<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="F5GZA5_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Solute carrier family 6 member 13 </Name>
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    <TOPDB id="SC6A4_HUMAN">
      <Alignment>
        <CrossRefSeq>SAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGY--AICIIAFYIASYYNTIMAWALYYLISSFTDQLPW</CrossRefSeq>
        <OrigSeq>SRVSGTTSNGETKPVYPVMEKK--EEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGEHCMEFQKTNGSLNG-TSENATSPVIEFWERRVLKISDGI-QHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPY</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SC6A1_MOUSE">
      <Alignment>
        <CrossRefSeq>LSFWLNIYYIVII---SWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPY</CrossRefSeq>
        <OrigSeq>MEFVLSVAGEIIGLGNVWRFPYLCYKNGGEHCMEFQKTNGSLNG--------TSENATSPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPY</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SC6A4_RAT">
      <Alignment>
        <CrossRefSeq>SAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGY--AICIIAFYIASYYNTIIAW</CrossRefSeq>
        <OrigSeq>SRVSGTTSNGETKPVYPVMEKK--EEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGEHCMEFQKTNGSLNG-TSENATSPVIEFWERRVLKISDGI-QHLGALRWELALCLLLAWVICYFCIWKGV</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="INE_DROME">
      <Alignment>
        <CrossRefSeq>VNPQTPPPLGVDDDDSYLD-MSDETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPL--FKGAGLASVVVSFLMSTYYSVIIGYS----IYYFFTSF</CrossRefSeq>
        <OrigSeq>MDSRVSGTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGEHCMEF-QKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVI-CYFCIWKGVKSTGKVVYFTATF</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="SC6A6_HUMAN">
      <Alignment>
        <CrossRefSeq>TRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPY</CrossRefSeq>
        <OrigSeq>PVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGEHCMEFQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="DAT_DROME">
      <Alignment>
        <CrossRefSeq>SPTGHISKSKTPTPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLF</CrossRefSeq>
        <OrigSeq>GTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGEHCMEFQKTNGSLNGTSEN</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="NAAT1_DROME">
      <Alignment>
        <CrossRefSeq>KTDAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPY</CrossRefSeq>
        <OrigSeq>EKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGEHCMEFQ</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="150" CheckSum="8ad64031b5c71b131c2e5224a4d7835c">
    <Seq>
      MDSRVSGTTS NGETKPVYPV MEKKEEDGTL ERGHWNNKME FVLSVAGEII
      GLGNVWRFPY LCYKNGGEHC MEFQKTNGSL NGTSENATSP VIEFWERRVL
      KISDGIQHLG ALRWELALCL LLAWVICYFC IWKGVKSTGK VVYFTATFPY
      
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="74.05">
    <Region from="1" to="40" loc="I"/>
    <Region from="41" to="52" loc="M"/>
    <Region from="53" to="110" loc="O"/>
    <Region from="111" to="130" loc="M"/>
    <Region from="131" to="150" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="40" loc="I"/>
      <Region from="41" to="52" loc="M"/>
      <Region from="53" to="108" loc="O"/>
      <Region from="109" to="131" loc="M"/>
      <Region from="132" to="150" loc="I"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="40" loc="I"/>
      <Region from="41" to="57" loc="M"/>
