<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="F5GX48_HUMAN" transmembrane="yes" evidence="3D">
  <Name>V-type proton ATPase subunit a </Name>
  <CrossRef>
    <PDBTM id="6vq6">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6vq7">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6vq8">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6xby">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="9bry">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="9brz">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6wm2">
      <Chain id="R"/>
    </PDBTM>
    <PDBTM id="6wm3">
      <Chain id="R"/>
    </PDBTM>
    <PDBTM id="6wm4">
      <Chain id="R"/>
    </PDBTM>
    <PDBTM id="6xbw">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="7khr">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6c6l">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7fda">
      <Chain id="Q"/>
    </PDBTM>
    <PDBTM id="7fdb">
      <Chain id="Q"/>
    </PDBTM>
    <PDBTM id="7fdc">
      <Chain id="Q"/>
    </PDBTM>
    <PDBTM id="6o7u">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6pe4">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6pe5">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6vqc">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6vqg">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6vqh">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6m0r">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7tao">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7tap">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6o7t">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="7tmr">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6m0s">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8eau">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="8eas">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6wlw">
      <Chain id="R"/>
    </PDBTM>
    <PDBTM id="5i1m">
      <Chain id="V"/>
    </PDBTM>
    <PDBTM id="5vox">
      <Chain id="b"/>
    </PDBTM>
    <PDBTM id="5voy">
      <Chain id="b"/>
    </PDBTM>
    <PDBTM id="5voz">
      <Chain id="b"/>
    </PDBTM>
    <PDBTM id="9b8o">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6o7v">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6o7w">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6o7x">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="5tj5">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5gar">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="5gas">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="5tsj">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="6ly9">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="5y5x">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="5y5z">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="5y60">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="6r0z">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="6qum">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="6r0w">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="6r0y">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="6r10">
      <Chain id="N"/>
    </PDBTM>
    <TOPDB id="VPP1_HUMAN">
      <Alignment>
        <CrossRefSeq>EDEVFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLSVKSLAGGLVLFFFFTAFATLTVAILLIMEGLSAFLHALRLHWVEFQNKFYSGTGFKFLPFSFEHIREGKFEE</CrossRefSeq>
        <OrigSeq>DLSQFNFGEILMTQVIHSIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVIALFAVLTIFILLIMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPFSFSLL-SSKFNN</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="VPP2_MOUSE">
      <Alignment>
        <CrossRefSeq>EEFNFGEILMTQAIHSIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVMAFFAVLTIFILLVMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPFSFSLLSSKFSNDDSIA</CrossRefSeq>
        <OrigSeq>SQFNFGEILMTQVIHSIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVIALFAVLTIFILLIMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPFSFSLLSSKFNNDDSVA</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="VPP2_YEAST">
      <Alignment>
        <CrossRefSeq>EQGPFNFGDVMIHQVIHTIEFCLNCISHTASYLRLWALSLAHAQLSSVLWDMTISNAFSSKNSGSPLAVMKVVFLFAMWFVLTVCILVFMEGTSAMLHALRLHWVEAMSKFFEGEGYAYEPFSFRAIIE</CrossRefSeq>
        <OrigSeq>DLSQFNFGEILMTQVIHSIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLL---LLPVIALFAVLTIFILLIMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPFSFSLLSS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="VPP1_YEAST">
      <Alignment>
        <CrossRefSeq>DFGDIMIHQVIHTIEFCLNCVSHTASYLRLWALSLAHAQLSSVLWTMTIQIAFGFRGFVGVFMTVALFAMWFALTCAVLVLMEGTSAMLHSLRLHWVESMSKFFVGEGLPYEPFAFEYKDME</CrossRefSeq>
        <OrigSeq>NFGEILMTQVIHSIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVIALFAVLTIFILLIMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPFSFSLLSSK</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="VATM_DICDI">
      <Alignment>
