<?xml version="1.0" encoding="UTF-8"?>
<HtpItem id="F8VSK4_HUMAN" transmembrane="yes" evidence="3D">
  <Name>Acid sensing ion channel subunit 1 </Name>
  <CrossRef>
    <PDBTM id="6vtk">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6vtl">
      <Chain id="A"/>
      <Chain id="C"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="6l6i">
      <Chain id="B"/>
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6l6p">
      <Chain id="C"/>
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="7cfs">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="7rnn">
      <Chain id="D"/>
    </PDBTM>
    <PDBTM id="4fz1">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="E"/>
    </PDBTM>
    <PDBTM id="2qts">
      <Chain id="E"/>
      <Chain id="C"/>
      <Chain id="B"/>
      <Chain id="D"/>
      <Chain id="F"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="6ave">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6x9h">
      <Chain id="B"/>
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="4fz0">
      <Chain id="C"/>
      <Chain id="B"/>
      <Chain id="A"/>
    </PDBTM>
    <PDBTM id="5wku">
      <Chain id="B"/>
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5wkv">
      <Chain id="B"/>
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5wkx">
      <Chain id="B"/>
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="5wky">
      <Chain id="B"/>
      <Chain id="A"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6cmc">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="4nyk">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="6l6n">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="4ntw">
      <Chain id="A"/>
      <Chain id="D"/>
      <Chain id="G"/>
    </PDBTM>
    <PDBTM id="4ntx">
      <Chain id="A"/>
      <Chain id="D"/>
      <Chain id="G"/>
    </PDBTM>
    <PDBTM id="3s3w">
      <Chain id="C"/>
      <Chain id="A"/>
      <Chain id="B"/>
    </PDBTM>
    <PDBTM id="3s3x">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="3ij4">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="4nty">
      <Chain id="A"/>
      <Chain id="D"/>
      <Chain id="G"/>
    </PDBTM>
    <PDBTM id="7cft">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8on8">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8ona">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8on9">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <PDBTM id="8on7">
      <Chain id="A"/>
      <Chain id="B"/>
      <Chain id="C"/>
    </PDBTM>
    <TOPDB id="ASIC1_CHICK">
      <Alignment>
        <CrossRefSeq>MDLKVDEEEVDSGQPVSIQAFASSSTLHGISHIFSYERLSLKRVVWALCFMGSLALLALVCTNRIQYYFLYPHVTKLDEVAATRLTFPAVTFCNLNEFRFSRVTKNDLYHAGELLALLNNRYEIPDTQTADEKQLEILQDKANFRNFKPKPFNMLEFYDRAGHDIREMLLSCFFRGEQCSPEDFKV----VFTRYGKCYTFNAGQDGKPRLITMKGGTGNGLEIMLDIQQDEYLPVWGETDE</CrossRefSeq>
        <OrigSeq>MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCSAEDFKVKPMQVAKELRRCTLPGTVFQGTQ-------RARKGLHTLWKVLHVQLGPRWAAAAE</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="DEL10_CAEEL">
      <Alignment>
        <CrossRefSeq>IETDSGVIEVESDKQFLDAFKDANMDAVHHLNAASPVT--RGLWCMIIIAFVILVLVQCYSQIKLYISEPVATNIEAEYPSKISFPTVAICNNNQFRLTYLTGGRI--------MNRRSKSISGSLLSTGHDVESV-----FDTVLRKSWDMDAVKFLRSAAHWKSRMILGCTWPNGTSCKLSDFKAVWTTTGLCWAINTDPHNPYEVTGSGEGHGLRLLLNVESYE</CrossRefSeq>
        <OrigSeq>LKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNM--REFYDRAGHDIRDMLLSCHF-RGEVCSAEDFKVKPMQVAKELRRCTLPGTVFQGTQ-RARKGLHTLWKVLHVQ</OrigSeq>
      </Alignment>
    </TOPDB>
    <TOPDB id="UN105_CAEEL">
      <Alignment>
        <CrossRefSeq>KSFEKQSTFHGISHAATADGKW--RWFWYTAFTICLLALLIQIFFLISKYRQYGKTVDLD-LKFENAPFPSITICNLNPYKKSAIQSN</CrossRefSeq>
        <OrigSeq>QAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKN</OrigSeq>
      </Alignment>
    </TOPDB>
  </CrossRef>
  <Sequence Length="263" CheckSum="d4be6a5ad4dc4e3bf024ba30cb3c41de">
    <Seq>