      <Region from="58" to="114" loc="O"/>
      <Region from="115" to="132" loc="M"/>
      <Region from="133" to="150" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="38" loc="I"/>
      <Region from="39" to="59" loc="M"/>
      <Region from="60" to="116" loc="O"/>
      <Region from="117" to="131" loc="M"/>
      <Region from="132" to="132" loc="I"/>
      <Region from="133" to="147" loc="M"/>
      <Region from="148" to="150" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="110" loc="I"/>
      <Region from="111" to="135" loc="M"/>
      <Region from="136" to="150" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="115" loc="I"/>
      <Region from="116" to="135" loc="M"/>
      <Region from="136" to="150" loc="O"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="41" loc="I"/>
      <Region from="42" to="62" loc="M"/>
      <Region from="63" to="111" loc="O"/>
      <Region from="112" to="132" loc="M"/>
      <Region from="133" to="150" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="41" loc="I"/>
      <Region from="42" to="62" loc="M"/>
      <Region from="63" to="111" loc="O"/>
      <Region from="112" to="132" loc="M"/>
      <Region from="133" to="150" loc="I"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="111" loc="O"/>
      <Region from="112" to="131" loc="M"/>
      <Region from="132" to="150" loc="I"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="111" loc="O"/>
      <Region from="112" to="132" loc="M"/>
      <Region from="133" to="150" loc="I"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="109" loc="O"/>
      <Region from="110" to="132" loc="M"/>
      <Region from="133" to="150" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="8de3_A">
      <ConstraintRegion from="116" to="123" loc="I" subId="17028566" subSource="8de3_A"/>
      <ConstraintRegion from="124" to="142" loc="H" subId="17028568" subSource="8de3_A"/>
      <ConstraintRegion from="143" to="154" loc="O" subId="17028570" subSource="8de3_A"/>
      <ConstraintRegion from="155" to="174" loc="H" subId="17028572" subSource="8de3_A"/>
      <ConstraintRegion from="175" to="197" loc="I" subId="17028574" subSource="8de3_A"/>
      <ConstraintRegion from="198" to="222" loc="H" subId="17028576" subSource="8de3_A"/>
      <ConstraintRegion from="223" to="288" loc="O" subId="17028578" subSource="8de3_A"/>
      <ConstraintRegion from="289" to="308" loc="H" subId="17028580" subSource="8de3_A"/>
      <ConstraintRegion from="309" to="313" loc="I" subId="17028582" subSource="8de3_A"/>
      <ConstraintRegion from="314" to="333" loc="H" subId="17028584" subSource="8de3_A"/>
      <ConstraintRegion from="334" to="360" loc="O" subId="17028587" subSource="8de3_A"/>
      <ConstraintRegion from="361" to="382" loc="H" subId="17028589" subSource="8de3_A"/>
      <ConstraintRegion from="383" to="395" loc="I" subId="17028592" subSource="8de3_A"/>
      <ConstraintRegion from="396" to="413" loc="H" subId="17028595" subSource="8de3_A"/>
      <ConstraintRegion from="414" to="462" loc="O" subId="17028598" subSource="8de3_A"/>
      <ConstraintRegion from="463" to="484" loc="H" subId="17028601" subSource="8de3_A"/>
      <ConstraintRegion from="485" to="503" loc="I" subId="17028604" subSource="8de3_A"/>
      <ConstraintRegion from="504" to="519" loc="H" subId="17028607" subSource="8de3_A"/>
      <ConstraintRegion from="520" to="525" loc="O" subId="17028610" subSource="8de3_A"/>
