<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="F5H0T7_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Solute carrier family 22 member 6 </Name>
  <CrossRef>
    <PDBTM id="8bvt">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bvr">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bvs">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8bw7">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8omu">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8et9">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sdu">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sdz">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8sdy">
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="S22A6_MOUSE">
      <Alignment>
        <CrossRefSeq>MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPAHHCRPPANANLSKDGGLEAWLPLDKQGRPESCLRFPFPH------NGTEANGTGVTEPCLDGWVYDNSTFPSTIVTEWNLVCSHRAFRQLAQSLFMVGVLLGAMMFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYT-VYCIFRLLSGM</CrossRefSeq>
        <OrigSeq>MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEG--------PTPAGPVLVHGG---GAARSHGVRLPCRQARPPEGTHLELPADSCVRDLRSLRTQLPHLLRLPAPL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22A6_HUMAN">
      <Alignment>
        <CrossRefSeq>MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFP-IYCAFRLLSGM</CrossRefSeq>
        <OrigSeq>MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEG--------PTPAGPVLVHGG---GAARSHGVRLPCRQARPPEGTHLELPADSCVRDLRSLRTQLPHLLRLPAPL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22AB_HUMAN">
      <Alignment>
        <CrossRefSeq>MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAVSTNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTF</CrossRefSeq>
        <OrigSeq>MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLS-------KNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGT-GATEPCTDGWIYDNSTFPSTIV--------TEGPTPAGPVLVHGGGAARS---HGVRLPCRQARPPEGTHLELPADSCVRDLRSLR</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="S22A7_HUMAN">
      <Alignment>
        <CrossRefSeq>MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSY</CrossRefSeq>
        <OrigSeq>MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPAD-ANLS-KNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGT------EANGTGATEPCTDGWIYDNSTFPSTIVTEG----------PTPAGPVLVHGGGAAR---SHGVRLPCRQARPPEGTHLELPADSCVRDLRSLR</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="261" CheckSum="632bca6691d67daa8269244d9c8b5b92">
    <Seq>
      MAFNDLLQQV GGVGRFQQIQ VTLVVLPLLL MASHNTLQNF TAAIPTHHCR
      PPADANLSKN GGLEVWLPRD RQGQPESCLR FTSPQWGLPF LNGTEANGTG
      ATEPCTDGWI YDNSTFPSTI VTEGPTPAGP VLVHGGGAAR SHGVRLPCRQ
      ARPPEGTHLE LPADSCVRDL RSLRTQLPHL LRLPAPLGHG SGWHLPQLHD
      TECGVDAHSH TGLRGHLDWL CLQPGPVPPG WCGLRCAPLA PPAATGLCAF
      FCLLHLLLVL H
    </Seq>
  </Sequence>
  <Topology numTm="1" reliability="55.77">
    <Region from="1" to="238" loc="I"/>
    <Region from="239" to="259" loc="M"/>
    <Region from="260" to="261" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="245" loc="I"/>
      <Region from="246" to="260" loc="M"/>
      <Region from="261" to="261" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="18" loc="I"/>
      <Region from="19" to="37" loc="M"/>
      <Region from="38" to="241" loc="O"/>
      <Region from="242" to="258" loc="M"/>
      <Region from="259" to="261" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="36" loc="M"/>
      <Region from="37" to="131" loc="O"/>
      <Region from="132" to="139" loc="L"/>
      <Region from="140" to="183" loc="O"/>
      <Region from="184" to="190" loc="L"/>
      <Region from="191" to="220" loc="O"/>
      <Region from="221" to="226" loc="L"/>
      <Region from="227" to="239" loc="O"/>
      <Region from="240" to="260" loc="M"/>
      <Region from="261" to="261" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="237" loc="I"/>