      MELKAEEEEV GGVQPVSIQA FASSSTLHGL AHIFSYERLS LKRALWALCF
      LGSLAVLLCV CTERVQYYFH YHHVTKLDEV AASQLTFPAV TLCNLNEFRF
      SQVSKNDLYH AGELLALLNN RYEIPDTQMA DEKQLEILQD KANFRSFKPK
      PFNMREFYDR AGHDIRDMLL SCHFRGEVCS AEDFKVKPMQ VAKELRRCTL
      PGTVFQGTQR ARKGLHTLWK VLHVQLGPRW AAAAEDHEGW DGQWAGNHAG
      HPAGRVPACV GGD
    </Seq>
  </Sequence>
  <Topology numTm="1" reliability="87.77">
    <Region from="1" to="44" loc="I"/>
    <Region from="45" to="62" loc="M"/>
    <Region from="63" to="263" loc="O"/>
  </Topology>
  <Predictions>
    <Prediction name="Hmmtop">
      <Region from="1" to="43" loc="I"/>
      <Region from="44" to="61" loc="M"/>
      <Region from="62" to="263" loc="O"/>
    </Prediction>
    <Prediction name="Memsat">
      <Region from="1" to="43" loc="I"/>
      <Region from="44" to="66" loc="M"/>
      <Region from="67" to="263" loc="O"/>
    </Prediction>
    <Prediction name="Octopus">
      <Region from="1" to="27" loc="I"/>
      <Region from="28" to="34" loc="L"/>
      <Region from="35" to="42" loc="I"/>
      <Region from="43" to="63" loc="M"/>
      <Region from="64" to="75" loc="O"/>
      <Region from="76" to="96" loc="M"/>
      <Region from="97" to="106" loc="I"/>
      <Region from="107" to="114" loc="L"/>
      <Region from="115" to="263" loc="I"/>
    </Prediction>
    <Prediction name="Philius">
      <Region from="1" to="43" loc="I"/>
      <Region from="44" to="62" loc="M"/>
      <Region from="63" to="263" loc="O"/>
    </Prediction>
    <Prediction name="Phobius">
      <Region from="1" to="43" loc="O"/>
      <Region from="44" to="62" loc="M"/>
      <Region from="63" to="263" loc="I"/>
    </Prediction>
    <Prediction name="Pro">
      <Region from="1" to="15" loc="I"/>
      <Region from="16" to="36" loc="M"/>
      <Region from="37" to="40" loc="O"/>
      <Region from="41" to="61" loc="M"/>
      <Region from="62" to="263" loc="I"/>
    </Prediction>
    <Prediction name="Prodiv">
      <Region from="1" to="43" loc="I"/>
      <Region from="44" to="64" loc="M"/>
      <Region from="65" to="263" loc="O"/>
    </Prediction>
    <Prediction name="Scampi2">
      <Region from="1" to="43" loc="I"/>
      <Region from="44" to="64" loc="M"/>
      <Region from="65" to="263" loc="O"/>
    </Prediction>
    <Prediction name="ScampiMsa2">
      <Region from="1" to="43" loc="I"/>
      <Region from="44" to="64" loc="M"/>
      <Region from="65" to="263" loc="O"/>
    </Prediction>
    <Prediction name="SignalP">
      <Region/>
    </Prediction>
    <Prediction name="TMHMM">
      <Region/>
    </Prediction>
  </Predictions>
  <Constraints>
    <Constraint source="TOPDB" sourceId="8on8_A">
      <ConstraintRegion from="2" to="13" loc="I" subId="20887684" subSource="8on8_A"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887685" subSource="8on8_A"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887686" subSource="8on8_A"/>
      <ConstraintRegion from="30" to="53" loc="H" subId="20887687" subSource="8on8_A"/>
      <ConstraintRegion from="54" to="203" loc="O" subId="20887688" subSource="8on8_A"/>
      <ConstraintRegion from="208" to="494" loc="O" subId="20887690" subSource="8on8_A"/>
      <ConstraintRegion from="495" to="527" loc="H" subId="20887691" subSource="8on8_A"/>
      <ConstraintRegion from="528" to="529" loc="I" subId="20887692" subSource="8on8_A"/>
      <ConstraintRegion from="2" to="13" loc="I" subId="20887695" subSource="8on8_B"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887696" subSource="8on8_B"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887697" subSource="8on8_B"/>
      <ConstraintRegion from="30" to="53" loc="H" subId="20887698" subSource="8on8_B"/>
      <ConstraintRegion from="54" to="203" loc="O" subId="20887699" subSource="8on8_B"/>
      <ConstraintRegion from="208" to="494" loc="O" subId="20887701" subSource="8on8_B"/>
      <ConstraintRegion from="495" to="527" loc="H" subId="20887702" subSource="8on8_B"/>