      <ConstraintRegion from="526" to="548" loc="H" subId="17028613" subSource="8de3_A"/>
      <ConstraintRegion from="549" to="572" loc="I" subId="17028616" subSource="8de3_A"/>
      <ConstraintRegion from="573" to="595" loc="H" subId="17028619" subSource="8de3_A"/>
      <ConstraintRegion from="596" to="612" loc="O" subId="17028622" subSource="8de3_A"/>
      <ConstraintRegion from="613" to="631" loc="H" subId="17028625" subSource="8de3_A"/>
      <ConstraintRegion from="632" to="654" loc="I" subId="17028628" subSource="8de3_A"/>
      <ConstraintRegion from="116" to="123" loc="I" subId="17028648" subSource="8de4_A"/>
      <ConstraintRegion from="124" to="139" loc="H" subId="17028651" subSource="8de4_A"/>
      <ConstraintRegion from="140" to="155" loc="O" subId="17028655" subSource="8de4_A"/>
      <ConstraintRegion from="156" to="173" loc="H" subId="17028660" subSource="8de4_A"/>
      <ConstraintRegion from="174" to="201" loc="I" subId="17028664" subSource="8de4_A"/>
      <ConstraintRegion from="202" to="221" loc="H" subId="17028668" subSource="8de4_A"/>
      <ConstraintRegion from="222" to="288" loc="O" subId="17028673" subSource="8de4_A"/>
      <ConstraintRegion from="289" to="308" loc="H" subId="17028678" subSource="8de4_A"/>
      <ConstraintRegion from="309" to="313" loc="I" subId="17028682" subSource="8de4_A"/>
      <ConstraintRegion from="314" to="330" loc="H" subId="17028685" subSource="8de4_A"/>
      <ConstraintRegion from="331" to="363" loc="O" subId="17028690" subSource="8de4_A"/>
      <ConstraintRegion from="364" to="381" loc="H" subId="17028695" subSource="8de4_A"/>
      <ConstraintRegion from="382" to="395" loc="I" subId="17028699" subSource="8de4_A"/>
      <ConstraintRegion from="396" to="412" loc="H" subId="17028706" subSource="8de4_A"/>
      <ConstraintRegion from="413" to="465" loc="O" subId="17028710" subSource="8de4_A"/>
      <ConstraintRegion from="466" to="483" loc="H" subId="17028713" subSource="8de4_A"/>
      <ConstraintRegion from="484" to="503" loc="I" subId="17028717" subSource="8de4_A"/>
      <ConstraintRegion from="504" to="519" loc="H" subId="17028720" subSource="8de4_A"/>
      <ConstraintRegion from="520" to="525" loc="O" subId="17028721" subSource="8de4_A"/>
      <ConstraintRegion from="526" to="546" loc="H" subId="17028722" subSource="8de4_A"/>
      <ConstraintRegion from="547" to="576" loc="I" subId="17028723" subSource="8de4_A"/>
      <ConstraintRegion from="577" to="598" loc="H" subId="17028725" subSource="8de4_A"/>
      <ConstraintRegion from="599" to="610" loc="O" subId="17028727" subSource="8de4_A"/>
      <ConstraintRegion from="611" to="625" loc="H" subId="17028729" subSource="8de4_A"/>
      <ConstraintRegion from="626" to="654" loc="I" subId="17028731" subSource="8de4_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6yu2_A">
      <ConstraintRegion from="8" to="19" loc="I" subId="17447217" subSource="6yu2_A"/>
      <ConstraintRegion from="20" to="36" loc="H" subId="17447218" subSource="6yu2_A"/>
      <ConstraintRegion from="37" to="48" loc="O" subId="17447219" subSource="6yu2_A"/>
      <ConstraintRegion from="49" to="67" loc="H" subId="17447220" subSource="6yu2_A"/>
      <ConstraintRegion from="68" to="88" loc="I" subId="17447221" subSource="6yu2_A"/>
      <ConstraintRegion from="89" to="125" loc="H" subId="17447222" subSource="6yu2_A"/>
