraintRegion from="1" to="8" loc="I" subId="16988147" subSource="6b85_F"/>
      <ConstraintRegion from="9" to="31" loc="H" subId="16988149" subSource="6b85_F"/>
      <ConstraintRegion from="32" to="42" loc="O" subId="16988152" subSource="6b85_F"/>
      <ConstraintRegion from="43" to="65" loc="H" subId="16988155" subSource="6b85_F"/>
      <ConstraintRegion from="66" to="215" loc="I" subId="16988158" subSource="6b85_F"/>
    </Constraint>
  </Constraints>
</HtpItem>