      <Region from="238" to="259" loc="M"/>
      <Region from="260" to="261" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="238" loc="O"/>
      <Region from="239" to="260" loc="M"/>
      <Region from="261" to="261" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="11" loc="I"/>
      <Region from="12" to="32" loc="M"/>
      <Region from="33" to="123" loc="O"/>
      <Region from="124" to="144" loc="M"/>
      <Region from="145" to="153" loc="I"/>
      <Region from="154" to="174" loc="M"/>
      <Region from="175" to="239" loc="O"/>
      <Region from="240" to="260" loc="M"/>
      <Region from="261" to="261" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="11" loc="I"/>
      <Region from="12" to="32" loc="M"/>
      <Region from="33" to="123" loc="O"/>
      <Region from="124" to="144" loc="M"/>
      <Region from="145" to="153" loc="I"/>
      <Region from="154" to="174" loc="M"/>
      <Region from="175" to="261" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="239" loc="I"/>
      <Region from="240" to="260" loc="M"/>
      <Region from="261" to="261" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="239" loc="I"/>
      <Region from="240" to="260" loc="M"/>
      <Region from="261" to="261" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="237" loc="O"/>
      <Region from="238" to="260" loc="M"/>
      <Region from="261" to="261" loc="I"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="8et9_A">
      <ConstraintRegion from="3" to="23" loc="I" subId="17063953" subSource="8et9_A"/>
      <ConstraintRegion from="24" to="40" loc="H" subId="17063955" subSource="8et9_A"/>
      <ConstraintRegion from="41" to="151" loc="O" subId="17063957" subSource="8et9_A"/>
      <ConstraintRegion from="152" to="168" loc="H" subId="17063959" subSource="8et9_A"/>
      <ConstraintRegion from="169" to="179" loc="I" subId="17063961" subSource="8et9_A"/>
      <ConstraintRegion from="180" to="197" loc="H" subId="17063962" subSource="8et9_A"/>
      <ConstraintRegion from="198" to="201" loc="O" subId="17063964" subSource="8et9_A"/>
      <ConstraintRegion from="202" to="222" loc="H" subId="17063966" subSource="8et9_A"/>
      <ConstraintRegion from="223" to="236" loc="I" subId="17063968" subSource="8et9_A"/>
      <ConstraintRegion from="237" to="255" loc="H" subId="17063969" subSource="8et9_A"/>
      <ConstraintRegion from="256" to="265" loc="O" subId="17063971" subSource="8et9_A"/>
      <ConstraintRegion from="266" to="280" loc="H" subId="17063973" subSource="8et9_A"/>
      <ConstraintRegion from="281" to="317" loc="I" subId="17063975" subSource="8et9_A"/>
      <ConstraintRegion from="329" to="349" loc="I" subId="17063979" subSource="8et9_A"/>
      <ConstraintRegion from="350" to="367" loc="H" subId="17063981" subSource="8et9_A"/>
      <ConstraintRegion from="368" to="380" loc="O" subId="17063983" subSource="8et9_A"/>
      <ConstraintRegion from="381" to="398" loc="H" subId="17063985" subSource="8et9_A"/>
      <ConstraintRegion from="399" to="403" loc="I" subId="17063987" subSource="8et9_A"/>
      <ConstraintRegion from="404" to="421" loc="H" subId="17063989" subSource="8et9_A"/>
      <ConstraintRegion from="422" to="423" loc="O" subId="17063991" subSource="8et9_A"/>
      <ConstraintRegion from="428" to="434" loc="O" subId="17063995" subSource="8et9_A"/>
      <ConstraintRegion from="435" to="454" loc="H" subId="17063997" subSource="8et9_A"/>
      <ConstraintRegion from="455" to="467" loc="I" subId="17063999" subSource="8et9_A"/>
      <ConstraintRegion from="468" to="485" loc="H" subId="17064001" subSource="8et9_A"/>
      <ConstraintRegion from="486" to="496" loc="O" subId="17064002" subSource="8et9_A"/>
      <ConstraintRegion from="497" to="512" loc="H" subId="17064003" subSource="8et9_A"/>
      <ConstraintRegion from="513" to="534" loc="I" subId="17064004" subSource="8et9_A"/>
    </Constraint>
  </Constraints>
</HtpItem>