      <ConstraintRegion from="126" to="133" loc="O" subId="17447223" subSource="6yu2_A"/>
      <ConstraintRegion from="134" to="143" loc="F" subId="17447224" subSource="6yu2_A"/>
      <ConstraintRegion from="144" to="147" loc="O" subId="17447225" subSource="6yu2_A"/>
      <ConstraintRegion from="148" to="165" loc="H" subId="17447226" subSource="6yu2_A"/>
      <ConstraintRegion from="166" to="175" loc="I" subId="17447227" subSource="6yu2_A"/>
      <ConstraintRegion from="176" to="193" loc="H" subId="17447228" subSource="6yu2_A"/>
      <ConstraintRegion from="194" to="199" loc="O" subId="17447229" subSource="6yu2_A"/>
      <ConstraintRegion from="200" to="208" loc="F" subId="17447230" subSource="6yu2_A"/>
      <ConstraintRegion from="209" to="221" loc="O" subId="17447231" subSource="6yu2_A"/>
      <ConstraintRegion from="222" to="242" loc="H" subId="17447232" subSource="6yu2_A"/>
      <ConstraintRegion from="243" to="253" loc="I" subId="17447233" subSource="6yu2_A"/>
      <ConstraintRegion from="254" to="273" loc="H" subId="17447234" subSource="6yu2_A"/>
      <ConstraintRegion from="274" to="291" loc="O" subId="17447235" subSource="6yu2_A"/>
      <ConstraintRegion from="292" to="300" loc="F" subId="17447236" subSource="6yu2_A"/>
      <ConstraintRegion from="301" to="305" loc="O" subId="17447237" subSource="6yu2_A"/>
      <ConstraintRegion from="306" to="333" loc="H" subId="17447238" subSource="6yu2_A"/>
      <ConstraintRegion from="334" to="347" loc="I" subId="17447239" subSource="6yu2_A"/>
      <ConstraintRegion from="348" to="363" loc="H" subId="17447240" subSource="6yu2_A"/>
      <ConstraintRegion from="364" to="383" loc="O" subId="17447241" subSource="6yu2_A"/>
      <ConstraintRegion from="384" to="407" loc="H" subId="17447242" subSource="6yu2_A"/>
      <ConstraintRegion from="408" to="409" loc="I" subId="17447243" subSource="6yu2_A"/>
      <ConstraintRegion from="410" to="416" loc="F" subId="17447244" subSource="6yu2_A"/>
      <ConstraintRegion from="417" to="423" loc="I" subId="17447245" subSource="6yu2_A"/>
      <ConstraintRegion from="424" to="445" loc="H" subId="17447246" subSource="6yu2_A"/>
      <ConstraintRegion from="446" to="448" loc="O" subId="17447247" subSource="6yu2_A"/>
      <ConstraintRegion from="8" to="19" loc="I" subId="17447248" subSource="6yu2_B"/>
      <ConstraintRegion from="20" to="36" loc="H" subId="17447249" subSource="6yu2_B"/>
      <ConstraintRegion from="37" to="48" loc="O" subId="17447250" subSource="6yu2_B"/>
      <ConstraintRegion from="49" to="67" loc="H" subId="17447251" subSource="6yu2_B"/>
      <ConstraintRegion from="68" to="88" loc="I" subId="17447252" subSource="6yu2_B"/>
      <ConstraintRegion from="89" to="125" loc="H" subId="17447253" subSource="6yu2_B"/>
      <ConstraintRegion from="126" to="133" loc="O" subId="17447254" subSource="6yu2_B"/>
      <ConstraintRegion from="134" to="144" loc="F" subId="17447255" subSource="6yu2_B"/>
      <ConstraintRegion from="145" to="147" loc="O" subId="17447256" subSource="6yu2_B"/>
      <ConstraintRegion from="148" to="165" loc="H" subId="17447257" subSource="6yu2_B"/>
      <ConstraintRegion from="166" to="175" loc="I" subId="17447258" subSource="6yu2_B"/>
      <ConstraintRegion from="176" to="193" loc="H" subId="17447259" subSource="6yu2_B"/>
      <ConstraintRegion from="194" to="199" loc="O" subId="17447260" subSource="6yu2_B"/>
