<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="F5H847_HUMAN" transmembrane="yes" evidence="3D">
  <Name>V-type proton ATPase subunit a </Name>
  <CrossRef>
    <PDBTM id="6vq6">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6vq7">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6vq8">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6xby">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="9bry">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="9brz">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6xbw">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="7khr">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6wm2">
      <Chain id="R"/>
    </PDBTM>
    <PDBTM id="6wm3">
      <Chain id="R"/>
    </PDBTM>
    <PDBTM id="6wm4">
      <Chain id="R"/>
    </PDBTM>
    <PDBTM id="6c6l">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6pe4">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6pe5">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7fda">
      <Chain id="Q"/>
    </PDBTM>
    <PDBTM id="7fdb">
      <Chain id="Q"/>
    </PDBTM>
    <PDBTM id="7fdc">
      <Chain id="Q"/>
    </PDBTM>
    <PDBTM id="6m0r">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7tao">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="7tap">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6o7t">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="7tmr">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6m0s">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="8eau">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6vqc">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6vqg">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6vqh">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="8eas">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6o7u">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="5i1m">
      <Chain id="V"/>
    </PDBTM>
    <PDBTM id="6wlw">
      <Chain id="R"/>
    </PDBTM>
    <PDBTM id="5vox">
      <Chain id="b"/>
    </PDBTM>
    <PDBTM id="5voy">
      <Chain id="b"/>
    </PDBTM>
    <PDBTM id="5voz">
      <Chain id="b"/>
    </PDBTM>
    <PDBTM id="9b8o">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6o7v">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6o7w">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="6o7x">
      <Chain id="a"/>
    </PDBTM>
    <PDBTM id="5tj5">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5gar">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="5gas">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="5tsj">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="6ly9">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="5y5x">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="5y5z">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="5y60">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="6r0z">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="6qum">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="6r0w">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="6r0y">
      <Chain id="N"/>
    </PDBTM>
    <PDBTM id="6r10">
      <Chain id="N"/>
    </PDBTM>
    <TOPDB id="VPP2_MOUSE">
      <Alignment>
        <CrossRefSeq>VTCEEFNFGEILMTQAIHSIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVMAFFAVLTIFILLVMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVP</CrossRefSeq>
        <OrigSeq>MACEEFNFGEILMTQVIHSIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVIALFAVLTIFILLIMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVP</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="VPP1_HUMAN">
      <Alignment>
        <CrossRefSeq>EVFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLSVKSLAGGLVLFFFFTAFATLTVAILLIMEGLSAFLHALRLHWVEFQNKFYSGTGFKFLPFSFEHIREGKFEE</CrossRefSeq>
        <OrigSeq>EEFNFGEILMTQVIHSIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVIALFAVLTIFILLIMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPFSFSLL-SSKFNN</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="VPP1_YEAST">
      <Alignment>
        <CrossRefSeq>DFGDIMIHQVIHTIEFCLNCVSHTASYLRLWALSLAHAQLSSVLWTMTIQIAFGFRGFVGVFMTVALFAMWFALTCAVLVLMEGTSAMLHSLRLHWVESMSKFFVGEGLPYEPFAFEYKDME</CrossRefSeq>
        <OrigSeq>NFGEILMTQVIHSIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVIALFAVLTIFILLIMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPFSFSLLSSK</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="VPP2_YEAST">
      <Alignment>
        <CrossRefSeq>PFNFGDVMIHQVIHTIEFCLNCISHTASYLRLWALSLAHAQLSSVLWDMTISNAFSSKNSGSPLAVMKVVFLFAMWFVLTVCILVFMEGTSAMLHALRLHWVEAMSKFFEGEGYAYEPFSFRAIIE</CrossRefSeq>
        <OrigSeq>EFNFGEILMTQVIHSIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLL---LLPVIALFAVLTIFILLIMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPFSFSLLSS</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="VATM_DICDI">
      <Alignment>
        <CrossRefSeq>EEFEMGEVFVHQVIHTIEFVLGAVSNTASYLRLWALSLAHSELSSVFWE---RILIGQVERGNPFLAFVGFGAWLGASVAVLLLMESLSAFLHALRLHWVEFQNKFYIGDGVRFIPYSATRILSEDDE</CrossRefSeq>