        <CrossRefSeq>EEFEMGEVFVHQVIHTIEFVLGAVSNTASYLRLWALSLAHSELSSVFWE---RILIGQVERGNPFLAFVGFGAWLGASVAVLLLMESLSAFLHALRLHWVEFQNKFYIGDGVRFIPYSATRILSEDDE</CrossRefSeq>
        <OrigSeq>SQFNFGEILMTQVIHSIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVIALFAVLTIFILLIMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPFSFSLLSSKFNN</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="D3PQI8_MEIRD">
      <Alignment>
        <CrossRefSeq>FVGVALSREVLMIAELPGKGGQILSYIRLYAVGVAGGVLASLANQVGFGLAERFGFIGG-----ILGFLVGLLLILAIIVITTLGHVIQPIRLLWIEFSTNFGFFEETGRPYRPFRSVRSD</CrossRefSeq>
        <OrigSeq>FGEILMTQVIHSIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVIALFAVLTIFILLIMEGLSAFLHAIRLHWVEFQNK--FYVGAGTKFVPFSFSLLS</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="138" CheckSum="84db3c7e195e68746d5d9d396a9c11b7">
    <Seq>
      MLCDLSQFNF GEILMTQVIH SIEYCLGCIS NTASYLRLWA LSLAHAQLSD
      VLWAMLMRVG LRVDTTYGVL LLLPVIALFA VLTIFILLIM EGLSAFLHAI
      RLHWVEFQNK FYVGAGTKFV PFSFSLLSSK FNNDDSVA
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="74.66">
    <Region from="1" to="20" loc="I"/>
    <Region from="21" to="48" loc="M"/>
    <Region from="49" to="71" loc="O"/>
    <Region from="72" to="99" loc="M"/>
    <Region from="100" to="138" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="37" loc="O"/>
      <Region from="38" to="63" loc="M"/>
      <Region from="64" to="65" loc="I"/>
      <Region from="66" to="89" loc="M"/>
      <Region from="90" to="138" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="31" loc="M"/>
      <Region from="32" to="39" loc="O"/>
      <Region from="40" to="63" loc="M"/>
      <Region from="64" to="66" loc="I"/>
      <Region from="67" to="97" loc="M"/>
      <Region from="98" to="138" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="21" loc="O"/>
      <Region from="22" to="52" loc="M"/>
      <Region from="53" to="53" loc="I"/>
      <Region from="54" to="74" loc="M"/>
      <Region from="75" to="75" loc="O"/>
      <Region from="76" to="106" loc="M"/>
      <Region from="107" to="138" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="34" loc="I"/>
      <Region from="35" to="57" loc="M"/>
      <Region from="58" to="66" loc="O"/>
      <Region from="67" to="90" loc="M"/>
      <Region from="91" to="138" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="35" loc="O"/>
      <Region from="36" to="56" loc="M"/>
      <Region from="57" to="67" loc="I"/>
      <Region from="68" to="90" loc="M"/>
      <Region from="91" to="138" loc="O"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="69" loc="I"/>
      <Region from="70" to="90" loc="M"/>
      <Region from="91" to="138" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="42" loc="I"/>
      <Region from="43" to="63" loc="M"/>
      <Region from="64" to="74" loc="O"/>
      <Region from="75" to="95" loc="M"/>
      <Region from="96" to="138" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="69" loc="I"/>
      <Region from="70" to="90" loc="M"/>
      <Region from="91" to="138" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="69" loc="I"/>
      <Region from="70" to="90" loc="M"/>
      <Region from="91" to="138" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="66" loc="I"/>
      <Region from="67" to="89" loc="M"/>
      <Region from="90" to="138" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="6ly9_N">
      <ConstraintRegion from="4" to="349" loc="I" subId="17178737" subSource="6ly9_N"/>
      <ConstraintRegion from="350" to="366" loc="H" subId="17178738" subSource="6ly9_N"/>
      <ConstraintRegion from="367" to="367" loc="O" subId="17178739" subSource="6ly9_N"/>
      <ConstraintRegion from="368" to="378" loc="H" subId="17178740" subSource="6ly9_N"/>
      <ConstraintRegion from="379" to="408" loc="I" subId="17178741" subSource="6ly9_N"/>
      <ConstraintRegion from="409" to="425" loc="H" subId="17178742" subSource="6ly9_N"/>
      <ConstraintRegion from="426" to="460" loc="O" subId="17178743" subSource="6ly9_N"/>
      <ConstraintRegion from="461" to="484" loc="H" subId="17178744" subSource="6ly9_N"/>
      <ConstraintRegion from="485" to="494" loc="I" subId="17178745" subSource="6ly9_N"/>
      <ConstraintRegion from="495" to="513" loc="H" subId="17178746" subSource="6ly9_N"/>
      <ConstraintRegion from="514" to="522" loc="O" subId="17178747" subSource="6ly9_N"/>
      <ConstraintRegion from="523" to="543" loc="H" subId="17178748" subSource="6ly9_N"/>
      <ConstraintRegion from="544" to="544" loc="I" subId="17178749" subSource="6ly9_N"/>
      <ConstraintRegion from="545" to="583" loc="H" subId="17178750" subSource="6ly9_N"/>
      <ConstraintRegion from="584" to="591" loc="O" subId="17178751" subSource="6ly9_N"/>
      <ConstraintRegion from="592" to="632" loc="H" subId="17178752" subSource="6ly9_N"/>
      <ConstraintRegion from="633" to="652" loc="I" subId="17178753" subSource="6ly9_N"/>
    </Constraint>
  </Constraints>
</HtpItem>