      <ConstraintRegion from="200" to="208" loc="F" subId="17447261" subSource="6yu2_B"/>
      <ConstraintRegion from="209" to="221" loc="O" subId="17447262" subSource="6yu2_B"/>
      <ConstraintRegion from="222" to="242" loc="H" subId="17447263" subSource="6yu2_B"/>
      <ConstraintRegion from="243" to="253" loc="I" subId="17447264" subSource="6yu2_B"/>
      <ConstraintRegion from="254" to="273" loc="H" subId="17447265" subSource="6yu2_B"/>
      <ConstraintRegion from="274" to="290" loc="O" subId="17447266" subSource="6yu2_B"/>
      <ConstraintRegion from="291" to="302" loc="F" subId="17447267" subSource="6yu2_B"/>
      <ConstraintRegion from="303" to="305" loc="O" subId="17447268" subSource="6yu2_B"/>
      <ConstraintRegion from="306" to="333" loc="H" subId="17447269" subSource="6yu2_B"/>
      <ConstraintRegion from="334" to="347" loc="I" subId="17447270" subSource="6yu2_B"/>
      <ConstraintRegion from="348" to="363" loc="H" subId="17447271" subSource="6yu2_B"/>
      <ConstraintRegion from="364" to="383" loc="O" subId="17447272" subSource="6yu2_B"/>
      <ConstraintRegion from="384" to="407" loc="H" subId="17447273" subSource="6yu2_B"/>
      <ConstraintRegion from="408" to="409" loc="I" subId="17447274" subSource="6yu2_B"/>
      <ConstraintRegion from="410" to="415" loc="F" subId="17447275" subSource="6yu2_B"/>
      <ConstraintRegion from="416" to="423" loc="I" subId="17447276" subSource="6yu2_B"/>
      <ConstraintRegion from="424" to="445" loc="H" subId="17447277" subSource="6yu2_B"/>
      <ConstraintRegion from="446" to="448" loc="O" subId="17447278" subSource="6yu2_B"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6yu4_A">
      <ConstraintRegion from="8" to="19" loc="I" subId="17447354" subSource="6yu4_A"/>
      <ConstraintRegion from="20" to="39" loc="H" subId="17447356" subSource="6yu4_A"/>
      <ConstraintRegion from="40" to="44" loc="O" subId="17447358" subSource="6yu4_A"/>
      <ConstraintRegion from="45" to="64" loc="H" subId="17447360" subSource="6yu4_A"/>
      <ConstraintRegion from="65" to="92" loc="I" subId="17447362" subSource="6yu4_A"/>
      <ConstraintRegion from="93" to="120" loc="H" subId="17447364" subSource="6yu4_A"/>
      <ConstraintRegion from="121" to="133" loc="O" subId="17447366" subSource="6yu4_A"/>
      <ConstraintRegion from="134" to="144" loc="F" subId="17447368" subSource="6yu4_A"/>
      <ConstraintRegion from="145" to="149" loc="O" subId="17447370" subSource="6yu4_A"/>
      <ConstraintRegion from="150" to="167" loc="H" subId="17447372" subSource="6yu4_A"/>
      <ConstraintRegion from="168" to="171" loc="I" subId="17447374" subSource="6yu4_A"/>
      <ConstraintRegion from="172" to="192" loc="H" subId="17447376" subSource="6yu4_A"/>
      <ConstraintRegion from="193" to="215" loc="O" subId="17447378" subSource="6yu4_A"/>
      <ConstraintRegion from="216" to="242" loc="H" subId="17447380" subSource="6yu4_A"/>
      <ConstraintRegion from="243" to="255" loc="I" subId="17447382" subSource="6yu4_A"/>
      <ConstraintRegion from="256" to="273" loc="H" subId="17447384" subSource="6yu4_A"/>
      <ConstraintRegion from="274" to="290" loc="O" subId="17447386" subSource="6yu4_A"/>
      <ConstraintRegion from="291" to="301" loc="F" subId="17447388" subSource="6yu4_A"/>
      <ConstraintRegion from="302" to="308" loc="O" subId="17447390" subSource="6yu4_A"/>