      <ConstraintRegion from="528" to="529" loc="I" subId="20887703" subSource="8on8_B"/>
      <ConstraintRegion from="2" to="13" loc="I" subId="20887706" subSource="8on8_C"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887707" subSource="8on8_C"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887708" subSource="8on8_C"/>
      <ConstraintRegion from="30" to="53" loc="H" subId="20887709" subSource="8on8_C"/>
      <ConstraintRegion from="54" to="203" loc="O" subId="20887710" subSource="8on8_C"/>
      <ConstraintRegion from="208" to="494" loc="O" subId="20887712" subSource="8on8_C"/>
      <ConstraintRegion from="495" to="527" loc="H" subId="20887713" subSource="8on8_C"/>
      <ConstraintRegion from="528" to="529" loc="I" subId="20887714" subSource="8on8_C"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="8ona_A">
      <ConstraintRegion from="2" to="13" loc="I" subId="20887753" subSource="8ona_A"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887754" subSource="8ona_A"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887755" subSource="8ona_A"/>
      <ConstraintRegion from="30" to="56" loc="H" subId="20887756" subSource="8ona_A"/>
      <ConstraintRegion from="57" to="205" loc="O" subId="20887757" subSource="8ona_A"/>
      <ConstraintRegion from="211" to="493" loc="O" subId="20887759" subSource="8ona_A"/>
      <ConstraintRegion from="494" to="511" loc="H" subId="20887760" subSource="8ona_A"/>
      <ConstraintRegion from="513" to="527" loc="H" subId="20887761" subSource="8ona_A"/>
      <ConstraintRegion from="528" to="529" loc="I" subId="20887762" subSource="8ona_A"/>
      <ConstraintRegion from="2" to="13" loc="I" subId="20887765" subSource="8ona_B"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887766" subSource="8ona_B"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887767" subSource="8ona_B"/>
      <ConstraintRegion from="30" to="56" loc="H" subId="20887768" subSource="8ona_B"/>
      <ConstraintRegion from="57" to="205" loc="O" subId="20887769" subSource="8ona_B"/>
      <ConstraintRegion from="211" to="493" loc="O" subId="20887771" subSource="8ona_B"/>
      <ConstraintRegion from="494" to="511" loc="H" subId="20887772" subSource="8ona_B"/>
      <ConstraintRegion from="513" to="527" loc="H" subId="20887773" subSource="8ona_B"/>
      <ConstraintRegion from="528" to="529" loc="I" subId="20887774" subSource="8ona_B"/>
      <ConstraintRegion from="2" to="13" loc="I" subId="20887777" subSource="8ona_C"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887778" subSource="8ona_C"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887779" subSource="8ona_C"/>
      <ConstraintRegion from="30" to="56" loc="H" subId="20887780" subSource="8ona_C"/>
      <ConstraintRegion from="57" to="205" loc="O" subId="20887781" subSource="8ona_C"/>
      <ConstraintRegion from="211" to="493" loc="O" subId="20887783" subSource="8ona_C"/>
      <ConstraintRegion from="494" to="511" loc="H" subId="20887784" subSource="8ona_C"/>
      <ConstraintRegion from="513" to="527" loc="H" subId="20887785" subSource="8ona_C"/>
      <ConstraintRegion from="528" to="529" loc="I" subId="20887786" subSource="8ona_C"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="8on9_A">
      <ConstraintRegion from="2" to="13" loc="I" subId="20887717" subSource="8on9_A"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887718" subSource="8on9_A"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887719" subSource="8on9_A"/>
      <ConstraintRegion from="30" to="54" loc="H" subId="20887720" subSource="8on9_A"/>
      <ConstraintRegion from="55" to="205" loc="O" subId="20887721" subSource="8on9_A"/>
      <ConstraintRegion from="211" to="494" loc="O" subId="20887723" subSource="8on9_A"/>
      <ConstraintRegion from="495" to="511" loc="H" subId="20887724" subSource="8on9_A"/>