        <OrigSeq>EEFNFGEILMTQVIHSIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVIALFAVLTIFILLIMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPFSFSLLSSKFNN</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="D3PQI8_MEIRD">
      <Alignment>
        <CrossRefSeq>LFFVGVALSREVLMIAELPGKGGQILSYIRLYAVGVAGGVLASLANQVGFGLAERF-----GFIGGILGFLVGLLLILAIIVITTLGHVIQPIRLLWIEFSTNFGFFEETGRPYRPFRSVRSD</CrossRefSeq>
        <OrigSeq>FNFGEILMTQVIHSIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVIALFAVLTIFILLIMEGLSAFLHAIRLHWVEFQNK--FYVGAGTKFVPFSFSLLS</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="131" CheckSum="2285cf3fa331ccfdf972585c1fc2d72d">
    <Seq>
      MACEEFNFGE ILMTQVIHSI EYCLGCISNT ASYLRLWALS LAHAQLSDVL
      WAMLMRVGLR VDTTYGVLLL LPVIALFAVL TIFILLIMEG LSAFLHAIRL
      HWVEFQNKFY VGAGTKFVPF SFSLLSSKFN N
    </Seq>
  </Sequence>
  <Topology numTm="2" reliability="73.27">
    <Region from="1" to="15" loc="I"/>
    <Region from="16" to="43" loc="M"/>
    <Region from="44" to="69" loc="O"/>
    <Region from="70" to="97" loc="M"/>
    <Region from="98" to="131" loc="I"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="35" loc="O"/>
      <Region from="36" to="61" loc="M"/>
      <Region from="62" to="63" loc="I"/>
      <Region from="64" to="87" loc="M"/>
      <Region from="88" to="131" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="13" loc="I"/>
      <Region from="14" to="29" loc="M"/>
      <Region from="30" to="37" loc="O"/>
      <Region from="38" to="61" loc="M"/>
      <Region from="62" to="64" loc="I"/>
      <Region from="65" to="95" loc="M"/>
      <Region from="96" to="131" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="15" loc="O"/>
      <Region from="16" to="46" loc="M"/>
      <Region from="47" to="47" loc="I"/>
      <Region from="48" to="78" loc="M"/>
      <Region from="79" to="79" loc="O"/>
      <Region from="80" to="100" loc="M"/>
      <Region from="101" to="104" loc="I"/>
      <Region from="105" to="107" loc="L"/>
      <Region from="108" to="131" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="35" loc="I"/>
      <Region from="36" to="55" loc="M"/>
      <Region from="56" to="64" loc="O"/>
      <Region from="65" to="88" loc="M"/>
      <Region from="89" to="131" loc="I"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="33" loc="O"/>
      <Region from="34" to="54" loc="M"/>
      <Region from="55" to="65" loc="I"/>
      <Region from="66" to="88" loc="M"/>
      <Region from="89" to="107" loc="O"/>
      <Region from="108" to="125" loc="M"/>
      <Region from="126" to="131" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="36" loc="M"/>
      <Region from="37" to="40" loc="O"/>
      <Region from="41" to="61" loc="M"/>
      <Region from="62" to="67" loc="I"/>
      <Region from="68" to="88" loc="M"/>
      <Region from="89" to="131" loc="O"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="11" loc="I"/>
      <Region from="12" to="32" loc="M"/>
      <Region from="33" to="37" loc="O"/>
      <Region from="38" to="58" loc="M"/>
      <Region from="59" to="72" loc="I"/>
      <Region from="73" to="93" loc="M"/>
      <Region from="94" to="131" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="67" loc="I"/>
      <Region from="68" to="88" loc="M"/>
      <Region from="89" to="131" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="67" loc="I"/>
      <Region from="68" to="88" loc="M"/>
      <Region from="89" to="131" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="64" loc="I"/>
      <Region from="65" to="87" loc="M"/>
      <Region from="88" to="131" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="6ly9_N">
      <ConstraintRegion from="4" to="349" loc="I" subId="17178737" subSource="6ly9_N"/>
      <ConstraintRegion from="350" to="366" loc="H" subId="17178738" subSource="6ly9_N"/>
      <ConstraintRegion from="367" to="367" loc="O" subId="17178739" subSource="6ly9_N"/>
      <ConstraintRegion from="368" to="378" loc="H" subId="17178740" subSource="6ly9_N"/>
      <ConstraintRegion from="379" to="408" loc="I" subId="17178741" subSource="6ly9_N"/>
      <ConstraintRegion from="409" to="425" loc="H" subId="17178742" subSource="6ly9_N"/>
      <ConstraintRegion from="426" to="460" loc="O" subId="17178743" subSource="6ly9_N"/>
      <ConstraintRegion from="461" to="484" loc="H" subId="17178744" subSource="6ly9_N"/>
      <ConstraintRegion from="485" to="494" loc="I" subId="17178745" subSource="6ly9_N"/>
      <ConstraintRegion from="495" to="513" loc="H" subId="17178746" subSource="6ly9_N"/>
      <ConstraintRegion from="514" to="522" loc="O" subId="17178747" subSource="6ly9_N"/>
      <ConstraintRegion from="523" to="543" loc="H" subId="17178748" subSource="6ly9_N"/>
      <ConstraintRegion from="544" to="544" loc="I" subId="17178749" subSource="6ly9_N"/>
      <ConstraintRegion from="545" to="583" loc="H" subId="17178750" subSource="6ly9_N"/>
      <ConstraintRegion from="584" to="591" loc="O" subId="17178751" subSource="6ly9_N"/>
      <ConstraintRegion from="592" to="632" loc="H" subId="17178752" subSource="6ly9_N"/>
      <ConstraintRegion from="633" to="652" loc="I" subId="17178753" subSource="6ly9_N"/>
    </Constraint>
  </Constraints>
</HtpItem>