      <ConstraintRegion from="309" to="336" loc="H" subId="17447392" subSource="6yu4_A"/>
      <ConstraintRegion from="337" to="344" loc="I" subId="17447394" subSource="6yu4_A"/>
      <ConstraintRegion from="345" to="363" loc="H" subId="17447396" subSource="6yu4_A"/>
      <ConstraintRegion from="364" to="380" loc="O" subId="17447398" subSource="6yu4_A"/>
      <ConstraintRegion from="381" to="402" loc="H" subId="17447400" subSource="6yu4_A"/>
      <ConstraintRegion from="403" to="422" loc="I" subId="17447401" subSource="6yu4_A"/>
      <ConstraintRegion from="423" to="430" loc="F" subId="17447402" subSource="6yu4_A"/>
      <ConstraintRegion from="431" to="449" loc="H" subId="17447403" subSource="6yu4_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6yu6_A">
      <ConstraintRegion from="8" to="20" loc="I" subId="17447493" subSource="6yu6_A"/>
      <ConstraintRegion from="21" to="36" loc="H" subId="17447495" subSource="6yu6_A"/>
      <ConstraintRegion from="37" to="45" loc="O" subId="17447497" subSource="6yu6_A"/>
      <ConstraintRegion from="46" to="63" loc="H" subId="17447499" subSource="6yu6_A"/>
      <ConstraintRegion from="64" to="89" loc="I" subId="17447501" subSource="6yu6_A"/>
      <ConstraintRegion from="90" to="113" loc="H" subId="17447503" subSource="6yu6_A"/>
      <ConstraintRegion from="114" to="123" loc="F" subId="17447505" subSource="6yu6_A"/>
      <ConstraintRegion from="124" to="151" loc="O" subId="17447507" subSource="6yu6_A"/>
      <ConstraintRegion from="152" to="167" loc="H" subId="17447508" subSource="6yu6_A"/>
      <ConstraintRegion from="168" to="174" loc="I" subId="17447509" subSource="6yu6_A"/>
      <ConstraintRegion from="175" to="193" loc="H" subId="17447510" subSource="6yu6_A"/>
      <ConstraintRegion from="194" to="218" loc="O" subId="17447511" subSource="6yu6_A"/>
      <ConstraintRegion from="219" to="242" loc="H" subId="17447512" subSource="6yu6_A"/>
      <ConstraintRegion from="243" to="256" loc="I" subId="17447513" subSource="6yu6_A"/>
      <ConstraintRegion from="257" to="273" loc="H" subId="17447514" subSource="6yu6_A"/>
      <ConstraintRegion from="274" to="290" loc="O" subId="17447515" subSource="6yu6_A"/>
      <ConstraintRegion from="291" to="302" loc="F" subId="17447516" subSource="6yu6_A"/>
      <ConstraintRegion from="303" to="308" loc="O" subId="17447517" subSource="6yu6_A"/>
      <ConstraintRegion from="309" to="337" loc="H" subId="17447518" subSource="6yu6_A"/>
      <ConstraintRegion from="338" to="342" loc="I" subId="17447519" subSource="6yu6_A"/>
      <ConstraintRegion from="343" to="360" loc="H" subId="17447520" subSource="6yu6_A"/>
      <ConstraintRegion from="361" to="383" loc="O" subId="17447521" subSource="6yu6_A"/>
      <ConstraintRegion from="384" to="402" loc="H" subId="17447522" subSource="6yu6_A"/>
      <ConstraintRegion from="403" to="431" loc="I" subId="17447523" subSource="6yu6_A"/>
      <ConstraintRegion from="432" to="448" loc="H" subId="17447524" subSource="6yu6_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6yu5_A">
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      <ConstraintRegion from="19" to="39" loc="H" subId="17447421" subSource="6yu5_A"/>
      <ConstraintRegion from="40" to="44" loc="O" subId="17447423" subSource="6yu5_A"/>
      <ConstraintRegion from="45" to="67" loc="H" subId="17447425" subSource="6yu5_A"/>
      <ConstraintRegion from="68" to="90" loc="I" subId="17447427" subSource="6yu5_A"/>