      <ConstraintRegion from="513" to="528" loc="H" subId="20887725" subSource="8on9_A"/>
      <ConstraintRegion from="529" to="530" loc="I" subId="20887726" subSource="8on9_A"/>
      <ConstraintRegion from="2" to="13" loc="I" subId="20887729" subSource="8on9_B"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887730" subSource="8on9_B"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887731" subSource="8on9_B"/>
      <ConstraintRegion from="30" to="54" loc="H" subId="20887732" subSource="8on9_B"/>
      <ConstraintRegion from="55" to="205" loc="O" subId="20887733" subSource="8on9_B"/>
      <ConstraintRegion from="211" to="494" loc="O" subId="20887735" subSource="8on9_B"/>
      <ConstraintRegion from="495" to="511" loc="H" subId="20887736" subSource="8on9_B"/>
      <ConstraintRegion from="513" to="528" loc="H" subId="20887737" subSource="8on9_B"/>
      <ConstraintRegion from="529" to="530" loc="I" subId="20887738" subSource="8on9_B"/>
      <ConstraintRegion from="2" to="13" loc="I" subId="20887741" subSource="8on9_C"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887742" subSource="8on9_C"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887743" subSource="8on9_C"/>
      <ConstraintRegion from="30" to="54" loc="H" subId="20887744" subSource="8on9_C"/>
      <ConstraintRegion from="55" to="205" loc="O" subId="20887745" subSource="8on9_C"/>
      <ConstraintRegion from="211" to="494" loc="O" subId="20887747" subSource="8on9_C"/>
      <ConstraintRegion from="495" to="511" loc="H" subId="20887748" subSource="8on9_C"/>
      <ConstraintRegion from="513" to="527" loc="H" subId="20887749" subSource="8on9_C"/>
      <ConstraintRegion from="528" to="530" loc="I" subId="20887750" subSource="8on9_C"/>
    </Constraint>
    <Constraint source="TOPDB" sourceId="8on7_A">
      <ConstraintRegion from="2" to="13" loc="I" subId="20887651" subSource="8on7_A"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887652" subSource="8on7_A"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887653" subSource="8on7_A"/>
      <ConstraintRegion from="30" to="54" loc="H" subId="20887654" subSource="8on7_A"/>
      <ConstraintRegion from="55" to="205" loc="O" subId="20887655" subSource="8on7_A"/>
      <ConstraintRegion from="209" to="494" loc="O" subId="20887657" subSource="8on7_A"/>
      <ConstraintRegion from="495" to="527" loc="H" subId="20887658" subSource="8on7_A"/>
      <ConstraintRegion from="528" to="529" loc="I" subId="20887659" subSource="8on7_A"/>
      <ConstraintRegion from="2" to="13" loc="I" subId="20887662" subSource="8on7_B"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887663" subSource="8on7_B"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887664" subSource="8on7_B"/>
      <ConstraintRegion from="30" to="54" loc="H" subId="20887665" subSource="8on7_B"/>
      <ConstraintRegion from="55" to="205" loc="O" subId="20887666" subSource="8on7_B"/>
      <ConstraintRegion from="209" to="494" loc="O" subId="20887668" subSource="8on7_B"/>
      <ConstraintRegion from="495" to="527" loc="H" subId="20887669" subSource="8on7_B"/>
      <ConstraintRegion from="528" to="529" loc="I" subId="20887670" subSource="8on7_B"/>
      <ConstraintRegion from="2" to="13" loc="I" subId="20887673" subSource="8on7_C"/>
      <ConstraintRegion from="14" to="23" loc="L" subId="20887674" subSource="8on7_C"/>
      <ConstraintRegion from="24" to="29" loc="I" subId="20887675" subSource="8on7_C"/>
      <ConstraintRegion from="30" to="54" loc="H" subId="20887676" subSource="8on7_C"/>
      <ConstraintRegion from="55" to="205" loc="O" subId="20887677" subSource="8on7_C"/>
      <ConstraintRegion from="209" to="494" loc="O" subId="20887679" subSource="8on7_C"/>
      <ConstraintRegion from="495" to="527" loc="H" subId="20887680" subSource="8on7_C"/>
      <ConstraintRegion from="528" to="529" loc="I" subId="20887681" subSource="8on7_C"/>
    </Constraint>
  </Constraints>
</HtpItem>
