<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="F6S8M0_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Glucosamine (N-acetyl)-6-sulfatase </Name>
  <CrossRef>
    <PDBTM id="6xlp">
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5i5h">
      <Chain id="A"/>
    </PDBTM>
    <TOPDB id="GNS_HUMAN">
      <Alignment>
        <CrossRefSeq>MRLLPLAPGRLRRGSPRHLPSCSPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEVLGGM--------------------------------TPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPILRGASNLTWRSDVLVEYQGEGRNVTDPTCPSLSPGVSQCFPDCVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTIDPELLGKMNYRLMMLQSCSGPTCRTPGVFDPGYRFDPRLMFSNRGSVRTRRFSKHLL</CrossRefSeq>
        <OrigSeq>MRLLPLAPGRLRRGSPRHLPSCSPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEVLGGMAFSEYSTTNCQTGLQGEELGQEHLRTYLEPSRTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPILRGASNLTWRSDVLVEYQGEGRNVTDPTCPSLSPGVSQCFPDCVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTIDPELLGKMNYRLMMLQSCSGPTCRTPGVFDPGYRFDPRLMFSNRGSVRTRRFSKHLL</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="YEJM_ECO57">
      <Alignment>
        <CrossRefSeq>FTSPLYRQALLSDFSMPSVRTQSDEQTATQWINWLGRYAQEDNRWFSWVSFNGTNIDDSNQQAFARKYSRAAGNVDDQINRVLNALRDSGKLDNTVVIITAGRGIPLSEEEETFDWS---HGHLQVPLVIHWPG-TPAQRINALTDHTDLMTTLMQRLLHVSTPASEYSQGQDL</CrossRefSeq>
        <OrigSeq>WTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPM-------------TNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILD-IAGYDLNKTQM-DGMSL</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="584" CheckSum="bb4b2d86aad873c592c9d5900a63c650">
    <Seq>
      MRLLPLAPGR LRRGSPRHLP SCSPALLLLV LGGCLGVFGV AAGTRRPNVV
      LLLTDDQDEV LGGMAFSEYS TTNCQTGLQG EELGQEHLRT YLEPSRTPLK
      KTKALIGEMG MTFSSAYVPS ALCCPSRASI LTGKYPHNHH VVNNTLEGNC
      SSKSWQKIQE PNTFPAILRS MCGYQTFFAG KYLNEYGAPD AGGLEHVPLG
      WSYWYALEKN SKYYNYTLSI NGKARKHGEN YSVDYLTDVL ANVSLDFLDY
      KSNFEPFFMM IATPAPHSPW TAAPQYQKAF QNVFAPRNKN FNIHGTNKHW
      LIRQAKTPMT NSSIQFLDNA FRKRWQTLLS VDDLVEKLVK RLEFTGELNN
      TYIFYTSDNG YHTGQFSLPI DKRQLYEFDI KVPLLVRGPG IKPNQTSKML
      VANIDLGPTI LDIAGYDLNK TQMDGMSLLP ILRGASNLTW RSDVLVEYQG
      EGRNVTDPTC PSLSPGVSQC FPDCVCEDAY NNTYACVRTM SALWNLQYCE
      FDDQEVFVEV YNLTADPDQI TNIAKTIDPE LLGKMNYRLM MLQSCSGPTC
      RTPGVFDPGY RFDPRLMFSN RGSVRTRRFS KHLL
    </Seq>
  </Sequence>
  <Topology numTm="1" reliability="89.44">
    <Region from="1" to="20" loc="I"/>
    <Region from="21" to="41" loc="M"/>
    <Region from="42" to="584" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="25" loc="I"/>
      <Region from="26" to="43" loc="M"/>
      <Region from="44" to="584" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="117" loc="O"/>
      <Region from="118" to="133" loc="M"/>
      <Region from="134" to="584" loc="I"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="18" loc="I"/>
      <Region from="19" to="39" loc="M"/>
      <Region from="40" to="584" loc="O"/>
    </Prediction>
    <Prediction name="Philius">
      <Region/>
    </Prediction>
    <Prediction name="Phobius">
      <Region/>
    </Prediction>
    <Prediction name="Pro">
      <Region/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="20" loc="I"/>
      <Region from="21" to="41" loc="M"/>
      <Region from="42" to="584" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="21" loc="I"/>
      <Region from="22" to="42" loc="M"/>
      <Region from="43" to="584" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="21" loc="I"/>
      <Region from="22" to="42" loc="M"/>
      <Region from="43" to="584" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region from="1" to="20" loc="I"/>
      <Region from="21" to="43" loc="M"/>
      <Region from="44" to="584" loc="O"/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="YEJM_ECO57">
      <ConstraintRegion from="1" to="15" loc="I" subId="17421392" subSource="6xlp_A"/>
      <ConstraintRegion from="16" to="35" loc="H" subId="17421393" subSource="6xlp_A"/>
      <ConstraintRegion from="36" to="54" loc="O" subId="17421394" subSource="6xlp_A"/>
      <ConstraintRegion from="55" to="80" loc="H" subId="17421395" subSource="6xlp_A"/>
      <ConstraintRegion from="81" to="84" loc="I" subId="17421396" subSource="6xlp_A"/>
      <ConstraintRegion from="85" to="103" loc="H" subId="17421397" subSource="6xlp_A"/>
      <ConstraintRegion from="104" to="116" loc="O" subId="17421398" subSource="6xlp_A"/>
      <ConstraintRegion from="117" to="123" loc="F" subId="17421399" subSource="6xlp_A"/>
      <ConstraintRegion from="124" to="135" loc="O" subId="17421400" subSource="6xlp_A"/>
      <ConstraintRegion from="136" to="157" loc="H" subId="17421401" subSource="6xlp_A"/>
      <ConstraintRegion from="158" to="159" loc="I" subId="17421402" subSource="6xlp_A"/>
      <ConstraintRegion from="160" to="165" loc="F" subId="17421403" subSource="6xlp_A"/>
      <ConstraintRegion from="166" to="166" loc="I" subId="17421404" subSource="6xlp_A"/>
      <ConstraintRegion from="167" to="186" loc="H" subId="17421405" subSource="6xlp_A"/>
      <ConstraintRegion from="187" to="196" loc="O" subId="17421406" subSource="6xlp_A"/>
      <ConstraintRegion from="197" to="202" loc="F" subId="17421407" subSource="6xlp_A"/>
      <ConstraintRegion from="203" to="214" loc="O" subId="17421408" subSource="6xlp_A"/>
      <ConstraintRegion from="215" to="220" loc="F" subId="17421409" subSource="6xlp_A"/>
      <ConstraintRegion from="221" to="586" loc="O" subId="17421410" subSource="6xlp_A"/>
    </Constraint>
  </Constraints>
</HtpItem>