      <ConstraintRegion from="91" to="124" loc="H" subId="17447429" subSource="6yu5_A"/>
      <ConstraintRegion from="125" to="147" loc="O" subId="17447431" subSource="6yu5_A"/>
      <ConstraintRegion from="148" to="166" loc="H" subId="17447433" subSource="6yu5_A"/>
      <ConstraintRegion from="167" to="171" loc="I" subId="17447435" subSource="6yu5_A"/>
      <ConstraintRegion from="172" to="192" loc="H" subId="17447437" subSource="6yu5_A"/>
      <ConstraintRegion from="193" to="215" loc="O" subId="17447439" subSource="6yu5_A"/>
      <ConstraintRegion from="216" to="242" loc="H" subId="17447441" subSource="6yu5_A"/>
      <ConstraintRegion from="243" to="253" loc="I" subId="17447443" subSource="6yu5_A"/>
      <ConstraintRegion from="254" to="273" loc="H" subId="17447445" subSource="6yu5_A"/>
      <ConstraintRegion from="274" to="290" loc="O" subId="17447447" subSource="6yu5_A"/>
      <ConstraintRegion from="291" to="301" loc="F" subId="17447449" subSource="6yu5_A"/>
      <ConstraintRegion from="302" to="308" loc="O" subId="17447451" subSource="6yu5_A"/>
      <ConstraintRegion from="309" to="336" loc="H" subId="17447453" subSource="6yu5_A"/>
      <ConstraintRegion from="337" to="345" loc="I" subId="17447455" subSource="6yu5_A"/>
      <ConstraintRegion from="346" to="364" loc="H" subId="17447457" subSource="6yu5_A"/>
      <ConstraintRegion from="365" to="378" loc="O" subId="17447459" subSource="6yu5_A"/>
      <ConstraintRegion from="379" to="403" loc="H" subId="17447460" subSource="6yu5_A"/>
      <ConstraintRegion from="404" to="409" loc="I" subId="17447461" subSource="6yu5_A"/>
      <ConstraintRegion from="410" to="416" loc="F" subId="17447463" subSource="6yu5_A"/>
      <ConstraintRegion from="417" to="427" loc="I" subId="17447465" subSource="6yu5_A"/>
      <ConstraintRegion from="428" to="448" loc="H" subId="17447467" subSource="6yu5_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6yu7_A">
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      <ConstraintRegion from="18" to="39" loc="H" subId="17447526" subSource="6yu7_A"/>
      <ConstraintRegion from="40" to="44" loc="O" subId="17447527" subSource="6yu7_A"/>
      <ConstraintRegion from="45" to="67" loc="H" subId="17447528" subSource="6yu7_A"/>
      <ConstraintRegion from="68" to="89" loc="I" subId="17447529" subSource="6yu7_A"/>
      <ConstraintRegion from="90" to="125" loc="H" subId="17447530" subSource="6yu7_A"/>
      <ConstraintRegion from="126" to="146" loc="O" subId="17447531" subSource="6yu7_A"/>
      <ConstraintRegion from="147" to="166" loc="H" subId="17447532" subSource="6yu7_A"/>
      <ConstraintRegion from="167" to="171" loc="I" subId="17447533" subSource="6yu7_A"/>
      <ConstraintRegion from="172" to="192" loc="H" subId="17447534" subSource="6yu7_A"/>
      <ConstraintRegion from="193" to="217" loc="O" subId="17447535" subSource="6yu7_A"/>
      <ConstraintRegion from="218" to="242" loc="H" subId="17447536" subSource="6yu7_A"/>
      <ConstraintRegion from="243" to="253" loc="I" subId="17447537" subSource="6yu7_A"/>
      <ConstraintRegion from="254" to="274" loc="H" subId="17447538" subSource="6yu7_A"/>
      <ConstraintRegion from="275" to="290" loc="O" subId="17447539" subSource="6yu7_A"/>
      <ConstraintRegion from="291" to="301" loc="F" subId="17447540" subSource="6yu7_A"/>
      <ConstraintRegion from="302" to="307" loc="O" subId="17447541" subSource="6yu7_A"/>
      <ConstraintRegion from="308" to="336" loc="H" subId="17447542" subSource="6yu7_A"/>
      <ConstraintRegion from="337" to="345" loc="I" subId="17447543" subSource="6yu7_A"/>
      <ConstraintRegion from="346" to="366" loc="H" subId="17447544" subSource="6yu7_A"/>
      <ConstraintRegion from="367" to="378" loc="O" subId="17447545" subSource="6yu7_A"/>
      <ConstraintRegion from="379" to="406" loc="H" subId="17447546" subSource="6yu7_A"/>
      <ConstraintRegion from="407" to="409" loc="I" subId="17447547" subSource="6yu7_A"/>
      <ConstraintRegion from="410" to="416" loc="F" subId="17447548" subSource="6yu7_A"/>
      <ConstraintRegion from="417" to="423" loc="I" subId="17447549" subSource="6yu7_A"/>
      <ConstraintRegion from="424" to="449" loc="H" subId="17447550" subSource="6yu7_A"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="6yu3_A">
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      <ConstraintRegion from="20" to="39" loc="H" subId="17447285" subSource="6yu3_A"/>
      <ConstraintRegion from="40" to="44" loc="O" subId="17447287" subSource="6yu3_A"/>
      <ConstraintRegion from="45" to="67" loc="H" subId="17447289" subSource="6yu3_A"/>
      <ConstraintRegion from="68" to="89" loc="I" subId="17447291" subSource="6yu3_A"/>
      <ConstraintRegion from="90" to="120" loc="H" subId="17447293" subSource="6yu3_A"/>
      <ConstraintRegion from="121" to="133" loc="O" subId="17447295" subSource="6yu3_A"/>
      <ConstraintRegion from="134" to="144" loc="F" subId="17447297" subSource="6yu3_A"/>
      <ConstraintRegion from="145" to="149" loc="O" subId="17447299" subSource="6yu3_A"/>
      <ConstraintRegion from="150" to="168" loc="H" subId="17447301" subSource="6yu3_A"/>
      <ConstraintRegion from="169" to="171" loc="I" subId="17447303" subSource="6yu3_A"/>
      <ConstraintRegion from="172" to="193" loc="H" subId="17447305" subSource="6yu3_A"/>
      <ConstraintRegion from="194" to="218" loc="O" subId="17447307" subSource="6yu3_A"/>
      <ConstraintRegion from="219" to="242" loc="H" subId="17447309" subSource="6yu3_A"/>
      <ConstraintRegion from="243" to="254" loc="I" subId="17447311" subSource="6yu3_A"/>
      <ConstraintRegion from="255" to="274" loc="H" subId="17447313" subSource="6yu3_A"/>
      <ConstraintRegion from="275" to="290" loc="O" subId="17447315" subSource="6yu3_A"/>
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      <ConstraintRegion from="303" to="307" loc="O" subId="17447319" subSource="6yu3_A"/>
      <ConstraintRegion from="308" to="337" loc="H" subId="17447321" subSource="6yu3_A"/>
      <ConstraintRegion from="338" to="344" loc="I" subId="17447323" subSource="6yu3_A"/>
      <ConstraintRegion from="345" to="363" loc="H" subId="17447325" subSource="6yu3_A"/>
      <ConstraintRegion from="364" to="380" loc="O" subId="17447327" subSource="6yu3_A"/>
      <ConstraintRegion from="381" to="403" loc="H" subId="17447329" subSource="6yu3_A"/>
      <ConstraintRegion from="404" to="409" loc="I" subId="17447331" subSource="6yu3_A"/>
      <ConstraintRegion from="410" to="416" loc="F" subId="17447333" subSource="6yu3_A"/>
      <ConstraintRegion from="417" to="427" loc="I" subId="17447335" subSource="6yu3_A"/>
      <ConstraintRegion from="428" to="448" loc="H" subId="17447337" subSource="6yu3_A"/>
    </Constraint>
  </Constraints>
</HtpItem>
